Purine Nucleosides

Purines with a RIBOSE attached that can be phosphorylated to PURINE NUCLEOTIDES.
DrugDrug NameDrug Indication
DB00118AdemetionineS-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as a dietary supplement for the support of bone and joint health, as well as mood and emotional well being.
DB00194VidarabineFor treatment of chickenpox - varicella, herpes zoster and herpes simplex
DB00242CladribineFor the treatment of active hairy cell leukemia (leukemic reticuloendotheliosis) as defined by clinically significant anemia, neutropenia, thrombocytopenia, or disease-related symptoms. Also used as an alternative agent for the treatment of chronic lymphocytic leukemia (CLL), low-grade non-Hodgkin's lymphoma, and cutaneous T-cell lymphoma.
DB00640AdenosineUsed as an initial treatment for the termination of paroxysmal supraventricular tachycardia (PVST), including that associated with accessory bypass tracts, and is a drug of choice for terminating stable, narrow-complex supraventricular tachycardias (SVT). Also used as an adjunct to thallous chloride TI 201 myocardial perfusion scintigraphy (thallium stress test) in patients who are unable to exercise adequately, as well as an adjunct to vagal maneuvers and clinical assessment to establish a specific diagnosis of undefined, stable, narrow-complex SVT.
DB00900DidanosineFor use, in combination with other antiretroviral agents, in the treatment of HIV-1 infection in adults.
DB01073FludarabineFor the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
DB01910SinefunginNot Available
DB022825'-Deoxy-5'-MethylthioadenosineNot Available
DB023802'-DeoxyinosineNot Available
DB025028-Hydroxy-2'-DeoxyguanosineNot Available
DB027969-DeazainosineNot Available
DB02844S-Adenosyl-1,8-Diamino-3-ThiooctaneNot Available
DB02857GuanosineNot Available
DB02896MethylthioinosineNot Available
DB03172TubercidinNot Available
DB03326deoxycytidylyl-3',5'-guanosineNot Available
DB034937-MethylguanosineNot Available
DB036093-DeoxyguanosineNot Available
DB037165'-Fluoro-5'-DeoxyadenosineNot Available
DB04335InosineThe primary popular claim made for inosine, that it enhances exercise and athletic performance, is refuted by the available research data. There is some preliminary evidence that inosine may have some neurorestorative, anti-inflammatory, immunomodulatory and cardioprotective effects.
DB044412-FluoroadenosineNot Available
DB046045-iodotubercidinNot Available
DB04853BinodenosonFor cardiac pharmacologic stress SPECT imaging, which is used to diagnose coronary artery disease.
DB04860IsatoribineFor the treatment of Hepatitis C.
DB04954TecadenosonInvestigated for use/treatment in arrhythmia and atrial fibrillation.
DB05511PiclidenosonInvestigated for use/treatment in cancer/tumors (unspecified), eye disorders/infections, psoriasis and psoriatic disorders, and rheumatoid arthritis. Can-Fite BioPharma has reported that by targeting the adenosine A3-receptor, CF101 may also be used to treat Crohn's disease, a serious gastrointestinal disorder.
DB08437PuromycinNot Available
DB08816TicagrelorTicagrelor is indicated for the prevention of thrombotic events like stroke or heart attack in patients with acute coronary syndrome or myocardial infarction with ST elevation.
DB12156CordycepinNot Available
DB12443SonedenosonNot Available
DB12691UK-432097Not Available
DB13156Inosine pranobexInosine pranobex is also indicated for mucocutaneous infections due to herpes simplex virus (type 1 and type II) and for treatment of genital warts as adjunctive therapy to podophyllin or carbon dioxide laser.
