Aminobutyrates

Name
Aminobutyrates
Accession Number
DBCAT000424
Description

Derivatives of BUTYRIC ACID that contain one or more amino groups attached to the aliphatic structure. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the aminobutryrate structure.

ATC Classification
Drugs
DrugDrug Description
BaclofenA GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients.
PregabalinAn anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants.
ProgabideIndicated for the treatment of epilepsy.
GabapentinAn anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures.
VigabatrinAn irreversible GABA transaminase inhibitor used as an adjunct to treat refractory complex partial seizures in patients ≥10 years unresponsive to alternatives. May also be used as monotherapy to treat infantile spasms in infants 1 month to 2 years.
2-aminoisobutyric acidNot Available
BL-1020Investigated for use/treatment in schizophrenia and schizoaffective disorders.
Gabapentin enacarbilA gabapentin prodrug used to treat Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
Arbaclofen PlacarbilInvestigated for the treatment of spasticity in multiple sclerosis, acute back spasms, and GERD.
PD-217014PD-217,014 has been used in trials studying the treatment of Pain and Irritable Bowel Syndrome.
PivagabinePivagabine has been used in trials studying the treatment of Stress and Anxiety.
PhenibutNot Annotated
Hopantenic acidHopantenic acid (Pantogam) is a central nervous system depressant. Hopantenic acid has a unique spectrum of pharmacological effects (nootropic, anticonvulsant, mild activating) in the absence of addiction, hyperstimulation or withdrawal...
gamma-Aminobutyric acidThe most common inhibitory neurotransmitter in the central nervous system.
Drugs & Drug Targets
DrugTargetType
BaclofenGamma-aminobutyric acid type B receptor subunit 1target
BaclofenGamma-aminobutyric acid type B receptor subunit 2target
PregabalinExcitatory amino acid transporter 3transporter
PregabalinVoltage-dependent calcium channel subunit alpha-2/delta-1target
PregabalinLarge neutral amino acids transporter small subunit 1transporter
ProgabideGamma-aminobutyric acid receptor subunit alpha-1target
ProgabideGamma-aminobutyric acid type B receptor subunit 1target
GabapentinAdenosine receptor A1target
GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-1target
GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-2target
GabapentinBranched-chain-amino-acid aminotransferase, cytosolicenzyme
GabapentinLarge neutral amino acids transporter small subunit 1transporter
GabapentinVoltage-dependent N-type calcium channeltarget
GabapentinPotassium voltage-gated channel subfamily KQT member 3target
GabapentinPotassium voltage-gated channel subfamily KQT member 5target
Vigabatrin4-aminobutyrate aminotransferase, mitochondrialtarget
VigabatrinGamma-aminobutyric acid type B receptor subunit 1target
VigabatrinProton-coupled amino acid transporter 1transporter
VigabatrinCytochrome P450 2C9enzyme
2-aminoisobutyric acidCorticoliberintarget
2-aminoisobutyric acidPro-neuropeptide Ytarget
2-aminoisobutyric acidMonocarboxylate transporter 10transporter
BL-1020Dopamine D2 receptortarget
BL-10205-hydroxytryptamine receptor 2Atarget
Gabapentin enacarbilVoltage-dependent calcium channel subunit alpha-2/delta-1target
Gabapentin enacarbilVoltage-dependent calcium channel subunit alpha-2/delta-2target
Gabapentin enacarbilSodium-coupled monocarboxylate transporter 1transporter
Gabapentin enacarbilSodium-dependent multivitamin transportertransporter
Arbaclofen PlacarbilMonocarboxylate transporter 1transporter
Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 1target
Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 2target
gamma-Aminobutyric acidGlycine amidinotransferase, mitochondrialtarget
gamma-Aminobutyric acidProton-coupled amino acid transporter 1transporter
gamma-Aminobutyric acidGamma-aminobutyric acid type B receptor subunit 1target
gamma-Aminobutyric acidGamma-aminobutyric acid type B receptor subunit 2target