Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
DrugDrug NameDrug Description
DB00716NedocromilA pyrano quinoline used to treat allergic conjunctivitis.
DB00768OlopatadineA histamine H1 antagonist used to treat allergic conjunctivitis and rhinitis.
DB00920KetotifenA histamine H1 receptor blocker used to treat mild asthma and allergic conjunctivitis.
DB06794LodoxamideAn ophthalmic agent used for the treatment of the ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.
DB00043OmalizumabA monoclonal anti-immunoglobulin E antibody used in the treatment of severe asthma and chronic idiopathic urticaria.
DB00283ClemastineAn antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis.
DB00324FluorometholoneAn ophthalmic corticosteroid used for the relief of inflammation located in both the palpebral and bulbar conjunctiva, the cornea, and the anterior segment of the globe of the eye.
DB00341CetirizineA selective Histamine-1 antagonist drug used in allergic rhinitis and chronic urticaria.
DB00427TriprolidineA sedating antihistamine combined with pseudoephedrine and guaifenesin in various types of cold and allergy medications to relieve allergy symptoms, hay fever and common cold symptoms, and to aid in sleep.
DB00434CyproheptadineA serotonin and histamine antagonist used in the treatment of allergy symptoms and in combination with epinephrine in the treatment of anaphylaxis.
DB00455LoratadineA second generation antihistamine used to manage the symptoms of allergic rhinitis.
DB00588Fluticasone propionateA glucocorticoid used to treat asthma, inflammatory pruritic dermatoses, and nonallergic rhinitis.
DB00637AstemizoleA second generation antihistamine used to treat allergy symptoms.
DB00737MeclizineA histamine H1 antagonist used to treat nausea, vomiting, and dizziness associated with motion sickness.
DB00764MometasoneA corticosteroid used to treat asthma and allergic rhinitis.
DB00792TripelennamineA histamine H1 antagonist used to treat hypersensitivity reactions, coughs, and the common cold.
DB00835BrompheniramineA histamine H1 antagonist used to treat coughs, upper respiratory symptoms, and nasal congestion associated with allergies and the common cold.
DB14596Loteprednol etabonateA corticosteroid used to treat allergic conjunctivitis as well as inflammation and pain after ocular surgery.
DB00950FexofenadineAn antihistamine used to treat seasonal allergic rhinitis.
DB00972AzelastineA histamine H1-receptor antagonist used intranasally to treat allergic and vasomotor rhinitis and in an ophthalmic solution to treat allergic conjunctivitis.
DB01025AmlexanoxUsed as a paste in the mouth to treat aphthous ulcers (canker sores).
DB01047FluocinonideA high potency corticosteroid commonly used topically for a number of inflammatory skin conditions.
DB01069PromethazineA first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
DB01071MequitazineFor the treatment of Hay fever, urticaria (hives) and allergic rhinitis
DB01075DiphenhydramineA H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
DB01084EmedastineA selective H1-receptor antagonist used topically to manage symptoms of allergic conjunctivitis.
DB01114ChlorpheniramineA histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies.
DB01410CiclesonideA glucocorticoid used in the symptomatic relief of nasal symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents.
DB01620PheniramineAn antihistamine used to treat allergic rhinitis and pruritus.
DB04819MethapyrileneMethapyrilene, formerly marketed in many drug products, was shown to be a potent carcinogen. Manufacturers voluntarily withdrew methapyriline drug products from the market in May and June 1979.
DB06691MepyramineAn antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders.
DB07615TranilastFor the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
DB08799AntazolineAn antihistamine agent used for the symptomatic treatment of nasal congestion and allergic conjunctivitis.
DB08801DimetindeneIndicated as symptomatic treatment of allergic reactions: urticaria, allergies of the upper respiratory tract such as hey fever and perennial rhinitis, food and drug allergies; pruritus of various origins, except...
DB09091TixocortolA corticosteroid used for the symptomatic treatment of rhinitis, pharyngitis, and ulcerative colitis.
DB11487Dexamethasone isonicotinateDexamethasone isonicotinate is an anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, topically, and parenterally. Its unintended mineralocorticoid action may cause salt and water retention.
DB12877OxatomideOxatomide has been used in trials studying the treatment of Muscular Dystrophy, Duchenne.
DB13867FluticasoneFluticasone's 2 esters are indicated as inhalers for the treatment and management of asthma by prophylaxis[FDA Label] as well as inflammatory and pruritic dermatoses . A DB00588 nasal spray is...
DB01003Cromoglicic acidA medication used to treat asthma, allergic reactions of the eyes and nose, as well as other mast cell reactions.
DB01106LevocabastineA selective histamine H1 receptor antagonist indicated for the management of seasonal allergic conjunctivitis symptoms.
