Antimetabolites

Name
Antimetabolites
Accession Number
DBCAT000276
Description

Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033)

ATC Classification
Drugs
DrugDrug Description
RaltitrexedA folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer.
TioguanineA purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias.
GemcitabineA nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer.
FluorouracilA pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment.
ClofarabineA purine nucleoside used to treat relapsed or refractory acute lymphoblastic leukemia in patients 1 to 21 years old.
AzacitidineA pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome.
CytarabineA pyrimidine nucleoside analogue used to treat acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia.
MercaptopurineAn antineoplastic agent used to treat acute lymphocytic leukemia.
FludarabineA purine analog antimetabolite that inhibits DNA synthesis.
CapecitabineA nucleoside metabolic inhibitor indicated to treat colon, colorectal and breast cancer.
DecitabineA chemotherapeutic agent used for the treatment of myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, and conditions related to refractory anemia.
TegafurAn antineoplastic agent used in combination with other anticancer medications to treat advanced gastric and colorectal cancers.
FloxuridineAn antimetabolite used as palliative management for liver metastases of gastrointestinal malignancy.
MethotrexateAn antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis.
TrifluridineA nucleoside metabolic inhibitor used to treat keratoconjunctivitis and epithelial keratitis caused by simplex virus, and as a part of chemotherapy for certain types of metastatic gastrointestinal cancers.
CholineA nutrient found in a wide variety of vitamins including pre-natal formulations.
VidarabineAn antiviral agent used to treat various viral infections.
CycloserineA broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI).
AllopurinolA xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies.
ZidovudineA dideoxynucleoside used in the treatment of HIV infection.
PropylthiouracilA thiourea antithyroid agent used to treat hyperthyroidism.
StavudineA dideoxynucleoside used in the treatment of HIV infection.
RibavirinA guanosine nucleoside used to treat some forms of Hepatitis C.
DidanosineA reverse transcriptase inhibitor used to treat HIV.
ZalcitabineA dideoxynucleoside used to treat HIV.
AzathioprineAn immunosuppressant used to prevent renal transplant rejection, treat rheumatoid arthritis, Crohn's disease, and ulcerative colitis.
FlucytosineAn antifungal indicated only to treat severe infections throughout the body caused by susceptible strains of Candida or Cryptococcus.
ProguanilA medication indicated for prophylaxis and treatment of Plasmodium falciparum malaria.
TrimetrexateA folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin.
8-azaguanine8-azaguanine is one of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.
TubercidinAn antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic...
Sparfosic acidSparfosic acid is a solid. This compound belongs to the n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at the terminal nitrogen...
PuromycinPuromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting...
2-deoxyglucoseAs of July 2013, there is no approved therapeutic indication for 2-deoxyglucose. 2-deoxyglucose may have several potential indications as an adjunct to chemotherapy and radiotherapy in the treatment of solid...
BroxuridineBroxuridine has been used in trials studying the treatment of Leukemia, Stage I Prostate Cancer, Stage IIB Prostate Cancer, and Stage IIA Prostate Cancer.
TetrahydrouridineTetrahydrouridine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Sickle Cell Disease, and Head and Neck Cancer, among others.
LometrexolLometrexol has been used in trials studying the treatment of Lung Cancer, Drug/Agent Toxicity by Tissue/Organ, and Unspecified Adult Solid Tumor, Protocol Specific.
Buthionine SulfoximineButhionine Sulfoximine has been used in trials studying the treatment of Neuroblastoma and Melanoma (Skin).
NolatrexedNolatrexed is under investigation in clinical trial NCT00012324 (Nolatrexed Dihydrochloride Compared With Doxorubicin in Treating Patients With Recurrent or Unresectable Liver Cancer).
DoxifluridineDoxifluridine has been investigated for the treatment of Stomach Cancer.
TiazofurineTiazofurine has potential clinical use in cancer treatment as it is a potential inhibitor of Inosine- 5’-monophosphate (IMP) dehydrogenase .
