Blood Coagulation Factors

Name
Blood Coagulation Factors
Accession Number
DBCAT000075  (DBCAT003566)
Description

Endogenous substances, usually proteins, that promote the formation of blood clots.

ATC Classification
Drugs
DrugDrug Description
Coagulation factor VIIa Recombinant HumanA form of recombinant human coagulation Factor VII used to treat hemophilia A and B.
Von Willebrand Factor HumanA complex of von Willebrand Factor and Factor VIII used to treat bleeding episodes in von Willebrand disease.
Coagulation factor X humanA coagulation factor used to treat Factor X deficiency to control bleeding.
Antihemophilic factor, human recombinantA form of recombinant coagulation Factor VIII used to treat hemophilia A, von Willebrand disease, and Factor XIII deficiency.
Antihemophilic factor humanA Factor VIII replacement therapy used to treat hemophilia A.
Trenonacog alfaHuman coagulation factor IX (EC 3.4.21.22, Christmas factor, plasma thromboplastin component), produced in CHO cells.
CalciumA mineral found in over-the-counter supplements or prescription formulations used for the treatment of specific medical conditions related to calcium deficiency.
Platelet Activating FactorNot Available
Turoctocog alfaAn antihemorrhagic agent used for the treatment and prophylaxis of bleeding in patients of all ages with haemophilia A (congenital factor VIII deficiency).
Fibrinogen humanA hemostatic agent used for the treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency, including afibrinogenemia and hypofibrinogenemia.
ThrombinA coagulation factor used to stop bleeding during surgery.
ProthrombinA coagulation factor used for emergency reversal of vitamin K antagonist therapy.
Factor IX Complex (Human)A Factor IX complex used to prevent and treat bleeding episodes in hemophilia B or vitamin K antagonist therapy.
Rusalatide acetateChrysalin has been used in trials studying the treatment of Radius Fracture.
Vatreptacog alfaVatreptacog Alfa (Activated) has been used in trials studying the treatment of Haemophilia B, Haemophilia A, Congenital Bleeding Disorder, Haemophilia A With Inhibitors, and Haemophilia B With Inhibitors.
Factor XIII (human)A purified form of Factor XIII that is used to prevent and treat surgical bleeding in patients with a Factor XIII deficiency.
Coagulation factor VII humanA coagulation factor used to treat bleeding disorders such as hemophilia and Glanzmann's thrombasthenia.
KallidinogenaseNot Annotated
Nonacog beta pegolA recombinant coagulation Factor IX derivative used to treat hemophilia B.
Moroctocog alfaA recombinant Factor VIII used to treat hemophilia A to control bleeding.
Coagulation Factor IX (Recombinant)A form of recombinant human coagulation Factor IX used to treat hemophilia B.
CatridecacogA recombinant FXIII subunitā€A molecule evaluated for clotting factor replacement therapy in congenital FXIII deficiency.
Susoctocog alfaA recombinant Factor VIII used to treat and prevent bleeding in hemophilia A.
Anti-inhibitor coagulant complexA medication used to control bleeding episodes and prevent bleeding episodes in hemophilia A and B.
Calcium acetateA phosphate binder used in patients with end-stage renal disease (ESRD) to prevent elevated phosphate levels and resulting ectopic calcification and secondary hyperparathyroidism.
Calcium chlorideAn ionic compound used for the treatment of hypocalcemia and hyperkalemia, and as an antidote to magnesium intoxication due to overdosage of magnesium sulfate.
Calcium gluconateAn ingredient found in a variety of supplements and vitamins, and is used to lower potassium in the blood or treat magnesium poisoning.
Human thrombinA platelet activating factor used to treat minor bleeding.
Beroctocog alfaBeroctocog alfa is indicated for the prevention and control of bleeding in patients with hemophilia A or acquired Factor VIII (FVIII) deficiency. It is also indicated for surgical/invasive procedures in...
Andexanet alfaA recombinant Factor Xa used to reverse anticoagulation caused by rivaroxaban and apixaban.
Coagulation Factor IX HumanA coagulation factor used to treat hemophilia B or factor IX hemophilia.
Thrombin alfaA platelet activating factor used to treat minor bleeding.
Calcium cationNot Annotated
Pantothenic acidA vitamin B5 found in various nutritional supplements.
Formic acidFormic acid (systematically called methanoic acid) is the simplest carboxylic acid. It is an important intermediate in chemical synthesis and occurs naturally, most famously in the venom of bee and...
Calcium carbonateAn ionic compound used as a calcium supplement or antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.
Calcium citrateAn ingredient found in a variety of supplements and vitamins.
