Methionine-R-sulfoxide reductase B1
Details
- Name
- Methionine-R-sulfoxide reductase B1
- Synonyms
- 1.8.4.-
- MsrB1
- Selenoprotein X
- SelX
- SEPX1
- Gene Name
- MSRB1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0036984|Methionine-R-sulfoxide reductase B1 MSFCSFFGGEVFQNHFEPGVYVCAKCGYELFSSRSKYAHSSPWPAFTETIHADSVAKRPE HNRSEALKVSCGKCGNGLGHEFLNDGPKPGQSRFUIFSSSLKFVPKGKETSASQGH
- Number of residues
- 116
- Molecular Weight
- 12760.095
- Theoretical pI
- 8.39
- GO Classification
- Functionsactin binding / methionine-R-sulfoxide reductase activity / peptide-methionine (R)-S-oxide reductase activity / zinc ion bindingProcessesactin filament polymerization / innate immune response / protein repair / response to oxidative stressComponentsactin cytoskeleton / cytoplasm / nucleus
- General Function
- Zinc ion binding
- Specific Function
- Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages (By similarity).
- Pfam Domain Function
- SelR (PF01641)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0016056|Methionine-R-sulfoxide reductase B1 (MSRB1) ATGTCGTTCTGCAGCTTCTTCGGGGGCGAGGTTTTCCAGAATCACTTTGAACCTGGCGTT TACGTGTGTGCCAAGTGTGGCTATGAGCTGTTCTCCAGCCGCTCGAAGTATGCACACTCG TCTCCATGGCCGGCGTTCACCGAGACCATTCACGCCGACAGCGTGGCCAAGCGTCCGGAG CACAATAGATCTGAAGCCTTGAAGGTGTCCTGTGGCAAGTGTGGCAATGGGTTGGGCCAC GAGTTCCTGAACGACGGCCCCAAGCCGGGGCAGTCCCGATTCTGAATATTCAGCAGCTCG CTGAAGTTTGTCCCTAAAGGCAAAGAAACTTCTGCCTCCCAGGGTCACTAG
- Chromosome Location
- 16
- Locus
- 16p13.3
- External Identifiers
Resource Link UniProtKB ID Q9NZV6 UniProtKB Entry Name MSRB1_HUMAN GenBank Protein ID 6649219 GenBank Gene ID AF166124 GenAtlas ID SEPX1 HGNC ID HGNC:14133 - General References
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