Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Details
- Name
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B
- Synonyms
- 2.7.12.1
- Minibrain-related kinase
- MIRK
- Mirk protein kinase
- Gene Name
- DYRK1B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051742|Dual specificity tyrosine-phosphorylation-regulated kinase 1B MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR PPLPPPDDPATLGPHLGLRGVPQSTAASS
- Number of residues
- 629
- Molecular Weight
- 69197.19
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / protein kinase activity / protein serine/threonine kinase activity / protein serine/threonine/tyrosine kinase activity / protein tyrosine kinase activity / transcription coactivator activityProcessesadipose tissue development / myoblast fusion / positive regulation of transcription, DNA-templated / protein phosphorylationComponentsnucleus
- General Function
- Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).
- Specific Function
- Atp binding
- Pfam Domain Function
- Pkinase (PF00069)
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0051743|Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B) ATGGCCGTCCCACCGGGCCATGGTCCCTTCTCTGGCTTCCCAGGGCCCCAGGAGCACACG CAGGTATTGCCTGATGTGCGGCTACTGCCTCGGAGGCTGCCCCTGGCCTTCCGGGATGCA ACCTCAGCCCCGCTGCGTAAGCTCTCTGTGGACCTCATCAAGACCTACAAGCACATCAAT GAGGTATACTATGCGAAGAAGAAGCGGCGGGCCCAGCAGGCGCCACCCCAGGATTCGAGC AACAAGAAGGAGAAGAAGGTCCTGAACCATGGTTATGATGACGACAACCATGACTACATC GTGCGCAGTGGCGAGCGCTGGCTGGAGCGCTACGAAATTGACTCGCTCATTGGCAAAGGC TCCTTTGGCCAGGTGGTGAAAGCCTATGATCATCAGACCCAGGAGCTTGTGGCCATCAAG ATCATCAAGAACAAAAAGGCTTTCCTGAACCAGGCCCAGATTGAGCTGCGGCTGCTGGAG CTGATGAACCAGCATGACACGGAGATGAAGTACTATATAGTACACCTGAAGCGGCACTTC ATGTTCCGGAACCACCTGTGCCTGGTATTTGAGCTGCTGTCCTACAACCTGTACGACCTC CTGCGCAACACCCACTTCCGCGGCGTCTCGCTGAACCTGACCCGGAAGCTGGCGCAGCAG CTCTGCACGGCACTGCTCTTTCTGGCCACGCCTGAGCTCAGCATCATTCACTGCGACCTC AAGCCCGAAAACATCTTGCTGTGCAACCCCAAGCGCAGCGCCATCAAGATTGTGGACTTC GGCAGCTCCTGCCAGCTTGGCCAGAGGATCTACCAGTATATCCAGAGCCGCTTCTACCGC TCACCTGAGGTGCTCCTGGGCACACCCTACGACCTGGCCATTGACATGTGGTCCCTGGGC TGCATCCTTGTGGAGATGCACACCGGAGAGCCCCTCTTCAGTGGCTCCAATGAGGTCGAC CAGATGAACCGCATTGTGGAGGTGCTGGGCATCCCACCGGCCGCCATGCTGGACCAGGCG CCCAAGGCTCGCAAGTACTTTGAACGGCTGCCTGGGGGTGGCTGGACCCTACGAAGGACG AAAGAACTCAGGAAGGATTACCAGGGCCCCGGGACACGGCGGCTGCAGGAGGTGCTGGGC GTGCAGACGGGCGGGCCCGGGGGCCGGCGGGCGGGGGAGCCGGGCCACAGCCCCGCCGAC TACCTCCGCTTCCAGGACCTGGTGCTGCGCATGCTGGAGTATGAGCCCGCCGCCCGCATC AGCCCCCTGGGGGCTCTGCAGCACGGCTTCTTCCGCCGCACGGCCGACGAGGCCACCAAC ACGGGCCCGGCAGGCAGCAGTGCCTCCACCTCGCCCGCGCCCCTCGACACCTGCCCCTCT TCCAGCACCGCCAGCTCCATCTCCAGTTCTGGAGGCTCCAGTGGCTCCTCCAGTGACAAC CGGACCTACCGCTACAGCAACCGATATTGTGGGGGCCCTGGGCCCCCTATCACAGACTGT GAGATGAACAGCCCCCAGGTCCCACCCTCCCAGCCGCTGCGGCCCTGGGCAGGGGGTGAT GTGCCCCACAAGACACATCAAGCCCCTGCCTCTGCCTCGTCACTGCCTGGGACCGGGGCC CAGTTACCCCCCCAGCCCCGATACCTTGGTCGTCCCCCATCACCAACCTCACCACCACCC CCGGAGCTGATGGATGTGAGCCTGGTGGGCGGCCCTGCTGACTGCTCCCCACCTCACCCA GCGCCTGCCCCCCAGCACCCGGCTGCCTCAGCCCTCCGGACTCGGATGACTGGAGGTCGT CCACCCCTCCCGCCTCCTGATGACCCTGCCACTCTGGGGCCTCACCTGGGCCTCCGTGGT GTACCCCAGAGCACAGCAGCCAGCTCGTGA
- Chromosome Location
- 19
- Locus
- 19q13.2
- External Identifiers
Resource Link UniProtKB ID Q9Y463 UniProtKB Entry Name DYR1B_HUMAN HGNC ID HGNC:3092 - General References
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