4-carbon acids, salts, and derivatives of BUTYRIC ACID.
DrugDrug NameDrug Description
DB00181BaclofenA GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients.
DB00230PregabalinAn anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants.
DB00636ClofibrateA fibric acid derivative used to treat hypertriglyceridemia and high cholesterol.
DB00837ProgabideIndicated for the treatment of epilepsy.
DB00996GabapentinAn anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures.
DB01039FenofibrateA peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia.
DB01080VigabatrinAn irreversible GABA transaminase inhibitor used as an adjunct to treat refractory complex partial seizures in patients ≥10 years unresponsive to alternatives. May also be used as monotherapy to treat infantile spasms in infants 1 month to 2 years.
DB01241GemfibrozilA lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia.
DB01393BezafibrateA lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder.
DB01440gamma-Hydroxybutyric acidUsed as a general anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance.
DB02531Isobutyric acidNot Available
DB02821CanalineNot Available
DB029522-aminoisobutyric acidNot Available
DB03458N(4)-Adenosyl-N(4)-methyl-2,4-diaminobutanoic acidN(4)-adenosyl-n(4)-methyl-2,4-diaminobutanoic acid is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar.
DB03568Butyric AcidA four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.
DB03817L-2,4-diaminobutyric acidNot Available
DB04217L-2-amino-3-butynoic acidNot Available
DB04454Alpha-Aminobutyric AcidNot Available
DB05687BL-1020Investigated for use/treatment in schizophrenia and schizoaffective disorders.
DB06769BendamustineAn antineoplastic agent used for the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed following rituximab therapy.
DB08872Gabapentin enacarbilA gabapentin prodrug used to treat Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
DB08880TeriflunomideA pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis.
DB08892Arbaclofen PlacarbilInvestigated for the treatment of spasticity in multiple sclerosis, acute back spasms, and GERD.
DB08983EtofibrateEtofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin. These components separate in the body slowly allowing for pharmacokinetics similar to controlled-release formulations.
DB09064CiprofibrateNot Annotated
DB09072Sodium oxybateA central nervous system depressant used to treat cataplexy and excessive daytime sleepiness (EDS) associated with narcolepsy.
DB09292SacubitrilA neprilysin inhibitor used in combination with valsartan as an adjunct to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.
DB12493PD-217014PD-217,014 has been used in trials studying the treatment of Pain and Irritable Bowel Syndrome.
DB12951PivagabinePivagabine has been used in trials studying the treatment of Stress and Anxiety.
DB13433SimfibrateNot Annotated
DB13447PrethcamideNot Annotated
DB13455PhenibutNot Annotated
DB13849ClofibrideNot Annotated
DB13873Fenofibric acidA fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia.
DB14044Hopantenic acidHopantenic acid (Pantogam) is a central nervous system depressant. Hopantenic acid has a unique spectrum of pharmacological effects (nootropic, anticonvulsant, mild activating) in the absence of addiction, hyperstimulation or withdrawal...
DB14127SacubitrilatA metabolite of LCZ696 with neprilysin inhibitory activity.
DB02530gamma-Aminobutyric acidThe most common inhibitory neurotransmitter in the central nervous system.
