Tubulin monoglycylase TTLL3
Details
- Name
- Tubulin monoglycylase TTLL3
- Synonyms
- 6.3.2.-
- HOTTL
- Tubulin--tyrosine ligase-like protein 3
- Gene Name
- TTLL3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049726|Tubulin monoglycylase TTLL3 MNRLRNAKIYVERAVKQKKIFTIQGCYPVIRCLLRRRGWVEKKMVHRSGPTLLPPQKDLD SSAMGDSDTTEDEDEDEDEEFQPSQLFDFDDLLKFDDLDGTHALMVGLCLNLRNLPWFDE VDANSFFPRCYCLGAEDDKKAFIEDFWLTAARNVLKLVVKSEWKSYPIQAVEEEASGDKQ PKKQEKNPVLVSPEFVDEALCACEEYLSNLAHMDIDKDLEAPLYLTPEGWSLFLQRYYQV VHEGAELRHLDTQVQRCEDILQQLQAVVPQIDMEGDRNIWIVKPGAKSRGRGIMCMDHLE EMLKLVNGNPVVMKDGKWVVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIR FSTQPFSLKNLDNSVHLCNNSIQKHLENSCHRHPLLPPDNMWSSQRFQAHLQEMGAPNAW STIIVPGMKDAVIHALQTSQDTVQCRKASFELYGADFVFGEDFQPWLIEINASPTMAPST AVTARLCAGVQADTLRVVIDRMLDRNCDTGAFELIYKQPAVEVPQYVGIRLLVEGFTIKK PMAMCHRRMGVRPAVPLLTQRGSGEARHHFPSLHTKAQLPSPHVLRHQGQVLRRQHSKLV GTKALSTTGKALRTLPTAKVFISLPPNLDFKVAPSILKPRKAPALLCLRGPQLEVPCCLC PLKSEQFLAPVGRSRPKANSRPDCDKPRAEACPMKRLSPLKPLPLVGTFQRRRGLGDMKL GKPLLRFPTALVLDPTPNKKKQVKYLGLDSIAVGGSRVDGARPCTPGSTARA
- Number of residues
- 772
- Molecular Weight
- 87413.395
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / protein-glycine ligase activity / protein-glycine ligase activity, initiatingProcessesaxoneme assembly / cilium assembly / protein polyglycylationComponentsaxoneme / cilium / cytoplasm / microtubule / microtubule cytoskeleton
- General Function
- Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction.
- Specific Function
- Atp binding
- Pfam Domain Function
- TTL (PF03133)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0049727|Tubulin monoglycylase TTLL3 (TTLL3) ATGCAGGGCCCCGACGCGCCACTGCTCCTGAGCGCGAGGGAGCTGGGGCCCGGGCGCCGG GGCTCGGCCTCCTGGTACCGCCAGGAGGGCGGCGCGGTGTGCAACTGGCTGCGGAAGCCG CAGCCGCTCGAGCCACGCACCAGTTTCCCCTCGGCGCGCCGCTCCGAGTTCCGTCCACCC AGGAGGCTGCCATGGGCCGGCCCTGCCTCCGCCCAGTCCGAGGAGGGTCACGCAGGCGGC AGATGCCAGGCGGGCAGCCCCGCCCCTGCGCGCCGCCTCAGCGGCGCCTTCAAGACGCTG GTCCCAGGCACCCACGCCCAGGGCGCCTCGGATACCCACCCCCTCGGCCCCCCGCACACC CCGGTCCTCGACCCCTCTCCGCAGGATGGTTTCCCGGTCCTCTGGCGAGGATCCTCCAAG GCGTCTCACATGAACCGGCTCAGAAACGCCAAAATCTACGTGGAGAGAGCTGTCAAGCAG AAGAAGATCTTTACAATCCAAGGCTGCTACCCGGTGATCCGGTGTCTCTTGCGCCGGAGG GGCTGGGTGGAGAAGAAGATGGTCCATCGCTCAGGCCCCACCCTGCTGCCACCCCAGAAG GATCTGGATAGCTCAGCGATGGGTGACAGTGACACCACTGAGGATGAGGATGAAGATGAG