Chemically-Induced Disorders

Name
Chemically-Induced Disorders
Accession Number
DBCAT000397
Description

Disorders caused by the intentional or unintentional ingestion or exposure to chemical substances such as PHARMACEUTICAL PREPARATIONS; NOXAE; and PESTICIDES.

Drugs
DrugDrug Description
FluvoxamineA selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder.
TiclopidineA platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA).
NevirapineA non-nucleoside reverse transcriptase inhibitor used as part of a management regimen for HIV-1 virus infection.
EnoxacinFor the treatment of adults (≥18 years of age) with the following infections caused by susceptible strains of the designated microorganisms: (1) uncomplicated urethral or cervical gonorrhea due to Neisseria...
FluoxetineA selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I.
PefloxacinFor the treatment of uncomplicated gonococcal urethritis in males and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract.
CimetidineA histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.
RitonavirAn HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection.
CiprofloxacinA second generation fluoroquinolone used to treat various susceptible bacterial infections.
VoriconazoleA triazole compound used to treat fungal infections.
EfavirenzA non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV.
ModafinilA stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder.
QuinidineA medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.
TioconazoleAn imidazole antifungal used to treat vulvovaginal candidiasis.
RifampicinAn antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis.
NorfloxacinA broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine.
MiconazoleAn azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis.
EconazoleA topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.
OfloxacinAn antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract.
ItraconazoleAn antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis.
OrphenadrineA muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort.
PhenobarbitalA long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures.
ClarithromycinA macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection.
SaquinavirAn HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency.
GemfibrozilA lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia.
PosaconazoleA triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
MibefradilFor the treatment of angina and high blood pressure.
AbirateroneAn antiandrogen used in the treatment of prostate cancer.
AvasimibeInvestigated for use/treatment in peripheral vascular disease.
CobicistatA CYP3A inhibitor used to increase the systemic exposure of atazanavir or darunavir in combination with other antiretroviral agents in the treatment of HIV-1 infection.
PiperineBioperine has been used in trials studying the treatment of Multiple Myeloma and Deglutition Disorders.
TalarozoleTalarozole has been investigated for the treatment of Psoriasis and Cutaneous Inflammation.
FurafyllineFurafylline is a derivative of methylxanthine derivative. It was developed on the context of asthma as a long-acting alternative for theophylline.
ArmodafinilA stimulant used to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea, narcolepsy, or shift work disorder.
Drugs & Drug Targets
DrugTargetType
FluvoxamineSodium-dependent serotonin transportertarget
FluvoxamineCytochrome P450 1A2enzyme
FluvoxamineCytochrome P450 2D6enzyme
FluvoxamineCytochrome P450 2C9enzyme
FluvoxamineCytochrome P450 2C19enzyme
FluvoxamineCytochrome P450 1A1enzyme
FluvoxamineCytochrome P450 3A4enzyme
FluvoxamineCytochrome P450 3A Subfamilyenzyme
FluvoxamineP-glycoprotein 1transporter
FluvoxamineCytochrome P450 2B6enzyme
