Carotenoids

The general name for a group of fat-soluble pigments found in green, yellow, and leafy vegetables, and yellow fruits. They are aliphatic hydrocarbons consisting of a polyisoprene backbone.
DrugDrug NameDrug Description
DB00162Vitamin AA vitamin important for retinal function that is used clinically to correct vitamin A deficiency.
DB00459AcitretinAn oral retinoid used in the treatment of severe psoriasis.
DB00523AlitretinoinA vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis.
DB00755TretinoinA vitamin A derivative used to treat acne vulgaris, certain types of promyelocytic leukemia, and fine wrinkles.
DB00926EtretinateFor the treatment of severe psoriasis in adults.
DB00982IsotretinoinA retinoid used to treat severe recalcitrant acne.
DB026994-OxoretinolNot Available
DB02877Arotinoid acidArotinoid acid is a retinoic acid analog which acts as a selective RAR agonist.
DB03460ViolaxanthinNot Available
DB05076FenretinideInvestigated for use/treatment in macular degeneration.
DB05653IRX-5183Investigated for use/treatment in adverse effects (chemotherapy) and blood (blood forming organ disorders, unspecified).
DB06543AstaxanthinInvestigated for use/treatment in eye disorders/infections, cancer/tumors (unspecified), and asthma.
DB06755Beta caroteneA vitamin A precursor found in various nutritional supplements and health products.
DB070313-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acidNot Available
DB08455Ro 12-7310Not Available
DB11176ZeaxanthinZeaxanthin is a most common carotenoid alcohols found in nature that is involved in the xanthophyll cycle. As a coexistent isomer of lutein, zeaxanthin is synthesized in plants and some...
DB12112Zuretinol acetateZuretinol acetate has been used in trials studying the treatment of Impaired Dark Adaptation, RP (Retinitis Pigmentosa), Retinitis Pigmentosa (RP), and LCA (Leber Congenital Amaurosis).
DB13368MotretinideNot Annotated
DB1409713-cis-12-(3'-Carboxyphenyl)retinoic acidNot Annotated
DB00137LuteinXanthophylls are taken for nutritional supplementation, and also for treating dietary shortage or imbalance.
DB15462FucoxanthinFucoxanthin is under investigation in clinical trial NCT03613740 (Effect of Fucoxanthin on the Components of the Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion).
DB00307BexaroteneA retinoid drug used for cutaneous manifestations of T-cell lymphoma in patients who have not responded well to previous systemic therapy.
DB11231LycopeneAn ingredient found in a variety of supplements and vitamins.
DrugDrug NameTargetType
DB00162Vitamin ARetinol dehydrogenase 12target
DB00162Vitamin ARetinol-binding protein 1target
DB00162Vitamin A11-cis retinol dehydrogenasetarget
DB00162Vitamin ARetinol dehydrogenase 13target
DB00162Vitamin ARetinol-binding protein 3target
DB00162Vitamin ARetinol-binding protein 5carrier
DB00162Vitamin ARetinoid-binding protein 7carrier
DB00162Vitamin ARetinol-binding protein 4carrier
DB00162Vitamin ARetinol-binding protein 2carrier
DB00162Vitamin ARetinal dehydrogenase 2target
DB00162Vitamin ARetinal dehydrogenase 1target
DB00162Vitamin ARetinaldehyde-binding protein 1target
DB00162Vitamin ALecithin retinol acyltransferasetarget
DB00162Vitamin AShort-chain dehydrogenase/reductase 3target
DB00162Vitamin AAldehyde dehydrogenase family 1 member A3target
DB00162Vitamin AAll-trans-retinol 13,14-reductasetarget
DB00162Vitamin ARetinol dehydrogenase 11target
DB00162Vitamin ADehydrogenase/reductase SDR family member 4target
DB00162Vitamin ARetinol dehydrogenase 14target
DB00162Vitamin ARetinol dehydrogenase 8target
DB00162Vitamin ACytochrome P450 26A1enzyme
DB00162Vitamin AApolipoprotein Dtarget
DB00162Vitamin AHematopoietic prostaglandin D synthasetarget
DB00162Vitamin ASerum albumincarrier
DB00459AcitretinRetinoic acid receptor alphatarget
DB00459AcitretinRetinoic acid receptor RXR-betatarget
DB00459AcitretinRetinoic acid receptor gammatarget
DB00459AcitretinRetinoic acid receptor betatarget
DB00459AcitretinRetinoic acid receptor RXR-gammatarget
DB00459AcitretinRetinoic acid receptor RXR-alphatarget
