| DB00152 | Thiamine | For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis. |
| DB00205 | Pyrimethamine | For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine |
| DB00237 | Butabarbital | For short-term treatment of insomnia and anxiety disorders |
| DB00241 | Butalbital | Used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines, and pain. |
| DB00249 | Idoxuridine | For use in keratoconjunctivitis and keratitis caused by herpes simplex virus. |
| DB00306 | Talbutal | For use as a sedative and hypnotic. |
| DB00312 | Pentobarbital | For the short-term treatment of insomnia. |
| DB00322 | Floxuridine | For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means. Also for the palliative management of liver cancer (usually administered by hepatic intra-arterial infusion). |
| DB00350 | Minoxidil | For the treatment of severe hypertension and in the topical treatment (regrowth) of androgenic alopecia in males and females and stabilisation of hair loss in patients with androgenic alopecia. |
| DB00369 | Cidofovir | For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) |
| DB00418 | Secobarbital | For the Short-term treatment of intractable insomnia for patients habituated to barbiturates |
| DB00432 | Trifluridine | Trifluridine is used for the treatment of primay keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, types 1 and 2 in ophthalmic solutions.
Trifluridine, in combination with tipiracil as oral tablets, is indicated for the treatment of adult patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy [FDA Label]. |
| DB00440 | Trimethoprim | For the treatment of urinary tract infections, uncomplicated pyelonephritis (with sulfamethoxazole) and mild acute prostatitis. May be used as pericoital (with sulfamethoxazole) or continuous prophylaxis in females with recurrent cystitis. May be used as an alternative to treat asymptomatic bacteriuria during pregnancy (only before the last 6 weeks of pregnancy). Other uses include: alternative agent in respiratory tract infections (otitis, sinusitus, bronchitis and pneumonia), treatment of Pneumocystis jirovecii pneumonia (acute or prophylaxis), Nocardia infections, and traveller's diarrhea. |
| DB00441 | Gemcitabine | Gemcitabine is indicated for the treatment of advanced ovarian cancer that has relapsed at least 6 months after completion of platinum-based therapy; metastatic ovarian cancer; inoperable, locally advanced (Stage IIIA or IIIB), or metastatic (Stage IV) non-small cell lung cancer; and locally advanced (nonresectable Stage II or Stage III) or metastatic (Stage IV) adenocarcinoma of the pancreas. |
| DB00463 | Metharbital | Metharbital is used for the treatment of epilepsy. |
| DB00474 | Methohexital | Methohexital is indicated for use as an intravenous anaesthetic. It has also been commonly used to induce deep sedation. |
| DB00475 | Chlordiazepoxide | For the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety. |
| DB00490 | Buspirone | For the management of anxiety disorders or the short-term relief of the symptoms of anxiety, and also as an augmention of SSRI-treatment against depression. |
| DB00495 | Zidovudine | Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections. |
| DB00544 | Fluorouracil | For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid. |
| DB00550 | Propylthiouracil | Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave's disease). |
| DB00552 | Pentostatin | For the treatment of hairy cell leukaemia refractory to alpha interferon. |
| DB00599 | Thiopental | For use as the sole anesthetic agent for brief (15 minute) procedures, for induction of anesthesia prior to administration of other anesthetic agents, to supplement regional anesthesia, to provide hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation, for the control of convulsive states during or following inhalation anesthesia or local anesthesia, in neurosurgical patients with increased intracranial pressure, and for narcoanalysis and narcosynthesis in psychiatric disorders. |