FluvoxaminePotassium voltage-gated channel subfamily H member 2target
FluvoxamineBile salt export pumptransporter
TiclopidineP2Y purinoceptor 12target
TiclopidineCytochrome P450 2C19enzyme
TiclopidineCytochrome P450 2B6enzyme
TiclopidineCytochrome P450 2C9enzyme
TiclopidineCytochrome P450 2D6enzyme
TiclopidineMyeloperoxidaseenzyme
TiclopidineCytochrome P450 1A2enzyme
TiclopidineCytochrome P450 2C8enzyme
TiclopidineCytochrome P450 2E1enzyme
NevirapineCytochrome P450 3A4enzyme
NevirapineCytochrome P450 2B6enzyme
NevirapineCytochrome P450 3A5enzyme
NevirapineCytochrome P450 2C9enzyme
NevirapineCytochrome P450 2A6enzyme
NevirapineCytochrome P450 2D6enzyme
NevirapineReverse transcriptase/RNaseHtarget
NevirapineSerum albumincarrier
NevirapineCytochrome P450 1A2enzyme
NevirapineSolute carrier family 22 member 1transporter
NevirapineCytochrome P450 3A7enzyme
EnoxacinDNA gyrase subunit Atarget
EnoxacinDNA topoisomerase 4 subunit Atarget
EnoxacinDNA topoisomerase 2-alphatarget
EnoxacinCytochrome P450 1A2enzyme
FluoxetineSodium-dependent serotonin transportertarget
FluoxetineCytochrome P450 2C9enzyme
FluoxetineCytochrome P450 2D6enzyme
FluoxetineCYP2B proteinenzyme
FluoxetineCytochrome P450 1A2enzyme
FluoxetineCytochrome P450 3A4enzyme
FluoxetineCytochrome P450 2C19enzyme
FluoxetineP-glycoprotein 1transporter
FluoxetineCytochrome P450 2B6enzyme
FluoxetineCytochrome P450 3A5enzyme
FluoxetineSerum albumincarrier
FluoxetineAlpha-1-acid glycoprotein 1carrier
FluoxetinePotassium voltage-gated channel subfamily H member 2target
Fluoxetine5-hydroxytryptamine receptor 2Ctarget
FluoxetineCyclin-dependent kinases regulatory subunit 1target
FluoxetineNeuronal acetylcholine receptor subunit alpha-2target
FluoxetineNeuronal acetylcholine receptor subunit alpha-3target
FluoxetineNeuronal acetylcholine receptor subunit beta-4target
PefloxacinDNA gyrase subunit Atarget
PefloxacinDNA topoisomerase 4 subunit Atarget
PefloxacinDNA topoisomerase 2-alphatarget
PefloxacinCytochrome P450 1A2enzyme
PefloxacinDNA topoisomerase 1target
CimetidineHistamine H2 receptortarget
CimetidineCytochrome P450 1A2enzyme
CimetidineCytochrome P450 2D6enzyme
CimetidineCytochrome P450 2C19enzyme
CimetidineCytochrome P450 3A4enzyme
CimetidineCytochrome P450 3A5enzyme
CimetidineP-glycoprotein 1transporter
CimetidineSolute carrier family 22 member 2transporter
CimetidineSolute carrier family 22 member 1transporter
CimetidineSolute carrier family 22 member 3transporter
CimetidineSolute carrier family 22 member 5transporter
CimetidineSolute carrier family 22 member 6transporter
CimetidineSolute carrier family 22 member 8transporter
CimetidineMultidrug and toxin extrusion protein 1transporter
CimetidineSolute carrier family 22 member 4transporter
CimetidineSolute carrier family 22 member 11transporter
CimetidineSolute carrier family 22 member 7transporter
CimetidineCytochrome P450 11B1, mitochondrialenzyme
CimetidineCytochrome P450 2C8enzyme
CimetidineCytochrome P450 2C9enzyme
CimetidineCytochrome P450 2E1enzyme
CimetidineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
CimetidineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
CimetidineBile salt export pumptransporter
CimetidineMultidrug and toxin extrusion protein 2transporter
RitonavirHuman immunodeficiency virus type 1 proteasetarget
RitonavirCytochrome P450 2D6enzyme
RitonavirCytochrome P450 2C9enzyme
RitonavirCytochrome P450 2C19enzyme
RitonavirCytochrome P450 2B6enzyme
RitonavirCytochrome P450 2C8enzyme
RitonavirP-glycoprotein 1transporter
RitonavirMultidrug resistance-associated protein 1transporter
RitonavirCanalicular multispecific organic anion transporter 1transporter
RitonavirSolute carrier organic anion transporter family member 1A2transporter
RitonavirATP-binding cassette sub-family G member 2transporter
