Hydrolases

Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.
DrugDrug NameDrug Description
DB00003Dornase alfaA synthetic form of human deoxyribonuclease I used to break down extracellular DNA in the lungs, a major source of mucous viscosity in cystic fibrosis.
DB00009AlteplaseA recombinant form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli.
DB00013UrokinaseA low molecular weight form of human urokinase used to treat pulmonary embolism and myocardial infarction as well as to clear IV lines.
DB00015ReteplaseA purified form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli.
DB00023Asparaginase Escherichia coliAn asparaginase enzyme from E. coli used as part of treatment regimens for acute lymphoblastic leukemias.
DB00029AnistreplaseA form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli.
DB00031TenecteplaseA modified form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli.
DB00036Coagulation factor VIIa Recombinant HumanA form of recombinant human coagulation Factor VII used to treat hemophilia A and B.
DB00042Botulinum Toxin Type BA purified form of botulinum toxin type B used to block acetylcholine release in the treatment of cervical dystonia and sialorrhea.
DB00048Collagenase clostridium histolyticumA collagenase enzyme used to promote debridement of necrotic tissue in burns and skin ulcers as well as to treat Dupuytren's contracture and Peyronie's disease.
DB00053ImigluceraseA form of recombinant human beta-glucocerebrosidase enzyme used to replace the deficient endogenous enzyme in the treatment of Gaucher disease.
DB00059PegaspargaseA modified form of L-asparagine amidohydrolase used to treat acute lymphoblastic leukemia, which is dependent on an external source of asparagine.
DB00061PegademaseA modified form of bovine adenosine deaminase used to treat adenosine deaminase deficiency, a condition which leads to the formation of adenosine metabolites which are cytotoxic to lymphocytes.
DB00083Botulinum toxin type AA purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications.
DB00085PancrelipaseA purified form of porcine pancreatic lipase, amylase, and protease enzymes used to treat malabsorption associated with pancreatic insufficiency resulting from cystic fibrosis and pancreatitis.
DB00086StreptokinaseA purified fibrinolytic bacterial protein used to breakdown thrombosis in myocardial infarction, pulmonary embolism, and venous thromboembolism.
DB00088AlgluceraseA form of recombinant beta-glucocerebrosidase enzyme used to replace the deficient endogenous enzyme in the treatment of Gaucher disease.
DB00103Agalsidase betaA form of recombinant human alpha-galactosidase A enzyme used to treat Fabry disease, a genetic deficiency in the enzyme leading to buildup of globotriaosylceramide.
DB01271IdursulfaseA purified lysosomal enzyme used as a replacement therapy for Hunter syndrome in pediatric and adult patients.
DB01272Alglucosidase alfaAn acid alpha- glucosidase (GAA) derivative used as an enzyme replacement therapy for the treatment of Pompe disease in infants and pediatric patients caused by GAA deficiency.
DB01279GalsulfaseA recombinant human enzyme used as replacement enzyme therapy for the treatment of of adults and children with Mucopolysaccharidosis VI, a rare genetic disorder caused by a deficiency of a lysosomal enzyme.
DB04919AlfimepraseAlfimeprase is being evaluated as a potential treatment for acute ischemic stroke, catheter occlusion (CO) and acute peripheral arterial occlusion (PAO).
DB04925DesmoteplaseInvestigated for use/treatment in cerebral ischemia and strokes.
DB04950RanpirnaseFor the treatment of various forms of cancer.
DB05099AncrodAn anticoagulant purified from the venom of the Malayan pit viper that functions by inactivating circulating plasma fibrinogen. Not currently approved for use or marketed in any country.
DB05254FibrinolysinFibrinolysin assists with the healing of minor burns, superficial wounds, ulcers, surgical wounds, and superficial hematomas.
DB05330ALTU-135Investigated for use/treatment in cystic fibrosis and pancreatic disorders.
DB05584PraconaseInvestigated for use/treatment in spinal cord injuries.
DB05768Alkaline PhosphataseInvestigated for use/treatment in ulcerative colitis.
DB06245LanoteplaseInvestigated for use/treatment in myocardial infarction.
DB06326LatiglutenaseInvestigated for use/treatment in gastrointestinal diseases and disorders (miscellaneous) and autoimmune diseases such as celiac disease.
DB06679AmediplaseInvestigated for use/treatment in myocardial infarction and thrombosis.
DB06752ChymopapainChymopapain is indicated for the development of chemonucleolysis which is used for the digestion of the nucleus pulposus in patients with disc herniation confirmed by myelography. A disc herniation occurs...
DB06760SacrosidaseAn enzyme replacement therapy used for the treatment of congenital sucrase-isomaltase deficiency (CSID).
DB08839SerotoninFor temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product.
