Purine Nucleosides

Name
Purine Nucleosides
Accession Number
DBCAT000252
Description

Purines with a RIBOSE attached that can be phosphorylated to PURINE NUCLEOTIDES.

Drugs
DrugDrug Description
AdemetionineS-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as...
VidarabineAn antiviral agent used to treat various viral infections.
CladribineA purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs.
AdenosineA medication used in myocardial perfusion scintigraphy.
DidanosineA reverse transcriptase inhibitor used to treat HIV.
FludarabineA purine analog antimetabolite that inhibits DNA synthesis.
SinefunginSinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include...
5'-S-methyl-5'-thioadenosineNot Available
DeoxyinosineNot Available
8-hydroxy-2'-deoxyguanosineNot Available
9-deazainosineNot Available
S-Adenosyl-1,8-Diamino-3-ThiooctaneNot Available
GuanosineGuanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP...
MethylthioinosineAn analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position.
TubercidinAn antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic...
Deoxycytidylyl-3',5'-guanosineNot Available
7-MethylguanosineNot Available
5'-Fluoro-5'-DeoxyadenosineNot Available
InosineA nutritional supplement touted to improve athletic performance and a drug used in vitro as a red blood cell rejuvenator for a unit of red blood cells that will be used in a clinical setting.
2-FluoroadenosineNot Available
5-iodotubercidinNot Available
BinodenosonFor cardiac pharmacologic stress SPECT imaging, which is used to diagnose coronary artery disease.
IsatoribineFor the treatment of Hepatitis C.
TecadenosonInvestigated for use/treatment in arrhythmia and atrial fibrillation.
PiclidenosonInvestigated for use/treatment in cancer/tumors (unspecified), eye disorders/infections, psoriasis and psoriatic disorders, and rheumatoid arthritis. Can-Fite BioPharma has reported that by targeting the adenosine A3-receptor, CF101 may also be used...
PuromycinPuromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting...
TicagrelorA P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death.
CordycepinCordycepin has been used in trials studying the treatment of Leukemia.
SonedenosonSonedenoson has been used in trials studying the treatment of Foot Ulcer, Diabetic and Diabetes Complications.
UK-432097UK-432,097 has been used in trials studying the treatment of Pulmonary Disease, Chronic Obstructive.
Inosine pranobexA medication used to treat subacute sclerosing panencephalitis.
TrabodenosonTrabodenoson has been used in trials studying the treatment of Ocular Hypertension (OHT) and Primary Open-Angle Glaucoma (POAG).
S-adenosyl-L-homocysteine5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.
AZD-8848AZD-8848 is under investigation in clinical trial NCT01818869 (To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects).
CYC-065CYC-065 is under investigation in clinical trial NCT03739554 (CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory CLL).
5'-O-(N-(Alanyl)sulfamoyl)adenosineNot Available
3-DeazaadenosineNot Available
N(6)-dimethylallyladenineNot Available
IslatravirIslatravir is under investigation in clinical trial NCT04233216 (Doravirine/islatravir (DOR/ISL) in Heavily Treatment-experienced (HTE) Participants for Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-019)).
