Amino Acids, Branched-Chain

Amino acids which have a branched carbon chain.
DrugDrug NameDrug Indication
DB00149L-LeucineIndicated to assist in the prevention of the breakdown of muscle proteins that sometimes occur after trauma or severe stress.
DB00161L-ValinePromotes mental vigor, muscle coordination, and calm emotions. May also be of use in a minority of patients with hepatic encephalopathy and in some with phenylketonuria.
DB00167IsoleucineThe branched-chain amino acids may have antihepatic encephalopathy activity in some. They may also have anticatabolic and antitardive dyskinesia activity.
DB00420PromazineUsed as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.
DB00577ValaciclovirValacyclovir is a nucleoside analog DNA polymerase inhibitor indicated for [FDA label]: **Adults** • Cold Sores (Herpes Labialis) • Genital Herpes • Treatment of genital herpes lesions in immunocompetent patients (initial or recurrent episode) • Suppression of genital herpes lesions in immunocompetent or HIV-infected patients • Reduction of viral transmission • Herpes Zoster **Pediatric Patients** • Cold Sores (Herpes Labialis) • Chickenpox **Limitations of use** [FDA label] The efficacy and safety of valacyclovir have not been established in immunocompromised patients other than for the suppression of genital herpes in HIV-infected patients.
DB02386Leucine Phosphonic AcidNot Available
DB02952Alpha-Aminoisobutyric AcidNot Available
DB02978Beta-HydroxyleucineNot Available
DB03424UbenimexAn adjuvant therapy used for acute and chronic myelonous leukemia, lung cancer and nasopharyngeal cancer. It is also used to treat hypercholesterolaemia.
DB04185NorvalineNot Available
DB05864PPI-2458Investigated for use/treatment in lymphoma (non-hodgkin's) and solid tumors.
DB11915ValbenazineFor the treatment of tardive dyskinesia in adults [FDA Label].
DB12005NirogacestatNot Available
DB12271ORE-1001Not Available
DB12566DecernotinibNot Available
DB13226AcetylleucineNot Available
DB14941BMS-817399Not Available
DrugDrug NameTargetType
DB00149L-LeucineProbable leucine--tRNA ligase, mitochondrialtarget
DB00149L-LeucineLeucine carboxyl methyltransferase 2target
DB00149L-LeucineLeucine carboxyl methyltransferase 1target
DB00149L-LeucineLeucine--tRNA ligase, cytoplasmictarget
DB00149L-LeucineBranched-chain-amino-acid aminotransferase, mitochondrialtarget
DB00149L-LeucineBranched-chain-amino-acid aminotransferase, cytosolictarget
DB00149L-LeucineMonocarboxylate transporter 10transporter
DB00149L-LeucineMonocarboxylate transporter 8transporter
DB00161L-ValinePropionyl-CoA carboxylase beta chain, mitochondrialtarget
DB00161L-ValineBranched-chain-amino-acid aminotransferase, cytosolictarget
DB00161L-ValineValine--tRNA ligasetarget
DB00161L-ValineMonocarboxylate transporter 10transporter
DB00161L-ValineValine--tRNA ligaseenzyme
DB00161L-ValinePropionyl-CoA carboxylase beta chain, mitochondrialenzyme
DB00161L-ValineBranched-chain-amino-acid aminotransferase, cytosolicenzyme
DB00167IsoleucineShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
DB00167IsoleucineBranched-chain-amino-acid aminotransferase, cytosolictarget
DB00167IsoleucineBranched-chain-amino-acid aminotransferase, mitochondrialtarget
DB00167IsoleucineIsoleucine--tRNA ligase, cytoplasmictarget
DB00167IsoleucineIsoleucine--tRNA ligase, mitochondrialtarget
DB00167IsoleucineMonocarboxylate transporter 10transporter
DB00420PromazineD(2) dopamine receptortarget
DB00420PromazineMuscarinic acetylcholine receptor M4target
DB00420PromazineMuscarinic acetylcholine receptor M2target
DB00420PromazineMuscarinic acetylcholine receptor M3target
DB00420PromazineAlpha-1B adrenergic receptortarget
DB00420PromazineD(1A) dopamine receptortarget
DB00420PromazineMuscarinic acetylcholine receptor M5target
DB00420Promazine5-hydroxytryptamine receptor 2Atarget
DB00420Promazine5-hydroxytryptamine receptor 2Ctarget
DB00420PromazineAlpha-1A adrenergic receptortarget
DB00420PromazineMuscarinic acetylcholine receptor M1target
DB00420PromazineD(4) dopamine receptortarget
DB00420PromazineHistamine H1 receptortarget
DB00420PromazineAlpha-1D adrenergic receptortarget
DB00420PromazineCytochrome P450 2C19enzyme
DB00420PromazineCytochrome P450 1A2enzyme
DB00420PromazineCytochrome P450 3A4enzyme
DB00420PromazineCytochrome P450 2C9enzyme
DB00420PromazineCytochrome P450 2D6enzyme
DB00577ValaciclovirThymidine kinasetarget
DB00577ValaciclovirDNA polymerase catalytic subunittarget
DB00577ValaciclovirSolute carrier family 15 member 1transporter
DB00577ValaciclovirSolute carrier family 15 member 2transporter
DB00577ValaciclovirSolute carrier family 22 member 8transporter
DB00577ValaciclovirSolute carrier family 22 member 6transporter
DB00577ValaciclovirSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter
DB00577ValaciclovirIleal sodium/bile acid cotransportertransporter
DB00577ValaciclovirGuanylate kinaseenzyme
DB00577ValaciclovirHerpes simplex virus 1target
DB00577ValaciclovirVaricella Zoster Virus (VZV) (Human herpes virus 3)target
DB00577ValaciclovirCytomegalovirustarget
DB00577ValaciclovirHerpes simplex virus 2target
DB00577ValaciclovirEpstein-Barr Virus (EBV) (human herpes virus 4)target
DB00577ValaciclovirThymidine kinaseenzyme
DB02386Leucine Phosphonic AcidBacterial leucyl aminopeptidasetarget
DB02386Leucine Phosphonic AcidCytosol aminopeptidasetarget
DB02952Alpha-Aminoisobutyric AcidCorticoliberintarget
DB02952Alpha-Aminoisobutyric AcidPro-neuropeptide Ytarget
DB02952Alpha-Aminoisobutyric AcidMonocarboxylate transporter 10transporter
DB03424UbenimexBacterial leucyl aminopeptidasetarget
DB03424UbenimexLeukotriene A-4 hydrolasetarget
DB03424UbenimexSolute carrier family 15 member 1transporter
DB03424UbenimexSolute carrier family 15 member 2transporter
DB04185NorvalineGlycine amidinotransferase, mitochondrialtarget
DB04185NorvalineOrnithine carbamoyltransferase, mitochondrialtarget
DB05864PPI-2458Methionine aminopeptidase 2target
DB11915Valbenazinevesicular monoamine transporter 2 (VMAT2)target
DB11915ValbenazineCytochrome P450 2D6enzyme
DB11915ValbenazineCytochrome P450 3A4enzyme
DB11915ValbenazineCytochrome P450 3A5enzyme
DB12271ORE-1001Carboxypeptidase N catalytic chaintarget
DB12271ORE-1001Carboxypeptidase N subunit 2target