DB04890BepotastineAn ophthalmic H1 antagonist used to treat itchiness associated with allergic conjunctivitis.
DB14512Mometasone furoateA corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus.
DB00873LoteprednolNot Annotated
DrugDrug NameTargetType
DB00716NedocromilCysteinyl leukotriene receptor 1target
DB00716NedocromilCysteinyl leukotriene receptor 2target
DB00716NedocromilProstaglandin D2 receptortarget
DB00716NedocromilfMet-Leu-Phe receptortarget
DB00716NedocromilHeat shock protein HSP 90-alphatarget
DB00768OlopatadineHistamine H1 receptortarget
DB00768OlopatadineProtein S100-A1target
DB00768OlopatadineProtein S100-A12target
DB00768OlopatadineProtein S100-Btarget
DB00768OlopatadineProtein S100-A13target
DB00768OlopatadineProtein S100-A2target
DB00768OlopatadineCytochrome P450 3A4enzyme
DB00768OlopatadineSerum albumincarrier
DB00768OlopatadineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00768OlopatadineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00768OlopatadineP-glycoprotein 1transporter
DB00768OlopatadineHistamine H2 receptortarget
DB00768OlopatadineHistamine H3 receptortarget
DB00920KetotifenHistamine H1 receptortarget
DB00920Ketotifen6-phosphogluconate dehydrogenase, decarboxylatingtarget
DB00043OmalizumabHigh affinity immunoglobulin epsilon receptor subunit alphatarget
DB00043OmalizumabHigh affinity immunoglobulin epsilon receptor subunit betatarget
DB00283ClemastineHistamine H1 receptortarget
DB00283ClemastineCytochrome P450 2D6enzyme
DB00324FluorometholoneCorticosteroid-binding globulincarrier
DB00324FluorometholoneCytochrome P450 3A4enzyme
DB00324FluorometholoneGlucocorticoid receptortarget
DB00324FluorometholoneCytochrome P450 3A5enzyme
DB00341CetirizineHistamine H1 receptortarget
DB00341CetirizineP-glycoprotein 1transporter
DB00427TriprolidineHistamine H1 receptortarget
DB00434Cyproheptadine5-hydroxytryptamine receptor 2Atarget
DB00434CyproheptadineHistamine H1 receptortarget
DB00434CyproheptadineMuscarinic acetylcholine receptor M1target
DB00434CyproheptadineMuscarinic acetylcholine receptor M2target
DB00434CyproheptadineMuscarinic acetylcholine receptor M3target
DB00434Cyproheptadine5-hydroxytryptamine receptor 2Ctarget
DB00434CyproheptadineUDP-glucuronosyltransferase 1-3enzyme
DB00434Cyproheptadine5-hydroxytryptamine receptor 7target
DB00455LoratadineHistamine H1 receptortarget
DB00455LoratadineCytochrome P450 3A4enzyme
DB00455LoratadineCytochrome P450 2C19enzyme
DB00455LoratadineCytochrome P450 2D6enzyme
DB00455LoratadineCytochrome P450 2C8enzyme
DB00455LoratadineP-glycoprotein 1transporter
DB00455LoratadinePotassium voltage-gated channel subfamily H member 2target
DB00455LoratadineBile salt export pumptransporter
DB00455LoratadineCytochrome P450 1A1enzyme
DB00455LoratadineCytochrome P450 1A2enzyme
DB00455LoratadineCytochrome P450 2B6enzyme
DB00455LoratadineCytochrome P450 2C9enzyme
DB00455LoratadineCytochrome P450 3A5enzyme
DB00455LoratadineUDP-glucuronosyltransferase 2B10enzyme
DB00455LoratadineUDP-glucuronosyltransferase 1-1enzyme
DB00455LoratadineUDP-glucuronosyltransferase 1-3enzyme
DB00455LoratadineUDP-glucuronosyltransferase 2B15enzyme
DB00588Fluticasone propionateCorticosteroid-binding globulincarrier
DB00588Fluticasone propionateCytosolic phospholipase A2target
DB00588Fluticasone propionateGlucocorticoid receptortarget
DB00588Fluticasone propionateCytochrome P450 3A4enzyme
DB00588Fluticasone propionateProgesterone receptortarget
DB00588Fluticasone propionateMineralocorticoid receptortarget
DB00588Fluticasone propionateCytochrome P450 3A5enzyme
DB00588Fluticasone propionateCytochrome P450 3A7enzyme
DB00588Fluticasone propionateCytochrome P450 2C8enzyme
DB00588Fluticasone propionateP-glycoprotein 1carrier
DB00588Fluticasone propionateSolute carrier organic anion transporter family member 1B1carrier
