Hydrolases

Name
Hydrolases
Accession Number
DBCAT000070
Description

Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.

Drugs
DrugDrug Description
Dornase alfaA synthetic form of human deoxyribonuclease I used to break down extracellular DNA in the lungs, a major source of mucous viscosity in cystic fibrosis.
AlteplaseA recombinant form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli.
UrokinaseA low molecular weight form of human urokinase used to treat pulmonary embolism and myocardial infarction as well as to clear IV lines.
ReteplaseA purified form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli.
Asparaginase Escherichia coliAn asparaginase enzyme from E. coli used as part of treatment regimens for acute lymphoblastic leukemias.
AnistreplaseA form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli.
TenecteplaseA modified form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli.
Coagulation factor VIIa Recombinant HumanA form of recombinant human coagulation Factor VII used to treat hemophilia A and B.
Botulinum Toxin Type BA purified form of botulinum toxin type B used to block acetylcholine release in the treatment of cervical dystonia and sialorrhea.
Collagenase clostridium histolyticumA collagenase enzyme used to promote debridement of necrotic tissue in burns and skin ulcers as well as to treat Dupuytren's contracture and Peyronie's disease.
ImigluceraseA form of recombinant human beta-glucocerebrosidase enzyme used to replace the deficient endogenous enzyme in the treatment of Gaucher disease.
PegaspargaseA modified form of L-asparagine amidohydrolase used to treat acute lymphoblastic leukemia, which is dependent on an external source of asparagine.
PegademaseA modified form of bovine adenosine deaminase used to treat adenosine deaminase deficiency, a condition which leads to the formation of adenosine metabolites which are cytotoxic to lymphocytes.
Botulinum toxin type AA purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications.
PancrelipaseA purified form of porcine pancreatic lipase, amylase, and protease enzymes used to treat malabsorption associated with pancreatic insufficiency resulting from cystic fibrosis and pancreatitis.
StreptokinaseA purified fibrinolytic bacterial protein used to breakdown thrombosis in myocardial infarction, pulmonary embolism, and venous thromboembolism.
AlgluceraseA form of recombinant beta-glucocerebrosidase enzyme used to replace the deficient endogenous enzyme in the treatment of Gaucher disease.
Agalsidase betaA form of recombinant human alpha-galactosidase A enzyme used to treat Fabry disease, a genetic deficiency in the enzyme leading to buildup of globotriaosylceramide.
IdursulfaseA purified lysosomal enzyme used as a replacement therapy for Hunter syndrome in pediatric and adult patients.
Alglucosidase alfaAn acid alpha- glucosidase (GAA) derivative used as an enzyme replacement therapy for the treatment of Pompe disease in infants and pediatric patients caused by GAA deficiency.
GalsulfaseA recombinant human enzyme used as replacement enzyme therapy for the treatment of of adults and children with Mucopolysaccharidosis VI, a rare genetic disorder caused by a deficiency of a lysosomal enzyme.
AlfimepraseAlfimeprase is being evaluated as a potential treatment for acute ischemic stroke, catheter occlusion (CO) and acute peripheral arterial occlusion (PAO).
DesmoteplaseInvestigated for use/treatment in cerebral ischemia and strokes.
RanpirnaseFor the treatment of various forms of cancer.
AncrodAn anticoagulant purified from the venom of the Malayan pit viper that functions by inactivating circulating plasma fibrinogen. Not currently approved for use or marketed in any country.
FibrinolysinFibrinolysin assists with the healing of minor burns, superficial wounds, ulcers, surgical wounds, and superficial hematomas.
ALTU-135Investigated for use/treatment in cystic fibrosis and pancreatic disorders.
PraconaseInvestigated for use/treatment in spinal cord injuries.
Alkaline PhosphataseInvestigated for use/treatment in ulcerative colitis.
LanoteplaseInvestigated for use/treatment in myocardial infarction.
LatiglutenaseInvestigated for use/treatment in gastrointestinal diseases and disorders (miscellaneous) and autoimmune diseases such as celiac disease.
AmediplaseInvestigated for use/treatment in myocardial infarction and thrombosis.
ChymopapainChymopapain is indicated for the development of chemonucleolysis which is used for the digestion of the nucleus pulposus in patients with disc herniation confirmed by myelography. A disc herniation occurs...
