Pteridines

Name
Pteridines
Accession Number
DBCAT000333
Description

Compounds based on pyrazino[2,3-d]pyrimidine which is a pyrimidine fused to a pyrazine, containing four NITROGEN atoms.

Drugs
DrugDrug Description
Tetrahydrofolic acidFor nutritional supplementation, also for treating dietary shortage or imbalance.
RiboflavinA vitamin used to correct vitamin B2 deficiency.
Folic acidA nutrient used to treat megaloblastic anemia and is found in many supplements.
SapropterinA cofactor used as an adjunct to phenylalanine restriction in the treatment of phenylketonuria (PKU).
TriamtereneA potassium-sparing diuretic used in the treatment of edema and in the management of hypertension.
MethotrexateAn antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis.
LeucovorinA folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer.
6-Hydroxymethyl-7,8-DihydropterinNot Available
D-threo-neopterinA pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections. (From Stedman, 26th ed) Neopterin also serves as a...
Flavin adenine dinucleotideA coenzyme form of vitamin B2 used in clinical conditions associated with vitamin B2 deficiency.
6-HydroxymethylpterinNot Available
BiopterinA natural product that has been considered as a growth factor for some insects. [PubChem]
Coenzyme F420Not Available
Pteroic acidNot Available
LumichromeNot Available
L-erythro-7,8-dihydrobiopterin7,8-Dihydrobiopterin is an inhibitor of the enzyme dihydroneopterin aldolase (DHNA), which catalyzes the conversion of 7,8-Dihydrobiopterin to 6-hydroxymethyl-7,8-dihydropterin and glycolaldehyde.
7,8-DihydroneopterinNot Available
VintafolideInvestigated for use/treatment in solid tumors.
4'-Methylene-5,8,10-trideazaaminopterinInvestigated for use/treatment in inflammatory disorders (unspecified), psoriasis and psoriatic disorders, and rheumatoid arthritis.
TalotrexinInvestigated for use/treatment in solid tumors, lung cancer, leukemia (unspecified), and leukemia (lymphoid).
PralatrexateAn antineoplastic agent used for the treatment of relapsed or refractory peripheral T-cell lymphoma.
AminopterinPrior to its withdrawal, aminopterin was initially used in the treatment of childhood leukemia; specifically to induce remissions. Later, aminopterin was used off-label in the United States to treat psoriasis,...
LevoleucovorinA folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer.
EpofolateEpofolate has been used in trials studying the treatment of Advanced Solid Tumors.
RonopterinRonopterin has been used in trials studying the treatment of Traumatic Brain Injury.
LometrexolLometrexol has been used in trials studying the treatment of Lung Cancer, Drug/Agent Toxicity by Tissue/Organ, and Unspecified Adult Solid Tumor, Protocol Specific.
Flavin mononucleotideA form of vitamin B2 used to restore riboflavin in anemia, migraine, alcoholism, and hyperhomocysteinemia.
Riboflavin tetrabutyrateNot Annotated
NeopterinNeopterin is under investigation in clinical trial NCT02974192 (Neopterin Effects on Ischemic Stroke).
5-methyltetrahydrofolic acid5-methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. It is generated by methylenetetrahydrofolate reductase from 5,10-methylenetetrahydrofolate and used to recycle homocysteine back to methionine by 5-methyltetrahydrofolate-homocysteine methyltransferases (also called methionine...
Levomefolic acidA folate supplement used to prevent neural tube defects in pregnancy or folate deficiency.
