Central Nervous System Stimulants

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.
DrugDrug NameDrug Description
DB00182AmphetamineA CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD).
DB00201CaffeineA stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.
DB00422MethylphenidateA stimulant used in the management of Attention Deficit Hyperactivity Disorder (ADHD).
DB01255LisdexamfetamineA central nervous system (CNS) stimulant used to treat attention deficit hyperactivity disorder (ADHD) and moderate to severe eating disorders.
DB01576DextroamphetamineA sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
DB01577MetamfetamineA sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity.
DB06701DexmethylphenidateA norepinephrine-dopamine reuptake inhibitor used in the treatment of ADHD in conjunction with other therapies.
DB00351Megestrol acetateA progestin that is administered orally to treat anorexia and cachexia or serious unexplained weight loss and is also used as an antineoplastic agent to treat certain types of malignancy.
DB00466PicrotoxinUsed internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates.
DB00561DoxapramA short acting respiratory stimulant used to treat acute respiratory insufficiency in COPD patients.
DB00579MazindolA sympathomimetic used to treat obesity in combination with lifestyle modifications.
DB00745ModafinilA stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder.
DB00805MinaprineFor the treatment of depression
DB00830PhenmetrazineUsed as an anorectic in the treatment of obesity.
DB00865BenzphetamineA sympathomimetic used to manage exogenous obesity short term.
DB01230PemolineA central nervous system (CNS) stimulant that was previously used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy.
DB01364EphedrineAn alpha and beta-adrenergic agonist used for the management of respiratory conditions related to bronchial asthma, such as wheezing, shortness of breath, and tightness of chest.
DB01463FencamfaminFor the the treatment of depressive fatigue in convalescence and other debilitated states as well as in the treatment of depressive day-time fatigue, lack of concentration and lethargy.
DB01482FenethyllineNot Available
DB01560CathinoneCathinone is a monoamine alkaloid found in the shrub Catha edulis (Khat). Closely related to ephedrine, cathine and other amphetamines, it is probably the main contributor to the stimulant effect...
DB01579PhendimetrazineA sympathomimetic amine used as adjunct therapy for the short term management of exogenous obesity.
DB06413ArmodafinilA stimulant used to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea, narcolepsy, or shift work disorder.
DB08969FlurothylFlurothyl is a convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock therapy.
DB11562BicucullineBicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and...
DB12947DoxifluridineDoxifluridine has been investigated for the treatment of Stomach Cancer.
DB13438ProlintaneNot Annotated
DB13455PhenibutNot Annotated
DB13655NikethamideNot Annotated
DB13740BemegrideNot Annotated
DB13875HarmalineNot Annotated
DB13561ClobenzorexNot Annotated
DB014474-MethylaminorexNot Available
DB13415PentetrazolNot Annotated
DrugDrug NameTargetType
DB00182AmphetamineSodium-dependent dopamine transportertarget
DB00182AmphetamineCocaine- and amphetamine-regulated transcript proteintarget
DB00182AmphetamineTrace amine-associated receptor 1target
DB00182AmphetamineCytochrome P450 2D6enzyme
DB00182AmphetamineSolute carrier family 22 member 3transporter
