Serine/threonine-protein kinase tousled-like 1

Details

Name

Serine/threonine-protein kinase tousled-like 1

Synonyms

• 2.7.11.1
• KIAA0137
• PKU-beta
• Tousled-like kinase 1

Gene Name

TLK1

Organism

Humans

Amino acid sequence

>lcl|BSEQ0051672|Serine/threonine-protein kinase tousled-like 1
MSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQ
ELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESS
RGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTP
SSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRID
DLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRL
GHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAP
STNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAE
LERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQR
YAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEY
CEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTAC
GEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSV
GVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKE
DRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY

Number of residues

766

Molecular Weight

86698.925

Theoretical pI

Not Available

GO Classification

Functions

ATP binding / protein serine/threonine kinase activity

Processes

cell cycle / cellular response to DNA damage stimulus / chromatin organization / intracellular protein transport / intracellular signal transduction / protein phosphorylation / regulation of chromatin assembly or disassembly

Components

nucleus

General Function

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.

Specific Function

Atp binding

Pfam Domain Function

• Pkinase (PF00069)

Transmembrane Regions

Not Available

Cellular Location

Nucleus

Gene sequence

>lcl|BSEQ0051673|Serine/threonine-protein kinase tousled-like 1 (TLK1)
ATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCTTGGTCCCAGCTCTCC
ACGTCTCCAACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCA
TCCGGGAGGCCCAGGGAAGGTGCAATGGATGAGCTTCATAGTCTGGATCCAAGAAGGCAA
GAGTTATTGGAAGCTAGATTTACTGGAGTTGCAAGTGGGAGCACTGGAAGTACGGGCAGT
TGCAGTGTTGGAGCTAAAGCCTCAACAAATAACGAAAGCTCTAATCACAGTTTTGGAAGC
TTGGGATCTTTAAGTGACAAAGAATCAGAGACACCGGAGAAGAAACAATCGGAATCATCC
AGGGGAAGAAAGAGAAAAGCAGAAAACCAGAATGAAAGTAGTCAGGGAAAAAGTATTGGG
GGACGTGGCCACAAAATTAGCGACTATTTTGAATACCAGGGTGGAAATGGCTCAAGTCCA
GTAAGAGGCATACCTCCTGCAATCCGTTCTCCTCAAAATTCACATTCACATTCCACTCCT
TCCTCATCTGTTCGACCGAATAGCCCTTCTCCTACTGCATTAGCATTTGGGGACCACCCT
ATTGTACAACCAAAGCAATTATCCTTTAAAATTATTCAGACTGATCTCACAATGCTGAAA
TTAGCAGCATTAGAAAGTAATAAAATCCAGGACCTGGAAAAGAAGGAGGGACGTATAGAT
GATTTGCTCAGGGCTAACTGTGATCTCAGACGGCAAATAGATGAACAACAAAAATTACTT
GAAAAATACAAAGAACGATTAAATAAGTGCATATCAATGAGCAAGAAACTTCTTATTGAA
AAGAGTACACAAGAAAAGCTGTCAAGCAGAGAGAAGAGTATGCAAGATCGATTACGCCTC
GGGCACTTTACAACAGTTAGACATGGCGCTTCATTTACTGAACAATGGACAGATGGTTTT
GCATTTCAGAATCTTGTGAAGCAACAAGAATGGGTGAATCAGCAAAGGGAAGATATTGAA
AGGCAAAGGAAACTTCTAGCCAAACGCAAACCTCCCACAGCTAATAATTCTCAGGCACCC
TCTACCAATTCTGAACCAAAACAAAGGAAAAACAAAGCAGTCAATGGAGCAGAGAATGAT
CCCTTTGTTAGACCAAATTTACCACAACTGTTGACTTTGGCAGAATATCATGAACAGGAA
GAAATTTTCAAACTTAGACTAGGACATCTCAAAAAGGAAGAGGCAGAAATCCAGGCAGAA
CTTGAACGTTTGGAAAGAGTCAGAAATCTTCACATACGTGAGCTGAAAAGAATAAACAAT
GAAGATAATTCACAGTTCAAAGATCACCCAACATTAAATGAAAGATATTTATTACTTCAT
CTGCTTGGTAGAGGTGGCTTTAGTGAAGTGTATAAGGCTTTTGACCTTTATGAACAAAGA
TATGCTGCTGTGAAGATACATCAGCTTAATAAAAGCTGGAGAGATGAGAAGAAAGAAAAC
TACCACAAACATGCCTGCAGAGAGTATAGAATACACAAAGAACTGGATCACCCCAGAATA
GTTAAACTCTATGATTATTTCTCCTTGGATACAGATACGTTTTGTACAGTGTTAGAATAC
TGTGAAGGCAATGACTTGGATTTCTATCTGAAGCAACACAAGTTAATGTCAGAGAAAGAA
GCTCGGTCTATTGTAATGCAGATTGTAAATGCACTAAGATATCTCAATGAGATCAAACCC
CCTATTATACATTATGATCTTAAGCCAGGAAACATCCTACTGGTAGATGGAACAGCATGT
GGTGAAATCAAAATCACTGATTTTGGTCTGTCCAAGATTATGGATGATGATAGCTATGGT
GTAGATGGAATGGATCTAACTTCCCAGGGGGCAGGCACTTACTGGTATTTACCTCCTGAG
TGTTTTGTAGTTGGAAAAGAGCCACCAAAGATTTCCAACAAGGTTGATGTATGGTCGGTT
GGAGTCATCTTCTTTCAGTGTCTTTATGGTAGAAAGCCATTTGGTCACAATCAATCTCAA
CAAGACATTCTTCAAGAAAATACAATATTAAAAGCCACAGAAGTCCAGTTCCCTGTAAAA
CCGGTTGTAAGCAGTGAAGCCAAGGCATTTATAAGACGCTGTTTGGCATATCGAAAAGAA
GATCGATTTGATGTGCACCAGCTGGCAAATGACCCATACCTTCTCCCACACATGAGAAGA
TCAAATTCTTCAGGAAACCTACACATGGCTGGGCTGACAGCATCCCCTACACCCCCTTCT
TCAAGCATAATTACTTACTGA

Chromosome Location

2

Locus

2q31.1

External Identifiers

Resource	Link
UniProtKB ID	Q9UKI8
UniProtKB Entry Name	TLK1_HUMAN
HGNC ID	HGNC:11841

General References

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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB12010	Fostamatinib	approved, investigational	unknown	inhibitor	Details