Amino Acids, Aromatic

Amino acids containing an aromatic side chain.
DrugDrug NameDrug Indication
DB00120L-PhenylalanineL-phenylalanine may be helpful in some with depression. It may also be useful in the treatment of vitiligo. There is some evidence that L-phenylalanine may exacerbate tardive dyskinesia in some schizophrenic patients and in some who have used neuroleptic drugs.
DB00135TyrosineTyrosine is claimed to act as an effective antidepressant, however results are mixed. Tyrosine has also been claimed to reduce stress and combat narcolepsy and chronic fatigue, however these claims have been refuted by some studies.
DB00150L-TryptophanTryptophan may be useful in increasing serotonin production, promoting healthy sleep, managing depression by enhancing mental and emotional well-being, managing pain tolerance, and managing weight.
DB00451LevothyroxineLevothyroxine is indicated as replacement therapy in primary (thyroidal), secondary (pituitary) and tertiary (hypothalamic) congenital or acquired hypothyroidism. It is also indicated as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.
DB00509DextrothyroxineUsed to lower high cholesterol levels in the blood.
DB00731NateglinideFor the treatment of non-insulin dependent-diabetes mellitus in conjunction with diet and exercise.
DB00765MetyrosineFor use in the treatment of patients with pheochromocytoma, for preoperative preparation of patients for surgery, management of patients when surgery is contraindicated, and chronic treatment of patients with malignant pheochromocytoma.
DB00775TirofibanFor treatment, in combination with heparin, of acute coronary syndrome, including patients who are to be managed medically and those undergoing PTCA or atherectomy.
DB00968MethyldopaFor use in the treatment of hypertension.
DB01042MelphalanFor the palliative treatment of multiple myeloma and for the palliation of non-resectable epithelial carcinoma of the ovary. Has also been used alone or as part of various chemotherapeutic regimens as an adjunct to surgery in the treatment of breast cancer, alone or in combination regimens for palliative treatment of locally recurrent or unresectable in-transit metastatic melanoma of the extremities, as well as for the treatment of amyloidosis with prednisone.
DB01235LevodopaLevodopa on its own is formulated as an oral inhalation powder indicated for intermittent treatment of off episodes in Parkinson's patients who are already being treated with carbidopa and levodopa[FDA Label]. Levodopa is most commonly formulated as an oral tablet with a peripheral dopa decarboxylase inhibitor indicated for treatment of Parkinson's disease, post-encephalitic parkinsonism, and symptomatic parkinsonism following carbon monoxide intoxication or manganese intoxication[F4579].
DB01583LiotrixMay be used to treat primary, secondary or tertiary hypothyroidism. May also be used to suppress thyroid stimulating hormone (TSH) secretion in patients with simple (nontoxic) goiter, subacute or chronic lymphocytic thyroiditis multinodular goiter, and in the management of thyroid cancer. May be used in conjunction with other antithyroid agents to treat thyrotoxicosis to prevent goitrogenesis and hypothyroidism. May also be used for differential diagnosis of suspected mild hyperthyroidism or thyroid gland autonomy.
DB02959OxitriptanFor use as an antidepressant, appetite suppressant, and sleep aid.
DB03157N,O-Didansyl-L-TyrosineNot Available
DB03380L-tyrosinamideNot Available
DB035523-TyrosineNot Available
DB036604-Iodo-L-phenylalanineNot Available
DB03880BatimastatNot Available
DB04029Phenylalanine AmideNot Available
DB043346-hydroxydopa quinoneNot Available
DB04495RU81843Not Available
DB04584PhenyldehydroalanineNot Available
DB05092CDP323Investigated for use/treatment in multiple sclerosis.
DB05199LX1031Irritable bowel syndrome (IBS) and other gastrointestinal disorders
DB05476WX-UK1Investigated for use/treatment in solid tumors.
DB06508GW-559090Investigated for use/treatment in asthma and allergic rhinitis.
DB06535EtilevodopaInvestigated for use/treatment in parkinson's disease.
DB09272EluxadolineFor the treatment of irritable bowel syndrome with diarrhea (IBS-D).
DB11091Hydrogen peroxideIndicated to be used as a disinfectant and sterilizer.
