gamma-Aminobutyric Acid

Name
gamma-Aminobutyric Acid
Accession Number
DBCAT000423
Description

The most common inhibitory neurotransmitter in the central nervous system.

Drugs
DrugDrug Description
BaclofenA GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients.
PregabalinAn anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants.
VigabatrinAn irreversible GABA transaminase inhibitor used as an adjunct therapy to treat refractory complex partial seizures in patients ≥2 years unresponsive to alternatives. May also be used as monotherapy to treat infantile spasms in infants 1 month to 2 years.
Arbaclofen PlacarbilInvestigated for the treatment of spasticity in multiple sclerosis, acute back spasms, and GERD.
gamma-Aminobutyric acidThe most common inhibitory neurotransmitter in the central nervous system.
GabapentinAn anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures.
Drugs & Drug Targets
DrugTargetType
BaclofenGamma-aminobutyric acid type B receptor subunit 1target
BaclofenGamma-aminobutyric acid type B receptor subunit 2target
PregabalinExcitatory amino acid transporter 3transporter
PregabalinVoltage-dependent calcium channel subunit alpha-2/delta-1target
PregabalinLarge neutral amino acids transporter small subunit 1transporter
Vigabatrin4-aminobutyrate aminotransferase, mitochondrialtarget
VigabatrinProton-coupled amino acid transporter 1transporter
VigabatrinCytochrome P450 2C9enzyme
Arbaclofen PlacarbilMonocarboxylate transporter 1transporter
Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 1target
Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 2target
gamma-Aminobutyric acidGlycine amidinotransferase, mitochondrialtarget
gamma-Aminobutyric acidProton-coupled amino acid transporter 1transporter
gamma-Aminobutyric acidGamma-aminobutyric acid type B receptor subunit 1target
gamma-Aminobutyric acidGamma-aminobutyric acid type B receptor subunit 2target
GabapentinAdenosine receptor A1target
GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-1target
GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-2target
GabapentinBranched-chain-amino-acid aminotransferase, cytosolicenzyme
GabapentinLarge neutral amino acids transporter small subunit 1transporter
GabapentinVoltage-dependent N-type calcium channeltarget
GabapentinPotassium voltage-gated channel subfamily KQT member 3target
GabapentinPotassium voltage-gated channel subfamily KQT member 5target