Acyl-coenzyme A thioesterase 13

Details

Name
Acyl-coenzyme A thioesterase 13
Synonyms
  • 3.1.2.-
  • Acyl-CoA thioesterase 13
  • THEM2
  • Thioesterase superfamily member 2
Gene Name
ACOT13
Organism
Humans
Amino acid sequence
>lcl|BSEQ0008308|Acyl-coenzyme A thioesterase 13
MTSMTQSLREVIKAMTKARNFERVLGKITLVSAAPGKVICEMKVEEEHTNAIGTLHGGLT
ATLVDNISTMALLCTERGAPGVSVDMNITYMSPAKLGEDIVITAHVLKQGKTLAFTSVDL
TNKATGKLIAQGRHTKHLGN
Number of residues
140
Molecular Weight
14960.385
Theoretical pI
9.74
GO Classification
Functions
acyl-CoA hydrolase activity
Processes
cellular lipid metabolic process / long-chain fatty-acyl-CoA biosynthetic process / protein homotetramerization / small molecule metabolic process / triglyceride biosynthetic process
Components
cytosol / extracellular exosome / mitochondrion / nucleus / spindle
General Function
Acyl-coa hydrolase activity
Specific Function
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0019563|Acyl-coenzyme A thioesterase 13 (ACOT13)
ATGGTTAGAAAGATTACTCTTGTCTCTGCTGCTCCTGGGAAAGTGATTTGTGAAATGAAA
GTAGAAGAAGAGCATACCAATGCAATAGGCACTCTCCACGGCGGTTTGACAGCCACGTTA
GTAGATAACATATCAACAATGGCTCTGCTATGCACGGAAAGGGGAGCACCCGGAGTCAGT
GTCGATATGAACATAACGTACATGTCACCTGCAAAATTAGGAGAAGATATAGTGATTACA
GCACATGTTCTGAAGCAAGGAAAAACACTTGCATTTACCTCTGTGGATCTGACCAACAAG
GCCACAGGAAAATTAATAGCACAAGGAAGACACACAAAACACCTGGGAAACTGA
Chromosome Location
6
Locus
6p22.3
External Identifiers
ResourceLink
UniProtKB IDQ9NPJ3
UniProtKB Entry NameACO13_HUMAN
GenBank Protein ID7677052
GenBank Gene IDAF155649
HGNC IDHGNC:20999
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB086882-UndecanoneexperimentalunknownDetails