Toyocamycin4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry.
CladribineA purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs.
PemetrexedA folate analog used to treat mesothelioma and non-small cell lung cancer.
NelarabineA purine nucleoside analog and antineoplastic agent used for the treatment of with acute T-cell lymphoblastic leukemia and T-cell lymphoblastic lymphoma with inadequate clinical response to prior chemotherapeutic treatments.
PralatrexateAn antineoplastic agent used for the treatment of relapsed or refractory peripheral T-cell lymphoma.
CarmofurCarmofur is a derivative of fluorouracil, and is an antineoplastic agent that has been used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.
MeglutolAn antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as...
Insulin glargineA modified form of long-acting or basal insulin used to control hyperglycemia in diabetes mellitus.
PlatensimycinNot Available
EvolocumabA PCSK9 (proprotein convertase subtilisin kexin type 9) inhibitor antibody used as an adjunct to LDL cholesterol reducing therapies, aiding in the prevention of cardiovascular events and cardiovascular revascularization procedures.
BococizumabBococizumab has been used in trials studying the treatment and prevention of Dyslipidemia, Hyperlipidemia, Hypercholesterolemia, Cardiovascular Disease, and Heterozygous Familial Hypercholesterolemia.
Drugs & Drug Targets
DrugTargetType
RaltitrexedThymidylate synthasetarget
RaltitrexedFolylpolyglutamate synthase, mitochondrialtarget
TioguanineDNAtarget
TioguanineMultidrug resistance-associated protein 4transporter
TioguanineHypoxanthine-guanine phosphoribosyltransferaseenzyme
GemcitabineRibonucleoside-diphosphate reductase large subunittarget
GemcitabineUMP-CMP kinasetarget
GemcitabineThymidylate synthasetarget
GemcitabineCytidine deaminaseenzyme
GemcitabineDeoxycytidine kinaseenzyme
GemcitabineP-glycoprotein 1transporter
GemcitabineMultidrug resistance-associated protein 7transporter
GemcitabineEquilibrative nucleoside transporter 1transporter
GemcitabineDNAtarget
GemcitabineSodium/nucleoside cotransporter 1transporter
GemcitabineEquilibrative nucleoside transporter 2transporter
GemcitabineSolute carrier family 28 member 3transporter
FluorouracilThymidylate synthasetarget
FluorouracilCytochrome P450 1A2enzyme
FluorouracilThymidine phosphorylaseenzyme
FluorouracilSerum albumincarrier
FluorouracilCytochrome P450 2C9enzyme
FluorouracilDihydropyrimidine dehydrogenase [NADP(+)]enzyme
FluorouracilUridine phosphorylase 1enzyme
FluorouracilUridine phosphorylase 2enzyme
FluorouracilDNAtarget
FluorouracilRNAtarget
FluorouracilCytochrome P450 2A6enzyme
FluorouracilCytochrome P450 2C8enzyme
FluorouracilMethylenetetrahydrofolate reductaseenzyme
FluorouracilThymidylate synthaseenzyme
FluorouracilUridine 5'-monophosphate synthaseenzyme
FluorouracilAmidophosphoribosyltransferaseenzyme
FluorouracilSolute carrier family 22 member 7transporter
FluorouracilEquilibrative nucleoside transporter 1transporter
FluorouracilATP-binding cassette sub-family G member 2transporter
FluorouracilCanalicular multispecific organic anion transporter 2transporter
FluorouracilMultidrug resistance-associated protein 4transporter
FluorouracilMultidrug resistance-associated protein 5transporter
FluorouracilThyroxine-binding globulincarrier
ClofarabineDNA polymerase alpha catalytic subunittarget
