C-type lectin domain family 4 member E
Details
- Name
- C-type lectin domain family 4 member E
- Synonyms
- C-type lectin superfamily member 9
- CLECSF9
- Macrophage-inducible C-type lectin
- MINCLE
- Gene Name
- CLEC4E
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049901|C-type lectin domain family 4 member E MNSSKSSETQCTERGCFSSQMFLWTVAGIPILFLSACFITRCVVTFRIFQTCDEKKFQLP ENFTELSCYNYGSGSVKNCCPLNWEYFQSSCYFFSTDTISWALSLKNCSAMGAHLVVINS QEEQEFLSYKKPKMREFFIGLSDQVVEGQWQWVDGTPLTKSLSFWDVGEPNNIATLEDCA TMRDSSNPRQNWNDVTCFLNYFRICEMVGINPLNKGKSL
- Number of residues
- 219
- Molecular Weight
- 25072.31
- Theoretical pI
- Not Available
- GO Classification
- Functionscarbohydrate binding / receptor activityProcessesdefense response to bacterium / Fc-gamma receptor signaling pathway / innate immune response / positive regulation of cytokine secretion / stimulatory C-type lectin receptor signaling pathway / T cell differentiation involved in immune responseComponentsintegral component of membrane / plasma membrane
- General Function
- C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
- Specific Function
- Carbohydrate binding
- Pfam Domain Function
- Lectin_C (PF00059)
- Transmembrane Regions
- 20-40
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0049902|C-type lectin domain family 4 member E (CLEC4E) ATGAATTCATCTAAATCATCTGAAACACAATGCACAGAGAGAGGATGCTTCTCTTCCCAA ATGTTCTTATGGACTGTTGCTGGGATCCCCATCCTATTTCTCAGTGCCTGTTTCATCACC AGATGTGTTGTGACATTTCGCATCTTTCAAACCTGTGATGAGAAAAAGTTTCAGCTACCT GAGAATTTCACAGAGCTCTCCTGCTACAATTATGGATCAGGTTCAGTCAAGAATTGTTGT CCATTGAACTGGGAATATTTTCAATCCAGCTGCTACTTCTTTTCTACTGACACCATTTCC TGGGCGTTAAGTTTAAAGAACTGCTCAGCCATGGGGGCTCACCTGGTGGTTATCAACTCA CAGGAGGAGCAGGAATTCCTTTCCTACAAGAAACCTAAAATGAGAGAGTTTTTTATTGGA CTGTCAGACCAGGTTGTCGAGGGTCAGTGGCAATGGGTGGACGGCACACCTTTGACAAAG TCTCTGAGCTTCTGGGATGTAGGGGAGCCCAACAACATAGCTACCCTGGAGGACTGTGCC ACCATGAGAGACTCTTCAAACCCAAGGCAAAATTGGAATGATGTAACCTGTTTCCTCAAT TATTTTCGGATTTGTGAAATGGTAGGAATAAATCCTTTGAACAAAGGAAAATCTCTTTAA
- Chromosome Location
- 12
- Locus
- 12p13.31
- External Identifiers
Resource Link UniProtKB ID Q9ULY5 UniProtKB Entry Name CLC4E_HUMAN HGNC ID HGNC:14555 - General References
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