Angiotensin-Converting Enzyme Inhibitors

Name
Angiotensin-Converting Enzyme Inhibitors
Accession Number
DBCAT000415  (DBCAT002174)
Description

A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.

ATC Classification
Drugs
DrugDrug Description
RamiprilAn ACE inhibitor used for the management of hypertension and the reduction of cardiovascular mortality following myocardial infarction in hemodynamically stable patients with clinical signs of congestive heart failure.
FosinoprilAn ACE inhibitor used to treat mild to moderate hypertension, congestive heart failure, and to slow the progression of renal disease in hypertensive diabetics.
TrandolaprilA prodrug of an ACE inhibitor used to treat hypertension, congestive heart failure, and to improve survival following a myocardial infarction.
BenazeprilAn ACE inhibitor prodrug used to treat hypertension.
EnalaprilA prodrug of an ACE inhibitor used to treat hypertension and congestive heart failure.
MoexiprilAn angiotensin converting enzyme inhibitor prodrug used to treat hypertension.
LisinoprilAn ACE inhibitor used to treat hypertension, heart failure, and acute myocardial infarction.
PerindoprilAn ACE inhibitor prodrug used to treat hypertension, mild to moderate congestive heart failure, and to reduce cardiovascular risk in patients with hypertension or post-myocardial infarction.
QuinaprilAn ACE inhibitor prodrug used to treat hypertension, congestive heart failure, and slow rate of progression of renal disease.
CaptoprilAn ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy.
CilazaprilAn ACE inhibitor used for the management of hypertension and heart failure.
SpiraprilSpirapril is an ACE inhibitor class drug used to treat hypertension.
EnalaprilatAn antihypertensive agent used for the management of hypertension when oral therapy is not practical.
TemocaprilTemocapril is an ACE inhibitor primarily indicated in the treatment of hypertension and congestive heart failure, diabetic nephropathy, and improvement of prognosis for coronary artery diseases (including acute myocardial infarction).
ZofenoprilAn ACE inhibitor indicated in the treatment of hypertension.
OmapatrilatFor the treatment of hypertension.
ImidaprilAn ACE inhibitor used in the treatment of essential hypertension.
DelaprilAn ACE inhibitor indicated in the treatment of essential hypertension.
RescinnamineFor the treatment of hypertension.
BenazeprilatNot Annotated
FosinoprilatFosinoprilat is the active phosphinic acid metabolite of prodrug fosinopril, which is activated by esterases in vivo. It binds zinc with phosphinic acid group.
RamiprilatThe active metabolite of the prodrug Ramipril.
PerindoprilatThe active metabolite of the prodrug Perindopril.
QuinaprilatThe active metabolite of the prodrug quinapril.
TrandolaprilatThe active metabolite of the prodrug Trandolapril.
MoexiprilatThe active metabolite of the prodrug Moexipril.
CilazaprilatNot Annotated
N-(2-Aminoethyl)-1-aziridineethanamineAn experimental ACE2 inhibitor for the treatment of cardiovascular disease and Severe Acute Respiratory Syndrome.
Drugs & Drug Targets
DrugTargetType
RamiprilAngiotensin-converting enzymetarget
RamiprilSolute carrier family 15 member 1transporter
RamiprilSolute carrier family 15 member 2transporter
RamiprilCholinesteraseenzyme
RamiprilB1 bradykinin receptortarget
FosinoprilAngiotensin-converting enzymetarget
FosinoprilSolute carrier family 15 member 1transporter
FosinoprilSolute carrier family 15 member 2transporter
TrandolaprilAngiotensin-converting enzymetarget
TrandolaprilSolute carrier family 15 member 1transporter
TrandolaprilSolute carrier family 15 member 2transporter
TrandolaprilLiver carboxylesterase 1enzyme
BenazeprilAngiotensin-converting enzymetarget
BenazeprilMethylenetetrahydrofolate reductaseenzyme
BenazeprilSolute carrier family 15 member 1transporter
BenazeprilSolute carrier family 15 member 2transporter
EnalaprilAngiotensin-converting enzymetarget
EnalaprilP-glycoprotein 1transporter
EnalaprilSolute carrier family 15 member 1transporter
EnalaprilSolute carrier family 22 member 6transporter
EnalaprilSolute carrier family 22 member 8transporter
EnalaprilSolute carrier family 22 member 7transporter
EnalaprilSolute carrier organic anion transporter family member 1A2transporter
EnalaprilSerum albumincarrier
MoexiprilAngiotensin-converting enzymetarget
MoexiprilSolute carrier family 15 member 1transporter
MoexiprilSolute carrier family 15 member 2transporter
LisinoprilAngiotensin-converting enzymetarget
LisinoprilSolute carrier family 15 member 1transporter
LisinoprilSolute carrier family 15 member 2transporter
LisinoprilRenintarget
PerindoprilAngiotensin-converting enzymetarget
PerindoprilSolute carrier family 15 member 1transporter
PerindoprilSolute carrier family 15 member 2transporter
PerindoprilCholinesteraseenzyme
PerindoprilSecreted frizzled-related protein 4target
QuinaprilAngiotensin-converting enzymetarget
QuinaprilSolute carrier family 15 member 1transporter
QuinaprilSolute carrier family 15 member 2transporter
QuinaprilSolute carrier family 22 member 8transporter
QuinaprilLiver carboxylesterase 1enzyme
QuinaprilSerum albumincarrier
CaptoprilAngiotensin-converting enzymetarget
CaptoprilSerum albumincarrier
Captopril72 kDa type IV collagenasetarget
CaptoprilMatrix metalloproteinase-9target
CaptoprilP-glycoprotein 1transporter
CaptoprilSolute carrier family 15 member 1transporter
CaptoprilSolute carrier family 22 member 6transporter
CaptoprilLeukotriene A-4 hydrolasetarget
CaptoprilB1 bradykinin receptortarget
CilazaprilAngiotensin-converting enzymetarget
CilazaprilP-glycoprotein 1transporter
CilazaprilSolute carrier family 15 member 1transporter
CilazaprilSolute carrier family 15 member 2transporter
SpiraprilAngiotensin-converting enzymetarget
SpiraprilSolute carrier family 15 member 1transporter
SpiraprilSolute carrier family 15 member 2transporter
EnalaprilatAngiotensin-converting enzymetarget
EnalaprilatB1 bradykinin receptortarget
TemocaprilSolute carrier family 15 member 1transporter
TemocaprilSolute carrier organic anion transporter family member 1A2transporter
TemocaprilAngiotensin-converting enzymetarget
ZofenoprilAngiotensin-converting enzymetarget
OmapatrilatNeprilysintarget
OmapatrilatAngiotensin-converting enzymetarget
RescinnamineAngiotensin-converting enzymetarget
CilazaprilatAngiotensin-converting enzymetarget
N-(2-Aminoethyl)-1-aziridineethanamineAngiotensin-converting enzyme 2target