Radiation-Sensitizing Agents

Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.
DrugDrug NameDrug Description
DB00140RiboflavinA vitamin used to correct vitamin B2 deficiency.
DB00441GemcitabineA nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer.
DB00460VerteporfinA benzoporphyrin derivative used to treat pathological myopia, ocular histoplasmosis, and choroidal neovascularization in macular degeneration.
DB00515CisplatinA platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors.
DB00553MethoxsalenA furocoumarin used to treat psoriasis and vitiligo.
DB00707Porfimer sodiumA hematoporphyrin derivative used to treat esophageal cancer, endobronchial cancer, and high grade dysplasia in Barrett's Esophagus.
DB00821CarprofenFor use as a pain reliever in the treatment of joint pain and post-surgical pain.
DB00855Aminolevulinic acidA porphyrin precursor used to treat actinic keratosis of the face, scalp, and upper extremities, as well as to visualize a glioma.
DB01878BenzophenoneAn ingredient used in sunscreens to absorb UV radiation.
DB02285ProtoporphyrinNot Available
DB04253TretazicarTretazicar is under investigation in clinical trial NCT00746590 (Study of Anti-tumour Effects and Safety of Prolarix™ in Hepatocellular Carcinoma).
DB04571TrioxsalenA psoralen derivative that has been used in combination with UV light to treat vitiligo, but has been discontinued by its manufacturer.
DB04619AcetophenoneNot Available
DB04858TirapazamineFor the treatment of head and neck cancer.
DB05296Motexafin lutetiumInvestigated for use/treatment in brain cancer, breast cancer, cervical dysplasia/cancer, prostate cancer, cancer/tumors (unspecified), coronary artery disease, macular degeneration, and peripheral vascular disease.
DB05428Motexafin gadoliniumInvestigated for use/treatment in brain cancer, cancer/tumors (unspecified), lung cancer, and lymphoma (non-hodgkin's).
DB05786IrofulvenInvestigated for use/treatment in brain cancer, breast cancer, endometrial cancer, liver cancer, lung cancer, ovarian cancer, pancreatic cancer, pediatric indications, prostate cancer, and sarcoma.
DB05791PerflubronInvestigated for use/treatment in cardiac surgery, hemorrhage, and ileus.
DB06266LonidamineInvestigated for use/treatment in benign prostatic hyperplasia, prostate disorders, and cancer/tumors (unspecified).
DB06433TezacitabineInvestigated for use/treatment in colorectal cancer, lung cancer, leukemia (unspecified), and gastric cancer.
DB06659RostaporfinInvestigated for use/treatment in macular degeneration.
DB08486EfaproxiralNot Available
DB08908Dimethyl fumarateA medication used to treat patients with the relapsing-remitting form of multiple sclerosis.
DB09536Titanium dioxideA sunscreen agent found in sunscreens that absorbs UV rays.
DB11630TemoporfinA photosensitizer used to treat squamous cell carcinomas of the head and neck.
DB11716MisonidazoleMisonidazole is under investigation in clinical trial NCT00038038 (Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole).
DB11812TalaporfinTalaporfin has been investigated for the treatment of Port-Wine Stain and Benign Prostatic Hyperplasia.
DB12027SerdemetanSerdemetan has been used in trials studying the treatment of Neoplasms.
DB12028BroxuridineBroxuridine has been used in trials studying the treatment of Leukemia, Stage I Prostate Cancer, Stage IIB Prostate Cancer, and Stage IIA Prostate Cancer.
DB12216BergaptenBergapten is under investigation in clinical trial NCT00533195 (Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis).
DB12250CixutumumabCixutumumab has been used in trials studying the treatment of Lung Cancer, Malignant Neoplasm, Leukemia, Mast-Cell, Non-Small-Cell Lung Carcinoma, and Adenocarcinoma of the Prostate. Cixutumumab is a highly specific recombinant...
DB12406LisofyllineLisofylline has been investigated for the treatment of Type 1 Diabetes Mellitus.
DB12485PimonidazolePimonidazole is under investigation for the diagnostic of Prostate Cancer and Head and Neck Cancer.