DB00182AmphetamineSolute carrier family 22 member 5transporter
DB00182AmphetamineSynaptic vesicular amine transportertarget
DB00182AmphetamineCytochrome P450 2A6enzyme
DB00182AmphetamineSodium-dependent noradrenaline transportertarget
DB00182AmphetamineAlpha adrenergic receptortarget
DB00182AmphetamineBeta adrenergic receptortarget
DB00182AmphetamineDopamine D2 receptortarget
DB00182AmphetamineAmine oxidase [flavin-containing] Btarget
DB00182AmphetamineSodium-dependent serotonin transportertarget
DB00182AmphetamineMonoamine oxidasetarget
DB00182Amphetaminevesicular monoamine transporter 2 (VMAT2)target
DB00201CaffeineAdenosine receptor A1target
DB00201CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00201CaffeineAdenosine receptor A2atarget
DB00201CaffeineCytochrome P450 1A2enzyme
DB00201CaffeineRyanodine receptor 1target
DB00201CaffeineCytochrome P450 3A4enzyme
DB00201CaffeineCytochrome P450 2E1enzyme
DB00201CaffeineCytochrome P450 2C8enzyme
DB00201CaffeineCytochrome P450 2C9enzyme
DB00201CaffeineCytochrome P450 1A1enzyme
DB00201CaffeineCytochrome P450 1B1enzyme
DB00201CaffeineCytochrome P450 2D6enzyme
DB00201CaffeineCyclic nucleotide phosphodiesterasetarget
DB00201CaffeineDNA-dependent protein kinase catalytic subunittarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget
DB00201CaffeineInositol 1,4,5-trisphosphate receptortarget
DB00201CaffeineSerine-protein kinase ATMtarget
DB00201CaffeineATP-binding cassette sub-family G member 2transporter
DB00201CaffeineAdenosine receptor A2btarget
DB00201CaffeineAdenosine receptor A3target
DB00201CaffeinePhosphodiesterase enzymestarget
DB00422MethylphenidateSodium-dependent dopamine transportertarget
DB00422MethylphenidateSodium-dependent noradrenaline transportertarget
DB00422MethylphenidateCarboxylesteraseenzyme
DB00422Methylphenidate5-hydroxytryptamine receptor 1Atarget
DB01255LisdexamfetamineCytochrome P450 2D6enzyme
DB01255LisdexamfetamineSolute carrier family 15 member 1transporter
DB01255LisdexamfetamineTrace amine-associated receptor 1target
DB01576DextroamphetamineAlpha-1A adrenergic receptortarget
DB01576DextroamphetamineAlpha-1B adrenergic receptortarget
DB01576DextroamphetamineSodium-dependent dopamine transportertarget
DB01576DextroamphetamineSodium-dependent noradrenaline transportertarget
DB01576DextroamphetamineSynaptic vesicular amine transportertarget
DB01576DextroamphetamineTrace amine-associated receptor 1target
DB01576DextroamphetamineCytochrome P450 2D6enzyme
DB01576DextroamphetaminePrimary amine oxidaseenzyme
DB01576DextroamphetamineSodium-dependent dopamine transportertransporter
DB01577MetamfetamineCytochrome P450 2D6enzyme
DB01577MetamfetamineSolute carrier family 22 member 3transporter
DB01577MetamfetamineSolute carrier family 22 member 5transporter
DB01577MetamfetamineSodium-dependent dopamine transportertarget
DB01577MetamfetamineSynaptic vesicular amine transportertarget
DB01577MetamfetamineTrace amine-associated receptor 1target
DB01577MetamfetamineSodium-dependent serotonin transportertarget
DB01577MetamfetamineSodium-dependent noradrenaline transportertarget
DB01577MetamfetamineChromaffin granule amine transportertarget
DB01577MetamfetamineAmine oxidase [flavin-containing] Atarget
DB01577MetamfetamineAmine oxidase [flavin-containing] Btarget
DB01577MetamfetamineAlpha-2A adrenergic receptortarget
DB01577MetamfetamineAlpha-2B adrenergic receptortarget
DB01577MetamfetamineAlpha-2C adrenergic receptortarget
DB06701DexmethylphenidateSodium-dependent dopamine transportertarget