DB00637AstemizoleHistamine H1 receptortarget
DB00637AstemizolePotassium voltage-gated channel subfamily H member 2target
DB00637AstemizoleCytochrome P450 3A4enzyme
DB00637AstemizoleCytochrome P450 3A5enzyme
DB00637AstemizoleCytochrome P450 3A7enzyme
DB00637AstemizoleP-glycoprotein 1transporter
DB00637AstemizoleCytochrome P450 2D6enzyme
DB00637AstemizoleCytochrome P450 2J2enzyme
DB00637AstemizolePotassium voltage-gated channel subfamily H member 1target
DB00637AstemizoleMicrotubule-associated protein tautarget
DB00637AstemizoleBile salt export pumptransporter
DB00737MeclizineHistamine H1 receptortarget
DB00737MeclizineNuclear receptor subfamily 1 group I member 3target
DB00737MeclizineCytochrome P450 2D6enzyme
DB00737MeclizineSerum albumincarrier
DB00764MometasoneGlucocorticoid receptortarget
DB00764MometasoneCytochrome P450 2C8enzyme
DB00764MometasoneProgesterone receptortarget
DB00764MometasoneCytochrome P450 3A4enzyme
DB00764MometasoneCytochrome P450 3A5enzyme
DB00792TripelennamineHistamine H1 receptortarget
DB00792TripelennamineCytochrome P450 2D6enzyme
DB00835BrompheniramineHistamine H1 receptortarget
DB00835BrompheniramineMuscarinic acetylcholine receptor M1target
DB00835BrompheniramineMuscarinic acetylcholine receptor M2target
DB00835BrompheniramineMuscarinic acetylcholine receptor M3target
DB00835BrompheniramineMuscarinic acetylcholine receptor M4target
DB00835BrompheniramineMuscarinic acetylcholine receptor M5target
DB14596Loteprednol etabonateGlucocorticoid receptortarget
DB14596Loteprednol etabonateCytochrome P450 3A4enzyme
DB14596Loteprednol etabonateSerum paraoxonase/arylesterase 1enzyme
DB00950FexofenadineHistamine H1 receptortarget
DB00950FexofenadineP-glycoprotein 1transporter
DB00950FexofenadineSolute carrier organic anion transporter family member 2B1transporter
DB00950FexofenadineSolute carrier organic anion transporter family member 1A2transporter
DB00950FexofenadineSolute carrier organic anion transporter family member 1B1transporter
DB00950FexofenadineSolute carrier organic anion transporter family member 1B3transporter
DB00950FexofenadineSolute carrier family 22 member 8transporter
DB00972AzelastineHistamine H1 receptortarget
DB00972AzelastineCytochrome P450 1A2enzyme
DB00972AzelastineCytochrome P450 2D6enzyme
DB00972AzelastineCytochrome P450 3A4enzyme
DB00972AzelastineCytochrome P450 2C19enzyme
DB00972AzelastineCytochrome P450 1A1enzyme
DB00972AzelastineCytochrome P450 3A5enzyme
DB00972AzelastineCytochrome P450 2C9enzyme
DB00972AzelastineCytochrome P450 2C8enzyme
DB00972AzelastineP-glycoprotein 1transporter
DB00972AzelastineCytochrome P450 2A6enzyme
DB00972AzelastineCytochrome P450 2E1enzyme
DB00972AzelastineHistamine H2 receptortarget
DB00972AzelastinePhospholipase A2target
DB00972AzelastineLeukotriene C4 synthasetarget
DB00972AzelastineCytochrome P450 2B6enzyme
DB01025AmlexanoxInterleukin-3target
DB01025AmlexanoxProtein S100-A12target
DB01025AmlexanoxProtein S100-A13target
DB01025AmlexanoxFibroblast growth factor 1target
DB01047FluocinonideCorticosteroid-binding globulincarrier
DB01047FluocinonideGlucocorticoid receptortarget
DB01047FluocinonideSmoothened homologtarget
DB01047FluocinonideCytochrome P450 3A4enzyme
DB01047FluocinonideCytochrome P450 3A5enzyme
DB01069PromethazineDopamine D2 receptortarget
DB01069PromethazineHistamine H1 receptortarget
DB01069PromethazineMuscarinic acetylcholine receptor M4target
DB01069PromethazineMuscarinic acetylcholine receptor M1target
DB01069PromethazineMuscarinic acetylcholine receptor M5target
DB01069PromethazineAlpha-1A adrenergic receptortarget
DB01069Promethazine5-hydroxytryptamine receptor 2Atarget
DB01069PromethazineMuscarinic acetylcholine receptor M2target
DB01069PromethazineMuscarinic acetylcholine receptor M3target
DB01069PromethazineCalmodulintarget
