gamma-Aminobutyric Acid

The most common inhibitory neurotransmitter in the central nervous system.
DrugDrug NameDrug Indication
DB00181BaclofenBaclofen is administered for the relief of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and associated pain and clonus, in addition to muscular rigidity [FDA label]. Patients receiving this drug should have reversible spasticity for baclofen to promote the restoration of residual function. This drug is not indicated in the treatment of skeletal muscle spasm caused by rheumatic disorders. The efficacy of baclofen in stroke, cerebral palsy, and Parkinson's disease has not been determined and, therefore, baclofen is not recommended for these conditions [FDA label].
DB00230PregabalinPregabalin is used for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, and as adjunctive therapy for adult patients with partial onset seizures [FDA label].
DB01080VigabatrinFor use as an adjunct in treatment resistant epilepsy, refractory complex partial seizures, and secondary generalized seizures. It is also used as monotherapy in infantile spasms in West syndrome.
DB08892Arbaclofen PlacarbilInvestigated for the treatment of spasticity in multiple sclerosis, acute back spasms, and GERD.
DB02530gamma-Aminobutyric acidNot Available
DB00996GabapentinFor the management of postherpetic neuralgia in adults and as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy.
DrugDrug NameTargetType
DB00181BaclofenGamma-aminobutyric acid type B receptor subunit 1target
DB00181BaclofenGamma-aminobutyric acid type B receptor subunit 2target
DB00230PregabalinExcitatory amino acid transporter 3transporter
DB00230PregabalinVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00230PregabalinLarge neutral amino acids transporter small subunit 1transporter
DB01080Vigabatrin4-aminobutyrate aminotransferase, mitochondrialtarget
DB01080VigabatrinGamma-aminobutyric acid type B receptor subunit 1target
DB01080VigabatrinProton-coupled amino acid transporter 1transporter
DB01080VigabatrinCytochrome P450 2C9enzyme
DB08892Arbaclofen PlacarbilMonocarboxylate transporter 1transporter
DB08892Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 1target
DB08892Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 2target
DB02530gamma-Aminobutyric acidGlycine amidinotransferase, mitochondrialtarget
DB02530gamma-Aminobutyric acidProton-coupled amino acid transporter 1transporter
DB02530gamma-Aminobutyric acidGamma-aminobutyric acid type B receptor subunit 1target
DB02530gamma-Aminobutyric acidGamma-aminobutyric acid type B receptor subunit 2target
DB00996GabapentinAdenosine receptor A1target
DB00996GabapentinVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00996GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00996GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-2target
DB00996GabapentinBranched-chain-amino-acid aminotransferase, cytosolicenzyme
DB00996GabapentinNMDA receptortarget
DB00996GabapentinGamma-aminobutyric acid type B receptor subunit 1target
DB00996GabapentinGamma-aminobutyric acid type B receptor subunit 2target
DB00996GabapentinCytochrome P450 3A4enzyme