RitonavirSolute carrier organic anion transporter family member 1B1transporter
RitonavirCytochrome P450 1A2enzyme
RitonavirNuclear receptor subfamily 1 group I member 2target
RitonavirSerum albumincarrier
RitonavirCytochrome P450 3A4enzyme
RitonavirCytochrome P450 3A5enzyme
RitonavirCytochrome P450 3A7enzyme
RitonavirUDP-glucuronosyltransferases (UGTs)enzyme
RitonavirSolute carrier organic anion transporter family member 2B1transporter
RitonavirBile salt export pumptransporter
RitonavirAlpha-1-acid glycoprotein 1carrier
RitonavirSolute carrier organic anion transporter family member 1B3transporter
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Atarget
CiprofloxacinDNA topoisomerase 2-alphatarget
CiprofloxacinCytochrome P450 1A2enzyme
CiprofloxacinCytochrome P450 3A4enzyme
CiprofloxacinCytochrome P450 3A5enzyme
CiprofloxacinCytochrome P450 3A7enzyme
CiprofloxacinP-glycoprotein 1transporter
CiprofloxacinPotassium voltage-gated channel subfamily H member 2target
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Btarget
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinMultidrug resistance protein MdtKtarget
CiprofloxacinGyrase Atarget
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinMultidrug and toxin extrusion protein 1transporter
CiprofloxacinMultidrug and toxin extrusion protein 2transporter
CiprofloxacinSerum albumincarrier
VoriconazoleCytochrome P450 2C19enzyme
VoriconazoleCytochrome P450 3A4enzyme
VoriconazoleCytochrome P450 2C9enzyme
VoriconazoleDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
VoriconazoleDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
VoriconazoleCytochrome P450 3A5enzyme
VoriconazoleCytochrome P450 3A7enzyme
VoriconazoleProstaglandin G/H synthase 1enzyme
VoriconazoleCytochrome P450 51target
VoriconazoleCytochrome P450 2B6enzyme
EfavirenzCytochrome P450 2B6enzyme
EfavirenzCytochrome P450 3A4enzyme
EfavirenzCytochrome P450 2C19enzyme
EfavirenzCytochrome P450 2C9enzyme
EfavirenzCytochrome P450 1A2enzyme
EfavirenzCytochrome P450 2D6enzyme
EfavirenzReverse transcriptase/RNaseHtarget
EfavirenzCytochrome P450 2C8enzyme
EfavirenzSerum albumincarrier
EfavirenzCytochrome P450 3A5enzyme
EfavirenzCytochrome P450 3A7enzyme
EfavirenzUDP-glucuronosyltransferase 1-1enzyme
EfavirenzBile salt export pumptransporter
EfavirenzSolute carrier family 22 member 1transporter
ModafinilSodium-dependent dopamine transportertarget
ModafinilAlpha-1B adrenergic receptortarget
ModafinilCytochrome P450 3A4enzyme
ModafinilCytochrome P450 2C19enzyme
ModafinilCytochrome P450 1A2enzyme
ModafinilCytochrome P450 2B6enzyme
ModafinilCytochrome P450 2C9enzyme
ModafinilCytochrome P450 3A5enzyme
QuinidineSodium channel protein type 5 subunit alphatarget
QuinidineAlpha-1-acid glycoprotein 1carrier
QuinidinePotassium voltage-gated channel subfamily H member 2target
QuinidinePotassium channel subfamily K member 1target
QuinidinePotassium channel subfamily K member 6target
QuinidineCytochrome P450 1A2enzyme
QuinidineCytochrome P450 2E1enzyme
QuinidineCytochrome P450 1A1enzyme
QuinidineCytochrome P450 2D6enzyme
QuinidineCytochrome P450 3A4enzyme
QuinidineCytochrome P450 3A7enzyme
QuinidineSolute carrier family 22 member 2transporter
QuinidineSolute carrier family 22 member 1transporter
QuinidineSolute carrier family 22 member 5transporter
QuinidineP-glycoprotein 1transporter
QuinidineSolute carrier organic anion transporter family member 1A2transporter
QuinidineSolute carrier family 22 member 8transporter
QuinidineCanalicular multispecific organic anion transporter 1transporter
QuinidineSolute carrier family 22 member 4transporter
QuinidineSolute carrier organic anion transporter family member 1B1transporter
QuinidineCytochrome P450 2B6enzyme
QuinidineCytochrome P450 2C9enzyme
