tRNA-dihydrouridine synthase

Details

Name
tRNA-dihydrouridine synthase
Synonyms
  • 1.3.1.-
Gene Name
Not Available
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Amino acid sequence
>lcl|BSEQ0019370|tRNA-dihydrouridine synthase
MEVKVGLAPMAGYTDSAFRTLAFEWGADFAFSEMVSAKGFLMNSQKTEELLPQPHERNVA
VQIFGSEPNELSEAARILSEKYKWIDLNAGCPVRKVVKKGAGGALLKDLRHFRYIVRELR
KSVSGKFSVKTRLGWEKNEVEEIYRILVEEGVDEVFIHTRTVVQSFTGRAEWKALSVLEK
RIPTFVSGDIFTPEDAKRALEESGCDGLLVARGAIGRPWIFKQIKDFLRSGKYSEPSREE
ILRTFERHLELLIKTKGERKAVVEMRKFLAGYTKDLKGARRFREKVMKIEEVQILKEMFY
NFIKEV
Number of residues
306
Molecular Weight
35149.495
Theoretical pI
9.91
GO Classification
Functions
flavin adenine dinucleotide binding / tRNA dihydrouridine synthase activity
General Function
Trna dihydrouridine synthase activity
Specific Function
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0019371|tRNA-dihydrouridine synthase
ATGGAGGTTAAAGTCGGTCTTGCGCCGATGGCTGGATACACTGATTCAGCATTCCGCACT
CTGGCTTTCGAATGGGGTGCGGATTTTGCTTTCTCTGAAATGGTGAGTGCAAAGGGTTTT
CTCATGAACTCTCAAAAAACAGAAGAACTCTTACCACAACCACATGAAAGAAACGTGGCG
GTCCAGATCTTTGGAAGCGAACCGAACGAACTTTCTGAGGCAGCGAGGATTCTCTCTGAA
AAGTACAAGTGGATAGATTTGAACGCTGGTTGCCCTGTGAGAAAAGTTGTAAAAAAAGGA
GCAGGCGGAGCTTTGTTGAAAGATTTGAGACATTTTCGATACATTGTGAGGGAGCTCAGA
AAGAGTGTTTCTGGCAAATTTTCTGTGAAAACTCGCCTTGGATGGGAGAAAAATGAAGTC
GAGGAGATATATCGAATACTCGTTGAGGAAGGGGTGGATGAGGTATTCATTCACACGAGA
ACGGTGGTTCAGAGTTTCACTGGGAGGGCTGAATGGAAGGCGTTGAGTGTTCTGGAAAAG
AGAATTCCTACCTTTGTGAGTGGTGATATCTTCACTCCAGAAGACGCCAAGAGGGCTCTG
GAAGAAAGCGGATGTGATGGTCTTCTGGTAGCGAGAGGTGCTATAGGAAGACCTTGGATT
TTCAAACAGATAAAGGATTTCCTCCGAAGCGGAAAGTACTCTGAACCGTCCCGGGAAGAG
ATTCTTAGAACGTTCGAAAGACATCTCGAGCTGTTGATAAAGACGAAGGGTGAAAGAAAA
GCGGTTGTGGAAATGAGAAAGTTTCTGGCAGGTTATACAAAGGATCTGAAAGGCGCAAGG
AGATTCAGAGAGAAAGTTATGAAAATAGAAGAAGTTCAAATTTTAAAAGAGATGTTTTAT
AATTTCATCAAGGAGGTGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9WXV1
UniProtKB Entry NameQ9WXV1_THEMA
GenBank Gene IDAE000512
General References
  1. Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]
  2. Latif H, Lerman JA, Portnoy VA, Tarasova Y, Nagarajan H, Schrimpe-Rutledge AC, Smith RD, Adkins JN, Lee DH, Qiu Y, Zengler K: The genome organization of Thermotoga maritima reflects its lifestyle. PLoS Genet. 2013 Apr;9(4):e1003485. doi: 10.1371/journal.pgen.1003485. Epub 2013 Apr 25. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03247Flavin mononucleotideapproved, investigationalunknownDetails