Drugs & Drug Targets
DrugTargetType
AdemetionineGlycine N-methyltransferasetarget
AdemetionineS-adenosylmethionine decarboxylase proenzymetarget
AdemetionineS-adenosylmethionine synthase isoform type-2target
AdemetionineCystathionine beta-synthasetarget
AdemetionineS-adenosylmethionine synthase isoform type-1target
AdemetionineCytochrome P450 2E1enzyme
AdemetionineCatechol O-methyltransferasetarget
AdemetionineSpermidine synthaseenzyme
AdemetionineCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1target
AdemetionineArsenite methyltransferasetarget
VidarabineDNA polymerase catalytic subunittarget
VidarabineThymidine kinasetarget
VidarabineThymidine kinasetarget
VidarabineAdenosine deaminaseenzyme
CladribinePurine nucleoside phosphorylasetarget
CladribineDNAtarget
CladribineDeoxycytidine kinaseenzyme
CladribineRibonucleoside-diphosphate reductase large subunittarget
CladribineRibonucleoside-diphosphate reductase subunit M2target
CladribineRibonucleoside-diphosphate reductase subunit M2 Btarget
CladribineDNA polymerase alpha catalytic subunittarget
CladribineDNA polymerase epsilon catalytic subunit Atarget
CladribineDNA polymerase epsilon subunit 2target
CladribineDNA polymerase epsilon subunit 3target
CladribineDNA polymerase epsilon subunit 4target
CladribineATP-binding cassette sub-family G member 2transporter
CladribineSolute carrier family 28 member 3transporter
AdenosineAdenosine receptor A3target
AdenosineAdenosine deaminaseenzyme
AdenosineAdenosine kinaseenzyme
AdenosineAdenosine receptor A1target
AdenosineAdenosine receptor A2atarget
AdenosineAdenosine receptor A2btarget
AdenosineSolute carrier family 28 member 3transporter
DidanosineSolute carrier family 22 member 6transporter
DidanosinePurine nucleoside phosphorylasetarget
DidanosineReverse transcriptase/RNaseHtarget
DidanosineEquilibrative nucleoside transporter 1transporter
DidanosineEquilibrative nucleoside transporter 2transporter
DidanosineSerum albumincarrier
FludarabineDNA polymerase alpha catalytic subunittarget
FludarabineRibonucleoside-diphosphate reductase large subunittarget
FludarabineEquilibrative nucleoside transporter 1transporter
FludarabineDNAtarget
FludarabineDeoxycytidine kinasetarget
FludarabineSolute carrier family 28 member 3transporter
SinefunginModification methylase RsrItarget
SinefunginRdmBtarget
SinefunginrRNA adenine N-6-methyltransferasetarget
SinefunginModification methylase TaqItarget
5'-S-methyl-5'-thioadenosineModification methylase RsrItarget
5'-S-methyl-5'-thioadenosineS-methyl-5'-thioadenosine phosphorylasetarget
9-deazainosinePurine nucleoside phosphorylasetarget
S-Adenosyl-1,8-Diamino-3-ThiooctaneSpermidine synthasetarget
GuanosineDNA polymerasetarget
GuanosinePurine nucleoside phosphorylasetarget
GuanosinePurine nucleoside phosphorylasetarget
MethylthioinosinePurine nucleoside phosphorylase DeoD-typetarget
TubercidinPurine nucleoside phosphorylase DeoD-typetarget
Deoxycytidylyl-3',5'-guanosineRibonuclease pancreatictarget
7-MethylguanosineCap-specific mRNA (nucleoside-2'-O-)-methyltransferasetarget
5'-Fluoro-5'-Deoxyadenosine5'-fluoro-5'-deoxy-adenosine synthasetarget
InosinePurine nucleoside phosphorylasetarget
InosineIAG-nucleoside hydrolasetarget
InosinePurine nucleoside phosphorylase DeoD-typetarget
InosineXanthine dehydrogenase/oxidaseenzyme
InosineSolute carrier family 28 member 3transporter
2-FluoroadenosinePurine nucleoside phosphorylase DeoD-typetarget
5-iodotubercidinCasein kinase I isoform gamma-2target
5-iodotubercidinSerine/threonine-protein kinase haspintarget
5-iodotubercidinMitogen-activated protein kinase 3target