ClofarabineRibonucleoside-diphosphate reductase large subunittarget
ClofarabineDeoxycytidine kinaseenzyme
ClofarabineDNAtarget
ClofarabineATP-binding cassette sub-family G member 2transporter
AzacitidineDNA (cytosine-5)-methyltransferase 1target
AzacitidineCytidine deaminaseenzyme
AzacitidineDNAtarget
AzacitidineRNAtarget
CytarabineDNA polymerase betatarget
CytarabineCytidine deaminaseenzyme
CytarabineSolute carrier family 22 member 4transporter
CytarabineMultidrug resistance-associated protein 7transporter
CytarabineEquilibrative nucleoside transporter 1transporter
CytarabineDNAtarget
CytarabineCytochrome P450 3A4enzyme
CytarabineDeoxycytidine kinaseenzyme
Cytarabine5'-nucleotidaseenzyme
CytarabineDeoxycytidylate deaminaseenzyme
MercaptopurineThiopurine S-methyltransferaseenzyme
MercaptopurineXanthine dehydrogenase/oxidaseenzyme
MercaptopurineHypoxanthine-guanine phosphoribosyltransferasetarget
MercaptopurineSolute carrier family 22 member 8transporter
MercaptopurineMultidrug resistance-associated protein 4transporter
MercaptopurineMultidrug resistance-associated protein 5transporter
MercaptopurineSodium/nucleoside cotransporter 2transporter
MercaptopurineSolute carrier family 28 member 3transporter
MercaptopurineEquilibrative nucleoside transporter 1transporter
MercaptopurineEquilibrative nucleoside transporter 2transporter
MercaptopurineAldehyde oxidaseenzyme
MercaptopurineAmidophosphoribosyltransferasetarget
MercaptopurineInosine-5'-monophosphate dehydrogenasetarget
FludarabineDNA polymerase alpha catalytic subunittarget
FludarabineRibonucleoside-diphosphate reductase large subunittarget
FludarabineEquilibrative nucleoside transporter 1transporter
FludarabineDNAtarget
FludarabineDeoxycytidine kinasetarget
FludarabineSolute carrier family 28 member 3transporter
CapecitabineThymidylate synthasetarget
CapecitabineThymidine phosphorylaseenzyme
CapecitabineCytidine deaminaseenzyme
CapecitabineLiver carboxylesterase 1enzyme
CapecitabineDihydropyrimidine dehydrogenase [NADP(+)]enzyme
CapecitabineCytochrome P450 2C9enzyme
CapecitabineDNAtarget
CapecitabineRNAtarget
DecitabineDNAtarget
DecitabineDNA (cytosine-5)-methyltransferase 1target
DecitabineDeoxycytidine kinaseenzyme
TegafurCytochrome P450 2A6enzyme
TegafurThymidylate synthasetarget
TegafurCytochrome P450 1A2enzyme
TegafurCytochrome P450 2C8enzyme
TegafurCytochrome P450 2E1enzyme
TegafurCytochrome P450 3A5enzyme
TegafurThyroxine-binding globulincarrier
FloxuridineThymidylate synthasetarget
FloxuridineThymidine phosphorylaseenzyme
FloxuridineCytochrome P450 2C9enzyme
FloxuridineThyroxine-binding globulincarrier
MethotrexateDihydrofolate reductasetarget
MethotrexateAldehyde oxidaseenzyme
MethotrexateMethylenetetrahydrofolate reductaseenzyme
MethotrexateSerum albumincarrier
MethotrexateCanalicular multispecific organic anion transporter 2transporter
MethotrexateMultidrug resistance-associated protein 4transporter
MethotrexateMultidrug resistance-associated protein 1transporter
MethotrexateSolute carrier family 22 member 6transporter
MethotrexateMultidrug resistance-associated protein 7transporter
MethotrexateSolute carrier family 22 member 8transporter
MethotrexateCanalicular multispecific organic anion transporter 1transporter
MethotrexateP-glycoprotein 1transporter
MethotrexateSolute carrier organic anion transporter family member 1A2transporter
MethotrexateMonocarboxylate transporter 1transporter
MethotrexateATP-binding cassette sub-family C member 11transporter