SacrosidaseAn enzyme replacement therapy used for the treatment of congenital sucrase-isomaltase deficiency (CSID).
SerotoninFor temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product.
Taliglucerase alfaA hydrolytic lysosomal glucocerebroside specific enzyme, used for long term enzyme replacement therapy in patients with Type 1 Gaucher disease.
OcriplasminA proteolytic enzyme used to treat symptomatic vitreomacular adhesion by dissolving the protein matrix responsible for the adhesion between the vitreous and macula.
GlucarpidaseA carboxypeptidase enzyme used to treat toxic plasma methotrexate concentrations by providing an alternate elimination pathway for methotrexate in patients who have impaired renal function.
BatroxobinNo approved indications. Batroxobin is a defibrongenating agent which has been observed to reduce fibrinogen levels and thus reduce clot risk when used intravenously.
Elosulfase alfaA lysosomal glycosaminoglycan (GAG)-specific enzyme indicated as an enzyme replacement therapy for Mucopolysaccharidosis type IV A.
Asfotase alfaAn enzyme replacement therapy used for the treatment of perinatal/infantile and juvenile onset hypophosphatasia (HPP).
ChymotrypsinNo therapeutic indications.
Pancrelipase amylaseA lipase used to treat pancreatic exocrine insufficiency.
PapainNo FDA-approved therapeutic indications.
TrypsinTrypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide...
ThrombinA coagulation factor used to stop bleeding during surgery.
Sebelipase alfaA recombinant lysosomal acid lipase used to treat lysosomal acid lipase deficiency.
Rusalatide acetateChrysalin has been used in trials studying the treatment of Radius Fracture.
VonapanitaseVonapanitase is under investigation for the treatment of Chronic Kidney Disease.
Stem bromelainThe primary medical purpose for which stem bromelain (SB) is currently indicated for is the removal of eschar in adults with deep partial- and full-thickness thermal burns [FDA Label]. Besides...
Vatreptacog alfaVatreptacog Alfa (Activated) has been used in trials studying the treatment of Haemophilia B, Haemophilia A, Congenital Bleeding Disorder, Haemophilia A With Inhibitors, and Haemophilia B With Inhibitors.
AviscumineCy 503 is under investigation in clinical trial NCT00658437 (Aviscumine for the Treatment of Malignant Melanoma Stage IV After Failure of Prior Therapy).
MonteplaseMonteplase has been used in trials studying the treatment of Pulmonary Embolism.
Olipudase alfaOlipudase alfa has been used in trials studying the treatment of Sphingomyelin Lipidosis and Human Acid Sphingomyelinase Deficiency.
SerrapeptaseSerrapeptase is a proteolytic enzyme preparation used concomitantly with an antibiotic in osteoarticular infections. Serratiopeptidase is under investigation in clinical trial NCT02493179 (Efficacy Evaluation of the (Serodase 5 mg Tablet)...
KallidinogenaseNot Annotated
PepsinUsed as a pancreatic enzyme replacement in pancreatic insufficiency . It is intended to mimic naturally produced human pepsin . Pepsin powder is prepared from the gastric mucosa of pigs,...
BrinaseNot Annotated
LysozymeNot Annotated
BromelainsBromelain is a protease enzyme derived from the stems of pineapples that is composed of a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase,...
SaruplaseNot Annotated
TilactaseA beta-D-galactosidase use to treat lactose intolerance.
Ferric pyrophosphate citrateA soluble iron compound used to maintain hemoglobin levels in patients undergoing hemodialysis.
Andexanet alfaA recombinant Factor Xa used to reverse anticoagulation caused by rivaroxaban and apixaban.
SutilainSutilain was indicated, in the form of an ointment, as a biochemical debridement of second and third-degree burns, incisional traumatic and pyrogenic wounds and ulcers occurring due to peripheral vascular...
Calaspargase pegolAn asparagine specific enzyme used to treat acute lymphoblastic leukemia.
DiaPep 277Investigated for use/treatment in diabetes mellitus type 1, autoimmune diseases, and diabetes mellitus type 2.
HyaluronidaseAn enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents.
NattokinaseNattokinase is under investigation in clinical trial NCT00749801 (Efficacy and Safety of Geneferm Nattokinase).