BinodenosonAdenosine receptor A2atarget
IsatoribineToll-like receptor 7target
TecadenosonAdenosine receptor A1target
PiclidenosonAdenosine receptor A3target
Puromycin60S ribosomal protein L10-liketarget
Puromycin60S ribosomal protein L13atarget
Puromycin60S ribosomal protein L23target
Puromycin60S ribosomal protein L15target
Puromycin60S ribosomal protein L19target
Puromycin60S ribosomal protein L23atarget
PuromycinProbable ribosome biogenesis protein RLP24target
Puromycin60S ribosomal protein L26-like 1target
Puromycin60S ribosomal protein L8target
Puromycin60S ribosomal protein L37target
Puromycin60S ribosomal protein L3target
Puromycin60S ribosomal protein L11target
PuromycinLeucyl/phenylalanyl-tRNA--protein transferasetarget
TicagrelorCytochrome P450 3A4enzyme
TicagrelorP2Y purinoceptor 12target
TicagrelorP-glycoprotein 1transporter
TicagrelorCytochrome P450 2D6enzyme
TicagrelorCytochrome P450 2C9enzyme
S-adenosyl-L-homocysteineCap-specific mRNA (nucleoside-2'-O-)-methyltransferasetarget
S-adenosyl-L-homocysteineCobalt-precorrin-4 C(11)-methyltransferasetarget
S-adenosyl-L-homocysteineProtein-L-isoaspartate(D-aspartate) O-methyltransferasetarget
S-adenosyl-L-homocysteineGenome polyproteintarget
S-adenosyl-L-homocysteinePhenylethanolamine N-methyltransferasetarget
S-adenosyl-L-homocysteineCyclopropane mycolic acid synthase 2target
S-adenosyl-L-homocysteineModification methylase RsrItarget
S-adenosyl-L-homocysteineCatechol O-methyltransferase domain-containing protein 1target
S-adenosyl-L-homocysteineCarminomycin 4-O-methyltransferasetarget
S-adenosyl-L-homocysteineGuanidinoacetate N-methyltransferasetarget
S-adenosyl-L-homocysteineRelease factor glutamine methyltransferasetarget
S-adenosyl-L-homocysteineRelease factor glutamine methyltransferasetarget
S-adenosyl-L-homocysteineProtein arginine N-methyltransferase 3target
S-adenosyl-L-homocysteineHistamine N-methyltransferasetarget
S-adenosyl-L-homocysteineRibosomal RNA small subunit methyltransferase Htarget
S-adenosyl-L-homocysteinerRNA adenine N-6-methyltransferasetarget
S-adenosyl-L-homocysteinetRNA (cytosine(38)-C(5))-methyltransferasetarget
S-adenosyl-L-homocysteineGlycine N-methyltransferasetarget
S-adenosyl-L-homocysteinetRNA (cytidine(34)-2'-O)-methyltransferasetarget
S-adenosyl-L-homocysteineModification methylase PvuIItarget
S-adenosyl-L-homocysteineDNA adenine methylasetarget
S-adenosyl-L-homocysteineCyclopropane mycolic acid synthase 3target
S-adenosyl-L-homocysteineProtein arginine N-methyltransferase 1target
S-adenosyl-L-homocysteineSiroheme synthasetarget
S-adenosyl-L-homocysteineModification methylase HhaItarget
S-adenosyl-L-homocysteineHistone-lysine N-methyltransferase SETD7target
S-adenosyl-L-homocysteinetRNA (guanine-N(1)-)-methyltransferasetarget
S-adenosyl-L-homocysteineCyclopropane mycolic acid synthase MmaA2target
S-adenosyl-L-homocysteineDiphthine synthasetarget
S-adenosyl-L-homocysteineRdmBtarget
S-adenosyl-L-homocysteinetRNA (guanine-N(1)-)-methyltransferasetarget
S-adenosyl-L-homocysteineUroporphyrinogen-III C-methyltransferasetarget
S-adenosyl-L-homocysteineUncharacterized proteintarget
S-adenosyl-L-homocysteineChemotaxis protein methyltransferasetarget
S-adenosyl-L-homocysteineModification methylase TaqItarget
S-adenosyl-L-homocysteineProtein-L-isoaspartate O-methyltransferasetarget
S-adenosyl-L-homocysteineHistamine N-methyltransferaseenzyme
5'-O-(N-(Alanyl)sulfamoyl)adenosineBifunctional glutamate/proline--tRNA ligasetarget
3-DeazaadenosineIAG-nucleoside hydrolasetarget
N(6)-dimethylallyladenineCyclin-dependent kinase 2target