- Accession Number
Compounds based on 2-amino-4-hydroxypteridine.
Drug Drug Description Tetrahydrofolic acid For nutritional supplementation, also for treating dietary shortage or imbalance. Folic acid A nutrient used to treat megaloblastic anemia and is found in many supplements. Sapropterin A cofactor used as an adjunct to phenylalanine restriction in the treatment of phenylketonuria (PKU). Methotrexate An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis. Leucovorin A folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer. D-threo-neopterin A pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections. (From Stedman, 26th ed) Neopterin also serves as a... Biopterin A natural product that has been considered as a growth factor for some insects. [PubChem] L-erythro-7,8-dihydrobiopterin 7,8-Dihydrobiopterin is an inhibitor of the enzyme dihydroneopterin aldolase (DHNA), which catalyzes the conversion of 7,8-Dihydrobiopterin to 6-hydroxymethyl-7,8-dihydropterin and glycolaldehyde. 7,8-Dihydroneopterin Not Available Vintafolide Investigated for use/treatment in solid tumors. 4'-Methylene-5,8,10-trideazaaminopterin Investigated for use/treatment in inflammatory disorders (unspecified), psoriasis and psoriatic disorders, and rheumatoid arthritis. Pralatrexate An antineoplastic agent used for the treatment of relapsed or refractory peripheral T-cell lymphoma. Aminopterin Prior to its withdrawal, aminopterin was initially used in the treatment of childhood leukemia; specifically to induce remissions. Later, aminopterin was used off-label in the United States to treat psoriasis,... Levoleucovorin A folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer. Epofolate Epofolate has been used in trials studying the treatment of Advanced Solid Tumors. Ronopterin Ronopterin has been used in trials studying the treatment of Traumatic Brain Injury. Lometrexol Lometrexol has been used in trials studying the treatment of Lung Cancer, Drug/Agent Toxicity by Tissue/Organ, and Unspecified Adult Solid Tumor, Protocol Specific. Neopterin Neopterin is under investigation in clinical trial NCT02974192 (Neopterin Effects on Ischemic Stroke). 5-methyltetrahydrofolic acid 5-methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. It is generated by methylenetetrahydrofolate reductase from 5,10-methylenetetrahydrofolate and used to recycle homocysteine back to methionine by 5-methyltetrahydrofolate-homocysteine methyltransferases (also called methionine... Levomefolic acid A folate supplement used to prevent neural tube defects in pregnancy or folate deficiency.
- Drugs & Drug Targets