Diterpenes

Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.
DrugDrug NameDrug Description
DB00170MenadioneThe primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification.
DB01022PhylloquinoneA fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses.
DB01229PaclitaxelA taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer.
DB01248DocetaxelA taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer.
DB02426CarboxyatractylosideNot Available
DB02587ColforsinPotent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities;...
DB05265EcabetFor the treatment of reflux oesophagitis and peptic ulcer disease.
DB05297Paclitaxel docosahexaenoic acidInvestigated for use/treatment in breast cancer, colorectal cancer, gastric cancer, kidney cancer, lung cancer, pancreatic cancer, prostate cancer, and skin cancer.
DB05842AI-850Investigated for use/treatment in breast cancer and solid tumors.
DB06171Paclitaxel trevatideInvestigated for use/treatment in brain cancer.
DB06743Ginkgolide AGinkgolide A is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and...
DB06745ginkgolide-CNot Available
DB06746ginkgolide-JNot Available
DB06772CabazitaxelAn antineoplastic agent used for the treatment of hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing treatment regimen.
DB07814Gibberellic acidNot Available
DB07815GIBBERELLIN A4Not Available
DB11669OrtataxelOrtataxel has been used in trials studying the treatment of Lymphoma, Lung Cancer, Glioblastoma, and Kidney Cancer.
DB12019TesetaxelTesetaxel has been used in trials studying the treatment of Cancer, Melanoma, Prostate Cancer, Gastric Carcinoma, and Advanced Melanoma, among others.
DB12148MenatetrenoneMenatetrenone has been used in trials studying the treatment of Diabetes, Osteoporosis, Prediabetic State, and Hepatocellular Carcinoma.
DB12327Salvinorin ASalvinorin A has been investigated for the basic science of Pharmaceutical Preparations.
DB12334MilataxelMilataxel has been used in trials studying the treatment of Mesothelioma.
DB12434SteviolbiosideSteviolbioside has been used in trials studying the treatment of HIV-1 Infection.
DB12619BMS-188797BMS-188797 has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.
DB12633BMS-184476BMS-184476 has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.
DB12984LarotaxelLarotaxel has been used in trials studying the treatment of Cancer, Metastases, Breast Cancer, Breast Neoplasms, and Pancreatic Neoplasms, among others.
DB13075Menaquinone 7Menaquinone 7 is under investigation in clinical trial NCT00402974 (The Effect of Vitamin K Supplementation on Osteocalcin Carboxylation in Healthy Children).
DB13809Paclitaxel poliglumexNot Annotated
DB14650Menadiol diphosphateNot Annotated
DB14936Menaquinone 6Menaquinone 6 is under investigation in clinical trial NCT01194778 (Comparison of Efficacy of Different Dosages Vitamin K2).
DB15136Rebaudioside ARebaudioside A is under investigation in clinical trial NCT03510624 (Acute Effect of Rebaudioside A on Glucose Excursion During an Oral Glucose Tolerance Test in Type 2 Diabetes Mellitus).
DB15381MenaquinoneMenaquinone is under investigation in clinical trial NCT01533441 (Vitamin K2 Intervention in Patients With Vitamin K Antagonists).
DB15384SimotaxelSimotaxel is under investigation in clinical trial NCT00088647 (Study Evaluating MST-997 in Advanced Malignant Solid Tumors).