| DB00619 | Imatinib | For the treatment of Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML), Ph+ acute lymphoblastic leukaemia, myelodysplastic/myeloproliferative diseases, aggressive systemic mastocytosis, hypereosinophilic syndrome and/or chronic eosinophilic leukemia (CEL), dermatofibrosarcoma protuberans, and malignant gastrointestinal stromal tumors (GIST). |
| DB00649 | Stavudine | For the treatment of human immunovirus (HIV) infections. |
| DB00709 | Lamivudine | For the treatment of HIV infection and chronic hepatitis B (HBV). |
| DB00734 | Risperidone | Risperidone belongs to the class of medications known as second generation atypical antipsychotics [A1114, A1115, L1213]. It is widely used in the treatment of schizophrenia and mood disorders, including bipolar disorder and depression with pyschosis [A1115, A1116, L1212, L1213]. |
| DB00791 | Uracil mustard | Used for its antineoplastic properties. |
| DB00794 | Primidone | For the treatment of epilepsy |
| DB00849 | Methylphenobarbital | For the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy. |
| DB00879 | Emtricitabine | Indicated, in combination with other antiretroviral agents, for the treatment of HIV-1 infection in adults and for postexposure prophylaxis of HIV infection in health care workers and others exposed occupationally or nonoccupationally via percutaneous injury or mucous membrane or nonintact skin contact with blood, tissues, or other body fluids associated with risk for transmission of the virus. |
| DB00885 | Pemirolast | For the prevention of itching of the eyes caused by allergies such as hay fever, and allergic conjunctivitis |
| DB00928 | Azacitidine | For treatment of patients with the following French-American-British myelodysplastic syndrome subtypes: refractory anemia or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation (now classified as acute myelogenous leukemia with multilineage dysplasia), and chronic myelomonocytic leukemia. |
| DB00943 | Zalcitabine | For the treatment of Human immunovirus (HIV) infections in conjunction with other antivirals. |
| DB00975 | Dipyridamole | For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina. |
| DB00987 | Cytarabine | For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia. |
| DB01098 | Rosuvastatin | Used as an adjunct to dietary therapy to treat primary hyperlipidemia (heterozygous familial and nonfamilial), mixed dyslipidemia and hypertriglyceridemia. Also indicated for homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering therapies or when other such therapies are not available. Furthermore, it is used to slow the progression of atherosclerosis and for primary prevention of cardiovascular disease. |
| DB01099 | Flucytosine | For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections). |
| DB01101 | Capecitabine | For the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen. May also be used in combination with docetaxel for the treatment of metastatic breast cancer in patients who have failed to respond to, or recurred or relasped during or following anthracycline-containing chemotherapy. Capecitabine is used alone as an adjuvant therapy following the complete resection of primary tumor in patients with stage III colon cancer when monotherapy with fluroprymidine is preferred. The use or capecitabine in combination regimens for advanced gastric cancer is currently being investigated. |
| DB01154 | Thiamylal | Used for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, and for inducing a hypnotic state. |
| DB01174 | Phenobarbital | For the treatment of all types of seizures except absence seizures. |
| DB01254 | Dasatinib | For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy. |
| DB01262 | Decitabine | For treatment of patients with myelodysplastic syndromes (MDS) including previously treated and untreated, de novo and secondary MDS of all French-American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia) and intermediate-1, intermediate-2, and high-risk International Prognostic Scoring System groups (scores ≥0.5). |
| DB01265 | Telbivudine | For the treatment of chronic hepatitis B in adult and adolescent patients ≥16 years of age with evidence of viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease. |
| DB01267 | Paliperidone | For the treatment of schizophrenia. |
| DB01351 | Amobarbital | Not Available |
