Nuclear migration protein nudC

Details

Name

Nuclear migration protein nudC

Synonyms

• Nuclear distribution protein C homolog

Gene Name

NUDC

Organism

Humans

Amino acid sequence

>lcl|BSEQ0049773|Nuclear migration protein nudC
MGGEQEEERFDGMLLAMAQQHEGGVQELVNTFFSFLRRKTDFFIGGEEGMAEKLITQTFS
HHNQLAQKTRREKRARQEAERREKAERAARLAKEAKSETSGPQIKELTDEEAERLQLEID
QKKDAENHEAQLKNGSLDSPGKQDTEEDEEEDEKDKGKLKPNLGNGADLPNYRWTQTLSE
LDLAVPFCVNFRLKGKDMVVDIQRRHLRVGLKGQPAIIDGELYNEVKVEESSWLIEDGKV
VTVHLEKINKMEWWSRLVSSDPEINTKKINPENSKLSDLDSETRSMVEKMMYDQRQKSMG
LPTSDEQKKQEILKKFMDQHPEMDFSKAKFN

Number of residues

331

Molecular Weight

38242.7

Theoretical pI

Not Available

GO Classification

Functions

cadherin binding / unfolded protein binding

Processes

cell division / cell proliferation / multicellular organism development / protein folding / sister chromatid cohesion

Components

cytoplasm / cytosol / microtubule / nucleoplasm

General Function

Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.

Specific Function

Cadherin binding

Pfam Domain Function

• CS (PF04969)
• NuDC (PF16273)
• Nudc_N (PF14050)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0049774|Nuclear migration protein nudC (NUDC)
ATGGGCGGAGAGCAGGAGGAGGAGCGGTTCGACGGCATGTTGCTGGCCATGGCTCAGCAG
CACGAGGGCGGCGTGCAGGAGCTTGTGAACACCTTCTTCAGCTTCCTTCGACGCAAAACA
GACTTTTTCATTGGAGGAGAAGAAGGGATGGCAGAGAAGCTTATCACACAGACTTTCAGC
CACCACAATCAGCTGGCACAGAAGACCCGGCGGGAGAAGAGAGCCCGGCAGGAGGCCGAG
CGGCGGGAGAAGGCGGAGCGGGCGGCCAGACTGGCCAAGGAAGCCAAGTCAGAGACCTCA
GGGCCCCAGATCAAGGAGCTAACTGATGAAGAGGCAGAGAGGCTGCAGCTAGAGATTGAC
CAGAAAAAGGATGCAGAGAATCATGAGGCCCAGCTCAAGAACGGCAGCCTTGACTCCCCA
GGGAAGCAGGATACTGAGGAAGATGAGGAGGAAGATGAGAAGGACAAAGGAAAACTGAAG
CCCAACCTAGGCAACGGGGCAGACCTGCCCAATTACCGCTGGACCCAGACCCTGTCGGAG
CTGGACCTGGCGGTCCCTTTCTGTGTGAACTTCCGGCTGAAAGGGAAGGACATGGTGGTG
GACATCCAGCGGCGGCACCTCCGGGTGGGGCTCAAGGGGCAGCCAGCGATCATTGATGGG
GAGCTCTACAATGAAGTGAAGGTGGAGGAGAGCTCGTGGCTCATTGAGGACGGCAAGGTG
GTGACTGTGCATCTGGAGAAGATCAATAAGATGGAGTGGTGGAGCCGCTTGGTGTCCAGT
GACCCTGAGATCAACACCAAGAAGATTAACCCTGAGAATTCCAAGCTGTCAGACCTGGAC
AGTGAGACTCGCAGCATGGTGGAAAAGATGATGTATGACCAGCGACAGAAGTCCATGGGG
CTGCCAACTTCAGACGAACAGAAGAAACAGGAGATTCTGAAGAAGTTCATGGATCAACAT
CCGGAGATGGATTTTTCCAAGGCTAAATTCAACTAG

Chromosome Location

1

Locus

1p36.11

External Identifiers

Resource	Link
UniProtKB ID	Q9Y266
UniProtKB Entry Name	NUDC_HUMAN
HGNC ID	HGNC:8045

General References

1. Miller BA, Zhang MY, Gocke CD, De Souza C, Osmani AH, Lynch C, Davies J, Bell L, Osmani SA: A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis. Exp Hematol. 1999 Apr;27(4):742-50. [Article]
2. Matsumoto N, Ledbetter DH: Molecular cloning and characterization of the human NUDC gene. Hum Genet. 1999 Jun;104(6):498-504. [Article]
3. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A: Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res. 2001 Mar;11(3):422-35. [Article]
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5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
6. Zhou T, Aumais JP, Liu X, Yu-Lee LY, Erikson RL: A role for Plk1 phosphorylation of NudC in cytokinesis. Dev Cell. 2003 Jul;5(1):127-38. [Article]
7. Aumais JP, Williams SN, Luo W, Nishino M, Caldwell KA, Caldwell GA, Lin SH, Yu-Lee LY: Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis. J Cell Sci. 2003 May 15;116(Pt 10):1991-2003. Epub 2003 Apr 1. [Article]
8. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [Article]
9. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
10. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [Article]
11. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [Article]
12. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. [Article]
13. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
14. Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570. [Article]
15. Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S: Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71. doi: 10.1021/pr300630k. Epub 2012 Dec 18. [Article]
16. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
17. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB12695	Phenethyl Isothiocyanate	investigational	unknown		Details