- Accession Number
Nucleosides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)
Drug Drug Description Ademetionine S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as... Vidarabine An antiviral agent used to treat various viral infections. Cladribine A purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs. Idoxuridine A pyrimidine analog antiviral used for the treatment of viral eye infections, including herpes simplex keratitis. Floxuridine An antimetabolite used as palliative management for liver metastases of gastrointestinal malignancy. Gemcitabine A nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer. Pentostatin An adenosine deaminase inhibitor used to treat hairy cell leukemia. Adenosine A medication used in myocardial perfusion scintigraphy. Lamivudine A reverse transcriptase inhibitor used to treat HIV and hepatitis B infections. Ribavirin A guanosine nucleoside used to treat some forms of Hepatitis C. Emtricitabine A nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV. Didanosine A reverse transcriptase inhibitor used to treat HIV. Azacitidine A pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome. Zalcitabine A dideoxynucleoside used to treat HIV. Cytarabine A pyrimidine nucleoside analogue used to treat acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia. Fludarabine A purine analog antimetabolite that inhibits DNA synthesis. Capecitabine A nucleoside metabolic inhibitor indicated to treat colon, colorectal and breast cancer. Decitabine A chemotherapeutic pyrimidine nucleoside analogue used for the treatment of myelodysplastic syndromes (MDS) by inducing DNA hypomethylation and corresponding alterations in gene expression. 5-fluorouridine 5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compounds comprising a pyrimidine... Sinefungin Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include... Cytidine Not Available Formycin Not Available 5'-S-methyl-5'-thioadenosine Not Available Deoxyinosine Not Available 8-hydroxy-2'-deoxyguanosine Not Available Uridine Not Available 9-deazainosine Not Available S-Adenosyl-1,8-Diamino-3-Thiooctane Not Available Guanosine Guanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP... Methylthioinosine An analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position. Zebularine A chemically stable, cytidine analog that displays anti-tumor properties. It acts as a transition state analog inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. Also... Tubercidin An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic... Deoxycytidylyl-3',5'-guanosine Not Available 7-Methylguanosine Not Available 5'-Fluoro-5'-Deoxyadenosine Not Available Formycin B Not Available Inosine A nutritional supplement touted to improve athletic performance and a drug used in vitro as a red blood cell rejuvenator for a unit of red blood cells that will be used in a clinical setting. 3-Deazacytidine Not Available 2-Fluoroadenosine Not Available 5-iodotubercidin Not Available Cyclouridine Not Available Binodenoson For cardiac pharmacologic stress SPECT imaging, which is used to diagnose coronary artery disease. Isatoribine For the treatment of Hepatitis C. Tecadenoson Investigated for use/treatment in arrhythmia and atrial fibrillation. Denufosol For use as an inhaled treatment for cystic fibrosis. Thymectacin Investigated for use/treatment in colorectal cancer. Elacytarabine Investigated for use/treatment in leukemia (unspecified) and melanoma. Piclidenoson Investigated for use/treatment in cancer/tumors (unspecified), eye disorders/infections, psoriasis and psoriatic disorders, and rheumatoid arthritis. Can-Fite BioPharma has reported that by targeting the adenosine A3-receptor, CF101 may also be used... Elvucitabine Investigated for use/treatment in hepatitis (viral, B) and HIV infection. Taribavirin Investigated for use/treatment in hepatitis (viral, C). Tezacitabine Investigated for use/treatment in colorectal cancer, lung cancer, leukemia (unspecified), and gastric cancer. TAS-106 Investigated for use/treatment in solid tumors and cancer/tumors (unspecified). Clevudine Investigated for use/treatment in hepatitis (viral, B). Puromycin Puromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting... Ticagrelor A P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death. Sofosbuvir A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents. Uridine triacetate A pyrimidine analog used for the reversal of overdose, regardless of the presence of symptoms, and early-onset, severe or life-threatening CNS toxicity or cardiotoxicity of fluorouracil or capecitabine. 