Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
DrugDrug NameDrug Indication
DB00716NedocromilFor the treatment of mild to moderate asthma
DB00768OlopatadineOlopatadine is indicated for the symptomatic treatment of ocular itching associated with allergic conjunctivitis as ophthalmic solution.[L6781] In nasal spray, olopatadine is indicated for the symptomatic relief of seasonal allergic rhinitis in patients 12 years of age and older.[L6784]
DB00920KetotifenIndicated as an add-on or prophylactic oral medication in the chronic treatment of mild atopic asthmatic children. Also used as self-medication for the temporary relief of itching of the eye due to allergic conjunctivitis (ophthalmic).
DB06794LodoxamideIndicated in the treatment of the ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.
DB00043OmalizumabThis drug is an anti-IgE antibody indicated for: 1. Moderate to severe persistent asthma in patients 6 years of age and older with a positive skin test or in vitro reactivity to a perennial aeroallergen and symptoms that are inadequately controlled with inhaled corticosteroids [FDA label] 2. Chronic idiopathic urticaria in adults and adolescents 12 years of age and older who remain symptomatic despite H1 antihistamine treatment [FDA label]
DB00283ClemastineFor the relief of symptoms associated with allergic rhinitis such as sneezing, rhinorrhea, pruritus and acrimation. Also for the management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Used as self-medication for temporary relief of symptoms associated with the common cold.
DB00324FluorometholoneFor the ophthalmic treatment of corticosteroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe.
DB00341Cetirizine**Seasonal Allergic Rhinitis**: Indicated for the relief of symptoms associated with seasonal allergic rhinitis caused by allergens such as ragweed, grass and tree pollens in adults and children 2 years of age and above. Symptoms treated effectively include sneezing, rhinorrhea, nasal pruritus, ocular pruritus, tearing, and redness of the eyes [FDA label]. **Perennial allergic rhinitis**: This drug is indicated for the relief of symptoms associated with perennial allergic rhinitis due to allergens including dust mites, animal dander, and molds in adults and children 6 months of age and older. Symptoms treated effectively include sneezing, rhinorrhea, postnasal discharge, nasal pruritus, ocular pruritus, and tearing [FDA label]. **Chronic urticaria**: Cetirizine is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 months of age and older. It markedly reduces the occurrence, severity, and duration of hives and significantly reduces pruritus [FDA label].
DB00427TriprolidineFor the symptomatic relief of seasonal or perennial allergic rhinitis or nonallergic rhinitis; allergic conjunctivitis; and mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Also used in combination with other agents for the symptomatic relief of symptoms associated with the common cold.
DB00434CyproheptadineFor treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, cold urticaria, dermatographism, and as therapy for anaphylactic reactions adjunctive to epinephrine.
DB00455LoratadineLoratadine is a 2nd generation antihistamine and is typically used to manage symptoms of allergic rhinitis, wheal formation and urticaria.[A176435][A176438] Unlike 1st generation antihistamines, loratadine is non-sedating since it has minimal effect on the central nervous system with only a small amount entering the brain. [A176438]
DB00588Fluticasone propionateFluticasone propionate is indicated as an inhaler for the treatment and management of asthma by prophylaxis[FDA Label]as well as inflammatory and pruritic dermatoses[F4355]. A fluticasone propionate nasal spray is indicated for managing nonallergic rhinitis[F4358].
DB00637AstemizoleAstemizole was indicated for use in the relieving allergy symptoms, particularly rhinitis and conjunctivitis. It has been withdrawn from the market however due to concerns of arrhythmias.
DB00737MeclizineIndicated for the symptomatic treatment of nausea, vomiting, and dizziness associated with motion sickness,[L6772] and management of vertigo due to various causes, including radiation sickness, Meniere’s syndrome, labyrinthitis and other vestibular disturbances.[L6766]
DB00764MometasoneThe inhaler is indicated for the maintenance treatment of asthma as prophylactic therapy. The nasal spray is indicated for the treatment of the nasal symptoms of seasonal allergic and perennial allergic rhinitis.
DB00792TripelennamineUsed for the symptomatic relief of hypersensitivity reactions, coughs, and the common cold.
DB00835BrompheniramineFor the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing.
DB14596Loteprednol etabonateA number of prescription loteprednol etabonate ophthalmic products are specifically indicated for the treatment of post-operative inflammation and pain following ocular surgery [FDA Label].
DB00950FexofenadineFor management of Seasonal allergic rhinitis
DB00972AzelastineFor the symptomatic treatment of seasonal allergic rhinitis and non-allergic rhinitis, as well as symptomatic relief of ocular itching associated with allergic conjunctivitis.