DB00459AcitretinSerum albumincarrier
DB00459AcitretinRetinol-binding protein 1target
DB00523AlitretinoinRetinoic acid receptor alphatarget
DB00523AlitretinoinRetinoic acid receptor RXR-betatarget
DB00523AlitretinoinRetinoic acid receptor gammatarget
DB00523AlitretinoinRetinoic acid receptor betatarget
DB00523AlitretinoinRetinoic acid receptor RXR-gammatarget
DB00523AlitretinoinRetinoic acid receptor RXR-alphatarget
DB00523AlitretinoinCellular retinoic acid-binding protein 2carrier
DB00523AlitretinoinCellular retinoic acid-binding protein 1carrier
DB00523AlitretinoinP-glycoprotein 1transporter
DB00523AlitretinoinInsulin-like growth factor-binding protein 3target
DB00523AlitretinoinPregnancy-specific beta-1-glycoprotein 5target
DB00523AlitretinoinCytochrome P450 26C1target
DB00755TretinoinRetinoic acid receptor gammatarget
DB00755TretinoinRetinoic acid receptor RXR-betatarget
DB00755TretinoinRetinal dehydrogenase 1target
DB00755TretinoinRetinoic acid-induced protein 3target
DB00755TretinoinRetinoic acid receptor RXR-gammatarget
DB00755TretinoinNuclear receptor subfamily 0 group B member 1target
DB00755TretinoinRetinal dehydrogenase 2target
DB00755TretinoinRetinoic acid receptor responder protein 1target
DB00755TretinoinCytochrome P450 2C8enzyme
DB00755TretinoinCellular retinoic acid-binding protein 1transporter
DB00755TretinoinCellular retinoic acid-binding protein 2transporter
DB00755TretinoinCytochrome P450 2B6enzyme
DB00755TretinoinCytochrome P450 3A4enzyme
DB00755TretinoinCytochrome P450 3A5enzyme
DB00755TretinoinCytochrome P450 2A6enzyme
DB00755TretinoinCytochrome P450 3A7enzyme
DB00755TretinoinCytochrome P450 2C18enzyme
DB00755TretinoinCytochrome P450 2C9enzyme
DB00755TretinoinCytochrome P450 4A11enzyme
DB00755TretinoinCytochrome P450 1A1enzyme
DB00755TretinoinRetinoic acid receptor alphatarget
DB00755TretinoinRetinoic acid receptor betatarget
DB00755TretinoinLipocalin-1target
DB00755TretinoinOdorant-binding protein 2atarget
DB00755TretinoinRetinol-binding protein 4target
DB00755TretinoinSerum albumincarrier
DB00755Tretinoin[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrialtarget
DB00755TretinoinRetinoic acid receptor RXR-alphatarget
DB00755TretinoinCytochrome P450 26A1target
DB00755TretinoinCytochrome P450 26B1target
DB00755TretinoinCytochrome P450 26C1target
DB00755TretinoinHematopoietic prostaglandin D synthasetarget
DB00926EtretinateRetinoic acid receptor alphatarget
DB00926EtretinateRetinoic acid receptor RXR-betatarget
DB00926EtretinateRetinoic acid receptor gammatarget
DB00926EtretinateRetinoic acid receptor betatarget
DB00926EtretinateRetinoic acid receptor RXR-gammatarget
DB00926EtretinateRetinoic acid receptor RXR-alphatarget
DB00926EtretinateCellular retinoic acid-binding protein 1carrier
DB00926EtretinateCytochrome P450 19A1enzyme
DB00982IsotretinoinRetinoic acid receptor alphatarget
DB00982IsotretinoinSerum albumincarrier
DB00982IsotretinoinRetinoic acid receptor gammatarget
DB00982IsotretinoinCytochrome P450 3A4enzyme
DB02877Arotinoid acidRetinoic acid receptor betatarget
DB05076FenretinideRetinol-binding protein 4carrier
DB06543AstaxanthinNF-kappa-B inhibitor alphatarget
DB06755Beta caroteneBeta,beta-carotene 15,15'-dioxygenaseenzyme
DB06755Beta caroteneFree radicalstarget
DB06755Beta caroteneVery low-density lipoprotein receptorcarrier
DB06755Beta caroteneRetinol-binding protein 1carrier
DB06755Beta caroteneRetinol-binding protein 2carrier
DB06755Beta caroteneRetinol-binding protein 3carrier
DB06755Beta caroteneRetinol-binding protein 4carrier
DB06755Beta caroteneRetinol-binding protein 5carrier
DB070313-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acidRetinoic acid receptor gammatarget
DB08455Ro 12-7310Cellular retinoic acid-binding protein 2carrier
DB00137LuteinSerum albumincarrier
DB00307BexaroteneRetinoic acid receptor RXR-betatarget
DB00307BexaroteneCytochrome P450 3A4enzyme
DB00307BexaroteneRetinoic acid receptor RXR-alphatarget
DB00307BexaroteneRetinoic acid receptor RXR-gammatarget
DB00307BexaroteneCytochrome P450 2C8enzyme