Signal recognition particle receptor FtsY

Details

Name

Signal recognition particle receptor FtsY

Synonyms

• SRP receptor

Gene Name

ftsY

Organism

Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

Amino acid sequence

>lcl|BSEQ0012276|Signal recognition particle receptor FtsY
MGLFDFLKKGLQKTKETFFGRVVKLLKGKKLDDETREELEELLIQADVGVETTEYILERL
EEKDGDALESLKEIILEILNFDTKLNVPPEPPFVIMVVGVNGTGKTTSCGKLAKMFVDEG
KSVVLAAADTFRAAAIEQLKIWGERVGATVISHSEGADPAAVAFDAVAHALARNKDVVII
DTAGRLHTKKNLMEELRKVHRVVKKKIPDAPHETLLVIDATTGQNGLVQAKIFKEAVNVT
GIILTKLDGTAKGGITLAIARELGIPIKFIGVGEKAEDLRPFDPEAFVEVLLSE

Number of residues

294

Molecular Weight

32045.975

Theoretical pI

5.32

GO Classification

Functions

GTP binding / GTPase activity

Processes

cell division / SRP-dependent cotranslational protein targeting to membrane

Components

cytoplasm / intrinsic component of plasma membrane

General Function

Gtpase activity

Specific Function

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).

Pfam Domain Function

• SRP54 (PF00448)
• SRP54_N (PF02881)

Transmembrane Regions

Not Available

Cellular Location

Cell inner membrane

Gene sequence

>lcl|BSEQ0012277|Signal recognition particle receptor FtsY (ftsY)
ATGGGACTCTTCGATTTTTTGAAAAAGGGACTCCAGAAGACGAAAGAAACGTTTTTTGGA
CGAGTGGTGAAGCTCCTCAAAGGAAAAAAGCTGGACGATGAAACCCGCGAGGAGCTGGAA
GAACTTCTCATTCAAGCGGACGTGGGAGTCGAGACAACGGAATACATTCTGGAGAGATTG
GAAGAGAAGGACGGAGACGCTCTCGAGTCTCTCAAGGAAATCATTCTGGAAATTCTGAAC
TTCGATACGAAGCTGAACGTTCCTCCTGAACCCCCGTTCGTGATCATGGTTGTTGGTGTC
AACGGAACGGGAAAGACCACCTCCTGTGGAAAGCTCGCAAAGATGTTCGTGGATGAAGGA
AAGAGTGTGGTGCTCGCTGCGGCGGATACTTTCAGAGCAGCCGCCATAGAACAGCTGAAG
ATATGGGGAGAACGTGTCGGTGCCACGGTGATATCCCACTCGGAAGGAGCAGATCCGGCC
GCCGTTGCCTTTGACGCGGTGGCTCACGCTCTCGCCAGAAACAAAGATGTGGTCATAATA
GACACCGCCGGAAGACTTCACACGAAGAAGAATCTCATGGAGGAATTGCGGAAGGTTCAC
AGAGTTGTCAAGAAGAAGATCCCCGACGCTCCGCACGAAACGCTCCTCGTGATAGACGCC
ACCACCGGCCAAAACGGACTTGTTCAGGCAAAAATATTCAAAGAAGCAGTGAATGTCACC
GGTATAATTCTCACAAAGCTCGACGGAACCGCGAAAGGCGGAATAACTCTGGCCATTGCC
CGGGAACTGGGAATTCCCATAAAGTTCATCGGTGTCGGAGAAAAGGCAGAAGACCTGAGG
CCTTTCGATCCTGAGGCCTTTGTGGAGGTATTGCTTTCAGAATGA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q9WZ40
UniProtKB Entry Name	Q9WZ40_THEMA
GenBank Gene ID	AE000512

General References

1. Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]
2. Latif H, Lerman JA, Portnoy VA, Tarasova Y, Nagarajan H, Schrimpe-Rutledge AC, Smith RD, Adkins JN, Lee DH, Qiu Y, Zengler K: The genome organization of Thermotoga maritima reflects its lifestyle. PLoS Genet. 2013 Apr;9(4):e1003485. doi: 10.1371/journal.pgen.1003485. Epub 2013 Apr 25. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB04272	Citric acid	approved, nutraceutical, vet_approved	unknown		Details