Amino Acids, Essential
- Amino Acids, Essential
- Accession Number
Amino acids that are not synthesized by the human body in amounts sufficient to carry out physiological functions. They are obtained from dietary foodstuffs.
Drug Drug Description Histidine An amino acid commonly found as a component of total parenteral nutrition. Ademetionine S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as... Phenylalanine An amino acid commonly found as a component of total parenteral nutrition. L-Lysine An amino acid commonly found as a component of total parenteral nutrition. Arginine An amino acid commonly found as a component of total parenteral nutrition. Methionine An amino acid commonly found as a component in total parenteral nutrition. Leucine An amino acid commonly found as a component of total parenteral nutrition. Tryptophan An amino acid commonly found as a component of total parenteral nutrition. Threonine An amino acid commonly found as a component of total parenteral nutrition. Valine An amino acid commonly found as a component of total parenteral nutrition. Isoleucine An amino acid commonly found as a component of total parenteral nutrition. Promazine A phenothiazine used to manage schizophrenia. Valaciclovir An guanine nucleoside antiviral used to treat herpes exacerbations. Nateglinide A meglitinide used to treat non insulin dependent diabetes mellitus. Methyldopa An alpha-2 adrenergic agonist used to treat hypertension. Melphalan An alkylating antineoplastic agent used to treat multiple myeloma and ovarian carcinoma. Levodopa A dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. N-Acetylmethionine Not Available N,N-dimethylarginine Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells which... L-methionine (R)-S-oxide Not Available Leucine Phosphonic Acid Not Available Oxitriptan For use as an antidepressant, appetite suppressant, and sleep aid. Beta-Hydroxyleucine Not Available N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine Not Available Diphthamide Not Available RWJ-51084 Not Available Ubenimex An adjuvant therapy used for acute and chronic myelonous leukemia, lung cancer and nasopharyngeal cancer. It is also used to treat hypercholesterolaemia. 4-Iodo-L-phenylalanine Not Available Trifluoromethionine Not Available Batimastat Not Available Phenylalanylamide Not Available Norvaline Norvaline is an isomer of the more common amino acid valine. N(2)-(2-carboxyethyl)-L-arginine Not Available Nitroarginine An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in... 6-hydroxydopa quinone Not Available N-Formylmethionine N-Formylmethionine is effective in the initiation of protein synthesis. The initiating methionine residue enters the ribosome as N-formylmethionyl tRNA. This process occurs in Escherichia coli and other bacteria as well... Phenyldehydroalanine Not Available Dansyllysine Not Available CDP323 Investigated for use/treatment in multiple sclerosis. LX1031 Irritable bowel syndrome (IBS) and other gastrointestinal disorders WX-UK1 Investigated for use/treatment in solid tumors. Palifosfamide Investigated for use/treatment in cancer/tumors (unspecified), lymphoma (unspecified), and sarcoma. PPI-2458 Investigated for use/treatment in lymphoma (non-hodgkin's) and solid tumors. GW-559090 Investigated for use/treatment in asthma and allergic rhinitis. Etilevodopa Investigated for use/treatment in parkinson's disease. Clonixin Indicated for use in the management of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. Eluxadoline A mixed mu-opioid receptor agonist used to treat irritable bowel syndrome with diarrhea. Selenomethionine Selenomethionine is a naturally occuring amino acid in some plant materials such as cereal grains, soybeans and enriched yeast but it cannot be synthesized from animals or humans. It can... Lifitegrast A medication used to treat dry eye disease. Tilarginine Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow. Astodrimer Astodrimer has been used in trials studying the treatment and prevention of Bacterial Vaginosis. It is a lysine-based dendrimer with naphthalene disulfonic acid surface groups. Valbenazine A vesicular monoamine transporter 2 inhibitor used to treat tardive dyskinesia. Delanzomib Delanzomib has been used in trials studying the treatment of Solid Tumors, Multiple Myeloma, and Lymphoma, Non-Hodgkin. Nirogacestat Nirogacestat has been used in trials studying the treatment of Breast Cancer, HIV Infection, Desmoid Tumors, Advanced Solid Tumors, and Aggressive Fibromatosis, among others. Telotristat ethyl A tryptophan hydroxylase inhibitor used to treat carcinoid syndrome. ORE-1001 ORE1001 has been used in trials studying the treatment of Mild to Moderate Ulcerative Colitis. It is an ACE2 inhibitor. Decernotinib Decernotinib has been used in trials studying the treatment of Drug Interactions and Rheumatoid Arthritis. N-omega-nitro-L-arginine methyl ester L-NAME has been investigated for the treatment of Hypotension and Spinal Cord Injury. Indoximod Indoximod has been used in trials studying the treatment of Glioma, Melanoma, Ependymoma, Gliosarcoma, and Lung Cancer, among others. Buthionine Sulfoximine Buthionine Sulfoximine has been used in trials studying the treatment of Neuroblastoma and Melanoma (Skin). Macimorelin A medication used to treat adult growth hormone deficiency. Acetylleucine Used for treating vestibular-related imbalance and vertigo. Melevodopa Not Annotated Racemethionine A preparation of methionine that includes a mixture of D-methionine and L-methionine isomers. Nordazepam An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam. Methionine sulfoximine Not Annotated Telotristat A tryptophan hydroxylase inhibitor. Telotristat ethyl (brand name Xermelo) is a prodrug of telotristat. 5-fluorotryptophan 5-fluorotryptophan can be used as substrate analogue to study enzyme mechanisms by NMR spectroscopy. BMS-817399 BMS-817399 is under investigation in clinical trial NCT01404585 (Proof-of-Concept Study With BMS-817399 to Treat Moderate to Severe Rheumatoid Arthritis). GS-9191 GS-9191 is under investigation in clinical trial NCT00499967 (Safety and Effectiveness Study of an Experimental Topical Ointment (GS-9191) for the Treatment of Genital Warts). Fluorodopa (18F) Fluorodopa F 18 is indicated for use with positron emission tomography (PET) to visualize dopaminergic nerve terminals in the striatum for the evaluation of adult patients with suspected Parkinsonian syndromes... Solriamfetol Solriamfetol is indicated for treatment of daytime sleepiness associated with obstructive sleep apnea and narcolepsy, but is not a treatment for the underlying airway obstruction in apnea patients[FDA Label][A176534,A176744]. Ciraparantag Ciraparantag is under investigation in clinical trial NCT01826266 (Effects of a Double-Blind, Single Dose of PER977 Administered Alone, and Following a Single Dose of Edoxaban). L-homoarginine Not Available N-acetyl-L-arginine Not Available Epsilon-N-methyllysine Not Available L-alloisoleucine Not Available p-Benzoyl-L-phenylalanine Not Available 4-methylthio-2-oxobutanoic acid Not Available Symmetric dimethylarginine Not Available Tryptophanamide Not Available L-methionine sulfone Not Available Trimethyllysine Not Available 1-Methylhistidine Not Available L-Saccharopine Not Available methyl L-phenylalaninate Not Available Ravidasvir Ravidasvir is under investigation in clinical trial NCT02961426 (Sofosbuvir Plus Ravidasvir for the Treatment of HCV Chronic Infection).
- Drugs & Drug Targets