6-hydroxy-FADNot Available
LumiflavinNot Available
Drugs & Drug Targets
DrugTargetType
Tetrahydrofolic acidC-1-tetrahydrofolate synthase, cytoplasmictarget
Tetrahydrofolic acidBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialtarget
Tetrahydrofolic acidAminomethyltransferase, mitochondrialtarget
Tetrahydrofolic acidCytosolic 10-formyltetrahydrofolate dehydrogenasetarget
Tetrahydrofolic acidMethionine synthasetarget
Tetrahydrofolic acidFormimidoyltransferase-cyclodeaminasetarget
Tetrahydrofolic acidBifunctional purine biosynthesis protein PURHtarget
Tetrahydrofolic acidSerine hydroxymethyltransferase, cytosolictarget
Tetrahydrofolic acidSerine hydroxymethyltransferase, mitochondrialtarget
Tetrahydrofolic acidMethylenetetrahydrofolate reductasetarget
Tetrahydrofolic acidSerine hydroxymethyltransferasetarget
Tetrahydrofolic acidMethionyl-tRNA formyltransferase, mitochondrialtarget
Tetrahydrofolic acidCanalicular multispecific organic anion transporter 1transporter
RiboflavinFlavin reductase (NADPH)target
RiboflavinRiboflavin kinasetarget
RiboflavinRiboflavin synthasetarget
RiboflavinAmine oxidase [flavin-containing] Aenzyme
RiboflavinMethylenetetrahydrofolate reductaseenzyme
RiboflavinSolute carrier family 22 member 6transporter
Folic acidFolate receptor gammatarget
Folic acidFolate receptor betatarget
Folic acidMethylenetetrahydrofolate reductaseenzyme
Folic acidMultidrug resistance-associated protein 4transporter
Folic acidSolute carrier family 22 member 6transporter
Folic acidCanalicular multispecific organic anion transporter 2transporter
Folic acidATP-binding cassette sub-family C member 11transporter
Folic acidATP-binding cassette sub-family G member 2transporter
Folic acidProton-coupled folate transportertransporter
Folic acidMitochondrial folate transporter/carriertransporter
Folic acidGamma-glutamyl hydrolaseenzyme
Folic acidFolate receptor alphatarget
Folic acidDihydrofolate reductaseenzyme
SapropterinPhenylalanine-4-hydroxylasetarget
SapropterinNitric oxide synthase, endothelialtarget
SapropterinTyrosine 3-monooxygenasetarget
SapropterinTryptophan 5-hydroxylase 1target
SapropterinProstaglandin G/H synthase 2enzyme
TriamtereneAmiloride-sensitive sodium channel subunit gammatarget
TriamtereneAmiloride-sensitive sodium channel subunit alphatarget
TriamtereneAmiloride-sensitive sodium channel subunit betatarget
TriamtereneAmiloride-sensitive sodium channel subunit deltatarget
TriamtereneCytochrome P450 1A2enzyme
MethotrexateDihydrofolate reductasetarget
MethotrexateAldehyde oxidaseenzyme
MethotrexateMethylenetetrahydrofolate reductaseenzyme
MethotrexateSerum albumincarrier
MethotrexateCanalicular multispecific organic anion transporter 2transporter
MethotrexateMultidrug resistance-associated protein 4transporter
MethotrexateMultidrug resistance-associated protein 1transporter
MethotrexateSolute carrier family 22 member 6transporter
MethotrexateMultidrug resistance-associated protein 7transporter
MethotrexateSolute carrier family 22 member 8transporter
MethotrexateCanalicular multispecific organic anion transporter 1transporter
MethotrexateP-glycoprotein 1transporter
MethotrexateSolute carrier organic anion transporter family member 1A2transporter
MethotrexateMonocarboxylate transporter 1transporter
MethotrexateATP-binding cassette sub-family C member 11transporter
MethotrexateSolute carrier organic anion transporter family member 1B3transporter
MethotrexateSolute carrier family 22 member 11transporter
MethotrexateSolute carrier organic anion transporter family member 1C1transporter
MethotrexateSolute carrier organic anion transporter family member 3A1transporter
MethotrexateATP-binding cassette sub-family G member 2transporter
MethotrexateSolute carrier family 22 member 7transporter
MethotrexateSolute carrier organic anion transporter family member 1B1transporter
Methotrexate6-phosphogluconate dehydrogenase, decarboxylatingenzyme
