Name
Polyenes
Accession Number
DBCAT000363
Description

Hydrocarbons with more than one double bond. They are a reduced form of POLYYNES.

Drugs
DrugDrug Description
Vitamin AA vitamin important for retinal function that is used clinically to correct vitamin A deficiency.
AcitretinAn oral retinoid used in the treatment of severe psoriasis.
AlitretinoinA vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis.
AdenosineA medication used in myocardial perfusion scintigraphy.
TretinoinA vitamin A derivative used to treat acne vulgaris, certain types of promyelocytic leukemia, and fine wrinkles.
EtretinateFor the treatment of severe psoriasis in adults.
IsotretinoinA retinoid used to treat severe recalcitrant acne.
4-OxoretinolNot Available
Arotinoid acidArotinoid acid is a retinoic acid analog which acts as a selective RAR agonist.
PeridininNot Available
ViolaxanthinNot Available
AurodoxAurodox is an antibiotic obtained from a streptomyces variant considered as possibly effective against streptococcus pyogenes infections. It may promote growth in poultry.
FenretinideInvestigated for use/treatment in macular degeneration.
IRX-5183Investigated for use/treatment in adverse effects (chemotherapy) and blood (blood forming organ disorders, unspecified).
TranscrocetinateInvestigated for use/treatment in cancer/tumors (unspecified), hemorrhage, hypoxia, respiratory failure, and strokes.
AstaxanthinInvestigated for use/treatment in eye disorders/infections, cancer/tumors (unspecified), and asthma.
Beta caroteneA vitamin A precursor found in various nutritional supplements and health products.
Povidone-iodineA topical antiseptic agent used for the treatment and prevention of infection in wounds.
3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acidNot Available
Ro 12-7310Not Available
Polyvinyl alcoholA compound used as an ophthalmic lubricant.
PovidoneWhen in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.
ZeaxanthinZeaxanthin is a most common carotenoid alcohols found in nature that is involved in the xanthophyll cycle. As a coexistent isomer of lutein, zeaxanthin is synthesized in plants and some...
LycopeneAn ingredient found in a variety of supplements and vitamins.
SqualaneNot Annotated
SqualeneSqualene is originally obtained from shark liver oil. It is a natural 30-carbon isoprenoid compound and intermediate metabolite in the synthesis of cholesterol. It is not susceptible to lipid peroxidation...
CrocinCrocin has been investigated for the treatment of Hyperglycemia, Metabolic Syndrome, Hypertriglyceridemia, and Hypercholesterolemia.
Zuretinol acetateZuretinol acetate has been used in trials studying the treatment of Impaired Dark Adaptation, RP (Retinitis Pigmentosa), Retinitis Pigmentosa (RP), and LCA (Leber Congenital Amaurosis).
MotretinideNot Annotated
Sodium apolateNot Annotated
MepartricinNot Annotated
13-cis-12-(3'-Carboxyphenyl)retinoic acidNot Annotated
LuteinXanthophylls are taken for nutritional supplementation, and also for treating dietary shortage or imbalance.
NystatinA polyene ionophore antifungal used to treat cutaneous, mucocutaneous, and gastrointestinal mycotic infections, particularly those caused by Candida species.
Amphotericin BAn antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis.
NorbixinNorbixin is under investigation in clinical trial NCT03820245 (Effect of Short-term Annatto Carotenoids Supplementation on Oxidative Stress Status in Healthy Individuals).
FucoxanthinFucoxanthin is under investigation in clinical trial NCT03613740 (Effect of Fucoxanthin on the Components of the Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion).
BexaroteneA retinoid drug used for cutaneous manifestations of T-cell lymphoma in patients who have not responded well to previous systemic therapy.
TrifaroteneA topical retinoid indicated for the treatment of acne vulgaris.
Anhydrovitamin ANot Available
N-EthylretinamideN-Ethylretinamide is the ethylamide of all-trans B-retinoic acid.
