Name
Pterins
Accession Number
DBCAT000354
Description

Compounds based on 2-amino-4-hydroxypteridine.

Drugs
DrugDrug Description
Tetrahydrofolic acidFor nutritional supplementation, also for treating dietary shortage or imbalance.
Folic acidA nutrient used to treat megaloblastic anemia and is found in many supplements.
SapropterinA cofactor used as an adjunct to phenylalanine restriction in the treatment of phenylketonuria (PKU).
MethotrexateAn antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis.
LeucovorinA folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer.
D-threo-neopterinA pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections. (From Stedman, 26th ed) Neopterin also serves as a...
BiopterinA natural product that has been considered as a growth factor for some insects. [PubChem]
L-erythro-7,8-dihydrobiopterin7,8-Dihydrobiopterin is an inhibitor of the enzyme dihydroneopterin aldolase (DHNA), which catalyzes the conversion of 7,8-Dihydrobiopterin to 6-hydroxymethyl-7,8-dihydropterin and glycolaldehyde.
7,8-DihydroneopterinNot Available
VintafolideInvestigated for use/treatment in solid tumors.
4'-Methylene-5,8,10-trideazaaminopterinInvestigated for use/treatment in inflammatory disorders (unspecified), psoriasis and psoriatic disorders, and rheumatoid arthritis.
PralatrexateAn antineoplastic agent used for the treatment of relapsed or refractory peripheral T-cell lymphoma.
AminopterinPrior to its withdrawal, aminopterin was initially used in the treatment of childhood leukemia; specifically to induce remissions. Later, aminopterin was used off-label in the United States to treat psoriasis,...
LevoleucovorinA folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer.
EpofolateEpofolate has been used in trials studying the treatment of Advanced Solid Tumors.
RonopterinRonopterin has been used in trials studying the treatment of Traumatic Brain Injury.
LometrexolLometrexol has been used in trials studying the treatment of Lung Cancer, Drug/Agent Toxicity by Tissue/Organ, and Unspecified Adult Solid Tumor, Protocol Specific.
NeopterinNeopterin is under investigation in clinical trial NCT02974192 (Neopterin Effects on Ischemic Stroke).
5-methyltetrahydrofolic acid5-methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. It is generated by methylenetetrahydrofolate reductase from 5,10-methylenetetrahydrofolate and used to recycle homocysteine back to methionine by 5-methyltetrahydrofolate-homocysteine methyltransferases (also called methionine...
Levomefolic acidA folate supplement used to prevent neural tube defects in pregnancy or folate deficiency.
Drugs & Drug Targets
DrugTargetType
Tetrahydrofolic acidC-1-tetrahydrofolate synthase, cytoplasmictarget
Tetrahydrofolic acidBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialtarget
Tetrahydrofolic acidAminomethyltransferase, mitochondrialtarget
Tetrahydrofolic acidCytosolic 10-formyltetrahydrofolate dehydrogenasetarget
Tetrahydrofolic acidMethionine synthasetarget
Tetrahydrofolic acidFormimidoyltransferase-cyclodeaminasetarget
Tetrahydrofolic acidBifunctional purine biosynthesis protein PURHtarget
Tetrahydrofolic acidSerine hydroxymethyltransferase, cytosolictarget
Tetrahydrofolic acidSerine hydroxymethyltransferase, mitochondrialtarget
Tetrahydrofolic acidMethylenetetrahydrofolate reductasetarget
Tetrahydrofolic acidSerine hydroxymethyltransferasetarget
Tetrahydrofolic acidMethionyl-tRNA formyltransferase, mitochondrialtarget
Tetrahydrofolic acidCanalicular multispecific organic anion transporter 1transporter
Folic acidFolate receptor gammatarget
Folic acidFolate receptor betatarget
Folic acidMethylenetetrahydrofolate reductaseenzyme
Folic acidMultidrug resistance-associated protein 4transporter
Folic acidSolute carrier family 22 member 6transporter
Folic acidCanalicular multispecific organic anion transporter 2transporter
Folic acidATP-binding cassette sub-family C member 11transporter
Folic acidATP-binding cassette sub-family G member 2transporter
Folic acidProton-coupled folate transportertransporter
Folic acidMitochondrial folate transporter/carriertransporter
Folic acidGamma-glutamyl hydrolaseenzyme
