Coagulants

Name
Coagulants
Accession Number
DBCAT000113
Description

Agents that cause clotting.

Drugs
DrugDrug Description
DesmopressinA synthetic analog of vasopressin used to reduce renal excretion of water in central diabetes insipidus and nocturia.
VasopressinA peptide hormone used to increase blood pressure in patients with vasodilatory shock who are resistant to fluid and catecholamine therapy.
MenadioneThe primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification.
Tranexamic acidAn antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders.
Aminocaproic acidAn antifibrinolytic agent used to induce clotting postoperatively.
PhylloquinoneA fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses.
KallidinogenaseNot Annotated
NaftazoneA naphthoquinone derivative indicated in the treatment of varicose veins, hemorrhoids, and superficial thrombophlebitis.
Beroctocog alfaBeroctocog alfa is indicated for the prevention and control of bleeding in patients with hemophilia A or acquired Factor VIII (FVIII) deficiency. It is also indicated for surgical/invasive procedures in...
Andexanet alfaA recombinant Factor Xa used to reverse anticoagulation caused by rivaroxaban and apixaban.
Anti-inhibitor coagulant complexA medication used to control bleeding episodes and prevent bleeding episodes in hemophilia A and B.
AnivamersenAnivamersen is under investigation in clinical trial NCT01848106 (A Study to Determine the Efficacy and Safety of REG1 Compared to Bivalirudin in Patients Undergoing PCI).
Antihemophilic factor humanA Factor VIII replacement therapy used to treat hemophilia A.
Rurioctocog alfa pegolA pegylated recombinant human coagulation factor VIII used to treat and prevent bleeding episodes in patients 12 years and above with hemophilia A.
AprotininA serine protease inhibitor used to reduce the risk for perioperative blood loss and the need for blood transfusion in high-risk patients during cardiopulmonary bypass for coronary artery bypass graft surgery.
BatroxobinNo approved indications. Batroxobin is a defibrongenating agent which has been observed to reduce fibrinogen levels and thus reduce clot risk when used intravenously.
CarbazochromeIndicated for capillary and parenchymal hemorrhage (trauma, tonsillectomy, during surgery), intestinal bleeding, and thrombocytopenic purpura.
PoliglusamPoliglusam, or chitosan, is a linear polysaccharide consisting of D-glucosamine and N-acetyl-D-glucosamine. Naturally-occuring poliglusam is found in the cell walls of fungi, soil and sediments where it is produced from...
ThrombinA coagulation factor used to stop bleeding during surgery.
MenatetrenoneA form of vitamin K2 which is used in the treatment of osteoporosis to stimulate osteogenesis.
AminaphthoneA medication that inhibits erythrocyte aggregation in capillaries, improving venous return for the treatment of capillary fragility.
Menaquinone 7Menaquinone 7 is under investigation in clinical trial NCT00402974 (The Effect of Vitamin K Supplementation on Osteocalcin Carboxylation in Healthy Children).
AdrenaloneNot Annotated
OrnipressinNot Annotated
EtamsylateA hemostatic agent that acts by restoring capillary resistance and improving platelet adhesion.
Dobesilic acidA medication indicated in the treatment of hemorrhoids, venous insufficiency, and other microangiopathies.
Oxidized celluloseNot Annotated
ProtamineA heparin antagonist indicated in the treatment of heparin overdoses, to counteract heparins preoperatively, or during cardiac surgery and dialysis.
Ferric subsulfateFerric subsulfate is a stypic or hemostatic agent that causes agglutination of surface proteins resulting in local hemostasis. It has the chemical formula Fe4(OH)2(SO4)5. It is used after superficial skin...
Bismuth subgallateA medication used to deodorize flatulence and stools as well as hemostasis in soft tissue surgery.
Potassium triiodideNot Annotated
LypressinNot Annotated