DB11102N-acetyltyrosineN-acetyltyrosine is indicated, in combination with several other amino acids and dextrose, as a peripherally administered source of nitrogen for nutritional support in patients with adequate stores of body fat in whom, for short periods, oral administration cannot be tolerated, is undesirable, or inadequate [FDA Label]. It is also indicated, with other amino acids, 5-10% dextrose, and fat emulsion, for parenteral nutrition to preserve protein and reduce catabolism in stress conditions where oral administration is inadequate [FDA Label]. When administered with other amino acids and concentrated dextrose, it is indicated for central vein infusion to prevent or reverse negative nitrogen balance in patients where the alimentary tract by the oral, gastrostomy, or jejestomy routes cannot or should not be used or in patients in which gastrointestinal absorption of protein is impaired, metabolic requirements for protein are substantially increased, or morbidity and mortality may be reduced by replacing amino acids lost from tissue breakdown [FDA Label]
DB11611LifitegrastFor the treatment of signs and symptoms of keratoconjunctivitis sicca (dry eye syndrome).
DB12095Telotristat ethylAs a serotonin synthesis inhibitor, telotristat etiprate, has the potential to reduce serotonin levels and address the key elements of carcinoid syndrome.
DB126293,5-diiodothyropropionic acidNot Available
DB12827IndoximodNot Available
DB13074MacimorelinIndicated for the diagnosis of adult growth hormone deficiency (AGHD) [FDA Label].
DB13091TiropramideNot Available
DB13313MelevodopaNot Available
DB14028NordazepamNot Available
DB14218TelotristatNot Available
DB03604TiratricolNot Available
DB033145-fluorotryptophanNot Available
DB15084GS-9191Not Available
DB13848Fluorodopa (18F)Not Available
DB14754SolriamfetolSolriamfetol is indicated for treatment of daytime sleepiness associated with obstructive sleep apnea and narcolepsy, but is not a treatment for the underlying airway obstruction in apnea patients[FDA Label][A176534,A176744].
DrugDrug NameTargetType
DB00120L-PhenylalanineTyrosine aminotransferasetarget
DB00120L-PhenylalanineLarge neutral amino acids transporter small subunit 2target
DB00120L-PhenylalaninePhenylalanine--tRNA ligase alpha subunittarget
DB00120L-PhenylalaninePhenylalanine-4-hydroxylasetarget
DB00120L-PhenylalaninePhenylalanine--tRNA ligase, mitochondrialtarget
DB00120L-PhenylalaninePhenylalanine--tRNA ligase beta subunittarget
DB00120L-PhenylalanineTyrosine 3-monooxygenasetarget
DB00120L-PhenylalanineMonocarboxylate transporter 10transporter
DB00135TyrosineTyrosine 3-monooxygenasetarget
DB00135TyrosineTyrosine--tRNA ligase, mitochondrialtarget
DB00135TyrosineTyrosine--tRNA ligase, cytoplasmictarget
DB00135TyrosineTyrosine aminotransferasetarget
DB00135TyrosineMonocarboxylate transporter 8transporter
DB00135TyrosineMonocarboxylate transporter 10transporter
DB00150L-TryptophanTryptophan--tRNA ligase, cytoplasmictarget
DB00150L-TryptophanTryptophan--tRNA ligasetarget
DB00150L-TryptophanTryptophan--tRNA ligase, mitochondrialtarget
DB00150L-TryptophanTryptophan 2,3-dioxygenaseenzyme
DB00150L-TryptophanAromatic-L-amino-acid decarboxylaseenzyme
DB00150L-TryptophanMonocarboxylate transporter 8transporter
DB00150L-TryptophanMonocarboxylate transporter 10transporter
DB00150L-TryptophanTryptophan--tRNA ligaseenzyme
DB00150L-TryptophanTryptophan--tRNA ligase, mitochondrialenzyme
DB00150L-TryptophanTryptophan 5-hydroxylase 1enzyme
DB00150L-TryptophanTryptophan 5-hydroxylase 2enzyme
DB00150L-TryptophanTryptophan--tRNA ligase, cytoplasmicenzyme
DB00150L-TryptophanIndoleamine 2,3-dioxygenase 1enzyme
DB00451LevothyroxineThyroid hormone receptor alphatarget
DB00451LevothyroxineThyroid hormone receptor betatarget
DB00451LevothyroxineCytochrome P450 2C8enzyme