Calcium threonateNo approved therapeutic indications.
Calcium PhosphateA compound used in supplements and antacids.
Antihemophilic Factor (Recombinant), PEGylatedFor the management of hemophilia A (congenital factor VIII deficiency) [FDA label], . This medication is a human antihemophilic factor indicated in adolescent and adult patients (12 years and older)...
Damoctocog alfa pegolA recombinant Factor VIII used to treat hemophilia A to control bleeding, perioperative bleeding, and also for prophylaxis of bleeding.
EmicizumabAn antibody against Factor IXa and Factor X used to treat hemophilia A.
Turoctocog alfa pegolTuroctocog alfa pegol (N8-GP) is indicated for use in adults and children of all ages with hemophilia A (congenital factor VIII deficiency) for routine prophylaxis in reducing the frequency of...
Eftrenonacog alfaA recombinant Factor IX used to treat and prevent bleeding in hemophilia B.
Albutrepenonacog alfaA recombinant Factor IX fused to recombinant human albumin used to treat hemophilia B.
Calcium sulfateNot Annotated
Drugs & Drug Targets
DrugTargetType
Coagulation factor VIIa Recombinant HumanCoagulation factor Xtarget
Coagulation factor VIIa Recombinant HumanTissue factortarget
Coagulation factor VIIa Recombinant HumanTissue factor pathway inhibitortarget
Coagulation factor VIIa Recombinant HumanVitamin K-dependent gamma-carboxylasetarget
Coagulation factor VIIa Recombinant HumanCoagulation factor VIItarget
Von Willebrand Factor HumanCoagulation factor VIIItarget
Von Willebrand Factor HumanCollagen alpha-1(I) chaintarget
Von Willebrand Factor HumanA disintegrin and metalloproteinase with thrombospondin motifs 13enzyme
Antihemophilic factor, human recombinantCoagulation factor Xtarget
Antihemophilic factor, human recombinantPhytanoyl-CoA dioxygenase, peroxisomaltarget
Antihemophilic factor, human recombinantCoagulation factor IXtarget
Antihemophilic factor, human recombinantAsialoglycoprotein receptor 2target
Antihemophilic factor, human recombinant78 kDa glucose-regulated proteintarget
Antihemophilic factor, human recombinantCalreticulintarget
Antihemophilic factor, human recombinantCalnexintarget
Antihemophilic factor, human recombinantProtein ERGIC-53target
Antihemophilic factor, human recombinantProlow-density lipoprotein receptor-related protein 1target
Antihemophilic factor, human recombinantMultiple coagulation factor deficiency protein 2target
Antihemophilic factor, human recombinantvon Willebrand factortarget
Antihemophilic factor, human recombinantProthrombinenzyme
Antihemophilic factor, human recombinantVitamin K-dependent protein Cenzyme
Antihemophilic factor humanCoagulation factor IXtarget
Antihemophilic factor humanCoagulation factor Xtarget
Antihemophilic factor humanVitamin K-dependent protein Cenzyme
CalciumProtein S100-Btarget
CalciumCalpastatintarget
CalciumCartilage oligomeric matrix proteintarget
CalciumCalmodulintarget
CalciumSpectrin beta chain, non-erythrocytic 1target
CalciumVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
CalciumTroponin C, skeletal muscletarget
CalciumTroponin C, slow skeletal and cardiac musclestarget
CalciumCalcium-transporting ATPase type 2C member 1target
CalciumAmiloride-sensitive amine oxidase [copper-containing]target
CalciumProtein S100-A13target
CalciumAlkaline phosphatase, placental typetarget
CalciumProtein S100-A8target
CalciumProtein S100-A9target
CalciumProtein S100-A2target
CalciumCeruloplasmintarget
CalciumBone morphogenetic protein 4target
CalciumMatrix Gla proteintarget
CalciumProtocadherin-19target
CalciumProgrammed cell death protein 6target
Platelet Activating FactorGanglioside GM2 activatortarget
Platelet Activating FactorP-glycoprotein 1transporter
Platelet Activating FactorPlatelet-activating factor receptortarget
Turoctocog alfaCoagulation factor IXtarget
Turoctocog alfaCoagulation factor Xtarget
Turoctocog alfaProthrombintarget
ThrombinProteinase-activated receptor 1target
ThrombinProteinase-activated receptor 4target