QuinidineAlpha-1A adrenergic receptortarget
QuinidineAlpha-1B adrenergic receptortarget
QuinidineAlpha-1D adrenergic receptortarget
QuinidineBile salt export pumptransporter
QuinidineCytochrome P450 2C8enzyme
TioconazoleLanosterol 14-alpha demethylasetarget
TioconazoleCytochrome P450 19A1enzyme
TioconazoleCytochrome P450 2C19enzyme
TioconazoleCytochrome P450 2E1enzyme
TioconazoleCytochrome P450 3A4enzyme
TioconazoleCytochrome P450 51target
RifampicinDNA-directed RNA polymerase subunit betatarget
RifampicinNuclear receptor subfamily 1 group I member 2target
RifampicinCytochrome P450 3A4enzyme
RifampicinCytochrome P450 1A2enzyme
RifampicinCytochrome P450 2C8enzyme
RifampicinUDP-glucuronosyltransferase 1-1enzyme
RifampicinCytochrome P450 2C9enzyme
RifampicinCytochrome P450 2B6enzyme
RifampicinCytochrome P450 2C19enzyme
RifampicinCanalicular multispecific organic anion transporter 2transporter
RifampicinMultidrug resistance-associated protein 5transporter
RifampicinP-glycoprotein 1transporter
RifampicinCanalicular multispecific organic anion transporter 1transporter
RifampicinSolute carrier organic anion transporter family member 2B1transporter
RifampicinBile salt export pumptransporter
RifampicinMultidrug resistance-associated protein 1transporter
RifampicinSolute carrier organic anion transporter family member 1A2transporter
RifampicinSolute carrier organic anion transporter family member 1B3transporter
RifampicinSolute carrier family 22 member 7transporter
RifampicinSolute carrier organic anion transporter family member 1B1transporter
RifampicinCytochrome P450 2A6enzyme
RifampicinCytochrome P450 2E1enzyme
RifampicinCytochrome P450 3A43enzyme
RifampicinCytochrome P450 3A7enzyme
RifampicinSolute carrier family 22 member 6transporter
RifampicinSolute carrier family 22 member 8transporter
RifampicinUDP-glucuronosyltransferase 1-9enzyme
RifampicinCytochrome P450 3A5enzyme
RifampicinSerum albumincarrier
Rifampicinalpha1-acid glycoproteincarrier
NorfloxacinDNA gyrase subunit Atarget
NorfloxacinDNA topoisomerase 4 subunit Atarget
NorfloxacinDNA topoisomerase 2-alphatarget
NorfloxacinCytochrome P450 1A2enzyme
NorfloxacinCytochrome P450 3A4enzyme
NorfloxacinSolute carrier family 22 member 5transporter
NorfloxacinSolute carrier family 22 member 6transporter
NorfloxacinCytochrome P450 1A1enzyme
MiconazoleCytochrome P450 2C9enzyme
MiconazoleCytochrome P450 2D6enzyme
MiconazoleCytochrome P450 3A4enzyme
MiconazoleP-glycoprotein 1transporter
MiconazoleCytochrome P450 51target
MiconazoleNitric oxide synthase, endothelialtarget
MiconazoleNitric oxide synthase, inducibletarget
MiconazoleCytochrome P450 11B1, mitochondrialenzyme
MiconazoleCytochrome P450 2A6enzyme
MiconazoleCytochrome P450 2B6enzyme
MiconazoleCytochrome P450 2C19enzyme
MiconazoleCytochrome P450 2E1enzyme
MiconazoleNuclear receptor subfamily 1 group I member 2target
MiconazoleLanosterol 14-alpha demethylaseenzyme
MiconazoleCytochrome P450 19A1enzyme
MiconazoleCalcium-activated potassium channeltarget
MiconazoleVoltage-gated Potassium Channelstarget
MiconazoleInward rectifier potassium channeltarget
MiconazoleVoltage gated L-type calcium channeltarget
MiconazoleSerum albumincarrier
MiconazoleCytochrome P450 2C8enzyme
EconazoleCytochrome P450 19A1enzyme
EconazoleCytochrome P450 2E1enzyme
EconazoleCytochrome P450 3A4enzyme
EconazoleCytochrome P450 51target
EconazoleNuclear receptor subfamily 1 group I member 2target
OfloxacinDNA gyrase subunit Atarget
OfloxacinDNA topoisomerase 4 subunit Atarget
OfloxacinDNA topoisomerase 2-alphatarget
OfloxacinCytochrome P450 1A2enzyme
OfloxacinSolute carrier family 22 member 5transporter
OfloxacinMultidrug resistance-associated protein 1transporter
OfloxacinSolute carrier family 22 member 6transporter
OfloxacinCanalicular multispecific organic anion transporter 1transporter