DB06701DexmethylphenidateSodium-dependent noradrenaline transportertarget
DB06701DexmethylphenidateSodium-dependent serotonin transportertarget
DB06701DexmethylphenidateCarboxylesteraseenzyme
DB00351Megestrol acetateProgesterone receptortarget
DB00351Megestrol acetateGlucocorticoid receptortarget
DB00351Megestrol acetateP-glycoprotein 1transporter
DB00351Megestrol acetateCytochrome P450 3A4enzyme
DB00466PicrotoxinGamma-aminobutyric acid receptor subunit rho-1target
DB00466PicrotoxinGamma-aminobutyric acid receptor subunit alpha-1target
DB00466PicrotoxinGlycine receptor subunit alpha-2target
DB00466PicrotoxinGlycine receptor subunit alpha-3target
DB00466PicrotoxinCytochrome P450 1A1enzyme
DB00466PicrotoxinGlutamine synthetaseenzyme
DB00466PicrotoxinGlycine receptor subunit alpha-1target
DB00561DoxapramPotassium channel subfamily K member 3target
DB00561DoxapramPotassium channel subfamily K member 9target
DB00579MazindolSodium-dependent noradrenaline transportertarget
DB00579MazindolSodium-dependent dopamine transportertarget
DB00579MazindolSodium-dependent serotonin transportertarget
DB00579MazindolSynaptic vesicular amine transportertarget
DB00745ModafinilSodium-dependent dopamine transportertarget
DB00745ModafinilAlpha-1B adrenergic receptortarget
DB00745ModafinilCytochrome P450 3A4enzyme
DB00745ModafinilCytochrome P450 2C19enzyme
DB00745ModafinilCytochrome P450 1A2enzyme
DB00745ModafinilCytochrome P450 2B6enzyme
DB00745ModafinilCytochrome P450 2C9enzyme
DB00745ModafinilCytochrome P450 3A5enzyme
DB00805MinaprineDopamine D1 receptortarget
DB00805MinaprineDopamine D2 receptortarget
DB00805Minaprine5-hydroxytryptamine receptor 2Atarget
DB00805Minaprine5-hydroxytryptamine receptor 2Btarget
DB00805Minaprine5-hydroxytryptamine receptor 2Ctarget
DB00805MinaprineSodium-dependent serotonin transportertarget
DB00805MinaprineCytochrome P450 2D6enzyme
DB00805MinaprineMuscarinic acetylcholine receptor M1target
DB00805MinaprineAcetylcholinesterasetarget
DB00805MinaprineAmine oxidase [flavin-containing] Atarget
DB00830PhenmetrazineSodium-dependent noradrenaline transportertarget
DB00830PhenmetrazineSodium-dependent dopamine transportertarget
DB00865BenzphetamineAlpha-2A adrenergic receptortarget
DB00865BenzphetamineAlpha-1A adrenergic receptortarget
DB00865BenzphetamineCytochrome P450 3A4enzyme
DB00865BenzphetamineCytochrome P450 2B6enzyme
DB00865BenzphetamineNADPH--cytochrome P450 reductaseenzyme
DB00865BenzphetamineSynaptic vesicular amine transportertarget
DB00865BenzphetamineSodium-dependent dopamine transportertarget
DB01364EphedrineAcetylcholinesterasetarget
DB01364EphedrineAlpha-1A adrenergic receptortarget
DB01364EphedrineSodium-dependent noradrenaline transportertarget
DB01364EphedrineSynaptic vesicular amine transportertarget
DB01364EphedrineCholinesteraseenzyme
DB01463FencamfaminSodium-dependent dopamine transportertarget
DB01482FenethyllineCytochrome P450 1A2enzyme
DB01579PhendimetrazineAlpha-1A adrenergic receptortarget
DB01579PhendimetrazineAlpha-1B adrenergic receptortarget
DB01579PhendimetrazineSodium-dependent noradrenaline transportertarget
DB06413ArmodafinilCytochrome P450 2C19enzyme
DB06413ArmodafinilCytochrome P450 3A4enzyme
DB06413ArmodafinilCytochrome P450 1A2enzyme
DB06413ArmodafinilCytochrome P450 2B6enzyme
DB06413ArmodafinilCytochrome P450 3A5enzyme
DB06413ArmodafinilCytochrome P450 2C9enzyme
DB06413ArmodafinilSodium-dependent dopamine transportertarget
DB13875HarmalineHistamine N-methyltransferasetarget