ThrombinCoagulation factor XItarget
ThrombinCoagulation factor XIII A chaintarget
ThrombinCoagulation factor XIII B chaintarget
ThrombinFibrinogen alpha chaintarget
ThrombinFibrinogen beta chaintarget
ThrombinFibrinogen gamma chaintarget
ThrombinCoagulation factor Vtarget
ThrombinCoagulation factor VIIItarget
ProthrombinFibrinogen alpha chaintarget
ProthrombinFibrinogen beta chaintarget
ProthrombinCoagulation factor XIII A chaintarget
ProthrombinCarboxypeptidase B2target
ProthrombinCoagulation factor Xenzyme
Coagulation factor VII humanTissue factortarget
Coagulation factor VII humanCoagulation factor Xtarget
Coagulation factor VII humanCoagulation factor IXtarget
Nonacog beta pegolCoagulation factor VIItarget
Nonacog beta pegolCoagulation factor VIIItarget
Nonacog beta pegolCoagulation factor Xtarget
Moroctocog alfaCoagulation factor Xtarget
Moroctocog alfaPhytanoyl-CoA dioxygenase, peroxisomaltarget
Moroctocog alfaCoagulation factor IXtarget
Moroctocog alfaAsialoglycoprotein receptor 2target
Moroctocog alfa78 kDa glucose-regulated proteintarget
Moroctocog alfaCalreticulintarget
Moroctocog alfaCalnexintarget
Moroctocog alfaProtein ERGIC-53target
Moroctocog alfaProlow-density lipoprotein receptor-related protein 1target
Moroctocog alfaMultiple coagulation factor deficiency protein 2target
Moroctocog alfavon Willebrand factortarget
Moroctocog alfaProthrombinenzyme
Moroctocog alfaVitamin K-dependent protein Cenzyme
Coagulation Factor IX (Recombinant)Coagulation factor Xtarget
Coagulation Factor IX (Recombinant)Coagulation factor XItarget
Coagulation Factor IX (Recombinant)Coagulation factor VIIItarget
Coagulation Factor IX (Recombinant)Prothrombintarget
Coagulation Factor IX (Recombinant)Coagulation factor VIItarget
Coagulation Factor IX (Recombinant)Vitamin K-dependent gamma-carboxylasetarget
Coagulation Factor IX (Recombinant)Prolow-density lipoprotein receptor-related protein 1target
CatridecacogCoagulation factor XIII B chaintarget
Susoctocog alfavon Willebrand factortarget
Anti-inhibitor coagulant complexCoagulation factor Xtarget
Anti-inhibitor coagulant complexProthrombintarget
Anti-inhibitor coagulant complexFibrinogen alpha chaintarget
Anti-inhibitor coagulant complexFibrinogen beta chaintarget
Anti-inhibitor coagulant complexCoagulation factor XIII A chaintarget
Anti-inhibitor coagulant complexCoagulation factor Vtarget
Anti-inhibitor coagulant complexCoagulation factor VIIItarget
Anti-inhibitor coagulant complexCoagulation factor VIItarget
Anti-inhibitor coagulant complexProthrombinenzyme
Anti-inhibitor coagulant complexCoagulation factor VIIenzyme
Anti-inhibitor coagulant complexCoagulation factor VIIIenzyme
Anti-inhibitor coagulant complexCoagulation factor IXenzyme
Anti-inhibitor coagulant complexCoagulation factor Venzyme
Calcium acetatePhosphatetarget
Calcium chlorideProtein S100-A13target
Human thrombinCoagulation factor Vtarget
Human thrombinCoagulation factor VIIItarget
Human thrombinCoagulation factor XItarget
Human thrombinCoagulation factor XIII A chaintarget
Human thrombinCoagulation factor XIII B chaintarget
Human thrombinFibrinogen alpha chaintarget
Human thrombinFibrinogen beta chaintarget
Human thrombinFibrinogen gamma chaintarget
Andexanet alfaTissue factor pathway inhibitortarget
Coagulation Factor IX HumanCoagulation factor Xtarget
Coagulation Factor IX HumanCoagulation factor XItarget
Coagulation Factor IX HumanCoagulation factor VIItarget
Coagulation Factor IX HumanCoagulation factor VIIItarget
Coagulation Factor IX HumanProthrombintarget
Coagulation Factor IX HumanProlow-density lipoprotein receptor-related protein 1target
Coagulation Factor IX HumanVitamin K-dependent gamma-carboxylasetarget
Thrombin alfaCoagulation factor VIIItarget
Thrombin alfaCoagulation factor Vtarget
Thrombin alfaFibrinogen alpha chaintarget
Thrombin alfaFibrinogen beta chaintarget
Thrombin alfaFibrinogen gamma chaintarget
Pantothenic acidPantothenate kinasetarget
Formic acidPutative hydroxypyruvate isomerase YgbMtarget