Valanafusp alfaValanafusp alfa is under investigation in clinical trial NCT03071341 (Extension Study Evaluating Long Term Safety and Activity of AGT-181 in Children With MPS I).
Thrombin alfaA platelet activating factor used to treat minor bleeding.
Cerliponase alfaAn enzyme replacement therapy used to treat neuronal ceroid lipofuscinosis type 2 (CLN2) disease, also known as tripeptidyl peptidase 1 (TPP1) deficiency.
Vocimagene amiretrorepvecVocimagene amiretrorepvec is under investigation in clinical trial NCT02576665 (A Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Patients With Solid Tumors or Lymphoma (Toca...
Pancrelipase lipaseA lipase used to treat pancreatic exocrine insufficiency.
DesoxyribonucleaseDesoxyribonuclease is a crystalline enzyme that aids in the digestion of the thymus nucleic acid. The mechanism of action of the enzyme involves the splitting of thymus nucleic acid into...
Hyaluronidase (human recombinant)An enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents.
Talactoferrin alfaInvestigated for use/treatment in adverse effects (chemotherapy), cancer/tumors (unspecified), diabetic foot ulcers, lung cancer, solid tumors, and ulcers.
Drugs & Drug Targets
DrugTargetType
Dornase alfaDNAtarget
AlteplaseUrokinase plasminogen activator surface receptortarget
AlteplaseFibrinogen alpha chaintarget
AlteplasePlasminogentarget
AlteplasePlasminogen activator inhibitor 1target
UrokinaseUrokinase plasminogen activator surface receptortarget
UrokinasePlasminogentarget
UrokinasePlasminogen activator inhibitor 2target
UrokinasePlasminogen activator inhibitor 1target
UrokinasePlasma serine protease inhibitortarget
UrokinaseNidogen-1target
UrokinaseLow-density lipoprotein receptor-related protein 2target
UrokinaseSuppressor of tumorigenicity 14 proteintarget
UrokinaseMacrophage metalloelastaseenzyme
ReteplaseFibrinogen alpha chaintarget
ReteplasePlasminogentarget
ReteplasePlasminogen activator inhibitor 1target
Asparaginase Escherichia coliL-asparaginetarget
Asparaginase Escherichia coliThyroxine-binding globulincarrier
AnistreplaseFibrinogen alpha chaintarget
AnistreplasePlasminogentarget
AnistreplasePlasminogen activator inhibitor 1target
TenecteplaseUrokinase plasminogen activator surface receptortarget
TenecteplasePlasminogen activator inhibitor 1target
TenecteplaseFibrinogen alpha chaintarget
TenecteplasePlasminogen activator inhibitor 2target
TenecteplaseTetranectintarget
TenecteplaseKeratin, type II cytoskeletal 8target
TenecteplaseAnnexin A2target
TenecteplaseCalreticulintarget
TenecteplaseCalnexintarget
TenecteplaseProlow-density lipoprotein receptor-related protein 1target
TenecteplasePlasminogentarget
Coagulation factor VIIa Recombinant HumanCoagulation factor Xtarget
Coagulation factor VIIa Recombinant HumanTissue factortarget
Coagulation factor VIIa Recombinant HumanTissue factor pathway inhibitortarget
Coagulation factor VIIa Recombinant HumanVitamin K-dependent gamma-carboxylasetarget
Coagulation factor VIIa Recombinant HumanCoagulation factor VIItarget
Botulinum Toxin Type BVesicle-associated membrane protein 1target
Botulinum Toxin Type BVesicle-associated membrane protein 2target
Botulinum Toxin Type BSynaptotagmin-2target
Collagenase clostridium histolyticumCollagen alpha-1(I) chaintarget
Collagenase clostridium histolyticumCollagen alpha-1(II) chaintarget
Collagenase clostridium histolyticumCollagen alpha-1(III) chaintarget
Collagenase clostridium histolyticumCollagen alpha-2(I) chaintarget
ImigluceraseGlucocerebrosidetarget
PegaspargaseL-asparaginetarget
PegaspargaseThyroxine-binding globulincarrier
PegademaseAdenosinetarget