DrugDrug NameTargetType
DB00181BaclofenGamma-aminobutyric acid type B receptor subunit 1target
DB00181BaclofenGamma-aminobutyric acid type B receptor subunit 2target
DB00230PregabalinExcitatory amino acid transporter 3transporter
DB00230PregabalinVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00230PregabalinLarge neutral amino acids transporter small subunit 1transporter
DB00636ClofibratePeroxisome proliferator-activated receptor alphatarget
DB00636ClofibrateCytochrome P450 3A4enzyme
DB00636ClofibrateGlutathione S-transferase A2enzyme
DB00636ClofibrateCytochrome P450 2E1enzyme
DB00636ClofibrateCytochrome P450 1A1enzyme
DB00636ClofibrateCytochrome P450 4A11enzyme
DB00636ClofibrateThyroxine-binding globulincarrier
DB00837ProgabideGamma-aminobutyric acid receptor subunit alpha-1target
DB00837ProgabideGamma-aminobutyric acid type B receptor subunit 1target
DB00996GabapentinAdenosine receptor A1target
DB00996GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00996GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-2target
DB00996GabapentinBranched-chain-amino-acid aminotransferase, cytosolicenzyme
DB00996GabapentinLarge neutral amino acids transporter small subunit 1transporter
DB00996GabapentinVoltage-dependent N-type calcium channeltarget
DB00996GabapentinPotassium voltage-gated channel subfamily KQT member 3target
DB00996GabapentinPotassium voltage-gated channel subfamily KQT member 5target
DB01039FenofibratePeroxisome proliferator-activated receptor alphatarget
DB01039FenofibrateMatrix metalloproteinase-25target
DB01039FenofibrateCytochrome P450 2C8enzyme
DB01039FenofibrateCytochrome P450 2C9enzyme
DB01039FenofibrateNuclear receptor subfamily 1 group I member 2target
DB01039FenofibrateUDP-glucuronosyltransferase 1-9enzyme
DB01039FenofibrateBile salt export pumptransporter
DB01039FenofibrateSerum albumincarrier
DB01039FenofibrateCytochrome P450 2C19enzyme
DB01039FenofibrateCytochrome P450 2A6enzyme
DB01039FenofibrateLiver carboxylesterase 1enzyme
DB01039FenofibrateCarbonyl reductase [NADPH] 1enzyme
DB01039FenofibrateAldo-keto reductase family 1 member C1enzyme
DB01039FenofibrateAldo-keto reductase family 1 member C2enzyme
DB01039FenofibrateAldo-keto reductase family 1 member C3enzyme
DB01039FenofibrateAldose reductaseenzyme
DB01080Vigabatrin4-aminobutyrate aminotransferase, mitochondrialtarget
DB01080VigabatrinGamma-aminobutyric acid type B receptor subunit 1target
DB01080VigabatrinProton-coupled amino acid transporter 1transporter
DB01080VigabatrinCytochrome P450 2C9enzyme
DB01241GemfibrozilPeroxisome proliferator-activated receptor alphatarget
DB01241GemfibrozilCytochrome P450 2C9enzyme
DB01241GemfibrozilCytochrome P450 2C8enzyme
DB01241GemfibrozilCytochrome P450 1A2enzyme
DB01241GemfibrozilCytochrome P450 2C19enzyme
DB01241GemfibrozilUDP-glucuronosyltransferase 1-1enzyme
DB01241GemfibrozilCytochrome P450 3A4enzyme
DB01241GemfibrozilUDP-glucuronosyltransferase 1-3enzyme
DB01241GemfibrozilSolute carrier organic anion transporter family member 1B1target
DB01241GemfibrozilUDP-glucuronosyltransferase 2B7enzyme
DB01241GemfibrozilUDP-glucuronosyltransferase 1-9enzyme
DB01241GemfibrozilUDP-glucuronosyltransferase 2B4enzyme
DB01241GemfibrozilUDP-glucuronosyltransferase 2B17enzyme
DB01241GemfibrozilSerum albumincarrier
DB01241GemfibrozilSolute carrier family 22 member 8target
DB01241GemfibrozilSolute carrier organic anion transporter family member 2B1target
DB01241GemfibrozilSolute carrier organic anion transporter family member 1B3target
DB01393BezafibratePeroxisome proliferator-activated receptor alphatarget
DB01393BezafibrateSolute carrier organic anion transporter family member 1B1transporter
DB01393BezafibratePeroxisome proliferator-activated receptor deltatarget
DB01393BezafibratePeroxisome proliferator-activated receptor gammatarget
DB01393BezafibrateCytochrome P450 1A1enzyme
