| DB00152 | Thiamine | For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis. |
| DB00205 | Pyrimethamine | For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine |
| DB00237 | Butabarbital | For short-term treatment of insomnia and anxiety disorders |
| DB00241 | Butalbital | Used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines, and pain. |
| DB00249 | Idoxuridine | For use in keratoconjunctivitis and keratitis caused by herpes simplex virus. |
| DB00306 | Talbutal | For use as a sedative and hypnotic. |
| DB00312 | Pentobarbital | For the short-term treatment of insomnia. |
| DB00322 | Floxuridine | For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means. Also for the palliative management of liver cancer (usually administered by hepatic intra-arterial infusion). |
| DB00350 | Minoxidil | For the treatment of severe hypertension and in the topical treatment (regrowth) of androgenic alopecia in males and females and stabilisation of hair loss in patients with androgenic alopecia. |
| DB00369 | Cidofovir | For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) |
| DB00418 | Secobarbital | For the Short-term treatment of intractable insomnia for patients habituated to barbiturates |
| DB00432 | Trifluridine | Ophthalmic solution for the treatment of primay keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, types 1 and 2. |
| DB00440 | Trimethoprim | For the treatment of urinary tract infections, uncomplicated pyelonephritis (with sulfamethoxazole) and mild acute prostatitis. May be used as pericoital (with sulfamethoxazole) or continuous prophylaxis in females with recurrent cystitis. May be used as an alternative to treat asymptomatic bacteriuria during pregnancy (only before the last 6 weeks of pregnancy). Other uses include: alternative agent in respiratory tract infections (otitis, sinusitus, bronchitis and pneumonia), treatment of Pneumocystis jirovecii pneumonia (acute or prophylaxis), Nocardia infections, and traveller's diarrhea. |
| DB00441 | Gemcitabine | Gemcitabine is indicated for the treatment of advanced ovarian cancer that has relapsed at least 6 months after completion of platinum-based therapy; metastatic ovarian cancer; inoperable, locally advanced (Stage IIIA or IIIB), or metastatic (Stage IV) non-small cell lung cancer; and locally advanced (nonresectable Stage II or Stage III) or metastatic (Stage IV) adenocarcinoma of the pancreas. |
| DB00463 | Metharbital | Metharbital is used for the treatment of epilepsy. |
| DB00474 | Methohexital | Methohexital is indicated for use as an intravenous anaesthetic. It has also been commonly used to induce deep sedation. |
| DB00475 | Chlordiazepoxide | For the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety. |
| DB00490 | Buspirone | For the management of anxiety disorders or the short-term relief of the symptoms of anxiety, and also as an augmention of SSRI-treatment against depression. |
| DB00495 | Zidovudine | Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections. |
| DB00544 | Fluorouracil | For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid. |
| DB00550 | Propylthiouracil | Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave's disease). |
| DB00552 | Pentostatin | For the treatment of hairy cell leukaemia refractory to alpha interferon. |
| DB00599 | Thiopental | For use as the sole anesthetic agent for brief (15 minute) procedures, for induction of anesthesia prior to administration of other anesthetic agents, to supplement regional anesthesia, to provide hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation, for the control of convulsive states during or following inhalation anesthesia or local anesthesia, in neurosurgical patients with increased intracranial pressure, and for narcoanalysis and narcosynthesis in psychiatric disorders. |
| DB00619 | Imatinib | For the treatment of Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML), Ph+ acute lymphoblastic leukaemia, myelodysplastic/myeloproliferative diseases, aggressive systemic mastocytosis, hypereosinophilic syndrome and/or chronic eosinophilic leukemia (CEL), dermatofibrosarcoma protuberans, and malignant gastrointestinal stromal tumors (GIST). |
