Hydrocarbons with more than one double bond. They are a reduced form of POLYYNES.
DrugDrug NameDrug Indication
DB00162Vitamin AFor the treatment of vitamin A deficiency.
DB00459AcitretinFor the treatment of severe psoriasis in adults.
DB00523AlitretinoinFor topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma.
DB00640AdenosineUsed as an initial treatment for the termination of paroxysmal supraventricular tachycardia (PVST), including that associated with accessory bypass tracts, and is a drug of choice for terminating stable, narrow-complex supraventricular tachycardias (SVT). Also used as an adjunct to thallous chloride TI 201 myocardial perfusion scintigraphy (thallium stress test) in patients who are unable to exercise adequately, as well as an adjunct to vagal maneuvers and clinical assessment to establish a specific diagnosis of undefined, stable, narrow-complex SVT.
DB00755TretinoinFor the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
DB00926EtretinateFor the treatment of severe psoriasis in adults.
DB00982IsotretinoinIsotretinoin is indicated to treat severe recalcitrant nodular acne and patients ≥12 years enrolled in the iPLEDGE program.[Label,L6579]
DB026994-OxoretinolNot Available
DB02877Arotinoid acidNot Available
DB03001PeridininNot Available
DB03460ViolaxanthinNot Available
DB04124AurodoxNot Available
DB05076FenretinideInvestigated for use/treatment in macular degeneration.
DB05653IRX-5183Investigated for use/treatment in adverse effects (chemotherapy) and blood (blood forming organ disorders, unspecified).
DB05974TranscrocetinateInvestigated for use/treatment in cancer/tumors (unspecified), hemorrhage, hypoxia, respiratory failure, and strokes.
DB06543AstaxanthinInvestigated for use/treatment in eye disorders/infections, cancer/tumors (unspecified), and asthma.
DB06755Beta caroteneBeta-carotene is FDA approved to be used as a nutrient supplement and to be even added in infant formula as a source of vitamin A.[L2191] It is also approved to be used as a color additive for food products,[L2192] drugs (with the label of "only as a color additive")[L2193] and cosmetics.[L2194] It is used commonly for the reduction of photosensitivity in patients with erythropoietic protoporphyria and other photosensitivity diseases.[A32485]
DB06812Povidone-iodineFor topical application in the treatment and prevention of infection in wounds.
DB070313-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acidNot Available
DB08455Ro 12-7310Not Available
DB11060Polyvinyl alcoholFor use as a lubricant to prevent further irritation or to relieve dryness of the eye(s) [L2828].
DB11061PovidoneWhen in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.
DB11176ZeaxanthinNot Available
DB11231LycopeneNot Available
DB11420SqualaneNot Available
DB11460SqualeneNot Available
DB11874CrocinNot Available
DB12112Zuretinol acetateNot Available
DB13368MotretinideNot Available
DB13477Sodium apolateNot Available
DB13633MepartricinNot Available
DB1409713-cis-12-(3'-Carboxyphenyl)retinoic acidNot Available
DB00137LuteinXanthophylls are taken for nutritional supplementation, and also for treating dietary shortage or imbalance.
DB00646NystatinFor treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species
DB00681Amphotericin BUsed to treat potentially life threatening fungal infections.
DB15201NorbixinNot Available
DB15462FucoxanthinNot Available
DB00307BexaroteneUsed orally for the treatment of skin manifestations of cutaneous T-cell lymphoma (CTCL) in patients who are refractory to at least one prior systemic therapy. Also used topically for the treatment of skin lesions in early (stage IA and IB) CTCL in patients who experience refractory or persistent disease with the use of other therapies or are intolerant of other therapies.
