NAD(P)H dehydrogenase (quinone)
Details
- Name
- NAD(P)H dehydrogenase (quinone)
- Synonyms
- 1.6.5.2
- Flavoprotein WrbA
- NAD(P)H:quinone oxidoreductase
- NQO
- Gene Name
- Not Available
- Organism
- Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
- Amino acid sequence
>lcl|BSEQ0016973|NAD(P)H dehydrogenase (quinone) MTAPVKLAIVFYSSTGTGYAMAQEAAEAGRAAGAEVRLLKVRETAPQDVIDGQDAWKANI EAMKDVPEATPADLEWAEAIVFSSPTRFGGATSQMRAFIDTLGGLWSSGKLANKTFSAMT SAQNVNGGQETTLQTLYMTAMHWGAVLTPPGYTDEVIFKSGGNPYGASVTANGQPLLEND RASIRHQVRRQVELTAKLLG
- Number of residues
- 200
- Molecular Weight
- 21297.875
- Theoretical pI
- 5.27
- GO Classification
- FunctionsFMN binding / NAD(P)H dehydrogenase (quinone) activityProcessesnegative regulation of transcription, DNA-templated
- General Function
- Nad(p)h dehydrogenase (quinone) activity
- Specific Function
- It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide (By similarity).
- Pfam Domain Function
- FMN_red (PF03358)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016974|NAD(P)H dehydrogenase (quinone) ATGACCGCTCCTGTCAAGCTCGCCATCGTCTTTTATTCCAGCACCGGCACCGGCTACGCC ATGGCCCAGGAAGCCGCCGAGGCGGGCCGCGCCGCCGGGGCCGAGGTGCGGCTGCTCAAG GTGCGCGAAACTGCTCCGCAAGACGTGATTGACGGCCAGGACGCCTGGAAAGCCAACATC GAGGCGATGAAAGACGTACCAGAGGCGACCCCCGCCGACCTCGAATGGGCCGAAGCCATC GTGTTCAGCTCGCCCACCCGTTTCGGCGGCGCGACGAGCCAGATGCGGGCGTTCATCGAC ACCCTCGGCGGCCTGTGGTCAAGCGGCAAACTGGCGAACAAGACCTTCAGCGCAATGACT TCGGCCCAGAATGTCAACGGCGGCCAGGAAACTACCCTGCAAACGCTGTACATGACGGCG ATGCACTGGGGCGCGGTTCTGACGCCTCCCGGCTACACCGACGAGGTGATTTTCAAGTCC GGTGGCAACCCCTACGGCGCGAGCGTAACCGCCAACGGCCAGCCGCTGCTGGAGAATGAC CGGGCGAGCATCCGCCATCAGGTCAGGCGGCAGGTGGAGTTGACGGCGAAGCTGCTCGGC TGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9RYU4 UniProtKB Entry Name NQOR_DEIRA GenBank Gene ID AE001825 - General References
- White O, Eisen JA, Heidelberg JF, Hickey EK, Peterson JD, Dodson RJ, Haft DH, Gwinn ML, Nelson WC, Richardson DL, Moffat KS, Qin H, Jiang L, Pamphile W, Crosby M, Shen M, Vamathevan JJ, Lam P, McDonald L, Utterback T, Zalewski C, Makarova KS, Aravind L, Daly MJ, Minton KW, Fleischmann RD, Ketchum KA, Nelson KE, Salzberg S, Smith HO, Venter JC, Fraser CM: Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1. Science. 1999 Nov 19;286(5444):1571-7. [Article]
- Gorman J, Shapiro L: Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide. Protein Sci. 2005 Dec;14(12):3004-12. [Article]