DB01025AmlexanoxUsed as a paste in the mouth to treat aphthous ulcers (canker sores).
DB01047FluocinonideA topical anti-inflammatory product for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
DB01069PromethazineFor the treatment of allergic disorders, and nausea/vomiting.
DB01071MequitazineFor the treatment of Hay fever, urticaria (hives) and allergic rhinitis
DB01075DiphenhydramineDiphenhydramine is a first-generation histamine H1 receptor antagonist (H1 antihistamine) that is widely available as a non-prescription, over-the-counter (OTC) medication. As an OTC medication, diphenhydramine is typically formulated as tablets and creams indicated for use in treating sneezing, runny nose, itchy/watery eyes, itching of nose or throat, insomnia, pruritis, urticaria, insect bites/stings, allergic rashes, and nausea [L5263, L5266, L5269, F3379, A174541]. Additionally, when the use of oral diphenhydramine is impractical, there are also prescription-only formulations such as diphenhydramine injection products that are effective in adults and pediatric patients (other than premature infants and neonates) for: i) the amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standard measures after acute allergic reaction symptoms have been controlled, and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated [F3352]; ii) the active treatment of motion sickness [F3352]; and iii) use in parkinsonism when oral therapy is impossible or contraindicated, as follows: parkinsonism in the elderly who are unable to tolerate more potent agents; mild cases of parkinsonism in other age groups, and in other cases of parkinsonism in combination with centrally acting anticholinergic agents [F3352].
DB01084EmedastineFor the temporary relief of the signs and symptoms of allergic conjunctivitis.
DB01114ChlorphenamineFor the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever.
DB01410CiclesonideFor the treatment of nasal symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents 12 years of age and older.
DB01620PheniraminePheniramine is an antihistamine used to treat allergic conditions such as hay fever or urticaria.
DB04819MethapyrileneNot Available
DB06691MepyramineIndicated for the treatment of allergic conditions, symptomatic relief of hypersensitivity reaction, and treatment of pruritic skin disorders.
DB07615TranilastFor the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
DB08799AntazolineUsed to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.
DB08801DimetindeneIndicated as symptomatic treatment of allergic reactions: urticaria, allergies of the upper respiratory tract such as hey fever and perennial rhinitis, food and drug allergies; pruritus of various origins, except pruritus due to cholestasis; insect bites. Dimethindene is also indicated for pruritus in eruptive skin diseases such as chicken-pox. Dimethindene can also be used as an adjuvant in eczema and other pruriginous dermatoses of allergic origin.
DB09091TixocortolTixocortol is indicated for the treatment of rhinitis as a nasal suspension or aerosol. It is also used in the form of lozenges for the treatment of pharyngitis and in the form of enemas or rectal solution for the treatment of ulcerative colitis. Tixocortol can be used orally in a suspension or powder for the treatment of inflammatory conditions.[L1077] It is also the substance used for the screening of contact allergies to class A steroids.[A31435]
DB11487Dexamethasone isonicotinateNot Available
DB12877OxatomideNot Available
DB13867FluticasoneFluticasone's 2 esters are indicated as inhalers for the treatment and management of asthma by prophylaxis[FDA Label][F4364]as well as inflammatory and pruritic dermatoses[F4355]. A [DB00588] nasal spray is indicated for managing nonallergic rhinitis[F4358] while the [DB08906] nasal spray is indicated for treating season and perennial allergic rhinitis[F4361,A177130].
DB01003Cromoglicic acidFor the management of patients with bronchial asthma. Also used in the treatment of vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.
DB01106LevocabastineAs an ophthalmic for the temporary relief of the signs and symptoms of seasonal allergic conjunctivitis. Also used as a nasal spray for allergic rhinitis.
DB04890BepotastineFor the symptomatic treatment of itchy eyes (caused by IgE-induced mast cell degranulation) due to allergic conjunctivitis.
DB14512Mometasone furoateThere are 3 formulations of mometasone furoate with various indications. The inhaler is indicated for prophylaxis of asthma in patients ≥4 years[FDA Label]. The nasal spray is indicated for treating nasal symptoms of allergic rhinitis in patients ≥2 years, treating symptoms of nasal congestion from seasonal allergic rhinitis in patients ≥2 years, treating nasal polyps in patients ≥18 years, and prophylaxis of seasonal allergic rhinitis in patients ≥12 years[F4292]. The ointment is indicated for symptomatic treatment of dermatitis and pruritis in patients ≥2 years[F4295].