DB12808TrifaroteneNot Available
DrugDrug NameTargetType
DB00162Vitamin ARetinol dehydrogenase 12target
DB00162Vitamin ARetinol-binding protein 1target
DB00162Vitamin A11-cis retinol dehydrogenasetarget
DB00162Vitamin ARetinol dehydrogenase 13target
DB00162Vitamin ARetinol-binding protein 3target
DB00162Vitamin ARetinol-binding protein 5carrier
DB00162Vitamin ARetinoid-binding protein 7carrier
DB00162Vitamin ARetinol-binding protein 4carrier
DB00162Vitamin ARetinol-binding protein 2carrier
DB00162Vitamin ARetinal dehydrogenase 2target
DB00162Vitamin ARetinal dehydrogenase 1target
DB00162Vitamin ARetinaldehyde-binding protein 1target
DB00162Vitamin ALecithin retinol acyltransferasetarget
DB00162Vitamin AShort-chain dehydrogenase/reductase 3target
DB00162Vitamin AAldehyde dehydrogenase family 1 member A3target
DB00162Vitamin AAll-trans-retinol 13,14-reductasetarget
DB00162Vitamin ARetinol dehydrogenase 11target
DB00162Vitamin ADehydrogenase/reductase SDR family member 4target
DB00162Vitamin ARetinol dehydrogenase 14target
DB00162Vitamin ARetinol dehydrogenase 8target
DB00162Vitamin ACytochrome P450 26A1enzyme
DB00162Vitamin AApolipoprotein Dtarget
DB00162Vitamin AHematopoietic prostaglandin D synthasetarget
DB00162Vitamin ASerum albumincarrier
DB00459AcitretinRetinoic acid receptor alphatarget
DB00459AcitretinRetinoic acid receptor RXR-betatarget
DB00459AcitretinRetinoic acid receptor gammatarget
DB00459AcitretinRetinoic acid receptor betatarget
DB00459AcitretinRetinoic acid receptor RXR-gammatarget
DB00459AcitretinRetinoic acid receptor RXR-alphatarget
DB00459AcitretinSerum albumincarrier
DB00459AcitretinRetinol-binding protein 1target
DB00459AcitretinCytochrome P450 26A1enzyme
DB00523AlitretinoinRetinoic acid receptor alphatarget
DB00523AlitretinoinRetinoic acid receptor RXR-betatarget
DB00523AlitretinoinRetinoic acid receptor gammatarget
DB00523AlitretinoinRetinoic acid receptor betatarget
DB00523AlitretinoinRetinoic acid receptor RXR-gammatarget
DB00523AlitretinoinRetinoic acid receptor RXR-alphatarget
DB00523AlitretinoinCellular retinoic acid-binding protein 2carrier
DB00523AlitretinoinCellular retinoic acid-binding protein 1carrier
DB00523AlitretinoinMultidrug resistance protein 1transporter
DB00523AlitretinoinInsulin-like growth factor-binding protein 3target
DB00523AlitretinoinPregnancy-specific beta-1-glycoprotein 5target
DB00523AlitretinoinCytochrome P450 26C1target
DB00640AdenosineAdenosine receptor A3target
DB00640AdenosineAdenosine deaminaseenzyme
DB00640AdenosineAdenosine kinaseenzyme
DB00640AdenosineAdenosine receptor A1target
DB00640AdenosineAdenosine receptor A2atarget
DB00640AdenosineAdenosine receptor A2btarget
DB00640AdenosineSolute carrier family 28 member 3transporter
DB00755TretinoinRetinoic acid receptor gammatarget
DB00755TretinoinRetinoic acid receptor RXR-betatarget
DB00755TretinoinRetinal dehydrogenase 1target
DB00755TretinoinRetinoic acid-induced protein 3target
DB00755TretinoinRetinoic acid receptor RXR-gammatarget
DB00755TretinoinNuclear receptor subfamily 0 group B member 1target
DB00755TretinoinRetinal dehydrogenase 2target
DB00755TretinoinRetinoic acid receptor responder protein 1target
DB00755TretinoinCytochrome P450 2C8enzyme