DB13122TrabodenosonNot Available
DB01752S-adenosyl-L-homocysteineNot Available
DB14868AZD-8848Not Available
DB15425CYC-065Not Available
DrugDrug NameTargetType
DB00118AdemetionineGlycine N-methyltransferasetarget
DB00118AdemetionineS-adenosylmethionine decarboxylase proenzymetarget
DB00118AdemetionineS-adenosylmethionine synthase isoform type-2target
DB00118AdemetionineCystathionine beta-synthasetarget
DB00118AdemetionineS-adenosylmethionine synthase isoform type-1target
DB00118AdemetionineCytochrome P450 2E1enzyme
DB00118AdemetionineCatechol O-methyltransferasetarget
DB00118AdemetionineSpermidine synthaseenzyme
DB00118AdemetionineCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1target
DB00118AdemetionineArsenite methyltransferasetarget
DB00194VidarabineDNAtarget
DB00194VidarabineDNA polymerase catalytic subunittarget
DB00194VidarabineThymidine kinasetarget
DB00194VidarabineThymidine kinasetarget
DB00194VidarabineAdenosine deaminaseenzyme
DB00242CladribinePurine nucleoside phosphorylasetarget
DB00242CladribineDNAtarget
DB00242CladribineDeoxycytidine kinaseenzyme
DB00242CladribineRibonucleoside-diphosphate reductase large subunittarget
DB00242CladribineRibonucleoside-diphosphate reductase subunit M2target
DB00242CladribineRibonucleoside-diphosphate reductase subunit M2 Btarget
DB00242CladribineDNA polymerase alpha catalytic subunittarget
DB00242CladribineDNA polymerase epsilon catalytic subunit Atarget
DB00242CladribineDNA polymerase epsilon subunit 2target
DB00242CladribineDNA polymerase epsilon subunit 3target
DB00242CladribineDNA polymerase epsilon subunit 4target
DB00242CladribineATP-binding cassette sub-family G member 2transporter
DB00242CladribineSolute carrier family 28 member 3transporter
DB00640AdenosineAdenosine receptor A3target
DB00640AdenosineAdenosine deaminaseenzyme
DB00640AdenosineAdenosine kinaseenzyme
DB00640AdenosineAdenosine receptor A1target
DB00640AdenosineAdenosine receptor A2atarget
DB00640AdenosineAdenosine receptor A2btarget
DB00640AdenosineSolute carrier family 28 member 3transporter
DB00900DidanosineSolute carrier family 22 member 6transporter
DB00900DidanosinePurine nucleoside phosphorylasetarget
DB00900DidanosineReverse transcriptase/RNaseHtarget
DB00900DidanosineEquilibrative nucleoside transporter 1transporter
DB00900DidanosineEquilibrative nucleoside transporter 2transporter
DB00900DidanosineSerum albumincarrier
DB01073FludarabineDNA polymerase alpha catalytic subunittarget
DB01073FludarabineRibonucleoside-diphosphate reductase large subunittarget
DB01073FludarabineEquilibrative nucleoside transporter 1transporter
DB01073FludarabineDNAtarget
DB01073FludarabineDeoxycytidine kinasetarget
DB01073FludarabineSolute carrier family 28 member 3transporter
DB01910SinefunginModification methylase RsrItarget
DB01910SinefunginRdmBtarget
DB01910SinefunginrRNA adenine N-6-methyltransferasetarget
DB01910SinefunginModification methylase TaqItarget
DB022825'-Deoxy-5'-MethylthioadenosineModification methylase RsrItarget
DB022825'-Deoxy-5'-MethylthioadenosineS-methyl-5'-thioadenosine phosphorylasetarget
DB027969-DeazainosinePurine nucleoside phosphorylasetarget
DB02844S-Adenosyl-1,8-Diamino-3-ThiooctaneSpermidine synthasetarget
DB02857GuanosineDNA polymerasetarget
DB02857GuanosinePurine nucleoside phosphorylasetarget
DB02857GuanosinePurine nucleoside phosphorylasetarget
DB02896MethylthioinosinePurine nucleoside phosphorylase DeoD-typetarget
DB03172TubercidinPurine nucleoside phosphorylase DeoD-typetarget
DB03326deoxycytidylyl-3',5'-guanosineRibonuclease pancreatictarget
DB034937-MethylguanosineCap-specific mRNA (nucleoside-2'-O-)-methyltransferasetarget
DB036093-DeoxyguanosinePurine nucleoside phosphorylasetarget
DB037165'-Fluoro-5'-Deoxyadenosine5'-fluoro-5'-deoxy-adenosine synthasetarget
DB04335InosinePurine nucleoside phosphorylasetarget
DB04335InosineIAG-nucleoside hydrolasetarget
DB04335InosinePurine nucleoside phosphorylase DeoD-typetarget
DB04335InosineXanthine dehydrogenase/oxidaseenzyme
DB04335InosineSolute carrier family 28 member 3transporter
