Secosteroids

Steroids in which fission of one or more ring structures and concomitant addition of a hydrogen atom at each terminal group has occurred.
DrugDrug NameDrug Indication
DB00136CalcitriolUsed to treat vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.
DB00146CalcifediolUsed to treat vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.
DB00153ErgocalciferolFor use in the management of hypocalcemia and its clinical manifestations in patients with hypoparathyroidism, as well as for the treatment of familial hypophosphatemia (vitamin D resistant rickets). This drug has also been used in the treatment of nutritional rickets or osteomalacia, vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis).
DB00169CholecalciferolFor the treatment of vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.
DB00910ParicalcitolFor treatment of secondary hyperparathyroidism associated with chronic kidney disease (CKD) Stage 3 and 4
DB01070DihydrotachysterolUsed for the prevention and treatment of rickets or osteomalacia, and to manage hypocalcemia associated with hypoparathyroidism or pseudohypoparathyroidism. Also used for the treatment of vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis).
DB01436AlfacalcidolAlfacalcidol is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism.
DB02300CalcipotriolFor the treatment of moderate plaque psoriasis in adults.
DB04258SeocalcitolNot Available
DB04796InecalcitolInvestigated for use/treatment in prostate cancer, psoriasis and hyperparathyroidism.
DB04891BecocalcidiolFor topical treatment of psoriasis and psoriatic disorders.
DB05295EldecalcitolInvestigated for use/treatment in osteoporosis.
DB06194ElocalcitolInvestigated for use/treatment in benign prostatic hyperplasia, urinary incontinence, prostate disorders, and infertility.
DB06272MaxacalcitolNot Available
DB06410DoxercalciferolDoxercalciferol is indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, as well as for the treatment of secondary hyperparathyroidism in patients with Stage 3 or Stage 4 chronic kidney disease.
DB11094Vitamin DVitamin D is indicated for use in the treatment of hypoparathyroidism, refractory rickets (also known as vitamin D resistant rickets), and familial hypophosphatemia [FDA Label].
DB130971alpha-Hydroxyvitamin D5Not Available
DB13689TacalcitolNot Available
DrugDrug NameTargetType
DB00136Calcitriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB00136CalcitriolCytochrome P450 3A4enzyme
DB00136CalcitriolVitamin D3 receptortarget
DB00136CalcitriolHomeobox protein Hox-A10target
DB00136CalcitriolVitamin D-binding proteintarget
DB00146Calcifediol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
DB00146Calcifediol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB00146CalcifediolVitamin D3 receptortarget
DB00153Ergocalciferol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB00153Ergocalciferol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
DB00153ErgocalciferolSterol 26-hydroxylase, mitochondrialenzyme
DB00153ErgocalciferolCytochrome P450 3A4enzyme
DB00153ErgocalciferolVitamin D 25-hydroxylaseenzyme
DB00153ErgocalciferolVitamin D3 receptortarget
DB00169CholecalciferolVitamin D-binding proteincarrier
DB00169CholecalciferolCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB00169CholecalciferolVitamin D 25-hydroxylaseenzyme
DB00169CholecalciferolSterol 26-hydroxylase, mitochondrialenzyme
DB00169CholecalciferolCytochrome P450 2J2enzyme
DB00169CholecalciferolCytochrome P450 3A4enzyme
DB00169CholecalciferolCytochrome P450 1A1enzyme
DB00169CholecalciferolCytochrome P450 2B6enzyme
DB00169CholecalciferolCytochrome P450 2C8enzyme
DB00169CholecalciferolCytochrome P450 2D6enzyme
DB00169CholecalciferolVitamin D3 receptortarget
DB00910Paricalcitol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB00910ParicalcitolCytochrome P450 3A4enzyme
DB00910ParicalcitolUDP-glucuronosyltransferase 1-4enzyme
DB00910ParicalcitolVitamin D3 receptortarget
DB01070DihydrotachysterolVitamin D3 receptortarget
DB01436AlfacalcidolVitamin D-binding proteincarrier
DB01436AlfacalcidolVitamin D3 receptortarget
DB01436Alfacalcidol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialtarget
DB01436AlfacalcidolRetinoic acid receptor RXR-alphatarget
DB02300CalcipotriolMyeloperoxidaseenzyme
DB02300Calcipotriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB02300CalcipotriolVitamin D3 receptortarget
DB04258SeocalcitolVitamin D3 receptortarget
DB04796InecalcitolVitamin D3 receptortarget
DB04891BecocalcidiolMediator of RNA polymerase II transcription subunit 1target
DB04891BecocalcidiolVitamin D3 receptortarget
DB05295EldecalcitolVitamin D3 receptortarget
DB06194ElocalcitolVitamin D3 receptortarget
DB06410DoxercalciferolSterol 26-hydroxylase, mitochondrialenzyme
DB06410DoxercalciferolVitamin D3 receptortarget
DB11094Vitamin DVitamin D 25-hydroxylaseenzyme
DB11094Vitamin D25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
DB11094Vitamin DCytochrome P450 3A4enzyme
DB11094Vitamin DVitamin D3 receptortarget
DB11094Vitamin DVitamin D-binding proteintarget