| DB00649 | Stavudine | For the treatment of human immunovirus (HIV) infections. |
| DB00709 | Lamivudine | For the treatment of HIV infection and chronic hepatitis B (HBV). |
| DB00734 | Risperidone | For the treatment of schizophrenia in adults and in adolescents, ages 13 to 17, and for the short-term treatment of manic or mixed episodes of bipolar I disorder in children and adolescents ages 10 to 17. May also be used to manage symptoms of inappropriate behavior due to aggression and/or psychosis in patients with severe dementia. |
| DB00791 | Uracil mustard | Used for its antineoplastic properties. |
| DB00794 | Primidone | For the treatment of epilepsy |
| DB00849 | Methylphenobarbital | For the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy. |
| DB00879 | Emtricitabine | Indicated, in combination with other antiretroviral agents, for the treatment of HIV-1 infection in adults and for postexposure prophylaxis of HIV infection in health care workers and others exposed occupationally or nonoccupationally via percutaneous injury or mucous membrane or nonintact skin contact with blood, tissues, or other body fluids associated with risk for transmission of the virus. |
| DB00885 | Pemirolast | For the prevention of itching of the eyes caused by allergies such as hay fever, and allergic conjunctivitis |
| DB00928 | Azacitidine | For treatment of patients with the following French-American-British myelodysplastic syndrome subtypes: refractory anemia or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation (now classified as acute myelogenous leukemia with multilineage dysplasia), and chronic myelomonocytic leukemia. |
| DB00943 | Zalcitabine | For the treatment of Human immunovirus (HIV) infections in conjunction with other antivirals. |
| DB00975 | Dipyridamole | For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina. |
| DB00987 | Cytarabine | For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia. |
| DB01098 | Rosuvastatin | Used as an adjunct to dietary therapy to treat primary hyperlipidemia (heterozygous familial and nonfamilial), mixed dyslipidemia and hypertriglyceridemia. Also indicated for homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering therapies or when other such therapies are not available. Furthermore, it is used to slow the progression of atherosclerosis and for primary prevention of cardiovascular disease. |
| DB01099 | Flucytosine | For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections). |
| DB01101 | Capecitabine | For the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen. May also be used in combination with docetaxel for the treatment of metastatic breast cancer in patients who have failed to respond to, or recurred or relasped during or following anthracycline-containing chemotherapy. Capecitabine is used alone as an adjuvant therapy following the complete resection of primary tumor in patients with stage III colon cancer when monotherapy with fluroprymidine is preferred. The use or capecitabine in combination regimens for advanced gastric cancer is currently being investigated. |
| DB01154 | Thiamylal | Used for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, and for inducing a hypnotic state. |
| DB01174 | Phenobarbital | For the treatment of all types of seizures except absence seizures. |
| DB01254 | Dasatinib | For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy. |
| DB01262 | Decitabine | For treatment of patients with myelodysplastic syndromes (MDS) including previously treated and untreated, de novo and secondary MDS of all French-American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia) and intermediate-1, intermediate-2, and high-risk International Prognostic Scoring System groups (scores ≥0.5). |
| DB01265 | Telbivudine | For the treatment of chronic hepatitis B in adult and adolescent patients ≥16 years of age with evidence of viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease. |
| DB01267 | Paliperidone | For the treatment of schizophrenia. |
| DB01351 | Amobarbital | Not Available |
| DB01352 | Aprobarbital | Not Available |
| DB01353 | Butethal | For the treatment of insomnia. |
| DB01354 | Heptabarbital | Used mainly for sedation and hypnosis. |