PegademaseGrowth factor receptor-bound protein 2target
Botulinum toxin type ASynaptosomal-associated protein 25target
Botulinum toxin type ARho-related GTP-binding protein RhoBtarget
PancrelipaseDietary fattarget
PancrelipaseDietary proteintarget
PancrelipaseDietary starchtarget
StreptokinasePlasminogentarget
StreptokinaseProteinase-activated receptor 1target
StreptokinaseCytosolic phospholipase A2enzyme
AlgluceraseGlucocerebrosidetarget
Agalsidase betaGlobotriaosylceramidetarget
IdursulfasePerilipin-3target
IdursulfaseDermatan sulfatetarget
IdursulfaseHeparan sulfatetarget
Alglucosidase alfaCation-dependent mannose-6-phosphate receptortarget
Alglucosidase alfaGlycogentarget
GalsulfasePerilipin-3target
GalsulfaseDermatan sulfatetarget
AlfimepraseFibrinogen alpha chaintarget
AlfimepraseFibrinogen beta chaintarget
DesmoteplasePlasminogentarget
RanpirnaseDNAtarget
AncrodFibrinogen alpha chaintarget
FibrinolysinPlasminogen activator inhibitor 1target
FibrinolysinUrokinase-type plasminogen activatortarget
LanoteplaseUrokinase plasminogen activator surface receptortarget
LanoteplaseFibrinogen alpha chaintarget
LanoteplaseKallikrein-1target
LanoteplaseLaminin subunit alpha-5target
LanoteplaseCoagulation factor Xtarget
LanoteplaseFibronectintarget
LanoteplasePlasminogen activator inhibitor 2target
LanoteplaseTetranectintarget
LanoteplaseKeratin, type II cytoskeletal 8target
LanoteplaseAnnexin A2target
LanoteplaseLaminin subunit beta-1target
LanoteplaseLaminin subunit gamma-1target
LanoteplaseLaminin subunit alpha-1target
LanoteplaseCalreticulintarget
LanoteplaseCalnexintarget
LanoteplaseProlow-density lipoprotein receptor-related protein 1target
LanoteplaseLaminin subunit alpha-3target
ChymopapainBone marrow proteoglycantarget
SerotoninSolute carrier family 22 member 2transporter
SerotoninSodium-dependent serotonin transportertarget
Serotonin5-hydroxytryptamine receptor 2Atarget
Serotonin5-hydroxytryptamine receptor 3Atarget
Serotonin5-hydroxytryptamine receptor 3Btarget
SerotoninSynaptic vesicular amine transportertarget
Taliglucerase alfaGlucocerebrosidetarget
OcriplasminAlpha-2-macroglobulintarget
OcriplasminAlpha-2-antiplasmintarget
OcriplasminFibronectintarget
GlucarpidaseMethotrexatetarget
Asfotase alfaSphingosine 1-phosphate receptor 1target
Asfotase alfaPyrophosphatetarget
Pancrelipase amylaseDietary starchtarget
PapainToll-like receptor 4target
ThrombinProteinase-activated receptor 1target
ThrombinProteinase-activated receptor 4target
ThrombinCoagulation factor XItarget
ThrombinCoagulation factor XIII A chaintarget
ThrombinCoagulation factor XIII B chaintarget
ThrombinFibrinogen alpha chaintarget
ThrombinFibrinogen beta chaintarget
ThrombinFibrinogen gamma chaintarget
ThrombinCoagulation factor Vtarget
ThrombinCoagulation factor VIIItarget
TilactaseLactosetarget
Ferric pyrophosphate citrateFerritin light chaintarget
Ferric pyrophosphate citrateFerritin heavy chaintarget
Ferric pyrophosphate citrateHemoglobin subunit alphatarget
Ferric pyrophosphate citrateHemoglobin subunit betatarget
Andexanet alfaTissue factor pathway inhibitortarget
Calaspargase pegolL-asparaginetarget
HyaluronidaseHyaluronic acidtarget
HyaluronidaseTransforming growth factor beta-1target
Thrombin alfaCoagulation factor VIIItarget
Thrombin alfaCoagulation factor Vtarget
Thrombin alfaFibrinogen alpha chaintarget
Thrombin alfaFibrinogen beta chaintarget
Thrombin alfaFibrinogen gamma chaintarget
Cerliponase alfaCation-independent mannose-6-phosphate receptortarget
Pancrelipase lipaseDietary fattarget
Hyaluronidase (human recombinant)Hyaluronic acidtarget
Hyaluronidase (human recombinant)Transforming growth factor beta-1target