MethotrexateSolute carrier organic anion transporter family member 1B3transporter
MethotrexateSolute carrier family 22 member 11transporter
MethotrexateSolute carrier organic anion transporter family member 1C1transporter
MethotrexateSolute carrier organic anion transporter family member 3A1transporter
MethotrexateATP-binding cassette sub-family G member 2transporter
MethotrexateSolute carrier family 22 member 7transporter
MethotrexateSolute carrier organic anion transporter family member 1B1transporter
Methotrexate6-phosphogluconate dehydrogenase, decarboxylatingenzyme
MethotrexateProton-coupled folate transportertransporter
MethotrexateFolylpolyglutamate synthase, mitochondrialenzyme
MethotrexateGamma-glutamyl hydrolaseenzyme
MethotrexateDihydrofolate reductaseenzyme
MethotrexateThymidylate synthaseenzyme
MethotrexateBifunctional purine biosynthesis protein PURHenzyme
MethotrexateSolute carrier organic anion transporter family member 4C1transporter
MethotrexateFolate transporter 1transporter
MethotrexateFolate receptor alphatransporter
MethotrexateCytochrome P450 3A4enzyme
MethotrexateThymidylate synthasetarget
MethotrexateBifunctional purine biosynthesis protein PURHtarget
MethotrexateFolate receptor betatransporter
MethotrexateSolute carrier family 15 member 1transporter
MethotrexateProton-coupled amino acid transporter 1transporter
TrifluridineThymidylate synthasetarget
TrifluridineDNAtarget
TrifluridineThymidine kinase, cytosolicenzyme
TrifluridineThymidine phosphorylaseenzyme
TrifluridineSolute carrier family 22 member 6transporter
TrifluridineSodium/nucleoside cotransporter 1transporter
TrifluridineEquilibrative nucleoside transporter 1transporter
TrifluridineEquilibrative nucleoside transporter 2transporter
TrifluridineSerum albumincarrier
CholineCholine-phosphate cytidylyltransferase Btarget
CholineAcetylcholinesterasetarget
CholineCholine-phosphate cytidylyltransferase Atarget
CholinePhospholipase D2target
CholineCholinesterasetarget
CholinePhospholipase D1target
CholinePhosphoethanolamine/phosphocholine phosphatasetarget
CholineSolute carrier family 22 member 2transporter
CholineSolute carrier family 22 member 1transporter
CholineSolute carrier family 22 member 3transporter
CholineSolute carrier family 22 member 5transporter
CholineSolute carrier family 22 member 4transporter
CholineCholine/ethanolaminephosphotransferase 1enzyme
CholineCholine transporter-like protein 1transporter
CholineCholine transporter-like protein 4transporter
CholineCholine transporter-like protein 2transporter
CholineCholine transporter-like protein 3transporter
CholineCholine/ethanolamine kinaseenzyme
CholineCholine O-acetyltransferaseenzyme
CholineCholine kinase alphaenzyme
CholineCholine dehydrogenase, mitochondrialenzyme
CholineHigh affinity choline transporter 1transporter
CholineNeuronal acetylcholine receptor subunit alpha-7target
VidarabineDNAtarget
VidarabineDNA polymerase catalytic subunittarget
VidarabineThymidine kinasetarget
VidarabineThymidine kinasetarget
VidarabineAdenosine deaminaseenzyme
CycloserineD-alanine--D-alanine ligase Atarget
CycloserineAlanine racemasetarget
CycloserineAromatic-L-amino-acid decarboxylaseenzyme
CycloserineProton-coupled amino acid transporter 2transporter
AllopurinolXanthine dehydrogenase/oxidasetarget
AllopurinolSolute carrier family 22 member 8transporter
AllopurinolSolute carrier family 22 member 7transporter
