Radiation-Sensitizing Agents

Name
Radiation-Sensitizing Agents
Accession Number
DBCAT000334
Description

Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.

Drugs
DrugDrug Description
RiboflavinA vitamin used to correct vitamin B2 deficiency.
GemcitabineA nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer.
VerteporfinA benzoporphyrin derivative used to treat pathological myopia, ocular histoplasmosis, and choroidal neovascularization in macular degeneration.
CisplatinA platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors.
MethoxsalenA furocoumarin used to treat psoriasis and vitiligo.
Porfimer sodiumA hematoporphyrin derivative used to treat esophageal cancer, endobronchial cancer, and high grade dysplasia in Barrett's Esophagus.
CarprofenFor use as a pain reliever in the treatment of joint pain and post-surgical pain.
Aminolevulinic acidA porphyrin precursor used to treat actinic keratosis of the face, scalp, and upper extremities, as well as to visualize a glioma.
BenzophenoneAn ingredient used in sunscreens to absorb UV radiation.
ProtoporphyrinNot Available
TretazicarTretazicar is under investigation in clinical trial NCT00746590 (Study of Anti-tumour Effects and Safety of Prolarix™ in Hepatocellular Carcinoma).
TrioxsalenA psoralen derivative that has been used in combination with UV light to treat vitiligo, but has been discontinued by its manufacturer.
AcetophenoneNot Available
TirapazamineFor the treatment of head and neck cancer.
Motexafin lutetiumInvestigated for use/treatment in brain cancer, breast cancer, cervical dysplasia/cancer, prostate cancer, cancer/tumors (unspecified), coronary artery disease, macular degeneration, and peripheral vascular disease.
Motexafin gadoliniumInvestigated for use/treatment in brain cancer, cancer/tumors (unspecified), lung cancer, and lymphoma (non-hodgkin's).
IrofulvenInvestigated for use/treatment in brain cancer, breast cancer, endometrial cancer, liver cancer, lung cancer, ovarian cancer, pancreatic cancer, pediatric indications, prostate cancer, and sarcoma.
PerflubronInvestigated for use/treatment in cardiac surgery, hemorrhage, and ileus.
LonidamineInvestigated for use/treatment in benign prostatic hyperplasia, prostate disorders, and cancer/tumors (unspecified).
TezacitabineInvestigated for use/treatment in colorectal cancer, lung cancer, leukemia (unspecified), and gastric cancer.
RostaporfinInvestigated for use/treatment in macular degeneration.
EfaproxiralNot Available
Dimethyl fumarateA medication used to treat patients with the relapsing-remitting form of multiple sclerosis.
Titanium dioxideA sunscreen agent found in sunscreens that absorbs UV rays.
TemoporfinA photosensitizer used to treat squamous cell carcinomas of the head and neck.
MisonidazoleMisonidazole is under investigation in clinical trial NCT00038038 (Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole).
TalaporfinTalaporfin has been investigated for the treatment of Port-Wine Stain and Benign Prostatic Hyperplasia.
SerdemetanSerdemetan has been used in trials studying the treatment of Neoplasms.
BroxuridineBroxuridine has been used in trials studying the treatment of Leukemia, Stage I Prostate Cancer, Stage IIB Prostate Cancer, and Stage IIA Prostate Cancer.
BergaptenBergapten is under investigation in clinical trial NCT00533195 (Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis).
CixutumumabCixutumumab has been used in trials studying the treatment of Lung Cancer, Malignant Neoplasm, Leukemia, Mast-Cell, Non-Small-Cell Lung Carcinoma, and Adenocarcinoma of the Prostate. Cixutumumab is a highly specific recombinant...
LisofyllineLisofylline has been investigated for the treatment of Type 1 Diabetes Mellitus.
PimonidazolePimonidazole is under investigation for the diagnostic of Prostate Cancer and Head and Neck Cancer.
EtanidazoleEtanidazole has been used in trials studying the diagnostic of Adult Ependymoma, Malignant Ascites, Adult Gliosarcoma, Adult Mixed Glioma, and Adult Glioblastoma, among others.
Buthionine SulfoximineButhionine Sulfoximine has been used in trials studying the treatment of Neuroblastoma and Melanoma (Skin).
PhthalocyaninePhthalocyanine is under investigation in clinical trial NCT00103246 (Photodynamic Therapy Using Silicon Phthalocyanine 4 in Treating Patients With Actinic Keratosis, Bowen's Disease, Skin Cancer, or Stage I or Stage II...
HypericinHypericin is under investigation for the treatment of Cutaneous T-cell Lymphoma.
OrnidazoleOrnidazole has been used in trials studying the prevention of Elective Colorectal Surgery.
WortmanninWortmannin is a steroid metabolite of Penicillium funiculosum and Talaromyces wortmannii fungi. This drug acts as a nonspecific, covalent inhibitor of phosphoinositide 3-kinase enzymes (PI3Ks).
PlatinumPlatinum is under investigation for the treatment of Metastatic Breast Cancer, Non-small Cell Lung Cancer, Gastric Large Cell Neuroendocrine Carcinoma, Colorectal Large Cell Neuroendocrine Carcinoma, and Pancreatic Large Cell Neuroendocrine...