2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine 2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine has been used in trials studying the treatment of Advanced Colorectal Cancer. Guadecitabine Guadecitabine is under investigation for the treatment of Previously Treated Metastatic Colorectal Cancer. Sorivudine Sorivudine has been used in trials studying the treatment of Chickenpox and HIV Infections. Broxuridine Broxuridine has been used in trials studying the treatment of Leukemia, Stage I Prostate Cancer, Stage IIB Prostate Cancer, and Stage IIA Prostate Cancer. Mericitabine Mericitabine has been investigated for the treatment of Hepatitis C, Chronic. Mericitabine is a polymerase inhibitor being developed for the treatment of chronic hepatitis C. Mericitabine is a prodrug of... Cordycepin Cordycepin has been used in trials studying the treatment of Leukemia. Sonedenoson Sonedenoson has been used in trials studying the treatment of Foot Ulcer, Diabetic and Diabetes Complications. Dexelvucitabine Dexelvucitabine has been used in trials studying the treatment of HIV Infections and Human Immunodeficiency Virus. Tetrahydrouridine Tetrahydrouridine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Sickle Cell Disease, and Head and Neck Cancer, among others. Gemcitabine elaidate Gemcitabine elaidate has been used in trials studying the treatment of Solid Tumor, Lung Cancer, Non-small-cell Lung Cancer, and Metastatic Pancreatic Adenocarcinoma. Netivudine Netivudine has been used in trials studying the treatment of Chickenpox and HIV Infections. UK-432097 UK-432,097 has been used in trials studying the treatment of Pulmonary Disease, Chronic Obstructive. Racivir Racivir, also known as RCV, is an oxothiolane nucleoside reverse transcriptase inhibitor similar to emtricitabine and lamivudine. Racivir is a 50:50 mixture of emtricitabine DB00879 and its positive enantiomer. Racivir... Apricitabine Apricitabine has been used in trials studying the treatment of HIV Infections. Fiacitabine Fiacitabine has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections. LY-2334737 LY2334737 has been used in trials studying the treatment of Solid Tumor, Metastatic Tumor, and Malignant Solid Tumor. Doxifluridine Doxifluridine has been investigated for the treatment of Stomach Cancer. 5-fluoro-2'-deoxycytidine 5-fluoro-2'-deoxycytidine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, and Urinary Bladder Neoplasms, among others. 2'-fluoro-5-ethylarabinosyluracil 2'-fluoro-5-ethylarabinosyluracil (FAU) has been used in trials studying the treatment of Small Intestine Lymphoma, Stage IV Mantle Cell Lymphoma, Waldenström Macroglobulinemia, Splenic Marginal Zone Lymphoma, and Recurrent Mantle Cell Lymphoma,... Inosine pranobex A medication used to treat subacute sclerosing panencephalitis. Tiazofurine Tiazofurine has potential clinical use in cancer treatment as it is a potential inhibitor of Inosine- 5’-monophosphate (IMP) dehydrogenase . Edoxudine A deoxythymidine analog used to treat herpetic keratitis. Toyocamycin 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry. 2'-C-methylcytidine A nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks... Trabodenoson Trabodenoson has been used in trials studying the treatment of Ocular Hypertension (OHT) and Primary Open-Angle Glaucoma (POAG). S-adenosyl-L-homocysteine 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions. Brivudine Brivudine is used in the treatment of herpes zoster. Although not approved in the U.S. or Canada, it is approved in several European countries. Lumicitabine Lumicitabine is under investigation in clinical trial NCT03010059 (A Study to Assess the Relative Bioavailability of JNJ64041575 Administered as 2 Different New Concept Formulations (Oral Suspension and Tablet) Compared to... AZD-8848 AZD-8848 is under investigation in clinical trial NCT01818869 (To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects). Fialuridine Fialuridine is under investigation in clinical trial NCT01337466 (Biodistribution and Dosimetry Evaluation of [124I]FIAU). Adafosbuvir Adafosbuvir is under investigation in clinical trial NCT02894905 (A Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of AL-335). Uprifosbuvir Uprifosbuvir is under investigation in clinical trial NCT02332707 (Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Genotype (GT)1 and... CYC-065 CYC-065 is under investigation in clinical trial NCT03739554 (CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory CLL). 5'-O-(N-(Alanyl)sulfamoyl)adenosine Not Available 3-Deazaadenosine Not Available N(6)-dimethylallyladenine Not Available Dichlororibofuranosylbenzimidazole Not Available Islatravir Islatravir is under investigation in clinical trial NCT04233216 (Doravirine/islatravir (DOR/ISL) in Heavily Treatment-experienced (HTE) Participants for Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-019)). N4-Hydroxycytidine A cytidine analog being investigated to treat COVID-19.
- Drugs & Drug Targets