| DB01352 | Aprobarbital | Not Available |
| DB01353 | Butethal | For the treatment of insomnia. |
| DB01354 | Heptabarbital | Used mainly for sedation and hypnosis. |
| DB01355 | Hexobarbital | For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. |
| DB01483 | Barbital | Not Available |
| DB01601 | Lopinavir | Indicated in combination with other antiretroviral agents for the treatment of HIV-infection. |
| DB01629 | 5-Fluorouridine | Not Available |
| DB01643 | Thymidine-5'-Phosphate | Not Available |
| DB02097 | Cytidine | Not Available |
| DB02230 | Immucillin-G | Not Available |
| DB02254 | Trifluoro-thiamin phosphate | Not Available |
| DB02262 | Orotic Acid | Not Available |
| DB02281 | Formycin | Not Available |
| DB02745 | Uridine | Not Available |
| DB03041 | UDP-alpha-D-glucuronic acid | Not Available |
| DB03068 | Zebularine | Not Available |
| DB03326 | deoxycytidylyl-3',5'-guanosine | Not Available |
| DB03419 | Uracil | Not Available |
| DB03462 | Thymine | Not Available |
| DB03501 | Galactose-uridine-5'-diphosphate | Not Available |
| DB03516 | Eniluracil | For the treatment of cancer in combination with 5-fluorouracil. |
| DB03554 | 5-Iodouracil | Not Available |
| DB03668 | 1-(5'-Phospho-Beta-D-Ribofuranosyl)Barbituric Acid | Not Available |
| DB03718 | 6-Aza-Ump | Not Available |
| DB03761 | 5-Fluoro-2'-Deoxyuridine-5'-Monophosphate | Not Available |
| DB03765 | 2'-cytidylic acid | Not Available |
| DB03800 | 2'-deoxyuridylic acid | Not Available |
| DB03826 | 5,6-Diaminouracil | Not Available |
| DB03881 | MT-Immucillin-H | Not Available |
| DB04103 | 3-Methylcytosine | Not Available |
| DB04129 | Willardiine | Not Available |
| DB04198 | Formycin B | Not Available |
| DB04222 | Sparsomycin | Not Available |
| DB04314 | 1-Methylcytosine | Not Available |
| DB04385 | 3-Deazacytidine | Not Available |
| DB04485 | Deoxythymidine | Not Available |
| DB04627 | Cyclouridine | Not Available |
| DB04655 | Metoprine | Not Available |
| DB04672 | cyclic 3',5'-thymidine monophosphate | Not Available |
| DB04961 | Troxacitabine | Investigated for use/treatment in leukemia (myeloid). |
| DB04983 | Denufosol | For use as an inhaled treatment for cystic fibrosis. |
| DB05116 | Thymectacin | Investigated for use/treatment in colorectal cancer. |
| DB05262 | Oxypurinol | Intended for the treatment of congestive heart failure and hyperuricemia. |
| DB05494 | Elacytarabine | Investigated for use/treatment in leukemia (unspecified) and melanoma. |
| DB06185 | Forodesine | Investigated for use/treatment in lymphoma (non-hodgkin's) and leukemia (lymphoid). |
| DB06203 | Alogliptin | Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. |
| DB06229 | Ocaperidone | Investigated for use/treatment in schizophrenia and schizoaffective disorders. |
| DB06236 | Elvucitabine | Investigated for use/treatment in hepatitis (viral, B) and HIV infection. |
| DB06311 | Darapladib | Investigated for use/treatment in atherosclerosis. |
| DB06365 | Sapacitabine | Investigated for use/treatment in solid tumors, cutaneous t-cell lymphoma, myelodysplastic syndrome, and leukemia (lymphoid). |
| DB06433 | Tezacitabine | Investigated for use/treatment in colorectal cancer, lung cancer, leukemia (unspecified), and gastric cancer. |
| DB06656 | TAS-106 | Investigated for use/treatment in solid tumors and cancer/tumors (unspecified). |
| DB06683 | Clevudine | Investigated for use/treatment in hepatitis (viral, B). |
| DB08864 | Rilpivirine | Rilpivirine, in combination with other agents, is indicated for the treatment of HIV-1 infections in antiretroviral treatment-naive patients with HIV-1 RNA ≤100,000 copies/mL and CD4+ cell count >200 cells/mm3.[L1030] The FDA combination therapy approval of rilpivirine and dolutegravir is indicated for adults with HIV-1 infections whose virus is currently suppressed (< 50 copies/ml) on a stable regimen for at least six months, without history of treatment failure and no known substitutions associated to resistance to any of the two components of the therapy.[L1031] |
| DB08911 | Trametinib | Trametinib is indicated for the treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations, as detected by an FDA-approved test [FDA].