DB044412-FluoroadenosinePurine nucleoside phosphorylase DeoD-typetarget
DB046045-iodotubercidinCasein kinase I isoform gamma-2target
DB046045-iodotubercidinSerine/threonine-protein kinase haspintarget
DB046045-iodotubercidinMitogen-activated protein kinase 3target
DB04853BinodenosonAdenosine receptor A2atarget
DB04860IsatoribineToll-like receptor 7target
DB04954TecadenosonAdenosine receptor A1target
DB05511PiclidenosonAdenosine receptor A3target
DB08437Puromycin60S ribosomal protein L10-liketarget
DB08437Puromycin60S ribosomal protein L13atarget
DB08437Puromycin60S ribosomal protein L23target
DB08437Puromycin60S ribosomal protein L15target
DB08437Puromycin60S ribosomal protein L19target
DB08437Puromycin60S ribosomal protein L23atarget
DB08437PuromycinProbable ribosome biogenesis protein RLP24target
DB08437Puromycin60S ribosomal protein L26-like 1target
DB08437Puromycin60S ribosomal protein L8target
DB08437Puromycin60S ribosomal protein L37target
DB08437Puromycin60S ribosomal protein L3target
DB08437Puromycin60S ribosomal protein L11target
DB08437PuromycinLeucyl/phenylalanyl-tRNA--protein transferasetarget
DB08816TicagrelorCytochrome P450 3A4enzyme
DB08816TicagrelorP2Y purinoceptor 12target
DB08816TicagrelorMultidrug resistance protein 1transporter
DB08816TicagrelorCytochrome P450 2D6enzyme
DB08816TicagrelorCytochrome P450 2C9enzyme
DB01752S-adenosyl-L-homocysteineCap-specific mRNA (nucleoside-2'-O-)-methyltransferasetarget
DB01752S-adenosyl-L-homocysteineCobalt-precorrin-4 C(11)-methyltransferasetarget
DB01752S-adenosyl-L-homocysteineProtein-L-isoaspartate(D-aspartate) O-methyltransferasetarget
DB01752S-adenosyl-L-homocysteineGenome polyproteintarget
DB01752S-adenosyl-L-homocysteinePhenylethanolamine N-methyltransferasetarget
DB01752S-adenosyl-L-homocysteineCyclopropane mycolic acid synthase 2target
DB01752S-adenosyl-L-homocysteineModification methylase RsrItarget
DB01752S-adenosyl-L-homocysteineCatechol O-methyltransferase domain-containing protein 1target
DB01752S-adenosyl-L-homocysteineCarminomycin 4-O-methyltransferasetarget
DB01752S-adenosyl-L-homocysteineGuanidinoacetate N-methyltransferasetarget
DB01752S-adenosyl-L-homocysteineRelease factor glutamine methyltransferasetarget
DB01752S-adenosyl-L-homocysteineRelease factor glutamine methyltransferasetarget
DB01752S-adenosyl-L-homocysteineProtein arginine N-methyltransferase 3target
DB01752S-adenosyl-L-homocysteineHistamine N-methyltransferasetarget
DB01752S-adenosyl-L-homocysteineRibosomal RNA small subunit methyltransferase Htarget
DB01752S-adenosyl-L-homocysteinerRNA adenine N-6-methyltransferasetarget
DB01752S-adenosyl-L-homocysteinetRNA (cytosine(38)-C(5))-methyltransferasetarget
DB01752S-adenosyl-L-homocysteineGlycine N-methyltransferasetarget
DB01752S-adenosyl-L-homocysteinetRNA (cytidine(34)-2'-O)-methyltransferasetarget
DB01752S-adenosyl-L-homocysteineModification methylase PvuIItarget
DB01752S-adenosyl-L-homocysteineDNA adenine methylasetarget
DB01752S-adenosyl-L-homocysteineCyclopropane mycolic acid synthase 3target
DB01752S-adenosyl-L-homocysteineProtein arginine N-methyltransferase 1target
DB01752S-adenosyl-L-homocysteineSiroheme synthasetarget
DB01752S-adenosyl-L-homocysteineModification methylase HhaItarget
DB01752S-adenosyl-L-homocysteineHistone-lysine N-methyltransferase SETD7target
DB01752S-adenosyl-L-homocysteinetRNA (guanine-N(1)-)-methyltransferasetarget
DB01752S-adenosyl-L-homocysteineCyclopropane mycolic acid synthase MmaA2target
DB01752S-adenosyl-L-homocysteineDiphthine synthasetarget
DB01752S-adenosyl-L-homocysteineRdmBtarget
DB01752S-adenosyl-L-homocysteinetRNA (guanine-N(1)-)-methyltransferasetarget
DB01752S-adenosyl-L-homocysteineUroporphyrinogen-III C-methyltransferasetarget
DB01752S-adenosyl-L-homocysteineUncharacterized proteintarget
DB01752S-adenosyl-L-homocysteineChemotaxis protein methyltransferasetarget
DB01752S-adenosyl-L-homocysteineModification methylase TaqItarget
DB01752S-adenosyl-L-homocysteineProtein-L-isoaspartate O-methyltransferasetarget
DB01752S-adenosyl-L-homocysteineHistamine N-methyltransferaseenzyme