Pterins
- Name
- Pterins
- Accession Number
- DBCAT000354
- Description
Compounds based on 2-amino-4-hydroxypteridine.
- Drugs
Drug Drug Description Folic acid A nutrient used to treat megaloblastic anemia and is found in many supplements. Methotrexate An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis. Biopterin A natural product that has been considered as a growth factor for some insects. [PubChem] Aminopterin Prior to its withdrawal, aminopterin was initially used in the treatment of childhood leukemia; specifically to induce remissions. Later, aminopterin was used off-label in the United States to treat psoriasis,... Ronopterin Ronopterin has been used in trials studying the treatment of Traumatic Brain Injury. Sapropterin A cofactor used as an adjunct to phenylalanine restriction in the treatment of phenylketonuria (PKU). L-erythro-7,8-dihydrobiopterin 7,8-Dihydrobiopterin is an inhibitor of the enzyme dihydroneopterin aldolase (DHNA), which catalyzes the conversion of 7,8-Dihydrobiopterin to 6-hydroxymethyl-7,8-dihydropterin and glycolaldehyde. Tetrahydrofolic acid For nutritional supplementation, also for treating dietary shortage or imbalance. Leucovorin A folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer. D-threo-neopterin A pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections. (From Stedman, 26th ed) Neopterin also serves as a... 7,8-Dihydroneopterin Not Available 5-methyltetrahydrofolic acid 5-methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. It is generated by methylenetetrahydrofolate reductase from 5,10-methylenetetrahydrofolate and used to recycle homocysteine back to methionine by 5-methyltetrahydrofolate-homocysteine methyltransferases (also called methionine... Vintafolide Investigated for use/treatment in solid tumors. 4'-Methylene-5,8,10-trideazaaminopterin Investigated for use/treatment in inflammatory disorders (unspecified), psoriasis and psoriatic disorders, and rheumatoid arthritis. Pralatrexate An antineoplastic agent used for the treatment of relapsed or refractory peripheral T-cell lymphoma. Levomefolic acid A folate supplement used to prevent neural tube defects in pregnancy or folate deficiency. Levoleucovorin A folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer. Epofolate Epofolate has been used in trials studying the treatment of Advanced Solid Tumors. Epofolate (BMS-753493) is a folate conjugate of the epothilone analog BMS-748285 that was designed to selectively target... Lometrexol Lometrexol has been used in trials studying the treatment of Lung Cancer, Drug/Agent Toxicity by Tissue/Organ, and Unspecified Adult Solid Tumor, Protocol Specific. Neopterin Neopterin is under investigation in clinical trial NCT02974192 (Neopterin Effects on Ischemic Stroke). Pafolacianine An optical imaging agent indicated in adult patients with ovarian cancer as an adjunct for intraoperative identification of malignant lesions. Folitixorin Not Annotated - Drugs & Drug Targets