DB00755TretinoinCellular retinoic acid-binding protein 1transporter
DB00755TretinoinCellular retinoic acid-binding protein 2transporter
DB00755TretinoinCytochrome P450 2B6enzyme
DB00755TretinoinCytochrome P450 3A4enzyme
DB00755TretinoinCytochrome P450 3A5enzyme
DB00755TretinoinCytochrome P450 2A6enzyme
DB00755TretinoinCytochrome P450 3A7enzyme
DB00755TretinoinCytochrome P450 2C18enzyme
DB00755TretinoinCytochrome P450 2C9enzyme
DB00755TretinoinCytochrome P450 4A11enzyme
DB00755TretinoinCytochrome P450 1A1enzyme
DB00755TretinoinRetinoic acid receptor alphatarget
DB00755TretinoinRetinoic acid receptor betatarget
DB00755TretinoinLipocalin-1target
DB00755TretinoinOdorant-binding protein 2atarget
DB00755TretinoinRetinol-binding protein 4target
DB00755TretinoinSerum albumincarrier
DB00755Tretinoin[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrialtarget
DB00755TretinoinRetinoic acid receptor RXR-alphatarget
DB00755TretinoinCytochrome P450 26A1target
DB00755TretinoinCytochrome P450 26B1target
DB00755TretinoinCytochrome P450 26C1target
DB00755TretinoinHematopoietic prostaglandin D synthasetarget
DB00926EtretinateRetinoic acid receptor alphatarget
DB00926EtretinateRetinoic acid receptor RXR-betatarget
DB00926EtretinateRetinoic acid receptor gammatarget
DB00926EtretinateRetinoic acid receptor betatarget
DB00926EtretinateRetinoic acid receptor RXR-gammatarget
DB00926EtretinateRetinoic acid receptor RXR-alphatarget
DB00926EtretinateCellular retinoic acid-binding protein 1carrier
DB00926EtretinateCytochrome P450 19A1enzyme
DB00926EtretinateCytochrome P450 26A1enzyme
DB00982IsotretinoinRetinoic acid receptor alphatarget
DB00982IsotretinoinSerum albumincarrier
DB00982IsotretinoinRetinoic acid receptor gammatarget
DB00982IsotretinoinCytochrome P450 3A4enzyme
DB02877Arotinoid acidRetinoic acid receptor betatarget
DB04124AurodoxElongation factor Tu-Btarget
DB05076FenretinideRetinol-binding protein 4carrier
DB06543AstaxanthinNF-kappa-B inhibitor alphatarget
DB06755Beta caroteneBeta,beta-carotene 15,15'-dioxygenaseenzyme
DB06755Beta caroteneFree radicalstarget
DB06755Beta caroteneVery low-density lipoprotein receptorcarrier
DB06755Beta caroteneRetinol-binding protein 1carrier
DB06755Beta caroteneRetinol-binding protein 2carrier
DB06755Beta caroteneRetinol-binding protein 3carrier
DB06755Beta caroteneRetinol-binding protein 4carrier
DB06755Beta caroteneRetinol-binding protein 5carrier
DB070313-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acidRetinoic acid receptor gammatarget
DB08455Ro 12-7310Cellular retinoic acid-binding protein 2carrier
DB13633MepartricinCytochrome P450 3A4enzyme
DB00137LuteinSerum albumincarrier
DB00646NystatinErgosteroltarget
DB00646NystatinSolute carrier organic anion transporter family member 1B1transporter
DB00646NystatinSolute carrier organic anion transporter family member 1B3transporter
DB00646NystatinCytochrome P450 3A4enzyme
DB00681Amphotericin BErgosteroltarget
DB00681Amphotericin BCytochrome P450 3A4enzyme
DB00307BexaroteneRetinoic acid receptor RXR-betatarget
DB00307BexaroteneCytochrome P450 3A4enzyme
DB00307BexaroteneRetinoic acid receptor RXR-alphatarget
DB00307BexaroteneRetinoic acid receptor RXR-gammatarget
DB00307BexaroteneCytochrome P450 2C9enzyme
DB00307BexaroteneCytochrome P450 2C8enzyme