DB00451LevothyroxineTransthyretincarrier
DB00451LevothyroxineSerum albumincarrier
DB00451LevothyroxineThyroxine-binding globulincarrier
DB00451LevothyroxineMultidrug resistance protein 1transporter
DB00451LevothyroxineMonocarboxylate transporter 8transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 1C1transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 1A2transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 1B1transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 1B3transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 4A1transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 4C1transporter
DB00451LevothyroxineLarge neutral amino acids transporter small subunit 1transporter
DB00451LevothyroxineUDP-glucuronosyltransferase 1-1enzyme
DB00451LevothyroxineSolute carrier organic anion transporter family member 2B1transporter
DB00451LevothyroxineIntegrin alpha-Vtarget
DB00451LevothyroxineIntegrin beta-3target
DB00451LevothyroxineMultidrug resistance protein 1enzyme
DB00509DextrothyroxineThyroid hormone receptor alphatarget
DB00509DextrothyroxineThyroid hormone receptor betatarget
DB00509DextrothyroxineThyroid peroxidasetarget
DB00509DextrothyroxineSolute carrier organic anion transporter family member 1B1transporter
DB00509DextrothyroxineSolute carrier organic anion transporter family member 1C1transporter
DB00509DextrothyroxineSolute carrier organic anion transporter family member 4A1transporter
DB00509DextrothyroxineSolute carrier organic anion transporter family member 4C1transporter
DB00509DextrothyroxineLarge neutral amino acids transporter small subunit 1transporter
DB00731NateglinideATP-binding cassette sub-family C member 8target
DB00731NateglinideCytochrome P450 3A4enzyme
DB00731NateglinideCytochrome P450 2C9enzyme
DB00731NateglinidePeroxisome proliferator-activated receptor gammatarget
DB00731NateglinideCytochrome P450 3A5enzyme
DB00731NateglinideCytochrome P450 3A7enzyme
DB00731NateglinideSolute carrier family 15 member 1transporter
DB00731NateglinideSolute carrier family 15 member 2transporter
DB00731NateglinideSolute carrier family 22 member 6transporter
DB00731NateglinideMonocarboxylate transporter 1transporter
DB00731NateglinideProstaglandin G/H synthase 1enzyme
DB00731NateglinideUDP-glucuronosyltransferase 1-9enzyme
DB00731NateglinideCytochrome P450 2D6enzyme
DB00731NateglinideMultidrug resistance-associated protein 4transporter
DB00731NateglinideSerum albumincarrier
DB00731NateglinideAlpha-1-acid glycoprotein 1carrier
DB00765MetyrosineTyrosine 3-monooxygenasetarget
DB00775TirofibanIntegrin alpha-IIbtarget
DB00775TirofibanIntegrin beta-3target
DB00968MethyldopaAlpha-2A adrenergic receptortarget
DB00968MethyldopaCatechol O-methyltransferaseenzyme
DB00968MethyldopaSolute carrier family 15 member 1transporter
DB00968MethyldopaAromatic-L-amino-acid decarboxylasetarget
DB01042MelphalanDNAtarget
DB01042MelphalanSolute carrier family 22 member 3transporter
DB01042MelphalanLarge neutral amino acids transporter small subunit 1transporter
DB01235LevodopaD(1A) dopamine receptortarget
DB01235LevodopaD(2) dopamine receptortarget
DB01235LevodopaAromatic-L-amino-acid decarboxylaseenzyme
DB01235LevodopaSolute carrier family 15 member 1transporter
DB01235LevodopaMonocarboxylate transporter 10transporter
DB01235LevodopaD(3) dopamine receptortarget
DB01235LevodopaD(4) dopamine receptortarget
DB01235LevodopaD(1B) dopamine receptortarget
DB01235LevodopaLarge neutral amino acids transporter small subunit 1transporter
DB01235LevodopaLarge neutral amino acids transporter small subunit 2transporter
DB01235LevodopaSerum albumincarrier
DB01583LiotrixThyroid hormone receptor alphatarget
DB01583LiotrixThyroid hormone receptor betatarget
DB01583LiotrixCytochrome P450 2C8enzyme
DB01583LiotrixSolute carrier organic anion transporter family member 1A2transporter
