Photosensitizing Agents

Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.
DrugDrug NameDrug Indication
DB00140RiboflavinFor the treatment of ariboflavinosis (vitamin B2 deficiency).
DB00460VerteporfinFor the treatment of patients with predominantly classic subfoveal choroidal neovascularization due to age-related macular degeneration, pathologic myopia or presumed ocular histoplasmosis syndrome. Verteporfin can also be used to destroy tumors.
DB00553MethoxsalenFor the treatment of psoriasis and vitiligo
DB00707Porfimer sodiumIndicated in the treatment of esophageal cancer.
DB00821CarprofenFor use as a pain reliever in the treatment of joint pain and post-surgical pain.
DB00855Aminolevulinic acidAminolevulinic acid plus blue light illumination using a blue light photodynamic therapy illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp.
DB01600Tiaprofenic acidTiaprofenic acid is used to treat pain, especially arthritic pain.
DB01878BenzophenoneNot Available
DB02285ProtoporphyrinNot Available
DB04571TrioxsalenTrioxsalen is a pigmenting photosensitizing agent used in conjunction with ultraviolet light in the treatment of vitiligo.
DB04619ACETOPHENONENot Available
DB05296Motexafin lutetiumInvestigated for use/treatment in brain cancer, breast cancer, cervical dysplasia/cancer, prostate cancer, cancer/tumors (unspecified), coronary artery disease, macular degeneration, and peripheral vascular disease.
DB05428motexafin gadoliniumInvestigated for use/treatment in brain cancer, cancer/tumors (unspecified), lung cancer, and lymphoma (non-hodgkin's).
DB06261HexaminolevulinateHexaminolevulinate is indicated for use in the cystoscopic detection of non-muscle invasive papillary cancer of the bladder among patients suspected or known to have lesion(s) on the basis of a prior cystoscopy.
DB06659RostaporfinInvestigated for use/treatment in macular degeneration.
DB09000CyamemazineNot Available
DB09536Titanium dioxideIn the pharmaceutical industry, titanium dioxide is used in most sunscreens to block UVA and UVB rays, similar to zinc oxide. It is also commonly used as pigment for pharmaceutical products such as gelatin capsules, tablet coatings and syrups.
DB11630TemoporfinFor use in the treatment of patients with advanced squamous cell carcinoma of the head and neck failing standard therapies and who are unsuitable for radiotherapy, surgery, or systemic chemotherapy [FDA Label].
DB11812TalaporfinNot Available
DB12216BergaptenNot Available
DB00992Methyl aminolevulinateFor topical use, in combination with 570 to 670 nm wavelength red light illumination, in the treatment of non-hyperkeratotic actinic keratoses of the face and scalp in immunocompetent patients when used in conjunction with lesion preparation (debridement using a sharp dermal curette).
DrugDrug NameTargetType
DB00140RiboflavinFlavin reductase (NADPH)target
DB00140RiboflavinRiboflavin kinasetarget
DB00140RiboflavinRiboflavin synthasetarget
DB00140RiboflavinAmine oxidase [flavin-containing] Aenzyme
DB00140RiboflavinMethylenetetrahydrofolate reductaseenzyme
DB00140RiboflavinSolute carrier family 22 member 6transporter
DB00553MethoxsalenCytochrome P450 2A6enzyme
DB00553MethoxsalenCytochrome P450 1A2enzyme
DB00553MethoxsalenCytochrome P450 1A1enzyme
DB00553MethoxsalenCytochrome P450 2A13enzyme
DB00707Porfimer sodiumLow-density lipoprotein receptortarget
DB00707Porfimer sodiumHigh affinity immunoglobulin gamma Fc receptor Itarget
DB00821CarprofenProstaglandin G/H synthase 2target
DB00821CarprofenProstaglandin G/H synthase 1target
DB00821CarprofenSolute carrier family 22 member 6transporter
DB00855Aminolevulinic acidDelta-aminolevulinic acid dehydratasetarget
DB00855Aminolevulinic acidSolute carrier family 15 member 1transporter
DB00855Aminolevulinic acidSolute carrier family 15 member 2transporter
DB01600Tiaprofenic acidProstaglandin G/H synthase 2target
DB01600Tiaprofenic acidProstaglandin G/H synthase 1target
DB01878BenzophenoneEstrogen receptor alphatarget
DB01878BenzophenoneEstrogen receptor betatarget
DB02285ProtoporphyrinFerritin light chaintarget
DB04619ACETOPHENONER-specific alcohol dehydrogenasetarget
DB05428motexafin gadoliniumThioredoxin reductase 1, cytoplasmictarget
DB05428motexafin gadoliniumThioredoxin reductase 2, mitochondrialtarget
DB05428motexafin gadoliniumRibonucleoside-diphosphate reductase subunit M2target
DB09536Titanium dioxideMacrophage receptor MARCOtarget
DB11630TemoporfinHigh density lipoproteincarrier
DB11630TemoporfinLow density lipoproteincarrier
DB11630TemoporfinVery low density lipoproteincarrier
DB00992Methyl aminolevulinateHigh affinity immunoglobulin gamma Fc receptor Itarget