DB01069PromethazineCytochrome P450 2D6enzyme
DB01069PromethazineCytochrome P450 2B6enzyme
DB01069PromethazineP-glycoprotein 1transporter
DB01069PromethazineCytochrome P450 2C9enzyme
DB01069PromethazineHistamine H2 receptortarget
DB01071MequitazineHistamine H1 receptortarget
DB01071MequitazineCytochrome P450 2D6enzyme
DB01071MequitazineCytochrome P450 3A4enzyme
DB01075DiphenhydramineHistamine H1 receptortarget
DB01075DiphenhydramineCytochrome P450 2D6enzyme
DB01075DiphenhydramineCytochrome P450 2C9enzyme
DB01075DiphenhydramineCytochrome P450 2C19enzyme
DB01075DiphenhydramineSolute carrier family 22 member 2transporter
DB01075DiphenhydramineSolute carrier family 22 member 5transporter
DB01075DiphenhydramineProstaglandin G/H synthase 1enzyme
DB01075DiphenhydramineMuscarinic acetylcholine receptor M2target
DB01084EmedastineHistamine H1 receptortarget
DB01114ChlorpheniramineHistamine H1 receptortarget
DB01114ChlorpheniramineCytochrome P450 3A4enzyme
DB01114ChlorpheniramineCytochrome P450 2D6enzyme
DB01114ChlorpheniramineSodium-dependent serotonin transportertarget
DB01114ChlorpheniramineSodium-dependent noradrenaline transportertarget
DB01114ChlorpheniramineSodium-dependent dopamine transportertarget
DB01114ChlorpheniramineCytochrome P450 3A5enzyme
DB01114ChlorpheniramineCytochrome P450 3A7enzyme
DB01114ChlorpheniramineSolute carrier family 22 member 2transporter
DB01114ChlorpheniramineSolute carrier family 22 member 1transporter
DB01410CiclesonideCorticosteroid-binding globulincarrier
DB01410CiclesonideCytochrome P450 3A4enzyme
DB01410CiclesonideCytochrome P450 2D6enzyme
DB01410CiclesonideGlucocorticoid receptortarget
DB01410CiclesonideLiver carboxylesterase 1enzyme
DB01620PheniramineHistamine H1 receptortarget
DB01620PheniramineNuclear receptor subfamily 1 group I member 3target
DB01620PheniramineHistamine H4 receptortarget
DB06691MepyramineCytochrome P450 2D6enzyme
DB06691MepyramineHistamine H1 receptortarget
DB06691MepyramineSolute carrier family 22 member 4transporter
DB06691MepyramineSolute carrier family 22 member 5transporter
DB07615TranilastHematopoietic prostaglandin D synthasetarget
DB07615TranilastCytochrome P450 3A4enzyme
DB07615TranilastCytochrome P450 2C9enzyme
DB08799AntazolineHistamine H1 receptortarget
DB08801DimetindeneMuscarinic acetylcholine receptor M2target
DB08801DimetindeneHistamine H1 receptortarget
DB09091TixocortolGlucocorticoid receptortarget
DB09091TixocortolHistone deacetylase 2target
DB11487Dexamethasone isonicotinateCytochrome P450 3A4enzyme
DB11487Dexamethasone isonicotinateCytochrome P450 3A5enzyme
DB13867FluticasoneCytochrome P450 3A4enzyme
DB13867FluticasoneCytochrome P450 2C8enzyme
DB13867FluticasoneP-glycoprotein 1carrier
DB13867FluticasoneSolute carrier organic anion transporter family member 1B1carrier
DB13867FluticasoneP-glycoprotein 1transporter
DB13867FluticasoneSolute carrier organic anion transporter family member 1B1transporter
DB13867FluticasoneGlucocorticoid receptortarget
DB13867FluticasoneCorticosteroid-binding globulincarrier
DB13867FluticasoneCytochrome P450 3A5enzyme
DB13867FluticasoneCytochrome P450 3A7enzyme
DB13867FluticasoneProgesterone receptortarget
DB13867FluticasoneCytosolic phospholipase A2target
DB13867FluticasoneMineralocorticoid receptortarget
DB01003Cromoglicic acidCalcium-activated potassium channel subunit alpha-1target
DB01003Cromoglicic acidProtein S100-Ptarget
DB01106LevocabastineNeurotensin receptor type 2target
DB01106LevocabastineHistamine H1 receptortarget
DB04890BepotastineHistamine H1 receptortarget
DB14512Mometasone furoateGlucocorticoid receptortarget
DB14512Mometasone furoateCytochrome P450 2C8enzyme
DB14512Mometasone furoateProgesterone receptortarget
DB14512Mometasone furoateCytochrome P450 3A4enzyme
DB14512Mometasone furoateCytochrome P450 3A5enzyme