DrugDrug NameTargetType
DB00170MenadioneVitamin K-dependent protein Ztarget
DB00170MenadioneProthrombintarget
DB00170MenadioneVitamin K epoxide reductase complex subunit 1target
DB00170MenadioneCoagulation factor IXtarget
DB00170MenadioneCoagulation factor VIItarget
DB00170MenadioneCoagulation factor Xtarget
DB00170MenadioneVitamin K-dependent gamma-carboxylasetarget
DB00170MenadioneVitamin K-dependent protein Ctarget
DB00170MenadioneVitamin K-dependent protein Starget
DB00170MenadioneNAD(P)H dehydrogenase [quinone] 1target
DB00170MenadioneRibosyldihydronicotinamide dehydrogenase [quinone]target
DB00170MenadioneVitamin K epoxide reductase complex subunit 1-like protein 1target
DB00170MenadioneXanthine dehydrogenase/oxidaseenzyme
DB00170MenadioneAldehyde oxidaseenzyme
DB00170MenadioneMethylenetetrahydrofolate reductaseenzyme
DB00170MenadioneCytochrome P450 1A1enzyme
DB00170MenadioneOsteocalcintarget
DB00170MenadioneCytochrome P450 1A2enzyme
DB00170MenadioneCytochrome P450 2A6enzyme
DB01022PhylloquinoneVitamin K-dependent gamma-carboxylasetarget
DB01022PhylloquinoneOsteocalcintarget
DB01229PaclitaxelApoptosis regulator Bcl-2target
DB01229PaclitaxelTubulin beta-1 chaintarget
DB01229PaclitaxelCytochrome P450 2C8enzyme
DB01229PaclitaxelCytochrome P450 3A4enzyme
DB01229PaclitaxelCytochrome P450 3A5enzyme
DB01229PaclitaxelCytochrome P450 3A7enzyme
DB01229PaclitaxelBile salt export pumptransporter
DB01229PaclitaxelP-glycoprotein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 7transporter
DB01229PaclitaxelCytochrome P450 19A1enzyme
DB01229PaclitaxelCytochrome P450 1B1enzyme
DB01229PaclitaxelSolute carrier organic anion transporter family member 1B3transporter
DB01229PaclitaxelNuclear receptor subfamily 1 group I member 2target
DB01229PaclitaxelMicrotubule-associated protein 4target
DB01229PaclitaxelMicrotubule-associated protein 2target
DB01229PaclitaxelMicrotubule-associated protein tautarget
DB01229PaclitaxelCanalicular multispecific organic anion transporter 1transporter
DB01248DocetaxelApoptosis regulator Bcl-2target
DB01248DocetaxelTubulin beta-1 chaintarget
DB01248DocetaxelCytochrome P450 3A4enzyme
DB01248DocetaxelCytochrome P450 3A5enzyme
DB01248DocetaxelCytochrome P450 3A7enzyme
DB01248DocetaxelP-glycoprotein 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 7transporter
DB01248DocetaxelCytochrome P450 1B1enzyme
DB01248DocetaxelMicrotubule-associated protein 2target
DB01248DocetaxelMicrotubule-associated protein 4target
DB01248DocetaxelMicrotubule-associated protein tautarget
DB01248DocetaxelSolute carrier organic anion transporter family member 1B3transporter
DB01248DocetaxelSolute carrier family 22 member 7transporter
DB01248DocetaxelATP-binding cassette sub-family G member 2transporter
DB01248DocetaxelCanalicular multispecific organic anion transporter 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 1transporter
DB01248DocetaxelNuclear receptor subfamily 1 group I member 2target
DB02426CarboxyatractylosideADP/ATP translocase 1target
DB02587ColforsinP-glycoprotein 1transporter
DB02587ColforsinAdenylate cyclase type 2target
DB02587ColforsinGuanine nucleotide-binding protein G(s) subunit alpha isoforms shorttarget
DB02587ColforsinAdenylate cyclase type 5target
DB02587ColforsinCystic fibrosis transmembrane conductance regulatortarget
DB05265EcabetNADPH oxidase organizer 1target
DB05265EcabetUrease subunit alphatarget
DB05297Paclitaxel docosahexaenoic acidApoptosis regulator Bcl-2target
DB06772CabazitaxelCytochrome P450 3A4enzyme
DB06772CabazitaxelCytochrome P450 3A5enzyme
DB06772CabazitaxelCytochrome P450 2C8enzyme
DB06772CabazitaxelP-glycoprotein 1transporter
DB06772CabazitaxelATP-binding cassette sub-family G member 2transporter
DB06772CabazitaxelTubulin alpha-4A chaintarget
DB06772CabazitaxelTubulin beta-1 chaintarget
DB06772CabazitaxelSolute carrier organic anion transporter family member 1B1transporter
DB06772CabazitaxelSolute carrier organic anion transporter family member 1B3transporter
DB07814Gibberellic acidArylacetamide deacetylase-like 2target
DB07815GIBBERELLIN A4Arylacetamide deacetylase-like 2target
DB12334MilataxelTubulin beta-1 chaintarget
DB12334MilataxelTubulin beta chaintarget