MethotrexateProton-coupled folate transportertransporter
MethotrexateFolylpolyglutamate synthase, mitochondrialenzyme
MethotrexateGamma-glutamyl hydrolaseenzyme
MethotrexateDihydrofolate reductaseenzyme
MethotrexateThymidylate synthaseenzyme
MethotrexateBifunctional purine biosynthesis protein PURHenzyme
MethotrexateSolute carrier organic anion transporter family member 4C1transporter
MethotrexateFolate transporter 1transporter
MethotrexateFolate receptor alphatransporter
MethotrexateCytochrome P450 3A4enzyme
MethotrexateThymidylate synthasetarget
MethotrexateBifunctional purine biosynthesis protein PURHtarget
MethotrexateFolate receptor betatransporter
MethotrexateSolute carrier family 15 member 1transporter
MethotrexateProton-coupled amino acid transporter 1transporter
LeucovorinSolute carrier family 22 member 8transporter
6-Hydroxymethyl-7,8-Dihydropterin2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinasetarget
6-Hydroxymethyl-7,8-DihydropterinDihydroneopterin aldolasetarget
Flavin adenine dinucleotidep-hydroxybenzoate hydroxylasetarget
Flavin adenine dinucleotideNitric oxide synthase, braintarget
Flavin adenine dinucleotideNAD(P)H dehydrogenase [quinone] 1target
Flavin adenine dinucleotidep-hydroxybenzoate hydroxylasetarget
Flavin adenine dinucleotideFumarate reductase flavoprotein subunittarget
Flavin adenine dinucleotideERO1-like protein betatarget
Flavin adenine dinucleotideGlutathione reductase, mitochondrialtarget
Flavin adenine dinucleotideNADPH-ferredoxin reductase FprAtarget
Flavin adenine dinucleotideNADH-cytochrome b5 reductase 3target
Flavin adenine dinucleotideCholesterol oxidasetarget
Flavin adenine dinucleotideThymidylate synthase ThyXtarget
Flavin adenine dinucleotidePyruvate oxidasetarget
Flavin adenine dinucleotideGlutathione reductasetarget
Flavin adenine dinucleotideMonomeric sarcosine oxidasetarget
Flavin adenine dinucleotideTrypanothione reductasetarget
Flavin adenine dinucleotideRibosyldihydronicotinamide dehydrogenase [quinone]target
Flavin adenine dinucleotideIsovaleryl-CoA dehydrogenase, mitochondrialtarget
Flavin adenine dinucleotideXanthine dehydrogenase/oxidasetarget
Flavin adenine dinucleotideCholesterol oxidasetarget
Flavin adenine dinucleotideDihydropyrimidine dehydrogenase [NADP(+)]target
Flavin adenine dinucleotideD-lactate dehydrogenasetarget
Flavin adenine dinucleotideThioredoxin reductase 1, cytoplasmictarget
Flavin adenine dinucleotideIsobutyryl-CoA dehydrogenase, mitochondrialtarget
Flavin adenine dinucleotideApoptosis-inducing factor 1, mitochondrialtarget
Flavin adenine dinucleotideUDP-galactopyranose mutasetarget
Flavin adenine dinucleotideFlavohemoproteintarget
Flavin adenine dinucleotideGlycine oxidasetarget
Flavin adenine dinucleotideNADPH--cytochrome P450 reductasetarget
Flavin adenine dinucleotideGlutaryl-CoA dehydrogenase, mitochondrialtarget
Flavin adenine dinucleotideMedium-chain specific acyl-CoA dehydrogenase, mitochondrialtarget
Flavin adenine dinucleotideD-amino-acid oxidasetarget
Flavin adenine dinucleotideBifunctional protein PutAtarget
Flavin adenine dinucleotideDeoxyribodipyrimidine photo-lyasetarget
Flavin adenine dinucleotideAmine oxidase [flavin-containing] Atarget
Flavin adenine dinucleotideShort-chain specific acyl-CoA dehydrogenase, mitochondrialtarget
Flavin adenine dinucleotideL-amino-acid oxidasetarget
Flavin adenine dinucleotide2,4-dienoyl-CoA reductase [NADPH]target
Flavin adenine dinucleotide2-oxopropyl-CoM reductase, carboxylatingtarget
Flavin adenine dinucleotideFumarate reductase flavoprotein subunittarget
Flavin adenine dinucleotideThioredoxin reductasetarget
Flavin adenine dinucleotide5,10-methylenetetrahydrofolate reductasetarget
Flavin adenine dinucleotideN,N-dimethylglycine oxidasetarget
Flavin adenine dinucleotideNADH peroxidasetarget
Flavin adenine dinucleotideFerredoxin--NADP reductasetarget