DB12736EtanidazoleEtanidazole has been used in trials studying the diagnostic of Adult Ependymoma, Malignant Ascites, Adult Gliosarcoma, Adult Mixed Glioma, and Adult Glioblastoma, among others.
DB12870Buthionine SulfoximineButhionine Sulfoximine has been used in trials studying the treatment of Neuroblastoma and Melanoma (Skin).
DB12983PhthalocyaninePhthalocyanine is under investigation in clinical trial NCT00103246 (Photodynamic Therapy Using Silicon Phthalocyanine 4 in Treating Patients With Actinic Keratosis, Bowen's Disease, Skin Cancer, or Stage I or Stage II...
DB13014HypericinHypericin is under investigation for the treatment of Cutaneous T-cell Lymphoma.
DB13026OrnidazoleOrnidazole has been used in trials studying the prevention of Elective Colorectal Surgery.
DB08059WortmanninWortmannin is a steroid metabolite of Penicillium funiculosum and Talaromyces wortmannii fungi. This drug acts as a nonspecific, covalent inhibitor of phosphoinositide 3-kinase enzymes (PI3Ks).
DB12257PlatinumPlatinum is under investigation for the treatment of Metastatic Breast Cancer, Non-small Cell Lung Cancer, Gastric Large Cell Neuroendocrine Carcinoma, Colorectal Large Cell Neuroendocrine Carcinoma, and Pancreatic Large Cell Neuroendocrine...
DB11948LapachoneLapachone has been used in trials studying the treatment of Cancer, Carcinoma, Advanced Solid Tumors, Head and Neck Neoplasms, and Carcinoma, Squamous Cell.
DB00992Methyl aminolevulinateA porphyrin precursor used to treat non-hyperkeratotic, non-pigmented actinic keratosis of the face and scalp.
DB15426GiripladibGiripladib is under investigation in clinical trial NCT00396955 (A Study Comparing 4 Dose Regimens of PLA-695, Naproxen, and Placebo In Subjects With Osteoarthritis Of The Knee).
DrugDrug NameTargetType
DB00140RiboflavinFlavin reductase (NADPH)target
DB00140RiboflavinRiboflavin kinasetarget
DB00140RiboflavinRiboflavin synthasetarget
DB00140RiboflavinAmine oxidase [flavin-containing] Aenzyme
DB00140RiboflavinMethylenetetrahydrofolate reductaseenzyme
DB00140RiboflavinSolute carrier family 22 member 6transporter
DB00441GemcitabineRibonucleoside-diphosphate reductase large subunittarget
DB00441GemcitabineUMP-CMP kinasetarget
DB00441GemcitabineThymidylate synthasetarget
DB00441GemcitabineCytidine deaminaseenzyme
DB00441GemcitabineDeoxycytidine kinaseenzyme
DB00441GemcitabineP-glycoprotein 1transporter
DB00441GemcitabineMultidrug resistance-associated protein 7transporter
DB00441GemcitabineEquilibrative nucleoside transporter 1transporter
DB00441GemcitabineDNAtarget
DB00441GemcitabineSodium/nucleoside cotransporter 1transporter
DB00441GemcitabineEquilibrative nucleoside transporter 2transporter
DB00441GemcitabineSolute carrier family 28 member 3transporter
DB00515CisplatinDNAtarget
DB00515CisplatinCanalicular multispecific organic anion transporter 2transporter
DB00515CisplatinMultidrug resistance-associated protein 5transporter
DB00515CisplatinCanalicular multispecific organic anion transporter 1transporter
DB00515CisplatinSolute carrier family 22 member 2transporter
DB00515CisplatinHigh affinity copper uptake protein 1transporter
DB00515CisplatinProbable low affinity copper uptake protein 2transporter
DB00515CisplatinMultidrug resistance-associated protein 6transporter
DB00515CisplatinP-glycoprotein 1transporter
DB00515CisplatinCopper-transporting ATPase 2transporter
DB00515CisplatinCopper-transporting ATPase 1transporter
DB00515CisplatinProstaglandin G/H synthase 2enzyme
DB00515CisplatinMyeloperoxidaseenzyme