DB08876Taliglucerase alfaA hydrolytic lysosomal glucocerebroside specific enzyme, used for long term enzyme replacement therapy in patients with Type 1 Gaucher disease.
DB08888OcriplasminA proteolytic enzyme used to treat symptomatic vitreomacular adhesion by dissolving the protein matrix responsible for the adhesion between the vitreous and macula.
DB08898GlucarpidaseA carboxypeptidase enzyme used to treat toxic plasma methotrexate concentrations by providing an alternate elimination pathway for methotrexate in patients who have impaired renal function.
DB09005BatroxobinNo approved indications. Batroxobin is a defibrongenating agent which has been observed to reduce fibrinogen levels and thus reduce clot risk when used intravenously.
DB09051Elosulfase alfaA lysosomal glycosaminoglycan (GAG)-specific enzyme indicated as an enzyme replacement therapy for Mucopolysaccharidosis type IV A.
DB09105Asfotase alfaAn enzyme replacement therapy used for the treatment of perinatal/infantile and juvenile onset hypophosphatasia (HPP).
DB09375ChymotrypsinNo therapeutic indications.
DB11065Pancrelipase amylaseA lipase used to treat pancreatic exocrine insufficiency.
DB11193PapainNo FDA-approved therapeutic indications.
DB11237TrypsinTrypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide...
DB11300ThrombinA coagulation factor used to stop bleeding during surgery.
DB11563Sebelipase alfaA recombinant lysosomal acid lipase used to treat lysosomal acid lipase deficiency.
DB11668Rusalatide acetateChrysalin has been used in trials studying the treatment of Radius Fracture.
DB11690VonapanitaseVonapanitase is under investigation for the treatment of Chronic Kidney Disease.
DB12249Stem bromelainThe primary medical purpose for which stem bromelain (SB) is currently indicated for is the removal of eschar in adults with deep partial- and full-thickness thermal burns [FDA Label]. Besides...
DB12409Vatreptacog alfaVatreptacog Alfa (Activated) has been used in trials studying the treatment of Haemophilia B, Haemophilia A, Congenital Bleeding Disorder, Haemophilia A With Inhibitors, and Haemophilia B With Inhibitors.
DB12684AviscumineCy 503 is under investigation in clinical trial NCT00658437 (Aviscumine for the Treatment of Malignant Melanoma Stage IV After Failure of Prior Therapy).
DB12726MonteplaseMonteplase has been used in trials studying the treatment of Pulmonary Embolism.
DB12835Olipudase alfaOlipudase alfa has been used in trials studying the treatment of Sphingomyelin Lipidosis and Human Acid Sphingomyelinase Deficiency.
DB13131SerrapeptaseSerrapeptase is a proteolytic enzyme preparation used concomitantly with an antibiotic in osteoarticular infections. Serratiopeptidase is under investigation in clinical trial NCT02493179 (Efficacy Evaluation of the (Serodase 5 mg Tablet)...
DB13197KallidinogenaseNot Annotated
DB13198PepsinUsed as a pancreatic enzyme replacement in pancreatic insufficiency . It is intended to mimic naturally produced human pepsin . Pepsin powder is prepared from the gastric mucosa of pigs,...
DB13199BrinaseNot Annotated
DB13260LysozymeNot Annotated
DB13281BromelainsBromelain is a protease enzyme derived from the stems of pineapples that is composed of a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase,...
DB13646SaruplaseNot Annotated
DB13761TilactaseA beta-D-galactosidase use to treat lactose intolerance.
DB13995Ferric pyrophosphate citrateA soluble iron compound used to maintain hemoglobin levels in patients undergoing hemodialysis.
DB14562Andexanet alfaA recombinant Factor Xa used to reverse anticoagulation caused by rivaroxaban and apixaban.
DB09379SutilainSutilain was indicated, in the form of an ointment, as a biochemical debridement of second and third-degree burns, incisional traumatic and pyrogenic wounds and ulcers occurring due to peripheral vascular...
DB14730Calaspargase pegolAn asparagine specific enzyme used to treat acute lymphoblastic leukemia.
DB06651DiaPep 277Investigated for use/treatment in diabetes mellitus type 1, autoimmune diseases, and diabetes mellitus type 2.
DB14740HyaluronidaseAn enzyme used to improve the absorption of fluids, drugs, and contrast agents.
DB15329NattokinaseNattokinase is under investigation in clinical trial NCT00749801 (Efficacy and Safety of Geneferm Nattokinase).
DB15336Valanafusp alfaValanafusp alfa is under investigation in clinical trial NCT03071341 (Extension Study Evaluating Long Term Safety and Activity of AGT-181 in Children With MPS I).