OfloxacinSolute carrier family 22 member 4transporter
OfloxacinBile salt export pumptransporter
ItraconazoleLanosterol 14-alpha demethylasetarget
ItraconazoleLanosterol 14-alpha demethylasetarget
ItraconazoleCytochrome P450 3A4enzyme
ItraconazoleCytochrome P450 3A5enzyme
ItraconazoleCytochrome P450 3A7enzyme
ItraconazoleCytochrome P450 2B6enzyme
ItraconazoleP-glycoprotein 1transporter
ItraconazoleCytochrome P450 1A1enzyme
ItraconazoleCytochrome P450 2E1enzyme
ItraconazoleSolute carrier organic anion transporter family member 2B1transporter
OrphenadrineGlutamate receptor ionotropic, NMDA 1target
OrphenadrineGlutamate receptor ionotropic, NMDA 2Dtarget
OrphenadrineGlutamate receptor ionotropic, NMDA 3Btarget
OrphenadrineGlutamate receptor ionotropic, NMDA 3Atarget
OrphenadrineHistamine H1 receptortarget
OrphenadrineCytochrome P450 2B6enzyme
OrphenadrineCytochrome P450 2E1enzyme
OrphenadrineCytochrome P450 3A4enzyme
OrphenadrineSodium-dependent noradrenaline transportertarget
OrphenadrineSodium channel protein type 10 subunit alphatarget
OrphenadrineCytochrome P450 1A2enzyme
OrphenadrineCytochrome P450 2D6enzyme
PhenobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
PhenobarbitalCytochrome P450 2C19enzyme
PhenobarbitalCytochrome P450 2C9enzyme
PhenobarbitalCytochrome P450 2B6enzyme
PhenobarbitalCytochrome P450 2C8enzyme
PhenobarbitalCytochrome P450 1A2enzyme
PhenobarbitalCytochrome P450 3A4enzyme
PhenobarbitalCanalicular multispecific organic anion transporter 2transporter
PhenobarbitalBile salt export pumptransporter
PhenobarbitalP-glycoprotein 1transporter
PhenobarbitalMultidrug resistance-associated protein 1transporter
PhenobarbitalSolute carrier organic anion transporter family member 2A1transporter
PhenobarbitalCanalicular multispecific organic anion transporter 1transporter
PhenobarbitalNeuronal acetylcholine receptor subunit alpha-4target
PhenobarbitalNeuronal acetylcholine receptor subunit alpha-7target
PhenobarbitalGlutamate receptor 2target
PhenobarbitalGlutamate receptor ionotropic, kainate 2target
PhenobarbitalCytochrome P450 2A6enzyme
PhenobarbitalCytochrome P450 2E1enzyme
PhenobarbitalCytochrome P450 3A5enzyme
PhenobarbitalCytochrome P450 1A1enzyme
PhenobarbitalCytochrome P450 2C18enzyme
PhenobarbitalCytochrome P450 3A7enzyme
PhenobarbitalCytochrome P450 4B1enzyme
PhenobarbitalNMDA receptortarget
PhenobarbitalNuclear receptor subfamily 1 group I member 2target
PhenobarbitalUDP-glucuronosyltransferase 1-1enzyme
PhenobarbitalUDP-glucuronosyltransferase 2B7enzyme
Clarithromycin50S ribosomal protein L10target
ClarithromycinCytochrome P450 3A4enzyme
ClarithromycinCytochrome P450 3A5enzyme
ClarithromycinP-glycoprotein 1transporter
ClarithromycinSolute carrier family 22 member 7transporter
ClarithromycinPotassium voltage-gated channel subfamily H member 2target
ClarithromycinSolute carrier organic anion transporter family member 1B1target
ClarithromycinSolute carrier organic anion transporter family member 1B3target
ClarithromycinBile salt export pumptransporter
ClarithromycinSolute carrier organic anion transporter family member 1B1transporter
ClarithromycinSolute carrier organic anion transporter family member 1B3transporter
SaquinavirHuman immunodeficiency virus type 1 proteasetarget
SaquinavirCytochrome P450 3A4enzyme
SaquinavirCytochrome P450 3A5enzyme
SaquinavirAlpha-1-acid glycoprotein 1carrier
SaquinavirSerum albumincarrier
SaquinavirCytochrome P450 3A7enzyme
SaquinavirP-glycoprotein 1transporter
SaquinavirSolute carrier family 22 member 1transporter
SaquinavirSolute carrier organic anion transporter family member 1A2transporter
SaquinavirATP-binding cassette sub-family G member 2transporter
SaquinavirSolute carrier organic anion transporter family member 1B1transporter