AllopurinolAldehyde oxidaseenzyme
AllopurinolXanthine dehydrogenase/oxidaseenzyme
AllopurinolATP-binding cassette sub-family G member 2transporter
AllopurinolSolute carrier family 22 member 2transporter
ZidovudineSerum albumincarrier
ZidovudineCytochrome P450 2A6enzyme
ZidovudineCytochrome P450 2C9enzyme
ZidovudineCytochrome P450 3A4enzyme
ZidovudineReverse transcriptase/RNaseHtarget
ZidovudineSolute carrier family 22 member 2transporter
ZidovudineSolute carrier family 22 member 6transporter
ZidovudineSolute carrier family 22 member 7transporter
ZidovudineSolute carrier family 22 member 8transporter
ZidovudineSolute carrier family 22 member 11transporter
ZidovudineSodium/nucleoside cotransporter 1transporter
ZidovudineEquilibrative nucleoside transporter 2transporter
ZidovudineP-glycoprotein 1transporter
ZidovudineMultidrug resistance-associated protein 4transporter
ZidovudineMultidrug resistance-associated protein 5transporter
ZidovudineATP-binding cassette sub-family G member 2transporter
ZidovudineTelomerase reverse transcriptasetarget
ZidovudineThymidine kinase, cytosolicenzyme
ZidovudineUDP-glucuronosyltransferase 2B7enzyme
ZidovudineUDP-glucuronosyltransferase 1-1enzyme
PropylthiouracilThyroid peroxidasetarget
PropylthiouracilMyeloperoxidaseenzyme
PropylthiouracilDopamine beta-hydroxylaseenzyme
PropylthiouracilCytochrome P450 1A1enzyme
StavudineSolute carrier family 22 member 6transporter
StavudineReverse transcriptase/RNaseHtarget
StavudineSodium/nucleoside cotransporter 1transporter
StavudineSerum albumincarrier
RibavirinRNA-directed RNA polymerase Ltarget
RibavirinEctonucleotide pyrophosphatase/phosphodiesterase family member 1target
RibavirinRNA-directed RNA polymerase catalytic subunittarget
RibavirinCytosolic purine 5'-nucleotidasetarget
RibavirinInosine-5'-monophosphate dehydrogenase 1target
RibavirinGenome polyproteintarget
RibavirinInosine-5'-monophosphate dehydrogenase 2target
RibavirinAdenosine kinaseenzyme
RibavirinEquilibrative nucleoside transporter 1transporter
RibavirinSolute carrier family 28 member 3transporter
DidanosineSolute carrier family 22 member 6transporter
DidanosinePurine nucleoside phosphorylasetarget
DidanosineReverse transcriptase/RNaseHtarget
DidanosineEquilibrative nucleoside transporter 1transporter
DidanosineEquilibrative nucleoside transporter 2transporter
DidanosineSerum albumincarrier
ZalcitabineDeoxycytidine kinaseenzyme
ZalcitabineSolute carrier family 22 member 6transporter
ZalcitabineSolute carrier family 22 member 7transporter
ZalcitabineReverse transcriptase/RNaseHtarget
ZalcitabineEquilibrative nucleoside transporter 1transporter
ZalcitabineEquilibrative nucleoside transporter 2transporter
ZalcitabineSerum albumincarrier
AzathioprineThiopurine S-methyltransferaseenzyme
AzathioprineXanthine dehydrogenase/oxidaseenzyme
AzathioprineGlutathione S-transferase A1enzyme
AzathioprineGlutathione S-transferase A2enzyme
AzathioprineGlutathione S-transferase Mu 1enzyme
AzathioprineRas-related C3 botulinum toxin substrate 1target
AzathioprineCytochrome P450 1A2enzyme
AzathioprineHypoxanthine-guanine phosphoribosyltransferaseenzyme
AzathioprineNucleotide triphosphate diphosphatase NUDT15enzyme
AzathioprineEquilibrative nucleoside transporter 2transporter
AzathioprineSolute carrier family 28 member 3transporter
AzathioprineP-glycoprotein 1transporter
AzathioprineSolute carrier family 43 member 3transporter