In May 2018, it was approved for use with [DB08912] for the treatment of treat anaplastic thyroid cancer caused by an abnormal BRAF V600E gene [L2726]. |
| DB08934 | Sofosbuvir | Sofosbuvir is used in combination therapy with other antiviral medications to treat chronic hepatitis C virus (HCV) infected patients with HCV genoptypes 1-6, and to treat HCV and HIV co-infected patients. Depending on the level of cirrhosis or decompensation, combination therapy can also include either ribavirin alone or ribavirin and peg-interferon alfa.
When used in combination with [DB09027] as the combination product Harvoni, sofosbuvir has the following indications: treatment of genotypes 1, 4, 5, or 6 infection without cirrhosis or with compensated cirrhosis; in combination with [DB00811] for genotype 1 infection with decompensated cirrhosis; or in combination with [DB00811] for the treatment of genotype 1 or 4 infection who are liver transplant recipients without cirrhosis or with compensated cirrhosis.
When used in combination with [DB11613] as the combination product Epclusa, sofosbuvir is indicated for the treatment of adult patients with chronic hepatitis C virus (HCV) genotypes 1, 2, 3, 4, 5, or 6 infection without cirrhosis or with compensated cirrhosis, or in combination with [DB00811] if associated with decompensated cirrhosis.
Resistance: Reduced susceptibility to sofosbuvir has been associated with the NS5B substitution mutation S282T [A19634]. |
| DB08937 | TAS-102 | Not Available |
| DB08958 | Hexetidine | Not Available |
| DB08966 | Fursultiamine | Not Available |
| DB08991 | Epirizole | Not Available |
| DB09001 | Barbexaclone | Created for the treatment for epilepsy, with the intent of creating an antiepileptic with less sedative properties than phenobarbital.
|
| DB09010 | Carmofur | Not Available |
| DB09144 | Uridine triacetate | Marketed as the product Xuriden (FDA), uridine triacetate is indicated for the treatment of hereditary orotic aciduria.
Marketed as the product Vistogard (FDA), uridine triacetate is indicated for the emergency treatment of adult and pediatric patients in the following situations: following a fluorouracil or capecitabine overdose regardless of the presence of symptoms; or who exhibit early-onset, severe or life-threatening toxicity affecting the cardiac or central nervous system, and/or early-onset, unusually severe adverse reactions (e.g., gastrointestinal toxicity and/or neutropenia) within 96 hours following the end of fluorouracil or capecitabine administration. |
| DB09183 | Dasabuvir | Dasabuvir, in combination with [DB09296], [DB09297], and [DB00503] (as Viekira Pak) is indicated for the treatment of patients with HCV genotype 1a with [DB00811] or genotype 1b without [DB00811] including those with compensated cirrhosis [FDA Label]. |
| DB09256 | Tegafur | Indicated for the treatment of cancer usually in combination with other biochemically modulating drugs.
Indicated in adults for the treatment of advanced gastric cancer when given in combination with [DB00515] [L933].
Indicated for the first-line treatment of metastatic colorectal cancer with [DB03419] and calcium folinate [L934]. |
| DB09283 | Trapidil | Used in the treatment of chronic stable angina [A19770]. |
| DB11156 | Pyrantel | For the treatment of enterobiasis including roundworm (ascariasis), pinworm (enterobius) and hookworm (strongyloides) and hookworm (ancylostoma) in the pyrantel pamoate form [L1893].
Pyrantel is available in various formulations for humans, dogs, and cats as the pamoate (US Pharmacopeia nomenclature) or embonate (European Pharmacopoeia nomenclature) salt, which contains 34.7% pyrantel base combined with pamoic acid [L1893]. [L1900], [A32283].