Menaquinone 6Menaquinone 6 is under investigation in clinical trial NCT01194778 (Comparison of Efficacy of Different Dosages Vitamin K2).
MenaquinoneMenaquinone is under investigation in clinical trial NCT01533441 (Vitamin K2 Intervention in Patients With Vitamin K Antagonists).
Menadione bisulfiteNot Annotated
Carbazochrome sulfonic acidA hemostatic agent indicated to treat bleeding in capillary fragility.
Drugs & Drug Targets
DrugTargetType
DesmopressinVasopressin V1a receptortarget
DesmopressinVasopressin V1b receptortarget
DesmopressinVasopressin V2 receptortarget
DesmopressinProstaglandin G/H synthase 1enzyme
DesmopressinProstaglandin G/H synthase 2enzyme
VasopressinVasopressin V1a receptortarget
VasopressinVasopressin V2 receptortarget
VasopressinVasopressin V1b receptortarget
VasopressinCanalicular multispecific organic anion transporter 1transporter
VasopressinOxytocin receptortarget
MenadioneProthrombintarget
MenadioneVitamin K epoxide reductase complex subunit 1target
MenadioneCoagulation factor IXtarget
MenadioneVitamin K-dependent gamma-carboxylasetarget
MenadioneVitamin K-dependent protein Ctarget
MenadioneVitamin K-dependent protein Starget
MenadioneNAD(P)H dehydrogenase [quinone] 1target
MenadioneRibosyldihydronicotinamide dehydrogenase [quinone]target
MenadioneVitamin K epoxide reductase complex subunit 1-like protein 1target
MenadioneXanthine dehydrogenase/oxidaseenzyme
MenadioneAldehyde oxidaseenzyme
MenadioneMethylenetetrahydrofolate reductaseenzyme
MenadioneCytochrome P450 1A1enzyme
MenadioneOsteocalcintarget
MenadioneCytochrome P450 1A2enzyme
MenadioneCytochrome P450 2A6enzyme
MenadioneCytochrome P450 1B1enzyme
MenadioneCytochrome P450 2B6enzyme
MenadioneCytochrome P450 2C8enzyme
MenadioneCytochrome P450 2C9enzyme
MenadioneCytochrome P450 2C19enzyme
MenadioneCytochrome P450 2D6enzyme
MenadioneCytochrome P450 2E1enzyme
MenadioneCytochrome P450 3A4enzyme
MenadioneCytochrome P450 3A5enzyme
MenadioneCytochrome P450 3A7enzyme
Tranexamic acidPlasminogentarget
Aminocaproic acidPlasminogentarget
Aminocaproic acidTissue-type plasminogen activatortarget
Aminocaproic acidApolipoprotein(a)target
Aminocaproic acidAldehyde oxidaseenzyme
PhylloquinoneVitamin K-dependent gamma-carboxylasetarget
PhylloquinoneOsteocalcintarget
PhylloquinoneLeukotriene-B(4) omega-hydroxylase 1enzyme
PhylloquinoneUbiA prenyltransferase domain-containing protein 1enzyme
PhylloquinoneVitamin K epoxide reductase complex subunit 1enzyme
Andexanet alfaTissue factor pathway inhibitortarget
Anti-inhibitor coagulant complexCoagulation factor Xtarget
Anti-inhibitor coagulant complexProthrombintarget
Anti-inhibitor coagulant complexFibrinogen alpha chaintarget
Anti-inhibitor coagulant complexFibrinogen beta chaintarget
Anti-inhibitor coagulant complexCoagulation factor XIII A chaintarget
Anti-inhibitor coagulant complexCoagulation factor Vtarget
Anti-inhibitor coagulant complexCoagulation factor VIIItarget
Anti-inhibitor coagulant complexCoagulation factor VIItarget
Antihemophilic factor humanCoagulation factor IXtarget
Antihemophilic factor humanCoagulation factor Xtarget
Antihemophilic factor humanVitamin K-dependent protein Cenzyme
Rurioctocog alfa pegolvon Willebrand factortarget
Rurioctocog alfa pegolCoagulation factor VIIItarget
AprotininTrypsin-1target
AprotininChymotrypsinogen Btarget
AprotininPlasminogentarget
AprotininKallikrein-1target
AprotininCholinesteraseenzyme
ThrombinProteinase-activated receptor 1target
ThrombinProteinase-activated receptor 4target
ThrombinCoagulation factor XItarget
ThrombinCoagulation factor XIII A chaintarget
ThrombinCoagulation factor XIII B chaintarget
ThrombinFibrinogen alpha chaintarget
ThrombinFibrinogen beta chaintarget
ThrombinFibrinogen gamma chaintarget
ThrombinCoagulation factor Vtarget
ThrombinCoagulation factor VIIItarget
Bismuth subgallateSerum albumincarrier
LypressinVasopressin V1a receptortarget
LypressinVasopressin V2 receptortarget
LypressinVasopressin V1b receptortarget
LypressinCanalicular multispecific organic anion transporter 1transporter