Formic acidDelta-aminolevulinic acid dehydratasetarget
Formic acid3-phosphoshikimate 1-carboxyvinyltransferasetarget
Formic acidSubtilisin Carlsbergtarget
Formic acidFibroblast growth factor 1target
Formic acidPeptide deformylasetarget
Formic acidPara-aminobenzoate synthase component 1target
Formic acidCarbonic anhydrase 2target
Formic acidHeme oxygenase 1target
Formic acidRibonuclease pancreatictarget
Formic acidDihydroorotate dehydrogenase (quinone)target
Formic acid(S)-2-haloacid dehalogenasetarget
Formic acidBeta-lactamase OXA-2target
Formic acidCatalasetarget
Formic acidSignal recognition particle proteintarget
Formic acidStreptavidintarget
Formic acidMethylglyoxal synthasetarget
Formic acidC-terminal-binding protein 1target
Formic acid6-phosphogluconolactonasetarget
Formic acidCitrate lyase subunit beta-like proteintarget
Formic acidPeripheral plasma membrane protein CASKtarget
Formic acidGuanylate kinasetarget
Formic acidProbable butyrate kinase 2target
Formic acidGamma-glutamylaminecyclotransferasetarget
Formic acidParvalbumin alphatarget
Formic acidAcylphosphatase-2target
Formic acidUncharacterized proteintarget
Formic acidArginine N-succinyltransferase subunit alphatarget
Formic acidPutative mannose-6-phosphate isomerase YvyItarget
Formic acidNitric oxide synthase, braintarget
Formic acidABC-type transporter, periplasmic subunittarget
Formic acidProbable phosphatase YcdXtarget
Formic acidPhenazine biosynthesis protein PhzDtarget
Formic acidOxalate decarboxylase OxdCtarget
Formic acidPutative ketoacyl reductasetarget
Formic acidGephyrintarget
Formic acidGlyoxalase family proteintarget
Formic acidCytohesin-2target
Formic acidGlutaconyl-CoA decarboxylase subunit alphatarget
Formic acidTranscriptional regulator, IclR familytarget
Formic acidCatalasetarget
Formic acidPutative L-rhamnose mutarotasetarget
Formic acidGlutathione S-transferasetarget
Formic acidHypoxanthine-guanine phosphoribosyltransferasetarget
Formic acidGlutaminase 1target
Formic acidGlutaminase 1target
Formic acidMolybdopterin synthase catalytic subunittarget
Formic acidAminotransferase, putativetarget
Formic acidIron binding protein FbpAtarget
Formic acidDNA gyrase subunit Btarget
Formic acidMonocarboxylate transporter 4transporter
Calcium citrateTransient receptor potential cation channel subfamily V member 6transporter
Calcium citrateCalbindincarrier
Calcium citrateProtein S100-Gcarrier
Calcium citrateSodium/calcium exchanger 1transporter
Calcium citrateTransient receptor potential cation channel subfamily V member 5transporter
Calcium citrateExtracellular calcium-sensing receptortarget
Calcium citrateCalreticulintarget
Calcium citrateCalcium and integrin-binding protein 1target
Calcium citrateProgrammed cell death protein 6target
Calcium citrateSorcintarget
Calcium citrateCalcineurin B homologous protein 1target
Calcium citrateSPARCtarget
Calcium citrateCalnexintarget
Calcium citrateFibrillin-2target
Calcium citrateProtein S100-Btarget
Calcium citrateCalsequestrin-2target
Calcium citrateRegucalcintarget
Calcium citratePeflintarget
Calcium citrateProtein S100-A6target
Calcium citrateTranslationally-controlled tumor proteintarget
Calcium citrateCalcium and integrin-binding family member 2target
Calcium citrateProtein S100-A13target
Calcium citrateCalsequestrin-1target
Calcium citrateNucleobindin-1target
Calcium citrateNucleobindin-2target
Calcium citrateCalmodulintarget
Calcium citrateFibrillin-3target
Calcium citrateGrancalcintarget
Calcium citrateCalcium-dependent secretion activator 1target
Calcium citrateSerum albumincarrier
Calcium citrateCalmodulin-2target
Calcium citrateCalmodulin-3target
Calcium citrateProtein S100-A16target
Calcium citrateCalretinintarget
Calcium citrateCalcyphosintarget
Calcium citrateCalcium-dependent secretion activator 2target
Calcium citrateCalreticulin-3target
Calcium citrateRyanodine receptor 1transporter
Calcium citrateRyanodine receptor 2transporter
Calcium citratePolycystic kidney disease 2-like 1 proteintransporter