Pyrantel pamoate (embonate) ingested orally is effective for removal and control of ascarid and hookworm infections in puppies and dogs (adult Toxocara canis, Toxascaris leonina, Ancylostoma tubaeforme, An. braziliense, Uncinaria stenocephala), cats (adult Toxocara cati, Toxa. leonina, An. caninum, An. braziliense, U. stenocephala), horses and ponies (adult and immature Parascaris equorum, adult Strongylus vulgaris, S. edentatus, S. equinus, Cyathostomes (Triodontophorus spp., Cyathostomum spp., Cylicodontophorus spp., Cylicocyclus spp., Cylicostephanus spp., Poteriostomum spp.), Oxyuris equi, Anoplocephala perfoliata), swine (adult Ascaris suum, Oesophagostomum dentatum), and humans (adult A. lumbricoides, Enterobius vermicularis, An. duodenale, Necator americanus) [L1900]. |
| DB11667 | 2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine | Not Available |
| DB11671 | AZD-4877 | Not Available |
| DB11682 | Daprodustat | Not Available |
| DB11683 | PF-06282999 | Not Available |
| DB11748 | Benfotiamine | Not Available |
| DB11792 | Mirodenafil | Not Available |
| DB11853 | Relugolix | Not Available |
| DB11902 | Gisadenafil | Not Available |
| DB11918 | Guadecitabine | Not Available |
| DB11953 | PF-04447943 | Not Available |
| DB11984 | Letaxaban | Not Available |
| DB11998 | Sorivudine | Not Available |
| DB12028 | Broxuridine | Not Available |
| DB12045 | Mericitabine | Not Available |
| DB12074 | Censavudine | Not Available |
| DB12113 | CE-224535 | Not Available |
| DB12151 | Brincidofovir | Not Available |
| DB12153 | Citicoline | Not Available |
| DB12241 | TAK-733 | Not Available |
| DB12423 | Fozivudine Tidoxil | Not Available |
| DB12440 | Verdiperstat | Not Available |
| DB12470 | Dexelvucitabine | Not Available |
| DB12484 | Tetrahydrouridine | Not Available |
| DB12564 | Gemcitabine elaidate | Not Available |
| DB12606 | Netivudine | Not Available |
| DB12693 | Ritanserin | Not Available |
| DB12753 | Racivir | Not Available |
| DB12817 | Zoliflodacin | Not Available |
| DB12855 | Apricitabine | Not Available |
| DB12901 | Fiacitabine | Not Available |
| DB12906 | LY-2334737 | Not Available |
| DB12914 | MGL-3196 | Not Available |
| DB12947 | Doxifluridine | Not Available |
| DB12957 | 5-fluoro-2'-deoxycytidine | Not Available |
| DB13030 | 2'-fluoro-5-ethylarabinosyluracil | Not Available |
| DB13172 | Tunicamycin | Not Available |
| DB13229 | Enibomal | Not Available |
| DB13416 | Sulbutiamine | Not Available |
| DB13421 | Edoxudine | Edoxudine was used in Europe, in the form of a topical antiviral, for the treatment of human herpes keratitis.[A32643] Human herpes keratitis is an inflammation of the cornea in the eye caused by herpes simplex virus infection. This infection is a cause of significant morbidity whose incidence is significantly increased in the presence of recurrent infection and it can even produce corneal blindness.[A32645]
Edoxudine 3% cream was also indicated for the treatment of dermal herpes simplex virus.[A32643] This virus can produce an infection ubiquitously and it is highly contagious. There are two types of herpes virus, type 1 that is mainly transmitted by oral-to-oral contact and type 2 that is sexually transmitted.[L2411] |
| DB13786 | Magnesium orotate | Not Available |
| DB13920 | Valopicitabine | Not Available |
| DB13921 | 2'-C-methylcytidine | Not Available |