GACGAGGAGTTCCAGCCATCACAGCTGTTCGACTTCGATGATTTACTGAAATTTGATGAC CTAGATGGAACACATGCTCTGATGGTGGGTCTATGTCTCAATCTCCGGAATTTGCCGTGG TTTGATGAGGTTGATGCCAACTCCTTCTTCCCACGCTGCTACTGCCTGGGGGCTGAGGAT GACAAAAAAGCCTTCATAGAGGACTTCTGGCTGACTGCTGCCCGCAACGTTCTCAAGCTG GTGGTGAAGTCTGAGTGGAAGTCATACCCTATTCAGGCAGTAGAGGAAGAGGCCTCAGGA GACAAGCAGCCCAAGAAACAGGAGAAAAACCCAGTGTTGGTGTCCCCAGAGTTTGTGGAT GAAGCTCTGTGTGCGTGCGAGGAGTACCTTAGCAACTTGGCCCACATGGACATCGACAAG GACCTGGAGGCCCCGCTGTACCTCACCCCCGAGGGCTGGTCCCTCTTCCTCCAGCGCTAC TACCAAGTGGTCCACGAAGGGGCAGAACTCAGGCACCTCGACACTCAGGTCCAGCGCTGT GAGGACATCCTGCAGCAGCTGCAGGCCGTGGTACCCCAGATAGACATGGAAGGGGATCGC AACATCTGGATCGTGAAGCCAGGAGCCAAGTCCCGCGGACGAGGCATCATGTGCATGGAC CACCTGGAGGAGATGCTGAAGCTGGTGAACGGCAACCCCGTGGTGATGAAGGACGGCAAG TGGGTGGTGCAGAAGTATATTGAGCGGCCCCTCCTCATCTTTGGCACCAAGTTTGACCTC AGACAGTGGTTCCTGGTAACTGACTGGAACCCACTTACCGTGTGGTTCTACCGCGACAGC TATATCCGCTTTTCCACGCAGCCCTTCTCCCTGAAGAACCTGGACAACTCAGTGCACCTG TGCAACAACTCCATCCAGAAGCACCTGGAGAACTCATGCCATCGGCATCCACTGCTTCCG CCAGACAACATGTGGTCTAGCCAGAGGTTCCAGGCCCACCTGCAGGAGATGGGTGCCCCA AATGCTTGGTCCACCATCATCGTGCCTGGCATGAAGGATGCTGTGATCCACGCACTTCAG ACCTCCCAGGACACCGTGCAGTGTCGGAAGGCCAGCTTTGAGCTCTATGGCGCTGACTTC GTGTTCGGGGAGGACTTCCAGCCCTGGCTGATTGAGATCAACGCCAGCCCCACGATGGCA CCCTCCACAGCAGTCACTGCCCGGCTCTGTGCTGGCGTGCAAGCTGACACCCTGCGCGTG GTCATTGACCGGATGCTGGACCGCAACTGTGACACAGGAGCCTTTGAGCTCATCTATAAG CAGCCTGCTGTGGAGGTGCCTCAATATGTGGGCATCCGGCTCCTGGTAGAGGGCTTCACC ATCAAGAAGCCCATGGCGATGTGTCATCGGCGGATGGGGGTCCGCCCAGCAGTCCCTCTG CTGACCCAGCGAGGCTCTGGGGAAGCCCGTCACCACTTCCCCAGCCTCCACACCAAGGCC CAGCTGCCTTCTCCCCATGTACTCCGACACCAGGGCCAGGTCCTCAGACGACAGCACAGC AAGCTGGTGGGCACTAAGGCCCTGTCGACCACAGGCAAGGCCTTGAGGACTCTACCCACG GCTAAGGTCTTCATTTCCCTCCCACCGAACCTTGATTTCAAGGTGGCACCCAGCATCCTG AAGCCAAGAAAGGCTCCTGCTCTCCTGTGCCTCCGAGGCCCCCAGCTGGAAGTGCCTTGT TGCCTCTGCCCTTTGAAGTCGGAACAATTCCTAGCACCTGTCGGAAGGTCAAGGCCAAAG GCAAATTCAAGGCCAGACTGTGACAAACCCAGGGCTGAGGCCTGCCCCATGAAGAGGCTG AGCCCCCTGAAACCCCTGCCCCTTGTTGGTACATTCCAGAGGCGCAGGGGCCTGGGGGAT ATGAAGCTAGGGAAGCCCCTGCTTCGATTCCCCACTGCCCTTGTCCTGGATCCAACACCA AATAAAAAGAAACAAGTGAAGTATTTGGGGCTTGACTCCATTGCTGTTGGAGGGTCAAGA GTGGATGGGGCGAGGCCGTGTACCCCAGGGTCCACAGCAAGAGCCTGA
- Chromosome Location
- 3
- Locus
- 3p25.3
- External Identifiers
Resource Link UniProtKB ID Q9Y4R7 UniProtKB Entry Name TTLL3_HUMAN HGNC ID HGNC:24483 - General References
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