AzathioprineSerum albumincarrier
AzathioprineInosine-5'-monophosphate dehydrogenase 1enzyme
AzathioprineInosine-5'-monophosphate dehydrogenase 2enzyme
AzathioprineGMP synthase [glutamine-hydrolyzing]enzyme
AzathioprineInosine triphosphate pyrophosphataseenzyme
FlucytosineThymidylate synthasetarget
FlucytosineDNA (cytosine-5)-methyltransferase 1target
FlucytosineDNAtarget
ProguanilBifunctional dihydrofolate reductase-thymidylate synthasetarget
ProguanilDihydrofolate reductasetarget
ProguanilCytochrome P450 2C19enzyme
ProguanilCytochrome P450 2D6enzyme
ProguanilCytochrome P450 2C9enzyme
TrimetrexateDihydrofolate reductasetarget
TrimetrexateDihydrofolate reductaseenzyme
TrimetrexateFolate transporter 1transporter
8-azaguaninePurine nucleoside phosphorylasetarget
8-azaguanineCytochrome P450 1A2enzyme
TubercidinPurine nucleoside phosphorylase DeoD-typetarget
Sparfosic acidAspartate carbamoyltransferase catalytic chaintarget
Sparfosic acidCAD proteintarget
Puromycin60S ribosomal protein L10-liketarget
Puromycin60S ribosomal protein L13atarget
Puromycin60S ribosomal protein L23target
Puromycin60S ribosomal protein L15target
Puromycin60S ribosomal protein L19target
Puromycin60S ribosomal protein L23atarget
PuromycinProbable ribosome biogenesis protein RLP24target
Puromycin60S ribosomal protein L26-like 1target
Puromycin60S ribosomal protein L8target
Puromycin60S ribosomal protein L37target
Puromycin60S ribosomal protein L3target
Puromycin60S ribosomal protein L11target
PuromycinLeucyl/phenylalanyl-tRNA--protein transferasetarget
2-deoxyglucoseSolute carrier family 2, facilitated glucose transporter member 1transporter
LometrexolDihydrofolate reductasetarget
CladribinePurine nucleoside phosphorylasetarget
CladribineDNAtarget
CladribineDeoxycytidine kinaseenzyme
CladribineRibonucleoside-diphosphate reductase large subunittarget
CladribineRibonucleoside-diphosphate reductase subunit M2target
CladribineRibonucleoside-diphosphate reductase subunit M2 Btarget
CladribineDNA polymerase alpha catalytic subunittarget
CladribineDNA polymerase epsilon catalytic subunit Atarget
CladribineDNA polymerase epsilon subunit 2target
CladribineDNA polymerase epsilon subunit 3target
CladribineDNA polymerase epsilon subunit 4target
CladribineATP-binding cassette sub-family G member 2transporter
CladribineSolute carrier family 28 member 3transporter
PemetrexedThymidylate synthasetarget
PemetrexedDihydrofolate reductasetarget
PemetrexedTrifunctional purine biosynthetic protein adenosine-3target
PemetrexedDeoxycytidine kinaseenzyme
PemetrexedBifunctional purine biosynthesis protein PURHtarget
PemetrexedEquilibrative nucleoside transporter 1enzyme
PemetrexedSolute carrier family 22 member 8transporter
NelarabineDNAtarget
NelarabineAdenosine deaminaseenzyme
NelarabineDeoxycytidine kinaseenzyme
NelarabineDeoxyguanosine kinase, mitochondrialenzyme
NelarabineDNA polymerase alpha catalytic subunittarget
PralatrexateFolylpolyglutamate synthase, mitochondrialenzyme
PralatrexateDihydrofolate reductasetarget
PralatrexateThymidylate synthasetarget
PralatrexateFolate transporter 1transporter
Meglutol3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
Insulin glargineInsulin receptortarget
Insulin glargineInsulin-like growth factor 1 receptortarget
Insulin glargineCytochrome P450 1A2enzyme
Platensimycin3-oxoacyl-[acyl-carrier-protein] synthase 2target
EvolocumabProprotein convertase subtilisin/kexin type 9enzyme