Flavin adenine dinucleotideSulfite reductase [NADPH] flavoprotein alpha-componenttarget
Flavin adenine dinucleotideFerredoxin--NADP reductasetarget
Flavin adenine dinucleotideAcyl-CoA dehydrogenase, short-chain specifictarget
Flavin adenine dinucleotideFerredoxin reductasetarget
Flavin adenine dinucleotideDihydrolipoyl dehydrogenasetarget
Flavin adenine dinucleotideAmine oxidase, flavin-containing proteintarget
Flavin adenine dinucleotideDeoxyribodipyrimidine photo-lyasetarget
Flavin adenine dinucleotideDeoxyribodipyrimidine photo-lyasetarget
Flavin adenine dinucleotideL-aspartate oxidasetarget
Flavin adenine dinucleotideCryptochrome DASHtarget
Flavin adenine dinucleotideDihydrolipoyl dehydrogenase, mitochondrialtarget
Flavin adenine dinucleotideFumarate reductase flavoprotein subunittarget
Flavin adenine dinucleotideNADH-cytochrome b5 reductase 1target
Flavin adenine dinucleotideOxidoreductasetarget
Flavin adenine dinucleotideAmine oxidase [flavin-containing] Btarget
Flavin adenine dinucleotideNADPH:adrenodoxin oxidoreductase, mitochondrialtarget
Flavin adenine dinucleotidePeroxisomal acyl-coenzyme A oxidase 1target
Flavin adenine dinucleotideUDP-N-acetylenolpyruvoylglucosamine reductasetarget
Flavin adenine dinucleotideFAD-linked sulfhydryl oxidase ALRtarget
Flavin adenine dinucleotideUDP-N-acetylenolpyruvoylglucosamine reductasetarget
Flavin adenine dinucleotideFlavohemoproteintarget
Flavin adenine dinucleotidePhenol 2-hydroxylase component Btarget
Flavin adenine dinucleotideMethylenetetrahydrofolate reductasetarget
Flavin adenine dinucleotidePutidaredoxin reductasetarget
Flavin adenine dinucleotideNAD(P)H dehydrogenase (quinone)target
Flavin adenine dinucleotideUDP-galactopyranose mutasetarget
Flavin adenine dinucleotide4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerasetarget
Flavin adenine dinucleotide4-cresol dehydrogenase [hydroxylating] flavoprotein subunittarget
Flavin adenine dinucleotideAlkyl hydroperoxide reductase subunit Ftarget
Flavin adenine dinucleotideOuter membrane protein p64k or PM-6target
Flavin adenine dinucleotideGlutathione reductasetarget
Flavin adenine dinucleotidePhenylacetone monooxygenasetarget
Flavin adenine dinucleotideBenzoate 1,2-dioxygenase electron transfer componenttarget
Flavin adenine dinucleotidePutative acyl-CoA dehydrogenasetarget
Flavin adenine dinucleotideFkbItarget
Flavin adenine dinucleotideDihydrolipoyl dehydrogenasetarget
Flavin adenine dinucleotideDihydrolipoyl dehydrogenasetarget
Flavin adenine dinucleotideAlkyl hydroperoxide reductase subunit Ftarget
Flavin adenine dinucleotideFerredoxin--NADP reductasetarget
Flavin adenine dinucleotideFerredoxin--NADP reductasetarget
Flavin adenine dinucleotideMersacidin decarboxylasetarget
Flavin adenine dinucleotideAmine oxidase [flavin-containing] Benzyme
Flavin adenine dinucleotideNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialtarget
6-Hydroxymethylpterin2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinasetarget
BiopterinSepiapterin reductasetarget
Biopterin6-pyruvoyl tetrahydrobiopterin synthasetarget
BiopterinDihydrofolate reductasetarget
Pteroic acidDihydropteroate synthasetarget
LumichromeFlavin reductase (NADPH)target
LumichromeRiboflavin biosynthesis protein RibFtarget
L-erythro-7,8-dihydrobiopterinPhenylalanine-4-hydroxylasetarget
L-erythro-7,8-dihydrobiopterinPteridine reductase 1target
L-erythro-7,8-dihydrobiopterinNitric oxide synthase, inducibletarget
L-erythro-7,8-dihydrobiopterinTyrosine 3-monooxygenasetarget
L-erythro-7,8-dihydrobiopterinPterin-4-alpha-carbinolamine dehydratasetarget
L-erythro-7,8-dihydrobiopterinDihydroneopterin aldolasetarget
7,8-DihydroneopterinDihydroneopterin aldolasetarget
VintafolideFolate receptor betatarget
VintafolideFolate receptor gammatarget
VintafolideFolate receptor alphatarget
PralatrexateFolylpolyglutamate synthase, mitochondrialenzyme
PralatrexateDihydrofolate reductasetarget