DB01583LiotrixSolute carrier organic anion transporter family member 1B1transporter
DB01583LiotrixSolute carrier organic anion transporter family member 1B3transporter
DB01583LiotrixSolute carrier organic anion transporter family member 4C1transporter
DB01583LiotrixSodium/bile acid cotransportertransporter
DB01583LiotrixSolute carrier organic anion transporter family member 1C1transporter
DB01583LiotrixSolute carrier organic anion transporter family member 4A1transporter
DB01583LiotrixSolute carrier family 22 member 8transporter
DB01583LiotrixMonocarboxylate transporter 8transporter
DB01583LiotrixMonocarboxylate transporter 10transporter
DB01583LiotrixMultidrug resistance protein 1transporter
DB01583LiotrixTransthyretincarrier
DB01583LiotrixThyroxine-binding globulincarrier
DB01583LiotrixSerum albumincarrier
DB01583LiotrixCytochrome P450 3A4enzyme
DB02959OxitriptanTryptophan--tRNA ligase 2target
DB03157N,O-Didansyl-L-TyrosineThymidylate synthasetarget
DB03380L-tyrosinamidePro-neuropeptide Ytarget
DB03380L-tyrosinamideValacyclovir hydrolasetarget
DB035523-TyrosineTyrosine 3-monooxygenasetarget
DB036604-Iodo-L-phenylalanineLysozymetarget
DB036604-Iodo-L-phenylalaninePseudomonalisintarget
DB036604-Iodo-L-phenylalanineDipeptidyl peptidase 4target
DB036604-Iodo-L-phenylalanineAminopeptidase Starget
DB03880BatimastatNeutrophil collagenasetarget
DB03880BatimastatMacrophage metalloelastasetarget
DB03880BatimastatMatrix metalloproteinase-16target
DB03880BatimastatDisintegrin and metalloproteinase domain-containing protein 28target
DB03880BatimastatA disintegrin and metalloproteinase with thrombospondin motifs 5target
DB04029Phenylalanine AmideGenome polyproteintarget
DB04029Phenylalanine AmideGenome polyproteintarget
DB04029Phenylalanine AmideD-Amino acid amidasetarget
DB043346-hydroxydopa quinoneMembrane primary amine oxidasetarget
DB043346-hydroxydopa quinonePrimary amine oxidasetarget
DB043346-hydroxydopa quinonePhenylethylamine oxidasetarget
DB04495RU81843Proto-oncogene tyrosine-protein kinase Srctarget
DB05092CDP323Integrin alpha-4target
DB05199LX1031Tryptophan 5-hydroxylase 1target
DB05476WX-UK1Urokinase plasminogen activator surface receptortarget
DB09272EluxadolineMu-type opioid receptortarget
DB09272EluxadolineDelta-type opioid receptortarget
DB09272EluxadolineKappa-type opioid receptortarget
DB09272EluxadolineSolute carrier organic anion transporter family member 1B1transporter
DB09272EluxadolineCanalicular multispecific organic anion transporter 1transporter
DB09272EluxadolineSolute carrier family 22 member 8transporter
DB11091Hydrogen peroxideGlutathione peroxidase 1enzyme
DB11091Hydrogen peroxideCatalaseenzyme
DB11091Hydrogen peroxideAlkaline phosphatase, placental-likeenzyme
DB11611LifitegrastIntegrin alpha-Ltarget
DB11611LifitegrastCytochrome P450 2C9enzyme
DB11611LifitegrastSolute carrier organic anion transporter family member 1A2transporter
DB11611LifitegrastSolute carrier organic anion transporter family member 2B1transporter
DB12095Telotristat ethylTryptophan 5-hydroxylase 2target
DB12095Telotristat ethylTryptophan 5-hydroxylase 1target
DB126293,5-diiodothyropropionic acidCytochrome P450 3A4enzyme
DB13074MacimorelinGrowth hormone secretagogue receptor type 1target
DB13074MacimorelinCytochrome P450 3A4enzyme
DB03604TiratricolThyroid hormone receptor betatarget
DB033145-fluorotryptophanTriosephosphate isomerasetarget
DB033145-fluorotryptophanGlutathione S-transferase Mu 1target
DB14754SolriamfetolSolute carrier family 22 member 2transporter
DB14754SolriamfetolSolute carrier family 22 member 4transporter
DB14754SolriamfetolSolute carrier family 22 member 5transporter
DB14754SolriamfetolSodium-dependent dopamine transportertarget
DB14754SolriamfetolSodium-dependent noradrenaline transportertarget