The glyceryl esters of a fatty acid, or of a mixture of fatty acids. They are generally odorless, colorless, and tasteless if pure, but they may be flavored according to origin. Fats are insoluble in water, soluble in most organic solvents. They occur in animal and vegetable tissue and are generally obtained by boiling or by extraction under pressure. They are important in the diet (DIETARY FATS) as a source of energy. (Grant & Hackh's Chemical Dictionary, 5th ed)
DrugDrug NameDrug Indication
DB00132alpha-Linolenic acidFor nutritional supplementation and for treating dietary shortage or imbalance.
DB00159IcosapentEPA can be used for lowering elevated triglycerides in those who are hyperglyceridemic. In addition, EPA may play a therapeutic role in patients with cystic fibrosis by reducing disease severity and may play a similar role in type 2 diabetics in slowing the progression of diabetic nephropathy.
DB02955Ricinoleic AcidNot Available
DB08887Icosapent ethylIcosapent ethyl is used as adjunct therapy to reduce triglyceride (TG) levels in adults with severe (>500 mg/dL) hypertriglyceridemia.
DB09422Soybean oilIndicated for parenteral nutrition as a source of calories and essential fatty acids when oral or enteral nutrition is not possible, insufficient, or contraindicated.
DB09446Safflower oilNo approved therapeutic indications.
DB09539Omega-3-acid ethyl estersOmega-3-Acid Ethyl Esters capsules, USP are indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia (HTG)[FDA Label][A176687].
DB09567Olive oilFor use in adults as a source of calories and fatty acids in total parenteral nutrition [FDA Label]. Sometimes used as an additive in cosmetic products.
DB11086Cocoa butterIndicated for topical use in over-the-counter skin products for the treatment of skin dryness and reduction of striae gravidarum (stretch marks).
DB11113Castor oilIndicated for over-the-counter use as a laxative for oral use and as a soothing agent for topical use on skin and hair.
DB11133Omega-3 fatty acidsProvided as daily supplements. Aa preparation of omega-3-acid ethyl esters is licensed in UK for prevention of recurrent events after myocardial infarction in addition to treatment of hypertriglyceridaemia.
DB11172Sesame oilNot Available
DB11321Cod liver oilCod liver oil is predominantly manufactured, marketed, and used by the population at large as a general nutraceutical dietary supplement [A27154, A33159, L2872]. Historically, cod liver oil was often given to children because the vitamin d content in the oil had been shown to prevent or treat vitamin D deficiency and condition of rickets associated with it [A33159]. Over time, this common use in children growing up may have conferred upon cod liver oil its identity as a healthy and useful all-purpose dietary supplement. However, since cod liver oil is a composite of several other nutritional compounds including the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) as well as vitamin A and vitamin D [A33159, L2872, L2871], the presence in varying amounts of all of these compounds at once makes it difficult to recommend or use cod liver oil as an appropriate supplement to confer any one particular health effect or for any one particular nutritional deficiency. Regardless, because it does contain a combination of a number of important and healthy nutritional compounds, cod liver oil has sometimes been recommended in the literature for conferring the health effects of some of these compounds, such as the potential use of cod liver oil supplements in post-heart attack patients for secondary prophylaxis associated with the use of omega-3 fatty acids [A33165].
DB11357Linseed oilNot Available
DB13038Glyceryl TrioleateNot Available
DB13105Resolvin E1Not Available
DB03756DoconexentUsed as a high-docosahexaenoic acid (DHA) oral supplement.
DrugDrug NameTargetType
DB00132alpha-Linolenic acidFatty acid-binding protein, braincarrier
DB00132alpha-Linolenic acidFatty acid desaturase 1target
DB00132alpha-Linolenic acidFatty acid desaturase 2target
DB00132alpha-Linolenic acidSodium/calcium exchanger 1target
DB00132alpha-Linolenic acidTransient receptor potential cation channel subfamily V member 1target
DB00132alpha-Linolenic acidElongation of very long chain fatty acids protein 4target
DB00132alpha-Linolenic acidPeroxisome proliferator-activated receptor alphatarget
DB00132alpha-Linolenic acidBile acid receptortarget
DB00132alpha-Linolenic acidPeroxisome proliferator-activated receptor deltatarget
DB00132alpha-Linolenic acidPeroxisome proliferator-activated receptor gammatarget
DB00132alpha-Linolenic acidRetinoic acid receptor RXR-alphatarget
DB00159IcosapentProstaglandin G/H synthase 2target
DB00159IcosapentProstaglandin G/H synthase 1target
DB00159IcosapentFree fatty acid receptor 1target
DB00159IcosapentFatty acid-binding protein, braincarrier
DB00159IcosapentFatty acid desaturase 1target
DB00159IcosapentLong-chain-fatty-acid--CoA ligase 4target
DB00159IcosapentLong-chain-fatty-acid--CoA ligase 3target
DB00159IcosapentSodium/calcium exchanger 1target
DB00159IcosapentPeroxisome proliferator-activated receptor gammatarget
DB00159IcosapentPeroxisome proliferator-activated receptor deltatarget
DB00159IcosapentTransient receptor potential cation channel subfamily V member 1target
DB00159IcosapentPeroxisome proliferator-activated receptor alphatarget
DB00159IcosapentSerum albumincarrier
DB02955Ricinoleic AcidCannabinoid receptor 1target
DB02955Ricinoleic AcidCannabinoid receptor 2target
DB02955Ricinoleic AcidTransient receptor potential cation channel subfamily V member 1target
DB09422Soybean oilPeroxisome proliferator-activated receptor alphatarget
DB09539Omega-3-acid ethyl estersSterol O-acyltransferase 1enzyme
DB09539Omega-3-acid ethyl estersSterol regulatory element-binding protein 1target
DB11113Castor oilProstaglandin E2 receptor EP3 subtypetarget
DB11113Castor oilProstaglandin E2 receptor EP4 subtypetarget
DB11133Omega-3 fatty acidsPeroxisome proliferator-activated receptor gammatarget
DB11133Omega-3 fatty acidsProstaglandin G/H synthase 2enzyme
DB11133Omega-3 fatty acidsArachidonate 5-lipoxygenaseenzyme
DB11133Omega-3 fatty acidsPeroxisome proliferator-activated receptor alphatarget
DB11133Omega-3 fatty acidsSterol regulatory element-binding protein 1target
DB03756DoconexentFatty acid-binding protein, braincarrier
DB03756DoconexentCytochrome P450 2C9enzyme
DB03756DoconexentPeroxisome proliferator-activated receptor alphatarget
DB03756DoconexentPeroxisome proliferator-activated receptor gammatarget
DB03756DoconexentSterol regulatory element-binding protein 1target
DB03756DoconexentRetinoic acid receptor RXR-alphatarget
DB03756DoconexentRetinoic acid receptor RXR-betatarget
DB03756DoconexentRetinoic acid receptor RXR-gammatarget