DB01393BezafibrateCytochrome P450 2C8enzyme
DB01393BezafibrateCytochrome P450 3A4enzyme
DB01393BezafibrateNuclear receptor subfamily 1 group I member 2target
DB01393BezafibrateRetinoic acid receptor RXR-alphatarget
DB01393BezafibrateRetinoic acid receptor RXR-betatarget
DB01393BezafibrateRetinoic acid receptor RXR-gammatarget
DB01440gamma-Hydroxybutyric acidMonocarboxylate transporter 2transporter
DB01440gamma-Hydroxybutyric acidMonocarboxylate transporter 1transporter
DB01440gamma-Hydroxybutyric acidMonocarboxylate transporter 4transporter
DB01440gamma-Hydroxybutyric acidGamma-hydroxybutyrate (GHB) receptortarget
DB01440gamma-Hydroxybutyric acidGamma-aminobutyric acid receptor subunit beta-1target
DB02531Isobutyric acid2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolasetarget
DB02821CanalineOrnithine aminotransferase, mitochondrialtarget
DB029522-aminoisobutyric acidCorticoliberintarget
DB029522-aminoisobutyric acidPro-neuropeptide Ytarget
DB029522-aminoisobutyric acidMonocarboxylate transporter 10transporter
DB03568Butyric Acid(S)-2-haloacid dehalogenasetarget
DB03568Butyric AcidCholinesterasetarget
DB03568Butyric Acid2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolasetarget
DB03568Butyric AcidCholinesteraseenzyme
DB03817L-2,4-diaminobutyric acidEnvelope glycoprotein gp160target
DB04217L-2-amino-3-butynoic acidCysteine desulfurasetarget
DB04217L-2-amino-3-butynoic acidCystathionine gamma-lyasetarget
DB04454Alpha-Aminobutyric AcidGlycine amidinotransferase, mitochondrialtarget
DB04454Alpha-Aminobutyric AcidGag-Pol polyproteintarget
DB04454Alpha-Aminobutyric AcidPro-epidermal growth factortarget
DB04454Alpha-Aminobutyric AcidLantibiotic mersacidintarget
DB05687BL-1020Dopamine D2 receptortarget
DB05687BL-10205-hydroxytryptamine receptor 2Atarget
DB06769BendamustineCytochrome P450 1A2enzyme
DB08872Gabapentin enacarbilVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB08872Gabapentin enacarbilVoltage-dependent calcium channel subunit alpha-2/delta-2target
DB08872Gabapentin enacarbilSodium-coupled monocarboxylate transporter 1transporter
DB08872Gabapentin enacarbilSodium-dependent multivitamin transportertransporter
DB08880TeriflunomideATP-binding cassette sub-family G member 2transporter
DB08880TeriflunomideDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB08880TeriflunomideCytochrome P450 2C8enzyme
DB08880TeriflunomideSolute carrier organic anion transporter family member 1B1transporter
DB08880TeriflunomideCytochrome P450 1A2enzyme
DB08892Arbaclofen PlacarbilMonocarboxylate transporter 1transporter
DB08892Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 1target
DB08892Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 2target
DB09064CiprofibratePeroxisome proliferator-activated receptor alphatarget
DB09072Sodium oxybateSuccinate-semialdehyde dehydrogenase, mitochondrialenzyme
DB09072Sodium oxybateHydroxyacid-oxoacid transhydrogenase, mitochondrialenzyme
DB09292SacubitrilNeprilysintarget
DB09292SacubitrilSolute carrier organic anion transporter family member 1B1transporter
DB09292SacubitrilSolute carrier organic anion transporter family member 1B3transporter
DB13873Fenofibric acidPeroxisome proliferator-activated receptor alphatarget
DB13873Fenofibric acidMatrix metalloproteinase-25target
DB13873Fenofibric acidPeroxisome proliferator-activated receptor gammatarget
DB13873Fenofibric acidPeroxisome proliferator-activated receptor deltatarget
DB13873Fenofibric acidNuclear receptor subfamily 1 group I member 2target
DB02530gamma-Aminobutyric acidGlycine amidinotransferase, mitochondrialtarget
DB02530gamma-Aminobutyric acidProton-coupled amino acid transporter 1transporter
DB02530gamma-Aminobutyric acidGamma-aminobutyric acid type B receptor subunit 1target
DB02530gamma-Aminobutyric acidGamma-aminobutyric acid type B receptor subunit 2target