Folic acidFolate receptor alphatarget
Folic acidDihydrofolate reductaseenzyme
SapropterinPhenylalanine-4-hydroxylasetarget
SapropterinNitric oxide synthase, endothelialtarget
SapropterinTyrosine 3-monooxygenasetarget
SapropterinTryptophan 5-hydroxylase 1target
SapropterinProstaglandin G/H synthase 2enzyme
MethotrexateDihydrofolate reductasetarget
MethotrexateAldehyde oxidaseenzyme
MethotrexateMethylenetetrahydrofolate reductaseenzyme
MethotrexateSerum albumincarrier
MethotrexateCanalicular multispecific organic anion transporter 2transporter
MethotrexateMultidrug resistance-associated protein 4transporter
MethotrexateMultidrug resistance-associated protein 1transporter
MethotrexateSolute carrier family 22 member 6transporter
MethotrexateMultidrug resistance-associated protein 7transporter
MethotrexateSolute carrier family 22 member 8transporter
MethotrexateCanalicular multispecific organic anion transporter 1transporter
MethotrexateP-glycoprotein 1transporter
MethotrexateSolute carrier organic anion transporter family member 1A2transporter
MethotrexateMonocarboxylate transporter 1transporter
MethotrexateATP-binding cassette sub-family C member 11transporter
MethotrexateSolute carrier organic anion transporter family member 1B3transporter
MethotrexateSolute carrier family 22 member 11transporter
MethotrexateSolute carrier organic anion transporter family member 1C1transporter
MethotrexateSolute carrier organic anion transporter family member 3A1transporter
MethotrexateATP-binding cassette sub-family G member 2transporter
MethotrexateSolute carrier family 22 member 7transporter
MethotrexateSolute carrier organic anion transporter family member 1B1transporter
Methotrexate6-phosphogluconate dehydrogenase, decarboxylatingenzyme
MethotrexateProton-coupled folate transportertransporter
MethotrexateFolylpolyglutamate synthase, mitochondrialenzyme
MethotrexateGamma-glutamyl hydrolaseenzyme
MethotrexateDihydrofolate reductaseenzyme
MethotrexateThymidylate synthaseenzyme
MethotrexateBifunctional purine biosynthesis protein PURHenzyme
MethotrexateSolute carrier organic anion transporter family member 4C1transporter
MethotrexateFolate transporter 1transporter
MethotrexateFolate receptor alphatransporter
MethotrexateCytochrome P450 3A4enzyme
MethotrexateThymidylate synthasetarget
MethotrexateBifunctional purine biosynthesis protein PURHtarget
MethotrexateFolate receptor betatransporter
MethotrexateSolute carrier family 15 member 1transporter
MethotrexateProton-coupled amino acid transporter 1transporter
LeucovorinSolute carrier family 22 member 8transporter
BiopterinSepiapterin reductasetarget
Biopterin6-pyruvoyl tetrahydrobiopterin synthasetarget
BiopterinDihydrofolate reductasetarget
L-erythro-7,8-dihydrobiopterinPhenylalanine-4-hydroxylasetarget
L-erythro-7,8-dihydrobiopterinPteridine reductase 1target
L-erythro-7,8-dihydrobiopterinNitric oxide synthase, inducibletarget
L-erythro-7,8-dihydrobiopterinTyrosine 3-monooxygenasetarget
L-erythro-7,8-dihydrobiopterinPterin-4-alpha-carbinolamine dehydratasetarget
L-erythro-7,8-dihydrobiopterinDihydroneopterin aldolasetarget
7,8-DihydroneopterinDihydroneopterin aldolasetarget
VintafolideFolate receptor betatarget
VintafolideFolate receptor gammatarget
VintafolideFolate receptor alphatarget
PralatrexateFolylpolyglutamate synthase, mitochondrialenzyme
PralatrexateDihydrofolate reductasetarget
PralatrexateThymidylate synthasetarget
PralatrexateFolate transporter 1transporter
PralatrexateCanalicular multispecific organic anion transporter 1transporter
PralatrexateATP-binding cassette sub-family G member 2transporter
AminopterinProton-coupled folate transportertransporter
AminopterinDihydrofolate reductaseenzyme
LevoleucovorinSerine hydroxymethyltransferasetarget
EpofolateCytochrome P450 3A4enzyme
LometrexolDihydrofolate reductasetarget
5-methyltetrahydrofolic acidAminomethyltransferase, mitochondrialtarget
5-methyltetrahydrofolic acidCanalicular multispecific organic anion transporter 1transporter
Levomefolic acidProton-coupled folate transportertransporter
Levomefolic acidFolate transporter 1transporter
Levomefolic acidMethionine synthaseenzyme