LapachoneLapachone has been used in trials studying the treatment of Cancer, Carcinoma, Advanced Solid Tumors, Head and Neck Neoplasms, and Carcinoma, Squamous Cell.
Methyl aminolevulinateA porphyrin precursor used to treat non-hyperkeratotic, non-pigmented actinic keratosis of the face and scalp.
GiripladibGiripladib is under investigation in clinical trial NCT00396955 (A Study Comparing 4 Dose Regimens of PLA-695, Naproxen, and Placebo In Subjects With Osteoarthritis Of The Knee).
Drugs & Drug Targets
DrugTargetType
RiboflavinFlavin reductase (NADPH)target
RiboflavinRiboflavin kinasetarget
RiboflavinRiboflavin synthasetarget
RiboflavinAmine oxidase [flavin-containing] Aenzyme
RiboflavinMethylenetetrahydrofolate reductaseenzyme
RiboflavinSolute carrier family 22 member 6transporter
GemcitabineRibonucleoside-diphosphate reductase large subunittarget
GemcitabineUMP-CMP kinasetarget
GemcitabineThymidylate synthasetarget
GemcitabineCytidine deaminaseenzyme
GemcitabineDeoxycytidine kinaseenzyme
GemcitabineP-glycoprotein 1transporter
GemcitabineMultidrug resistance-associated protein 7transporter
GemcitabineEquilibrative nucleoside transporter 1transporter
GemcitabineDNAtarget
GemcitabineSodium/nucleoside cotransporter 1transporter
GemcitabineEquilibrative nucleoside transporter 2transporter
GemcitabineSolute carrier family 28 member 3transporter
CisplatinDNAtarget
CisplatinCanalicular multispecific organic anion transporter 2transporter
CisplatinMultidrug resistance-associated protein 5transporter
CisplatinCanalicular multispecific organic anion transporter 1transporter
CisplatinSolute carrier family 22 member 2transporter
CisplatinHigh affinity copper uptake protein 1transporter
CisplatinProbable low affinity copper uptake protein 2transporter
CisplatinMultidrug resistance-associated protein 6transporter
CisplatinP-glycoprotein 1transporter
CisplatinCopper-transporting ATPase 2transporter
CisplatinCopper-transporting ATPase 1transporter
CisplatinProstaglandin G/H synthase 2enzyme
CisplatinMyeloperoxidaseenzyme
CisplatinXanthine dehydrogenase/oxidaseenzyme
CisplatinArylamine N-acetyltransferaseenzyme
CisplatinCytochrome P450 2C9enzyme
CisplatinCytochrome P450 2B6enzyme
CisplatinCholinesteraseenzyme
CisplatinCytochrome P450 4A11enzyme
CisplatinATP-binding cassette sub-family G member 2transporter
CisplatinGlutathione S-transferase theta-1enzyme
CisplatinMetallothionein-1Aenzyme
CisplatinMetallothionein-2enzyme
CisplatinSuperoxide dismutase [Cu-Zn]enzyme
CisplatinGlutathione S-transferase Penzyme
CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
CisplatinGlutathione S-transferase Mu 1enzyme
CisplatinDNA-3-methyladenine glycosylasetarget
CisplatinAlpha-2-macroglobulintarget
CisplatinSerum albumincarrier
CisplatinSerotransferrintarget
CisplatinCopper transport protein ATOX1target
MethoxsalenDNAtarget
MethoxsalenCytochrome P450 2A6enzyme
MethoxsalenCytochrome P450 1A2enzyme
MethoxsalenCytochrome P450 1A1enzyme
MethoxsalenCytochrome P450 2A13enzyme
Porfimer sodiumLow-density lipoprotein receptortarget
Porfimer sodiumHigh affinity immunoglobulin gamma Fc receptor Itarget
CarprofenProstaglandin G/H synthase 2target
CarprofenProstaglandin G/H synthase 1target
CarprofenSolute carrier family 22 member 6transporter
Aminolevulinic acidDelta-aminolevulinic acid dehydratasetarget
Aminolevulinic acidSolute carrier family 15 member 1transporter
Aminolevulinic acidSolute carrier family 15 member 2transporter
BenzophenoneEstrogen receptor alphatarget
BenzophenoneEstrogen receptor betatarget
ProtoporphyrinFerritin light chaintarget
TretazicarOxygen-insensitive NAD(P)H nitroreductasetarget
TretazicarRibosyldihydronicotinamide dehydrogenase [quinone]target
TrioxsalenDNAtarget
AcetophenoneR-specific alcohol dehydrogenasetarget
TirapazamineDNAtarget
TirapazamineCytochrome P450 2E1enzyme
Motexafin gadoliniumThioredoxin reductase 1, cytoplasmictarget
Motexafin gadoliniumThioredoxin reductase 2, mitochondrialtarget
Motexafin gadoliniumRibonucleoside-diphosphate reductase subunit M2target
IrofulvenFar upstream element-binding protein 1target
LonidamineCystic fibrosis transmembrane conductance regulatortarget
LonidamineHexokinase-1target
TezacitabineRibonucleoside-diphosphate reductase large subunittarget
TezacitabineThymidine phosphorylaseenzyme
EfaproxiralHemoglobin subunit alphatarget
EfaproxiralHemoglobin subunit betatarget
Dimethyl fumarateKelch-like ECH-associated protein 1target
Dimethyl fumarateTranscription factor p65target
Titanium dioxideMacrophage receptor MARCOtarget
CixutumumabInsulin-like growth factor 1 receptortarget
LisofyllineCytochrome P450 1A2enzyme
HypericinSerum albumincarrier
HypericinGlutathione S-transferase A1target
HypericinGlutathione S-transferase Ptarget
WortmanninPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
WortmanninSerine/threonine-protein kinase PLK1target
WortmanninPhosphatidylinositol 3-kinase regulatory subunit alphatarget
WortmanninPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
LapachoneRetinol-binding protein 3target