Drugs & Drug Targets
DrugTargetType
Vitamin ARetinol dehydrogenase 12target
Vitamin A11-cis retinol dehydrogenasetarget
Vitamin ARetinol dehydrogenase 13target
Vitamin ARetinol-binding protein 5carrier
Vitamin ARetinoid-binding protein 7carrier
Vitamin ARetinol-binding protein 4carrier
Vitamin ARetinol-binding protein 2carrier
Vitamin ARetinal dehydrogenase 2target
Vitamin ARetinal dehydrogenase 1target
Vitamin ALecithin retinol acyltransferasetarget
Vitamin AShort-chain dehydrogenase/reductase 3target
Vitamin AAldehyde dehydrogenase family 1 member A3target
Vitamin AAll-trans-retinol 13,14-reductasetarget
Vitamin ARetinol dehydrogenase 11target
Vitamin ADehydrogenase/reductase SDR family member 4target
Vitamin ARetinol dehydrogenase 14target
Vitamin ARetinol dehydrogenase 8target
Vitamin ACytochrome P450 26A1enzyme
Vitamin AApolipoprotein Dtarget
Vitamin AProstaglandin-H2 D-isomerasetarget
Vitamin ASerum albumincarrier
Vitamin ARetinaldehyde-binding protein 1carrier
Vitamin ARetinol-binding protein 3carrier
Vitamin ARetinol-binding protein 1carrier
Vitamin AReceptor for retinol uptake STRA6transporter
AcitretinRetinoic acid receptor alphatarget
AcitretinRetinoic acid receptor RXR-betatarget
AcitretinRetinoic acid receptor gammatarget
AcitretinRetinoic acid receptor betatarget
AcitretinRetinoic acid receptor RXR-gammatarget
AcitretinRetinoic acid receptor RXR-alphatarget
AcitretinSerum albumincarrier
AcitretinRetinol-binding protein 1target
AcitretinRetinoic acid receptor RXRtarget
AlitretinoinRetinoic acid receptor alphatarget
AlitretinoinRetinoic acid receptor RXR-betatarget
AlitretinoinRetinoic acid receptor gammatarget
AlitretinoinRetinoic acid receptor betatarget
AlitretinoinRetinoic acid receptor RXR-gammatarget
AlitretinoinRetinoic acid receptor RXR-alphatarget
AlitretinoinCellular retinoic acid-binding protein 2carrier
AlitretinoinCellular retinoic acid-binding protein 1carrier
AlitretinoinP-glycoprotein 1transporter
AlitretinoinInsulin-like growth factor-binding protein 3target
AlitretinoinPregnancy-specific beta-1-glycoprotein 5target
AlitretinoinCytochrome P450 26C1target
AdenosineAdenosine receptor A3target
AdenosineAdenosine deaminaseenzyme
AdenosineAdenosine kinaseenzyme
AdenosineAdenosine receptor A1target
AdenosineAdenosine receptor A2atarget
AdenosineAdenosine receptor A2btarget
AdenosineSolute carrier family 28 member 3transporter
TretinoinRetinoic acid receptor gammatarget
TretinoinRetinoic acid receptor RXR-betatarget
TretinoinRetinal dehydrogenase 1target
TretinoinRetinoic acid-induced protein 3target
TretinoinRetinoic acid receptor RXR-gammatarget
TretinoinRetinal dehydrogenase 2target
TretinoinRetinoic acid receptor responder protein 1target
TretinoinCytochrome P450 2C8enzyme
TretinoinCellular retinoic acid-binding protein 1transporter
TretinoinCellular retinoic acid-binding protein 2transporter
TretinoinCytochrome P450 2B6enzyme
TretinoinCytochrome P450 3A4enzyme
TretinoinCytochrome P450 3A5enzyme
TretinoinCytochrome P450 2A6enzyme
TretinoinCytochrome P450 3A7enzyme
TretinoinCytochrome P450 2C18enzyme
TretinoinCytochrome P450 2C9enzyme
TretinoinCytochrome P450 4A11enzyme
TretinoinCytochrome P450 1A1enzyme
TretinoinRetinoic acid receptor alphatarget
TretinoinRetinoic acid receptor betatarget
TretinoinLipocalin-1target
TretinoinOdorant-binding protein 2atarget
TretinoinRetinol-binding protein 4target
TretinoinSerum albumincarrier
Tretinoin[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrialtarget
TretinoinRetinoic acid receptor RXR-alphatarget
TretinoinCytochrome P450 26A1target
TretinoinCytochrome P450 26B1target
TretinoinCytochrome P450 26C1target
TretinoinHematopoietic prostaglandin D synthasetarget
EtretinateRetinoic acid receptor alphatarget
EtretinateRetinoic acid receptor RXR-betatarget
EtretinateRetinoic acid receptor gammatarget
EtretinateRetinoic acid receptor betatarget
EtretinateRetinoic acid receptor RXR-gammatarget
EtretinateRetinoic acid receptor RXR-alphatarget
EtretinateCellular retinoic acid-binding protein 1carrier
EtretinateCytochrome P450 19A1enzyme
IsotretinoinRetinoic acid receptor alphatarget
IsotretinoinSerum albumincarrier
IsotretinoinRetinoic acid receptor gammatarget
IsotretinoinCytochrome P450 3A4enzyme
Arotinoid acidRetinoic acid receptor betatarget
AurodoxElongation factor Tu-Btarget
FenretinideRetinol-binding protein 4carrier
AstaxanthinNF-kappa-B inhibitor alphatarget
Beta caroteneBeta,beta-carotene 15,15'-dioxygenaseenzyme
Beta caroteneFree radicalstarget
Beta caroteneVery low-density lipoprotein receptorcarrier
Beta caroteneRetinol-binding protein 1carrier
Beta caroteneRetinol-binding protein 2carrier
Beta caroteneRetinol-binding protein 3carrier
Beta caroteneRetinol-binding protein 4carrier
Beta caroteneRetinol-binding protein 5carrier
3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acidRetinoic acid receptor gammatarget
Ro 12-7310Cellular retinoic acid-binding protein 2carrier
MepartricinCytochrome P450 3A4enzyme
LuteinSerum albumincarrier
NystatinErgosteroltarget
NystatinSolute carrier organic anion transporter family member 1B1transporter
NystatinSolute carrier organic anion transporter family member 1B3transporter
Amphotericin BErgosteroltarget
Amphotericin BCytochrome P450 3A4enzyme
BexaroteneRetinoic acid receptor RXR-betatarget
BexaroteneCytochrome P450 3A4enzyme
BexaroteneRetinoic acid receptor RXR-alphatarget
BexaroteneRetinoic acid receptor RXR-gammatarget
BexaroteneCytochrome P450 2C8enzyme
TrifaroteneCytochrome P450 2C9enzyme
TrifaroteneCytochrome P450 3A4enzyme
TrifaroteneCytochrome P450 2C8enzyme
TrifaroteneCytochrome P450 2B6enzyme
TrifaroteneRetinoic acid receptor gammatarget
TrifaroteneRetinoic acid receptor alphatarget
TrifaroteneRetinoic acid receptor betatarget
N-EthylretinamideRetinol-binding protein 4carrier