DB00515CisplatinXanthine dehydrogenase/oxidaseenzyme
DB00515CisplatinArylamine N-acetyltransferaseenzyme
DB00515CisplatinCytochrome P450 2C9enzyme
DB00515CisplatinCytochrome P450 2B6enzyme
DB00515CisplatinCholinesteraseenzyme
DB00515CisplatinCytochrome P450 4A11enzyme
DB00515CisplatinATP-binding cassette sub-family G member 2transporter
DB00515CisplatinGlutathione S-transferase theta-1enzyme
DB00515CisplatinMetallothionein-1Aenzyme
DB00515CisplatinMetallothionein-2enzyme
DB00515CisplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00515CisplatinGlutathione S-transferase Penzyme
DB00515CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00515CisplatinGlutathione S-transferase Mu 1enzyme
DB00515CisplatinDNA-3-methyladenine glycosylasetarget
DB00515CisplatinAlpha-2-macroglobulintarget
DB00515CisplatinSerum albumincarrier
DB00515CisplatinSerotransferrintarget
DB00515CisplatinCopper transport protein ATOX1target
DB00553MethoxsalenDNAtarget
DB00553MethoxsalenCytochrome P450 2A6enzyme
DB00553MethoxsalenCytochrome P450 1A2enzyme
DB00553MethoxsalenCytochrome P450 1A1enzyme
DB00553MethoxsalenCytochrome P450 2A13enzyme
DB00707Porfimer sodiumLow-density lipoprotein receptortarget
DB00707Porfimer sodiumHigh affinity immunoglobulin gamma Fc receptor Itarget
DB00821CarprofenProstaglandin G/H synthase 2target
DB00821CarprofenProstaglandin G/H synthase 1target
DB00821CarprofenSolute carrier family 22 member 6transporter
DB00855Aminolevulinic acidDelta-aminolevulinic acid dehydratasetarget
DB00855Aminolevulinic acidSolute carrier family 15 member 1transporter
DB00855Aminolevulinic acidSolute carrier family 15 member 2transporter
DB01878BenzophenoneEstrogen receptor alphatarget
DB01878BenzophenoneEstrogen receptor betatarget
DB02285ProtoporphyrinFerritin light chaintarget
DB04253TretazicarOxygen-insensitive NAD(P)H nitroreductasetarget
DB04253TretazicarRibosyldihydronicotinamide dehydrogenase [quinone]target
DB04571TrioxsalenDNAtarget
DB04619AcetophenoneR-specific alcohol dehydrogenasetarget
DB04858TirapazamineDNAtarget
DB04858TirapazamineCytochrome P450 2E1enzyme
DB05428Motexafin gadoliniumThioredoxin reductase 1, cytoplasmictarget
DB05428Motexafin gadoliniumThioredoxin reductase 2, mitochondrialtarget
DB05428Motexafin gadoliniumRibonucleoside-diphosphate reductase subunit M2target
DB05786IrofulvenFar upstream element-binding protein 1target
DB06266LonidamineCystic fibrosis transmembrane conductance regulatortarget
DB06266LonidamineHexokinase-1target
DB06433TezacitabineRibonucleoside-diphosphate reductase large subunittarget
DB06433TezacitabineThymidine phosphorylaseenzyme
DB08486EfaproxiralHemoglobin subunit alphatarget
DB08486EfaproxiralHemoglobin subunit betatarget
DB08908Dimethyl fumarateKelch-like ECH-associated protein 1target
DB08908Dimethyl fumarateTranscription factor p65target
DB09536Titanium dioxideMacrophage receptor MARCOtarget
DB12250CixutumumabInsulin-like growth factor 1 receptortarget
DB12406LisofyllineCytochrome P450 1A2enzyme
DB13014HypericinSerum albumincarrier
DB13014HypericinGlutathione S-transferase A1target
DB13014HypericinGlutathione S-transferase Ptarget
DB08059WortmanninPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
DB08059WortmanninSerine/threonine-protein kinase PLK1target
DB08059WortmanninPhosphatidylinositol 3-kinase regulatory subunit alphatarget
DB08059WortmanninPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
DB11948LapachoneRetinol-binding protein 3target
DB00992Methyl aminolevulinateHigh affinity immunoglobulin gamma Fc receptor Itarget