DB11572Thrombin alfaA platelet activating factor used to treat minor bleeding.
DB13173Cerliponase alfaAn enzyme replacement therapy used to treat neuronal ceroid lipofuscinosis type 2 (CLN2) disease, also known as tripeptidyl peptidase 1 (TPP1) deficiency.
DB15331Vocimagene amiretrorepvecVocimagene amiretrorepvec is under investigation in clinical trial NCT02576665 (A Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Patients With Solid Tumors or Lymphoma (Toca...
DrugDrug NameTargetType
DB00003Dornase alfaDNAtarget
DB00009AlteplaseUrokinase plasminogen activator surface receptortarget
DB00009AlteplaseFibrinogen alpha chaintarget
DB00009AlteplasePlasminogentarget
DB00009AlteplasePlasminogen activator inhibitor 1target
DB00013UrokinaseUrokinase plasminogen activator surface receptortarget
DB00013UrokinasePlasminogentarget
DB00013UrokinaseUrokinase-type plasminogen activatortarget
DB00013UrokinaseTissue-type plasminogen activatortarget
DB00013UrokinasePlasminogen activator inhibitor 2target
DB00013UrokinasePlasminogen activator inhibitor 1target
DB00013UrokinasePlasma serine protease inhibitortarget
DB00013UrokinaseNidogen-1target
DB00013UrokinaseLow-density lipoprotein receptor-related protein 2target
DB00013UrokinaseSuppressor of tumorigenicity 14 proteintarget
DB00015ReteplaseUrokinase plasminogen activator surface receptortarget
DB00015ReteplaseFibrinogen alpha chaintarget
DB00015ReteplasePlasminogentarget
DB00015ReteplasePlasminogen activator inhibitor 1target
DB00023Asparaginase Escherichia coliL-asparaginetarget
DB00023Asparaginase Escherichia coliThyroxine-binding globulincarrier
DB00029AnistreplaseUrokinase plasminogen activator surface receptortarget
DB00029AnistreplaseFibrinogen alpha chaintarget
DB00029AnistreplasePlasminogentarget
DB00029AnistreplasePlasminogen activator inhibitor 1target
DB00031TenecteplaseUrokinase plasminogen activator surface receptortarget
DB00031TenecteplasePlasminogen activator inhibitor 1target
DB00031TenecteplaseFibrinogen alpha chaintarget
DB00031TenecteplasePlasminogen activator inhibitor 2target
DB00031TenecteplaseTetranectintarget
DB00031TenecteplaseKeratin, type II cytoskeletal 8target
DB00031TenecteplaseAnnexin A2target
DB00031TenecteplaseCalreticulintarget
DB00031TenecteplaseCalnexintarget
DB00031TenecteplaseProlow-density lipoprotein receptor-related protein 1target
DB00031TenecteplasePlasminogentarget
DB00036Coagulation factor VIIa Recombinant HumanCoagulation factor Xtarget
DB00036Coagulation factor VIIa Recombinant HumanTissue factortarget
DB00036Coagulation factor VIIa Recombinant HumanSerine protease hepsintarget
DB00036Coagulation factor VIIa Recombinant HumanTissue factor pathway inhibitortarget
DB00036Coagulation factor VIIa Recombinant HumanVitamin K-dependent gamma-carboxylasetarget
DB00036Coagulation factor VIIa Recombinant HumanCoagulation factor VIItarget
DB00042Botulinum Toxin Type BVesicle-associated membrane protein 1target
DB00042Botulinum Toxin Type BVesicle-associated membrane protein 2target
DB00042Botulinum Toxin Type BSynaptotagmin-2target
DB00048Collagenase clostridium histolyticumCollagen alpha-1(I) chaintarget
DB00048Collagenase clostridium histolyticumCollagen alpha-1(II) chaintarget
DB00048Collagenase clostridium histolyticumCollagen alpha-1(III) chaintarget
DB00048Collagenase clostridium histolyticumCollagen alpha-2(I) chaintarget
DB00053ImigluceraseGlucocerebrosidetarget
DB00059PegaspargaseL-asparaginetarget
DB00059PegaspargaseThyroxine-binding globulincarrier
DB00061PegademaseAdenosinetarget
DB00061PegademaseGrowth factor receptor-bound protein 2target
DB00083Botulinum toxin type ASynaptosomal-associated protein 25target
DB00083Botulinum toxin type ARho-related GTP-binding protein RhoBtarget
DB00085PancrelipaseDietary fattarget
DB00085PancrelipaseDietary proteintarget
DB00085PancrelipaseDietary starchtarget
