Amino Acids, Branched-Chain

Name
Amino Acids, Branched-Chain
Accession Number
DBCAT000344
Description

Amino acids which have a branched carbon chain.

Drugs
DrugDrug Description
LeucineAn amino acid commonly found as a component of total parenteral nutrition.
ValineAn amino acid commonly found as a component of total parenteral nutrition.
IsoleucineAn amino acid commonly found as a component of total parenteral nutrition.
PromazineA phenothiazine used to manage schizophrenia.
ValaciclovirAn guanine nucleoside antiviral used to treat herpes exacerbations.
Leucine Phosphonic AcidNot Available
2-aminoisobutyric acidNot Available
Beta-HydroxyleucineNot Available
UbenimexAn adjuvant therapy used for acute and chronic myelonous leukemia, lung cancer and nasopharyngeal cancer. It is also used to treat hypercholesterolaemia.
NorvalineNorvaline is an isomer of the more common amino acid valine.
PPI-2458Investigated for use/treatment in lymphoma (non-hodgkin's) and solid tumors.
ValbenazineA vesicular monoamine transporter 2 inhibitor used to treat tardive dyskinesia.
NirogacestatNirogacestat has been used in trials studying the treatment of Breast Cancer, HIV Infection, Desmoid Tumors, Advanced Solid Tumors, and Aggressive Fibromatosis, among others.
ORE-1001ORE1001 has been used in trials studying the treatment of Mild to Moderate Ulcerative Colitis. It is an ACE2 inhibitor.
DecernotinibDecernotinib has been used in trials studying the treatment of Drug Interactions and Rheumatoid Arthritis.
AcetylleucineUsed for treating vestibular-related imbalance and vertigo.
BMS-817399BMS-817399 is under investigation in clinical trial NCT01404585 (Proof-of-Concept Study With BMS-817399 to Treat Moderate to Severe Rheumatoid Arthritis).
L-alloisoleucineNot Available
RavidasvirRavidasvir is under investigation in clinical trial NCT02961426 (Sofosbuvir Plus Ravidasvir for the Treatment of HCV Chronic Infection).
Drugs & Drug Targets
DrugTargetType
LeucineProbable leucine--tRNA ligase, mitochondrialtarget
LeucineLeucine carboxyl methyltransferase 2target
LeucineLeucine carboxyl methyltransferase 1target
LeucineLeucine--tRNA ligase, cytoplasmictarget
LeucineBranched-chain-amino-acid aminotransferase, mitochondrialtarget
LeucineBranched-chain-amino-acid aminotransferase, cytosolictarget
LeucineMonocarboxylate transporter 10transporter
LeucineMonocarboxylate transporter 8transporter
ValinePropionyl-CoA carboxylase beta chain, mitochondrialtarget
ValineBranched-chain-amino-acid aminotransferase, cytosolictarget
ValineValine--tRNA ligasetarget
ValineMonocarboxylate transporter 10transporter
ValineValine--tRNA ligaseenzyme
ValinePropionyl-CoA carboxylase beta chain, mitochondrialenzyme
ValineBranched-chain-amino-acid aminotransferase, cytosolicenzyme
IsoleucineShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
IsoleucineBranched-chain-amino-acid aminotransferase, cytosolictarget
IsoleucineBranched-chain-amino-acid aminotransferase, mitochondrialtarget
IsoleucineIsoleucine--tRNA ligase, cytoplasmictarget
IsoleucineIsoleucine--tRNA ligase, mitochondrialtarget
IsoleucineMonocarboxylate transporter 10transporter
PromazineDopamine D2 receptortarget
Promazine5-hydroxytryptamine receptor 2Atarget
Promazine5-hydroxytryptamine receptor 2Ctarget
PromazineAlpha-1A adrenergic receptortarget
PromazineMuscarinic acetylcholine receptor M1target
PromazineHistamine H1 receptortarget
PromazineCytochrome P450 2C19enzyme
PromazineCytochrome P450 1A2enzyme
PromazineCytochrome P450 3A4enzyme
PromazineCytochrome P450 2C9enzyme
PromazineCytochrome P450 2D6enzyme
ValaciclovirThymidine kinasetarget
ValaciclovirDNA polymerase catalytic subunittarget
ValaciclovirSolute carrier family 15 member 1transporter
ValaciclovirSolute carrier family 15 member 2transporter
ValaciclovirSolute carrier family 22 member 8transporter
ValaciclovirSolute carrier family 22 member 6transporter
ValaciclovirSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter
ValaciclovirIleal sodium/bile acid cotransportertransporter
ValaciclovirGuanylate kinaseenzyme
ValaciclovirThymidine kinaseenzyme
Leucine Phosphonic AcidBacterial leucyl aminopeptidasetarget
Leucine Phosphonic AcidCytosol aminopeptidasetarget
2-aminoisobutyric acidCorticoliberintarget
2-aminoisobutyric acidPro-neuropeptide Ytarget
2-aminoisobutyric acidMonocarboxylate transporter 10transporter
UbenimexBacterial leucyl aminopeptidasetarget
UbenimexLeukotriene A-4 hydrolasetarget
UbenimexSolute carrier family 15 member 1transporter
UbenimexSolute carrier family 15 member 2transporter
NorvalineGlycine amidinotransferase, mitochondrialtarget
NorvalineOrnithine carbamoyltransferase, mitochondrialtarget
PPI-2458Methionine aminopeptidase 2target
Valbenazinevesicular monoamine transporter 2 (VMAT2)target
ValbenazineCytochrome P450 2D6enzyme
ValbenazineCytochrome P450 3A4enzyme
ValbenazineCytochrome P450 3A5enzyme
ORE-1001Carboxypeptidase N catalytic chaintarget
ORE-1001Carboxypeptidase N subunit 2target