Lymphoid enhancer-binding factor 1

Details

Name
Lymphoid enhancer-binding factor 1
Synonyms
  • LEF-1
  • T cell-specific transcription factor 1-alpha
  • TCF1-alpha
Gene Name
LEF1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049735|Lymphoid enhancer-binding factor 1
MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE
SEIIPASNGHEVARQAQTSQEPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNM
NNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNS
KQGMSRHPPAPDIPTFYPLSPGGVGQITPPLGWQGQPVYPITGGFRQPYPSSLSVDTSMS
RFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIK
KPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHM
QLYPGWSARDNYGKKKKRKREKLQESASGTGPRMTAAYI
Number of residues
399
Molecular Weight
44200.41
Theoretical pI
Not Available
GO Classification
Functions
armadillo repeat domain binding / beta-catenin binding / C2H2 zinc finger domain binding / chromatin binding / cysteine-type endopeptidase inhibitor activity involved in apoptotic process / DNA binding / DNA binding, bending / enhancer binding / estrogen receptor activity / estrogen receptor binding / gamma-catenin binding / histone binding / histone deacetylase binding / RNA polymerase II core promoter proximal region sequence-specific DNA binding / RNA polymerase II regulatory region sequence-specific DNA binding / sequence-specific DNA binding / transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding / transcription factor activity, sequence-specific DNA binding / transcription factor binding / transcription regulatory region DNA binding / transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding / transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Processes
alpha-beta T cell differentiation / anatomical structure regression / apoptotic process involved in blood vessel morphogenesis / apoptotic process involved in morphogenesis / B cell proliferation / beta-catenin-TCF complex assembly / BMP signaling pathway / branching involved in blood vessel morphogenesis / canonical Wnt signaling pathway / cell chemotaxis / cellular response to cytokine stimulus / cellular response to interleukin-4 / chorio-allantoic fusion / dentate gyrus development / embryonic limb morphogenesis / epithelial to mesenchymal transition / eye pigmentation / face morphogenesis / forebrain neuroblast division / forebrain neuron differentiation / forebrain radial glial cell differentiation / formation of radial glial scaffolds / histone H3 acetylation / histone H4 acetylation / hypothalamus development / mammary gland development / muscle fiber development / negative regulation of apoptotic process / negative regulation of apoptotic process in bone marrow / negative regulation of canonical Wnt signaling pathway / negative regulation of cell-cell adhesion / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / negative regulation of DNA binding / negative regulation of estrogen receptor binding / negative regulation of interleukin-13 production / negative regulation of interleukin-4 production / negative regulation of interleukin-5 production / negative regulation of striated muscle tissue development / negative regulation of transcription from RNA polymerase II promoter / negative regulation of transcription, DNA-templated / neural crest cell migration / neutrophil differentiation / odontoblast differentiation / odontogenesis of dentin-containing tooth / osteoblast differentiation / palate development / paraxial mesoderm formation / positive regulation by host of viral transcription / positive regulation of cell cycle process / positive regulation of cell growth / positive regulation of cell migration / positive regulation of cell proliferation / positive regulation of cell proliferation in bone marrow / positive regulation of cell-cell adhesion / positive regulation of epithelial to mesenchymal transition / positive regulation of gene expression / positive regulation of granulocyte differentiation / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription, DNA-templated / regulation of cell-cell adhesion / regulation of striated muscle tissue development / sensory perception of taste / somitogenesis / sprouting angiogenesis / T cell receptor V(D)J recombination / T-helper 1 cell differentiation / tongue development / trachea gland development / transcription from RNA polymerase II promoter / Wnt signaling pathway / Wnt signaling pathway, calcium modulating pathway
Components
beta-catenin-TCF complex / cytoplasm / nucleoplasm / nucleus / protein-DNA complex / transcription factor complex
General Function
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
Specific Function
Armadillo repeat domain binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0049736|Lymphoid enhancer-binding factor 1 (LEF1)
ATGCCCCAACTCTCCGGAGGAGGTGGCGGCGGCGGGGGGGACCCGGAACTCTGCGCCACG
GACGAGATGATCCCCTTCAAGGACGAGGGCGATCCTCAGAAGGAAAAGATCTTCGCCGAG
ATCAGTCATCCCGAAGAGGAAGGCGATTTAGCTGACATCAAGTCTTCCTTGGTGAACGAG
TCTGAAATCATCCCGGCCAGCAACGGACACGAGGTGGCCAGACAAGCACAAACCTCTCAG
GAGCCCTACCACGACAAGGCCAGAGAACACCCCGATGACGGAAAGCATCCAGATGGAGGC
CTCTACAACAAGGGACCCTCCTACTCGAGTTATTCCGGGTACATAATGATGCCAAATATG
AATAACGACCCATACATGTCAAATGGATCTCTTTCTCCACCCATCCCGAGAACATCAAAT
AAAGTGCCCGTGGTGCAGCCATCCCATGCGGTCCATCCTCTCACCCCCCTCATCACTTAC
AGTGACGAGCACTTTTCTCCAGGATCACACCCGTCACACATCCCATCAGATGTCAACTCC
AAACAAGGCATGTCCAGACATCCTCCAGCTCCTGATATCCCTACTTTTTATCCCTTGTCT
CCGGGTGGTGTTGGACAGATCACCCCACCTCTTGGCTGGCAAGGTCAGCCTGTATATCCC
ATCACGGGTGGATTCAGGCAACCCTACCCATCCTCACTGTCAGTCGACACTTCCATGTCC
AGGTTTTCCCATCATATGATTCCCGGTCCTCCTGGTCCCCACACAACTGGCATCCCTCAT
CCAGCTATTGTAACACCTCAGGTCAAACAGGAACATCCCCACACTGACAGTGACCTAATG
CACGTGAAGCCTCAGCATGAACAGAGAAAGGAGCAGGAGCCAAAAAGACCTCACATTAAG
AAGCCTCTGAATGCTTTTATGTTATACATGAAAGAAATGAGAGCGAATGTCGTTGCTGAG
TGTACTCTAAAAGAAAGTGCAGCTATCAACCAGATTCTTGGCAGAAGGTGGCATGCCCTC
TCCCGTGAAGAGCAGGCTAAATATTATGAATTAGCACGGAAAGAAAGACAGCTACATATG
CAGCTTTATCCAGGCTGGTCTGCAAGAGACAATTATGGTAAGAAAAAGAAGAGGAAGAGA
GAGAAACTACAGGAATCTGCATCAGGTACAGGTCCAAGAATGACAGCTGCCTACATCTGA
Chromosome Location
4
Locus
4q25
External Identifiers
ResourceLink
UniProtKB IDQ9UJU2
UniProtKB Entry NameLEF1_HUMAN
HGNC IDHGNC:6551
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00903Etacrynic acidapproved, investigationalunknownDetails