DB00086StreptokinasePlasminogentarget
DB00086StreptokinaseProteinase-activated receptor 1target
DB00086StreptokinaseCytosolic phospholipase A2enzyme
DB00088AlgluceraseGlucocerebrosidetarget
DB00103Agalsidase betaGlobotriaosylceramidetarget
DB01271IdursulfasePerilipin-3target
DB01271IdursulfaseDermatan sulfatetarget
DB01271IdursulfaseHeparan sulfatetarget
DB01272Alglucosidase alfaCation-dependent mannose-6-phosphate receptortarget
DB01272Alglucosidase alfaGlycogentarget
DB01279GalsulfasePerilipin-3target
DB01279GalsulfaseDermatan sulfatetarget
DB04919AlfimepraseFibrinogen alpha chaintarget
DB04919AlfimepraseFibrinogen beta chaintarget
DB04925DesmoteplasePlasminogentarget
DB04950RanpirnaseDNAtarget
DB05099AncrodFibrinogen alpha chaintarget
DB05254FibrinolysinPlasminogen activator inhibitor 1target
DB05254FibrinolysinUrokinase-type plasminogen activatortarget
DB06245LanoteplaseUrokinase plasminogen activator surface receptortarget
DB06245LanoteplaseFibrinogen alpha chaintarget
DB06245LanoteplaseKallikrein-1target
DB06245LanoteplaseLaminin subunit alpha-5target
DB06245LanoteplaseCoagulation factor Xtarget
DB06245LanoteplaseFibronectintarget
DB06245LanoteplasePlasminogen activator inhibitor 2target
DB06245LanoteplaseTetranectintarget
DB06245LanoteplaseKeratin, type II cytoskeletal 8target
DB06245LanoteplaseAnnexin A2target
DB06245LanoteplaseLaminin subunit beta-1target
DB06245LanoteplaseLaminin subunit gamma-1target
DB06245LanoteplaseLaminin subunit alpha-1target
DB06245LanoteplaseCalreticulintarget
DB06245LanoteplaseCalnexintarget
DB06245LanoteplaseProlow-density lipoprotein receptor-related protein 1target
DB06245LanoteplaseLaminin subunit alpha-3target
DB06752ChymopapainBone marrow proteoglycantarget
DB08839SerotoninSolute carrier family 22 member 2transporter
DB08839SerotoninSodium-dependent serotonin transportertarget
DB08839Serotonin5-hydroxytryptamine receptor 2Atarget
DB08839Serotonin5-hydroxytryptamine receptor 3Atarget
DB08839Serotonin5-hydroxytryptamine receptor 3Btarget
DB08839SerotoninSynaptic vesicular amine transportertarget
DB08876Taliglucerase alfaGlucocerebrosidetarget
DB08888OcriplasminAlpha-2-macroglobulintarget
DB08888OcriplasminAlpha-2-antiplasmintarget
DB08888OcriplasminFibronectintarget
DB08898GlucarpidaseMethotrexatetarget
DB09105Asfotase alfaSphingosine 1-phosphate receptor 1target
DB09105Asfotase alfaPyrophosphatetarget
DB11065Pancrelipase amylaseDietary starchtarget
DB11193PapainToll-like receptor 4target
DB11300ThrombinProteinase-activated receptor 1target
DB11300ThrombinProteinase-activated receptor 4target
DB11300ThrombinCoagulation factor XItarget
DB11300ThrombinCoagulation factor XIII A chaintarget
DB11300ThrombinCoagulation factor XIII B chaintarget
DB11300ThrombinFibrinogen alpha chaintarget
DB11300ThrombinFibrinogen beta chaintarget
DB11300ThrombinFibrinogen gamma chaintarget
DB11300ThrombinCoagulation factor Vtarget
DB11300ThrombinCoagulation factor VIIItarget
DB13761TilactaseLactosetarget
DB13995Ferric pyrophosphate citrateFerritin light chaintarget
DB13995Ferric pyrophosphate citrateFerritin heavy chaintarget
DB13995Ferric pyrophosphate citrateHemoglobin subunit alphatarget
DB13995Ferric pyrophosphate citrateHemoglobin subunit betatarget
DB14562Andexanet alfaTissue factor pathway inhibitortarget
DB14730Calaspargase pegolL-asparaginetarget
DB11572Thrombin alfaCoagulation factor XItarget
DB11572Thrombin alfaCoagulation factor VIIItarget
DB11572Thrombin alfaCoagulation factor Vtarget
DB11572Thrombin alfaCoagulation factor XIII A chaintarget
DB11572Thrombin alfaCoagulation factor XIII B chaintarget
DB11572Thrombin alfaFibrinogen alpha chaintarget
DB11572Thrombin alfaFibrinogen beta chaintarget
DB11572Thrombin alfaFibrinogen gamma chaintarget
DB13173Cerliponase alfaCation-independent mannose-6-phosphate receptortarget