| DB01355 | Hexobarbital | For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. |
| DB01483 | Barbital | Not Available |
| DB01601 | Lopinavir | Indicated in combination with other antiretroviral agents for the treatment of HIV-infection. |
| DB01629 | 5-Fluorouridine | Not Available |
| DB01643 | Thymidine-5'-Phosphate | Not Available |
| DB02097 | Cytidine | Not Available |
| DB02230 | Immucillin-G | Not Available |
| DB02254 | Trifluoro-thiamin phosphate | Not Available |
| DB02262 | Orotic Acid | Not Available |
| DB02281 | Formycin | Not Available |
| DB02745 | Uridine | Not Available |
| DB03041 | UDP-alpha-D-glucuronic acid | Not Available |
| DB03068 | Zebularine | Not Available |
| DB03326 | deoxycytidylyl-3',5'-guanosine | Not Available |
| DB03419 | Uracil | Not Available |
| DB03462 | Thymine | Not Available |
| DB03501 | Galactose-uridine-5'-diphosphate | Not Available |
| DB03516 | Eniluracil | For the treatment of cancer in combination with 5-fluorouracil. |
| DB03554 | 5-Iodouracil | Not Available |
| DB03668 | 1-(5'-Phospho-Beta-D-Ribofuranosyl)Barbituric Acid | Not Available |
| DB03718 | 6-Aza-Ump | Not Available |
| DB03761 | 5-Fluoro-2'-Deoxyuridine-5'-Monophosphate | Not Available |
| DB03765 | 2'-cytidylic acid | Not Available |
| DB03800 | 2'-deoxyuridylic acid | Not Available |
| DB03826 | 5,6-Diaminouracil | Not Available |
| DB03881 | MT-Immucillin-H | Not Available |
| DB04103 | 3-Methylcytosine | Not Available |
| DB04129 | Willardiine | Not Available |
| DB04198 | Formycin B | Not Available |
| DB04222 | Sparsomycin | Not Available |
| DB04314 | 1-Methylcytosine | Not Available |
| DB04385 | 3-Deazacytidine | Not Available |
| DB04485 | Deoxythymidine | Not Available |
| DB04627 | Cyclouridine | Not Available |
| DB04655 | Metoprine | Not Available |
| DB04672 | cyclic 3',5'-thymidine monophosphate | Not Available |
| DB04900 | Thymalfasin | Indicated as an adjuvant for influenza vaccine in elderly patients and as an adjuvant for both influenza and hepatitis B vaccines in chronic hemodialysis patients who failed to achieve adequate antibody titers from previous immunization. |
| DB04961 | Troxacitabine | Investigated for use/treatment in leukemia (myeloid). |
| DB04983 | Denufosol | For use as an inhaled treatment for cystic fibrosis. |
| DB05116 | Thymectacin | Investigated for use/treatment in colorectal cancer. |
| DB05262 | Oxypurinol | Intended for the treatment of congestive heart failure and hyperuricemia. |
| DB05494 | Elacytarabine | Investigated for use/treatment in leukemia (unspecified) and melanoma. |
| DB06203 | Alogliptin | Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. |
| DB08864 | Rilpivirine | Treatment of HIV-1 infections in treatment-naive patients with HIV-1 RNA ≤100,000 copies/mL in combination with at least 2 other antiretroviral agents. |
| DB08911 | Trametinib | Trametinib is indicated for the treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations, as detected by an FDA-approved test. |
| DB08934 | Sofosbuvir | Sofosbuvir is used in combination therapy with other antiviral medications to treat chronic hepatitis C virus (HCV) infected patients with HCV genoptypes 1-6, and to treat HCV and HIV co-infected patients. Depending on the level of cirrhosis or decompensation, combination therapy can also include either ribavirin alone or ribavirin and peg-interferon alfa.
When used in combination with [DB09027] as the combination product Harvoni, sofosbuvir has the following indications: treatment of genotypes 1, 4, 5, or 6 infection without cirrhosis or with compensated cirrhosis; in combination with [DB00811] for genotype 1 infection with decompensated cirrhosis; or in combination with [DB00811] for the treatment of genotype 1 or 4 infection who are liver transplant recipients without cirrhosis or with compensated cirrhosis.
When used in combination with [DB11613] as the combination product Epclusa, sofosbuvir is indicated for the treatment of adult patients with chronic hepatitis C virus (HCV) genotypes 1, 2, 3, 4, 5, or 6 infection without cirrhosis or with compensated cirrhosis, or in combination with [DB00811] if associated with decompensated cirrhosis.
