SLAM family member 7
Details
- Name
- SLAM family member 7
- Synonyms
- CD2 subset 1
- CD2-like receptor-activating cytotoxic cells
- CRACC
- CS1
- Membrane protein FOAP-12
- Novel Ly9
- Protein 19A
- Gene Name
- SLAMF7
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006764|SLAM family member 7 MAGSPTCLTLIYILWQLTGSAASGPVKELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPL VTIQPEGGTIIVTQNRNRERVDFPDGGYSLKLSKLKKNDSGIYYVGIYSSSLQQPSTQEY VLHVYEHLSKPKVTMGLQSNKNGTCVTNLTCCMEHGEEDVIYTWKALGQAANESHNGSIL PISWRWGESDMTFICVARNPVSRNFSSPILARKLCEGAADDPDSSMVLLCLLLVPLLLSL FVLGLFLWFLKRERQEEYIEEKKRVDICRETPNICPHSGENTEYDTIPHTNRTILKEDPA NTVYSTVEIPKKMENPHSLLTMPDTPRLFAYENVI
- Number of residues
- 335
- Molecular Weight
- 37420.62
- Theoretical pI
- 6.4
- GO Classification
- Processescell adhesion / natural killer cell activation / natural killer cell mediated cytotoxicity / regulation of immune responseComponentsintegral component of membrane / plasma membrane
- General Function
- Not Available
- Specific Function
- Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).Isoform 3 does not mediate any NK cell activation.
- Pfam Domain Function
- V-set (PF07686)
- Transmembrane Regions
- 227-247
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0012434|SLAM family member 7 (SLAMF7) ATGGCTGGTTCCCCAACATGCCTCACCCTCATCTATATCCTTTGGCAGCTCACAGGGTCA GCAGCCTCTGGACCCGTGAAAGAGCTGGTCGGTTCCGTTGGTGGGGCCGTGACTTTCCCC CTGAAGTCCAAAGTAAAGCAAGTTGACTCTATTGTCTGGACCTTCAACACAACCCCTCTT GTCACCATACAGCCAGAAGGGGGCACTATCATAGTGACCCAAAATCGTAATAGGGAGAGA GTAGACTTCCCAGATGGAGGCTACTCCCTGAAGCTCAGCAAACTGAAGAAGAATGACTCA GGGATCTACTATGTGGGGATATACAGCTCATCACTCCAGCAGCCCTCCACCCAGGAGTAC GTGCTGCATGTCTACGAGAACAATCCTAAAGGAAGATCCAGCAAATACGGTTTACTCCAC TGTGGAAATACCGAAAAAGATGGAAAATCCCCACTCACTGCTCACGATGCCAGACACACC AAGGCTATTTGCCTATGA
- Chromosome Location
- 1
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9NQ25 UniProtKB Entry Name SLAF7_HUMAN GenBank Gene ID BC027867 GenAtlas ID SLAMF7 HGNC ID HGNC:21394 - General References
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