Fatty Acids, Omega-3

Name
Fatty Acids, Omega-3
Accession Number
DBCAT000294
Description

A group of fatty acids, often of marine origin, which have the first unsaturated bond in the third position from the omega carbon. These fatty acids are believed to reduce serum triglycerides, prevent insulin resistance, improve lipid profile, prolong bleeding times, reduce platelet counts, and decrease platelet adhesiveness.

Drugs
DrugDrug Description
IcosapentA polyunsaturated fatty acid, usually found in fish oils, that is used in many supplements.
Icosapent ethylAn ethyl ester of eicosapentaenoic acid (EPA) that reduces synthesis and enhances clearance of triglycerides that is used to treat patients with severe hypertriglyceridemia.
Omega-3-acid ethyl estersA mixture of fatty acids used as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe hypertriglyceridemia.
alpha-Linolenic acidA polyunsaturated omega-3 fatty acid found in many supplements.
Resolvin E1Resolvin E1 (RX 10001) is under investigation in clinical trial NCT00941018 (Single and Multiple Ascending Oral Dose Study of Resolvin E1 in Healthy Volunteers).
Omega-3-carboxylic acidsA medication used with other medications to lower triglyceride levels in adult patients with severe hypertriglyceridemia.
Omega-3 fatty acidsAn ingredient found in a variety of supplements and vitamins.
DoconexentAn omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health.
Drugs & Drug Targets
DrugTargetType
IcosapentProstaglandin G/H synthase 2target
IcosapentProstaglandin G/H synthase 1target
IcosapentFree fatty acid receptor 1target
IcosapentFatty acid-binding protein, braincarrier
IcosapentFatty acid desaturase 1target
IcosapentLong-chain-fatty-acid--CoA ligase 4target
IcosapentSodium/calcium exchanger 1target
IcosapentPeroxisome proliferator-activated receptor gammatarget
IcosapentPeroxisome proliferator-activated receptor deltatarget
IcosapentTransient receptor potential cation channel subfamily V member 1target
IcosapentPeroxisome proliferator-activated receptor alphatarget
IcosapentSerum albumincarrier
Omega-3-acid ethyl estersSterol O-acyltransferase 1enzyme
Omega-3-acid ethyl estersSterol regulatory element-binding protein 1target
alpha-Linolenic acidFatty acid-binding protein, braincarrier
alpha-Linolenic acidFatty acid desaturase 1target
alpha-Linolenic acidFatty acid desaturase 2target
alpha-Linolenic acidSodium/calcium exchanger 1target
alpha-Linolenic acidTransient receptor potential cation channel subfamily V member 1target
alpha-Linolenic acidPeroxisome proliferator-activated receptor alphatarget
alpha-Linolenic acidBile acid receptortarget
alpha-Linolenic acidPeroxisome proliferator-activated receptor deltatarget
alpha-Linolenic acidPeroxisome proliferator-activated receptor gammatarget
alpha-Linolenic acidRetinoic acid receptor RXR-alphatarget
alpha-Linolenic acidElongation of very long chain fatty acids protein 2target
alpha-Linolenic acidElongation of very long chain fatty acids protein 5target
Omega-3-carboxylic acidsPhosphatidylcholine transfer proteincarrier
Omega-3-carboxylic acidsPhosphatidylethanolamine-binding protein 1carrier
Omega-3-carboxylic acidsCytochrome P450 3A Subfamilyenzyme
Omega-3-carboxylic acidsLeukotriene-B(4) omega-hydroxylase 1enzyme
Omega-3-carboxylic acidsDiacylglycerol O-acyltransferase 2target
Omega-3-carboxylic acids3-hydroxyacyl-CoA dehydrogenase type-2target
Omega-3-carboxylic acidsEnoyl-CoA hydratase, mitochondrialtarget
Omega-3-carboxylic acidsHydroxyacyl-coenzyme A dehydrogenase, mitochondrialtarget
Omega-3-carboxylic acidsElongation of very long chain fatty acids protein 4target
Omega-3-carboxylic acidsLipoprotein lipasetarget
Omega-3 fatty acidsPeroxisome proliferator-activated receptor gammatarget
Omega-3 fatty acidsProstaglandin G/H synthase 2enzyme
Omega-3 fatty acidsArachidonate 5-lipoxygenaseenzyme
Omega-3 fatty acidsPeroxisome proliferator-activated receptor alphatarget
Omega-3 fatty acidsSterol regulatory element-binding protein 1target
DoconexentCytochrome P450 2C9enzyme
DoconexentPeroxisome proliferator-activated receptor alphatarget
DoconexentPeroxisome proliferator-activated receptor gammatarget
DoconexentSterol regulatory element-binding protein 1target
DoconexentRetinoic acid receptor RXR-alphatarget
DoconexentRetinoic acid receptor RXR-betatarget
DoconexentRetinoic acid receptor RXR-gammatarget