Resistance: Reduced susceptibility to sofosbuvir has been associated with the NS5B substitution mutation S282T [A19634]. |
| DB08937 | TAS-102 | Not Available |
| DB08958 | Hexetidine | Not Available |
| DB08966 | Fursultiamine | Not Available |
| DB08991 | Epirizole | Not Available |
| DB09001 | Barbexaclone | Created for the treatment for epilepsy, with the intent of creating an antiepileptic with less sedative properties than phenobarbital.
|
| DB09010 | Carmofur | Not Available |
| DB09144 | Uridine triacetate | Marketed as the product Xuriden (FDA), uridine triacetate is indicated for the treatment of hereditary orotic aciduria.
Marketed as the product Vistogard (FDA), uridine triacetate is indicated for the emergency treatment of adult and pediatric patients in the following situations: following a fluorouracil or capecitabine overdose regardless of the presence of symptoms; or who exhibit early-onset, severe or life-threatening toxicity affecting the cardiac or central nervous system, and/or early-onset, unusually severe adverse reactions (e.g., gastrointestinal toxicity and/or neutropenia) within 96 hours following the end of fluorouracil or capecitabine administration. |
| DB09183 | Dasabuvir | Dasabuvir, in combination with [DB09296], [DB09297], and [DB00503] (as Viekira Pak) is indicated for the treatment of patients with HCV genotype 1a with [DB00811] or genotype 1b without [DB00811] including those with compensated cirrhosis [FDA Label]. |
| DB09256 | Tegafur | Indicated for the treatment of cancer usually in combination with other biochemically modulating drugs. |
| DB09283 | Trapidil | Used in the treatment of chronic stable angina [A19770]. |
| DB11156 | Pyrantel | Not Available |
| DB11667 | 2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine | Not Available |
| DB11671 | AZD-4877 | Not Available |
| DB11682 | Daprodustat | Not Available |
| DB11683 | PF-06282999 | Not Available |
| DB11748 | Benfotiamine | Not Available |
| DB11792 | Mirodenafil | Not Available |
| DB11853 | Relugolix | Not Available |
| DB11902 | Gisadenafil | Not Available |
| DB11918 | Guadecitabine | Not Available |
| DB11953 | PF-04447943 | Not Available |
| DB11984 | Letaxaban | Not Available |
| DB11998 | Sorivudine | Not Available |
| DB12028 | Broxuridine | Not Available |
| DB12045 | Mericitabine | Not Available |
| DB12074 | Censavudine | Not Available |
| DB12113 | CE-224535 | Not Available |
| DB12151 | Brincidofovir | Not Available |
| DB12153 | Citicoline | Not Available |
| DB12241 | TAK-733 | Not Available |
| DB12423 | Fozivudine Tidoxil | Not Available |
| DB12440 | Verdiperstat | Not Available |
| DB12470 | Dexelvucitabine | Not Available |
| DB12484 | Tetrahydrouridine | Not Available |
| DB12564 | Gemcitabine elaidate | Not Available |
| DB12606 | Netivudine | Not Available |
| DB12693 | Ritanserin | Not Available |
| DB12753 | Racivir | Not Available |
| DB12817 | Zoliflodacin | Not Available |
| DB12855 | Apricitabine | Not Available |
| DB12901 | Fiacitabine | Not Available |
| DB12906 | LY-2334737 | Not Available |
| DB12914 | MGL-3196 | Not Available |
| DB12947 | Doxifluridine | Not Available |
| DB12957 | 5-fluoro-2'-deoxycytidine | Not Available |
| DB13030 | 2'-fluoro-5-ethylarabinosyluracil | Not Available |
| DB13172 | Tunicamycin | Not Available |
| DB13416 | Sulbutiamine | Not Available |
| DB13421 | Edoxudine | Not Available |
| DB13786 | Magnesium orotate | Not Available |