DB00873LoteprednolNot Available
DrugDrug NameTargetType
DB00716NedocromilCysteinyl leukotriene receptor 1target
DB00716NedocromilCysteinyl leukotriene receptor 2target
DB00716NedocromilProstaglandin D2 receptortarget
DB00716NedocromilfMet-Leu-Phe receptortarget
DB00716NedocromilHeat shock protein HSP 90-alphatarget
DB00768OlopatadineHistamine H1 receptortarget
DB00768OlopatadineProtein S100-A1target
DB00768OlopatadineProtein S100-A12target
DB00768OlopatadineProtein S100-Btarget
DB00768OlopatadineProtein S100-A13target
DB00768OlopatadineProtein S100-A2target
DB00768OlopatadineCytochrome P450 3A4enzyme
DB00768OlopatadineSerum albumincarrier
DB00768OlopatadineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00768OlopatadineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00768OlopatadineMultidrug resistance protein 1transporter
DB00768OlopatadineHistamine H2 receptortarget
DB00768OlopatadineHistamine H3 receptortarget
DB00920KetotifenHistamine H1 receptortarget
DB00920Ketotifen6-phosphogluconate dehydrogenase, decarboxylatingtarget
DB00043OmalizumabHigh affinity immunoglobulin epsilon receptor subunit alphatarget
DB00043OmalizumabHigh affinity immunoglobulin epsilon receptor subunit betatarget
DB00283ClemastineHistamine H1 receptortarget
DB00283ClemastineCytochrome P450 2D6enzyme
DB00324FluorometholoneCorticosteroid-binding globulincarrier
DB00324FluorometholoneCytochrome P450 3A4enzyme
DB00324FluorometholoneGlucocorticoid receptortarget
DB00341CetirizineHistamine H1 receptortarget
DB00341CetirizineMultidrug resistance protein 1transporter
DB00427TriprolidineHistamine H1 receptortarget
DB00434Cyproheptadine5-hydroxytryptamine receptor 2Atarget
DB00434CyproheptadineHistamine H1 receptortarget
DB00434CyproheptadineMuscarinic acetylcholine receptor M1target
DB00434CyproheptadineMuscarinic acetylcholine receptor M2target
DB00434CyproheptadineMuscarinic acetylcholine receptor M3target
DB00434Cyproheptadine5-hydroxytryptamine receptor 2Ctarget
DB00434CyproheptadineUDP-glucuronosyltransferase 1-3enzyme
DB00434Cyproheptadine5-hydroxytryptamine receptor 7target
DB00455LoratadineHistamine H1 receptortarget
DB00455LoratadineCytochrome P450 3A4enzyme
DB00455LoratadineCytochrome P450 2C19enzyme
DB00455LoratadineCytochrome P450 2D6enzyme
DB00455LoratadineCytochrome P450 2C8enzyme
DB00455LoratadineMultidrug resistance protein 1transporter
DB00455LoratadinePotassium voltage-gated channel subfamily H member 2target
DB00455LoratadineBile salt export pumptransporter
DB00455LoratadineCytochrome P450 1A1enzyme
DB00455LoratadineCytochrome P450 1A2enzyme
DB00455LoratadineCytochrome P450 2B6enzyme
DB00455LoratadineCytochrome P450 2C9enzyme
DB00455LoratadineCytochrome P450 3A5enzyme
DB00588Fluticasone propionateCorticosteroid-binding globulincarrier
DB00588Fluticasone propionateCytosolic phospholipase A2target
DB00588Fluticasone propionateGlucocorticoid receptortarget
DB00588Fluticasone propionateCytochrome P450 3A4enzyme
DB00588Fluticasone propionateProgesterone receptortarget
DB00588Fluticasone propionateMineralocorticoid receptortarget
DB00588Fluticasone propionateCytochrome P450 3A5enzyme
DB00588Fluticasone propionateCytochrome P450 3A7enzyme
DB00588Fluticasone propionateCytochrome P450 2C8enzyme
DB00588Fluticasone propionateMultidrug resistance protein 1carrier
DB00588Fluticasone propionateSolute carrier organic anion transporter family member 1B1carrier
DB00637AstemizoleHistamine H1 receptortarget
DB00637AstemizolePotassium voltage-gated channel subfamily H member 2target
DB00637AstemizoleCytochrome P450 3A4enzyme
DB00637AstemizoleCytochrome P450 3A5enzyme
DB00637AstemizoleCytochrome P450 3A7enzyme