PralatrexateThymidylate synthasetarget
PralatrexateFolate transporter 1transporter
PralatrexateCanalicular multispecific organic anion transporter 1transporter
PralatrexateATP-binding cassette sub-family G member 2transporter
AminopterinProton-coupled folate transportertransporter
AminopterinDihydrofolate reductaseenzyme
LevoleucovorinSerine hydroxymethyltransferasetarget
EpofolateCytochrome P450 3A4enzyme
LometrexolDihydrofolate reductasetarget
Flavin mononucleotideFlavin reductase (NADPH)target
Flavin mononucleotideHydroxyacid oxidase 1target
Flavin mononucleotidePyridoxine-5'-phosphate oxidasetarget
Flavin mononucleotideMajor NAD(P)H-flavin oxidoreductasetarget
Flavin mononucleotideRiboflavin kinasetarget
Flavin mononucleotideOxygen-insensitive NADPH nitroreductasetarget
Flavin mononucleotideNitric oxide synthase, braintarget
Flavin mononucleotideDihydroorotate dehydrogenase (quinone)target
Flavin mononucleotideDihydropyrimidine dehydrogenase [NADP(+)]target
Flavin mononucleotideDihydroorotate dehydrogenase (quinone), mitochondrialtarget
Flavin mononucleotideFlavodoxintarget
Flavin mononucleotideOxygen-insensitive NAD(P)H nitroreductasetarget
Flavin mononucleotideChorismate synthasetarget
Flavin mononucleotide2,4-dienoyl-CoA reductase [NADPH]target
Flavin mononucleotideDihydroorotate dehydrogenase A (fumarate)target
Flavin mononucleotidePyridoxine/pyridoxamine 5'-phosphate oxidasetarget
Flavin mononucleotidePentaerythritol tetranitrate reductasetarget
Flavin mononucleotideFMN-dependent NADH-azoreductasetarget
Flavin mononucleotideEpidermin decarboxylasetarget
Flavin mononucleotideFMN-dependent NADH-azoreductasetarget
Flavin mononucleotideChorismate synthasetarget
Flavin mononucleotideFlavodoxintarget
Flavin mononucleotideFlavodoxintarget
Flavin mononucleotideFlavodoxintarget
Flavin mononucleotidePutative uncharacterized proteintarget
Flavin mononucleotidePutative monooxygenase MoxCtarget
Flavin mononucleotidetRNA-dihydrouridine synthasetarget
Flavin mononucleotideProtein NrdItarget
Flavin mononucleotideProbable aromatic acid decarboxylasetarget
Flavin mononucleotide(S)-mandelate dehydrogenasetarget
Flavin mononucleotideFMN-dependent NADPH-azoreductasetarget
Flavin mononucleotideFlavodoxintarget
Flavin mononucleotideSerine/threonine-protein kinase Sgk1target
Flavin mononucleotideOxygen-insensitive NAD(P)H nitroreductasetarget
Flavin mononucleotideNitric oxide reductasetarget
Flavin mononucleotideIsopentenyl-diphosphate delta-isomerasetarget
Flavin mononucleotideTrimethylamine dehydrogenasetarget
Flavin mononucleotideRubredoxin-oxygen oxidoreductasetarget
Flavin mononucleotideRiboflavin biosynthesis protein RibFtarget
Flavin mononucleotideMorphinone reductasetarget
Flavin mononucleotideNADPH-flavin oxidoreductasetarget
Flavin mononucleotideRibosomal protein S6 kinase alpha-4target
Flavin mononucleotidePhenazine biosynthesis protein PhzGtarget
Flavin mononucleotideHydroxyacid oxidase 2target
Flavin mononucleotideNAD(P)H dehydrogenase (quinone)target
Flavin mononucleotideFlavodoxin-1target
Flavin mononucleotideIsopentenyl-diphosphate delta-isomerasetarget
Flavin mononucleotideNADH dehydrogenasetarget
Flavin mononucleotideFMN-binding proteintarget
Flavin mononucleotideNitroreductase family proteintarget
Flavin mononucleotideNADPH--cytochrome P450 reductasetarget
Flavin mononucleotidePhosphopantothenoylcysteine decarboxylasetarget
Flavin mononucleotidePhzGtarget
Flavin mononucleotideFerredoxin-dependent glutamate synthase 2target
Flavin mononucleotideNADPH--cytochrome P450 reductaseenzyme
5-methyltetrahydrofolic acidAminomethyltransferase, mitochondrialtarget
5-methyltetrahydrofolic acidCanalicular multispecific organic anion transporter 1transporter
Levomefolic acidProton-coupled folate transportertransporter
Levomefolic acidFolate transporter 1transporter
Levomefolic acidMethionine synthaseenzyme