SaquinavirMultidrug resistance-associated protein 1transporter
SaquinavirCanalicular multispecific organic anion transporter 1transporter
SaquinavirCytochrome P450 2C8enzyme
SaquinavirCytochrome P450 2D6enzyme
SaquinavirSolute carrier organic anion transporter family member 2B1transporter
SaquinavirBile salt export pumptransporter
GemfibrozilPeroxisome proliferator-activated receptor alphatarget
GemfibrozilCytochrome P450 2C9enzyme
GemfibrozilCytochrome P450 2C8enzyme
GemfibrozilCytochrome P450 1A2enzyme
GemfibrozilCytochrome P450 2C19enzyme
GemfibrozilUDP-glucuronosyltransferase 1-1enzyme
GemfibrozilCytochrome P450 3A4enzyme
GemfibrozilUDP-glucuronosyltransferase 1-3enzyme
GemfibrozilSolute carrier organic anion transporter family member 1B1target
GemfibrozilUDP-glucuronosyltransferase 2B7enzyme
GemfibrozilUDP-glucuronosyltransferase 1-9enzyme
GemfibrozilUDP-glucuronosyltransferase 2B4enzyme
GemfibrozilUDP-glucuronosyltransferase 2B17enzyme
GemfibrozilSerum albumincarrier
GemfibrozilSolute carrier family 22 member 8target
GemfibrozilSolute carrier organic anion transporter family member 2B1target
GemfibrozilSolute carrier organic anion transporter family member 1B3target
PosaconazoleCytochrome P450 3A4enzyme
PosaconazoleP-glycoprotein 1transporter
PosaconazoleCytochrome P450 51target
MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Htarget
MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
MibefradilVoltage-dependent L-type calcium channel subunit beta-1target
MibefradilCytochrome P450 3A4enzyme
MibefradilCytochrome P450 1A2enzyme
MibefradilCytochrome P450 2D6enzyme
MibefradilCytochrome P450 3A5enzyme
MibefradilCytochrome P450 3A7enzyme
MibefradilP-glycoprotein 1transporter
MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Itarget
MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Starget
MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
MibefradilVoltage-dependent L-type calcium channel subunit beta-2target
MibefradilVoltage-dependent L-type calcium channel subunit beta-3target
MibefradilVoltage-dependent L-type calcium channel subunit beta-4target
MibefradilCytochrome P450 11B1, mitochondrialenzyme
MibefradilCytochrome P450 11B2, mitochondrialenzyme
AbirateroneSteroid 17-alpha-hydroxylase/17,20 lyasetarget
AbirateroneSerum albumincarrier
AbirateroneAlpha-1-acid glycoprotein 1carrier
AbirateroneCytochrome P450 3A4enzyme
AbirateroneBile salt sulfotransferaseenzyme
AbirateroneMultidrug resistance-associated protein 1transporter
AbirateroneCytochrome P450 2D6enzyme
AbirateroneCytochrome P450 2C8enzyme
AbirateroneCytochrome P450 1A2enzyme
AbirateroneCytochrome P450 2C19enzyme
AbirateroneCytochrome P450 2C9enzyme
AvasimibeLiver carboxylesterase 1target
AvasimibeCytochrome P450 3A4enzyme
AvasimibeCytochrome P450 2C9enzyme
AvasimibeCytochrome P450 1A2enzyme
AvasimibeCytochrome P450 2C19enzyme
CobicistatCytochrome P450 2D6enzyme
CobicistatP-glycoprotein 1transporter
CobicistatATP-binding cassette sub-family G member 2transporter
CobicistatCytochrome P450 3A4enzyme
CobicistatCytochrome P450 3A5enzyme
CobicistatCytochrome P450 3A7enzyme
CobicistatCytochrome P450 3A43enzyme
CobicistatSolute carrier organic anion transporter family member 1B1transporter
CobicistatSolute carrier organic anion transporter family member 1B3transporter
PiperineNuclear receptor subfamily 1 group I member 2target
PiperineCytochrome P450 3A4enzyme
PiperineP-glycoprotein 1transporter
TalarozoleCytochrome P450 26A1target
FurafyllineCytochrome P450 1A2enzyme
ArmodafinilCytochrome P450 2C19enzyme
ArmodafinilCytochrome P450 3A4enzyme
ArmodafinilCytochrome P450 1A2enzyme
ArmodafinilCytochrome P450 2B6enzyme
ArmodafinilCytochrome P450 3A5enzyme
ArmodafinilCytochrome P450 2C9enzyme
ArmodafinilSodium-dependent dopamine transportertarget