DB00637AstemizoleMultidrug resistance protein 1transporter
DB00637AstemizoleCytochrome P450 2D6enzyme
DB00637AstemizoleCytochrome P450 2J2enzyme
DB00637AstemizolePotassium voltage-gated channel subfamily H member 1target
DB00637AstemizoleMicrotubule-associated protein tautarget
DB00637AstemizoleBile salt export pumptransporter
DB00737MeclizineHistamine H1 receptortarget
DB00737MeclizineNuclear receptor subfamily 1 group I member 3target
DB00737MeclizineCytochrome P450 2D6enzyme
DB00737MeclizineSerum albumincarrier
DB00764MometasoneGlucocorticoid receptortarget
DB00764MometasoneCytochrome P450 2C8enzyme
DB00764MometasoneProgesterone receptortarget
DB00764MometasoneCytochrome P450 3A4enzyme
DB00792TripelennamineHistamine H1 receptortarget
DB00792TripelennamineCytochrome P450 2D6enzyme
DB00835BrompheniramineHistamine H1 receptortarget
DB00835BrompheniramineMuscarinic acetylcholine receptor M1target
DB00835BrompheniramineMuscarinic acetylcholine receptor M2target
DB00835BrompheniramineMuscarinic acetylcholine receptor M3target
DB00835BrompheniramineMuscarinic acetylcholine receptor M4target
DB00835BrompheniramineMuscarinic acetylcholine receptor M5target
DB00835BrompheniramineCytochrome P450 2B6enzyme
DB00835BrompheniramineCytochrome P450 2C19enzyme
DB00835BrompheniramineCytochrome P450 2C8enzyme
DB00835BrompheniramineCytochrome P450 2E1enzyme
DB00835BrompheniramineCytochrome P450 3A4enzyme
DB14596Loteprednol etabonateGlucocorticoid receptortarget
DB14596Loteprednol etabonateCytochrome P450 3A4enzyme
DB14596Loteprednol etabonateSerum paraoxonase/arylesterase 1enzyme
DB00950FexofenadineHistamine H1 receptortarget
DB00950FexofenadineMultidrug resistance protein 1transporter
DB00950FexofenadineSolute carrier organic anion transporter family member 2B1transporter
DB00950FexofenadineSolute carrier organic anion transporter family member 1A2transporter
DB00950FexofenadineSolute carrier organic anion transporter family member 1B1transporter
DB00950FexofenadineSolute carrier organic anion transporter family member 1B3transporter
DB00950FexofenadineSolute carrier family 22 member 8transporter
DB00972AzelastineHistamine H1 receptortarget
DB00972AzelastineCytochrome P450 1A2enzyme
DB00972AzelastineCytochrome P450 2D6enzyme
DB00972AzelastineCytochrome P450 3A4enzyme
DB00972AzelastineCytochrome P450 2C19enzyme
DB00972AzelastineCytochrome P450 1A1enzyme
DB00972AzelastineCytochrome P450 3A5enzyme
DB00972AzelastineCytochrome P450 2C9enzyme
DB00972AzelastineCytochrome P450 2C8enzyme
DB00972AzelastineMultidrug resistance protein 1transporter
DB00972AzelastineCytochrome P450 2A6enzyme
DB00972AzelastineCytochrome P450 2B6enzyme
DB00972AzelastineCytochrome P450 2E1enzyme
DB01025AmlexanoxInterleukin-3target
DB01025AmlexanoxProtein S100-A12target
DB01025AmlexanoxProtein S100-A13target
DB01025AmlexanoxFibroblast growth factor 1target
DB01047FluocinonideCorticosteroid-binding globulincarrier
DB01047FluocinonideGlucocorticoid receptortarget
DB01047FluocinonideSmoothened homologtarget
DB01047FluocinonideCytochrome P450 3A4enzyme
DB01069PromethazineD(2) dopamine receptortarget
DB01069PromethazineHistamine H1 receptortarget
DB01069PromethazineMuscarinic acetylcholine receptor M4target
DB01069PromethazineMuscarinic acetylcholine receptor M1target
DB01069PromethazineMuscarinic acetylcholine receptor M5target
DB01069PromethazineAlpha-1A adrenergic receptortarget
DB01069Promethazine5-hydroxytryptamine receptor 2Atarget
DB01069PromethazineMuscarinic acetylcholine receptor M2target
DB01069PromethazineMuscarinic acetylcholine receptor M3target
DB01069PromethazineCalmodulintarget