Calcium citrateNeurexin-1target
Calcium citrateNeuronal calcium sensor 1target
Calcium citrateRyanodine receptor 3transporter
Calcium citratePolycystic kidney disease protein 1-like 3transporter
Calcium citrateCation channel sperm-associated protein 1transporter
Calcium citrateVoltage-dependent L-type calcium channeltransporter
Calcium citrateVoltage-dependent P/Q-type calcium channeltransporter
Calcium citrateVoltage-dependent T-type calcium channeltransporter
Calcium citrateVoltage-dependent R-type calcium channeltransporter
Calcium PhosphateSodium-dependent phosphate transporter 1transporter
Calcium PhosphateSodium-dependent phosphate transporter 2transporter
Calcium PhosphateSodium-dependent phosphate transport protein 2Atransporter
Calcium PhosphateSodium-dependent phosphate transport protein 2Btransporter
Calcium PhosphateSodium-dependent phosphate transport protein 2Ctransporter
Calcium PhosphateTransient receptor potential cation channel subfamily V member 6transporter
Calcium PhosphateCalbindincarrier
Calcium PhosphateProtein S100-Gcarrier
Calcium PhosphateSodium/calcium exchanger 1transporter
Calcium PhosphateTransient receptor potential cation channel subfamily V member 5transporter
Calcium PhosphateExtracellular calcium-sensing receptortarget
Calcium PhosphateCalreticulintarget
Calcium PhosphateCalcium and integrin-binding protein 1target
Calcium PhosphateProgrammed cell death protein 6target
Calcium PhosphateSorcintarget
Calcium PhosphateCalcineurin B homologous protein 1target
Calcium PhosphateSPARCtarget
Calcium PhosphateCalnexintarget
Calcium PhosphateFibrillin-2target
Calcium PhosphateProtein S100-Btarget
Calcium PhosphateCalsequestrin-2target
Calcium PhosphateRegucalcintarget
Calcium PhosphatePeflintarget
Calcium PhosphateProtein S100-A6target
Calcium PhosphateTranslationally-controlled tumor proteintarget
Calcium PhosphateCalcium and integrin-binding family member 2target
Calcium PhosphateProtein S100-A13target
Calcium PhosphateCalsequestrin-1target
Calcium PhosphateNucleobindin-1target
Calcium PhosphateNucleobindin-2target
Calcium PhosphateCalmodulintarget
Calcium PhosphateFibrillin-3target
Calcium PhosphateGrancalcintarget
Calcium PhosphateCalcium-dependent secretion activator 1target
Calcium PhosphateSerum albumincarrier
Calcium PhosphateCalmodulin-2target
Calcium PhosphateCalmodulin-3target
Calcium PhosphateProtein S100-A16target
Calcium PhosphateCalretinintarget
Calcium PhosphateCalcyphosintarget
Calcium PhosphateCalcium-dependent secretion activator 2target
Calcium PhosphateCalreticulin-3target
Calcium PhosphateRyanodine receptor 1transporter
Calcium PhosphateRyanodine receptor 2transporter
Calcium PhosphatePolycystic kidney disease 2-like 1 proteintransporter
Calcium PhosphateNeurexin-1target
Calcium PhosphateNeuronal calcium sensor 1target
Calcium PhosphateRyanodine receptor 3transporter
Calcium PhosphatePolycystic kidney disease protein 1-like 3transporter
Calcium PhosphateCation channel sperm-associated protein 1transporter
Calcium PhosphateVoltage-dependent L-type calcium channeltransporter
Calcium PhosphateVoltage-dependent P/Q-type calcium channeltransporter
Calcium PhosphateVoltage-dependent T-type calcium channeltransporter
Calcium PhosphateVoltage-dependent R-type calcium channeltransporter
Antihemophilic Factor (Recombinant), PEGylatedvon Willebrand factortarget
Antihemophilic Factor (Recombinant), PEGylatedvon Willebrand factorcarrier
Damoctocog alfa pegolCoagulation factor VIIItarget
EmicizumabCoagulation factor IXtarget
EmicizumabCoagulation factor Xtarget
Turoctocog alfa pegolVitamin K-dependent protein Cenzyme
Turoctocog alfa pegolCoagulation factor Xenzyme
Turoctocog alfa pegolCoagulation factor IXtarget
Turoctocog alfa pegolCoagulation factor Xtarget
Turoctocog alfa pegolProthrombintarget
Turoctocog alfa pegolvon Willebrand factorcarrier
Albutrepenonacog alfaCoagulation factor Xtarget
Albutrepenonacog alfaCoagulation factor VIIIenzyme