DB01069PromethazineCytochrome P450 2D6enzyme
DB01069PromethazineCytochrome P450 2B6enzyme
DB01069PromethazineMultidrug resistance protein 1transporter
DB01069PromethazineCytochrome P450 2C9enzyme
DB01069PromethazineHistamine H2 receptortarget
DB01071MequitazineHistamine H1 receptortarget
DB01071MequitazineCytochrome P450 2D6enzyme
DB01071MequitazineCytochrome P450 3A4enzyme
DB01075DiphenhydramineHistamine H1 receptortarget
DB01075DiphenhydramineCytochrome P450 2D6enzyme
DB01075DiphenhydramineCytochrome P450 2C9enzyme
DB01075DiphenhydramineCytochrome P450 2C19enzyme
DB01075DiphenhydramineSolute carrier family 22 member 2transporter
DB01075DiphenhydramineSolute carrier family 22 member 5transporter
DB01075DiphenhydramineProstaglandin G/H synthase 1enzyme
DB01075DiphenhydramineMuscarinic acetylcholine receptor M2target
DB01084EmedastineHistamine H1 receptortarget
DB01114ChlorphenamineHistamine H1 receptortarget
DB01114ChlorphenamineCytochrome P450 3A4enzyme
DB01114ChlorphenamineCytochrome P450 2D6enzyme
DB01114ChlorphenamineSodium-dependent serotonin transportertarget
DB01114ChlorphenamineSodium-dependent noradrenaline transportertarget
DB01114ChlorphenamineSodium-dependent dopamine transportertarget
DB01114ChlorphenamineCytochrome P450 3A5enzyme
DB01114ChlorphenamineCytochrome P450 3A7enzyme
DB01114ChlorphenamineSolute carrier family 22 member 2transporter
DB01114ChlorphenamineSolute carrier family 22 member 1transporter
DB01410CiclesonideCorticosteroid-binding globulincarrier
DB01410CiclesonideCytochrome P450 3A4enzyme
DB01410CiclesonideCytochrome P450 2D6enzyme
DB01410CiclesonideGlucocorticoid receptortarget
DB01410CiclesonideLiver carboxylesterase 1enzyme
DB01620PheniramineHistamine H1 receptortarget
DB01620PheniramineNuclear receptor subfamily 1 group I member 3target
DB06691MepyramineCytochrome P450 2D6enzyme
DB06691MepyramineHistamine H1 receptortarget
DB06691MepyramineSolute carrier family 22 member 4transporter
DB06691MepyramineSolute carrier family 22 member 5transporter
DB07615TranilastHematopoietic prostaglandin D synthasetarget
DB07615TranilastCytochrome P450 3A4enzyme
DB07615TranilastCytochrome P450 2C9enzyme
DB08799AntazolineHistamine H1 receptortarget
DB08801DimetindeneMuscarinic acetylcholine receptor M2target
DB08801DimetindeneHistamine H1 receptortarget
DB09091TixocortolGlucocorticoid receptortarget
DB09091TixocortolHistone deacetylase 2target
DB11487Dexamethasone isonicotinateCytochrome P450 3A4enzyme
DB13867FluticasoneCytochrome P450 3A4enzyme
DB13867FluticasoneCytochrome P450 2C8enzyme
DB13867FluticasoneMultidrug resistance protein 1carrier
DB13867FluticasoneSolute carrier organic anion transporter family member 1B1carrier
DB13867FluticasoneMultidrug resistance protein 1transporter
DB13867FluticasoneSolute carrier organic anion transporter family member 1B1transporter
DB13867FluticasoneGlucocorticoid receptortarget
DB13867FluticasoneCorticosteroid-binding globulincarrier
DB13867FluticasoneCytochrome P450 3A5enzyme
DB13867FluticasoneCytochrome P450 3A7enzyme
DB13867FluticasoneProgesterone receptortarget
DB13867FluticasoneCytosolic phospholipase A2target
DB13867FluticasoneMineralocorticoid receptortarget
DB01003Cromoglicic acidCalcium-activated potassium channel subunit alpha-1target
DB01003Cromoglicic acidProtein S100-Ptarget
DB01106LevocabastineNeurotensin receptor type 2target
DB01106LevocabastineHistamine H1 receptortarget
DB04890BepotastineHistamine H1 receptortarget
DB14512Mometasone furoateGlucocorticoid receptortarget
DB14512Mometasone furoateCytochrome P450 2C8enzyme
DB14512Mometasone furoateProgesterone receptortarget
DB14512Mometasone furoateCytochrome P450 3A4enzyme