Drugs that bind to and activate cholinergic receptors.
DrugDrug NameDrug Indication
DB00184NicotineFor the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
DB00185CevimelineFor the treatment of symptoms of dry mouth in patients with Sjögren's Syndrome.
DB00411CarbacholPrimarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.
DB01019BethanecholFor the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention.
DB01085PilocarpineFor the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome.
DB01273VareniclineFor use as an aid in smoking cessation.
DB03128AcetylcholineUsed to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.
DB04365ArecolineNot Available
DB05137LobelineInvestigated for use/treatment in addictions.
DB05708GTS-21Investigated for use/treatment in alzheimer's disease and schizophrenia and schizoaffective disorders.
DB06709MethacholineIt is most commonly used for diagnosing bronchial hyperreactivity, using the bronchial challenge test.
DB07720EpibatidineNot Available
DrugDrug NameTargetType
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-2target
DB00184NicotineNeuronal acetylcholine receptor subunit beta-2target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-7target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-4target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-10target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-9target
DB00184NicotineCytochrome P450 2A6enzyme
DB00184NicotineCytochrome P450 2E1enzyme
DB00184NicotineCytochrome P450 2A13enzyme
DB00184NicotineCytochrome P450 2B6enzyme
DB00184NicotineNeuronal acetylcholine receptor subunit beta-4target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-3target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-5target
DB00184NicotineNeuronal acetylcholine receptor subunit alpha-6target
DB00184NicotineNeuronal acetylcholine receptor subunit beta-3target
DB00184NicotineSolute carrier family 22 member 2transporter
DB00184NicotineSolute carrier family 22 member 1transporter
DB00184NicotineSolute carrier family 22 member 3transporter
DB00184NicotineSolute carrier family 22 member 5transporter
DB00184NicotineSolute carrier family 22 member 4transporter
DB00184NicotineCytochrome P450 1A1enzyme
DB00184NicotineCytochrome P450 1A2enzyme
DB00184NicotineCytochrome P450 2C19enzyme
DB00184NicotineCytochrome P450 2C8enzyme
DB00184NicotineCytochrome P450 2C9enzyme
DB00184NicotineCytochrome P450 2D6enzyme
DB00184NicotineCytochrome P450 3A4enzyme
DB00184NicotineAmine oxidase [flavin-containing] Aenzyme
DB00184NicotineAmine oxidase [flavin-containing] Benzyme
DB00184NicotineCytochrome P450 19A1target
DB00184NicotineCholine O-acetyltransferasetarget
DB00185CevimelineMuscarinic acetylcholine receptor M1target
DB00185CevimelineMuscarinic acetylcholine receptor M3target
DB00185CevimelineCytochrome P450 3A4enzyme
DB00185CevimelineCytochrome P450 2D6enzyme
DB00185CevimelineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00411CarbacholMuscarinic acetylcholine receptor M1target
DB00411CarbacholMuscarinic acetylcholine receptor M2target
DB00411CarbacholNeuronal acetylcholine receptor subunit alpha-2target
DB00411CarbacholCytosolic phospholipase A2enzyme
DB00411CarbacholAcetylcholinesterasetarget
DB00411CarbacholMuscarinic acetylcholine receptor M3target
DB00411CarbacholMuscarinic acetylcholine receptor M4target
DB01019BethanecholMuscarinic acetylcholine receptor M2target
DB01019BethanecholMuscarinic acetylcholine receptor M1target
DB01019BethanecholMuscarinic acetylcholine receptor M3target
DB01019BethanecholMuscarinic acetylcholine receptor M4target
DB01085PilocarpineMuscarinic acetylcholine receptor M1target
DB01085PilocarpineMuscarinic acetylcholine receptor M2target
DB01085PilocarpineCytochrome P450 2A6enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M3target
DB01085PilocarpineCytochrome P450 2E1enzyme
DB01085PilocarpineCytochrome P450 3A4enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M4target
DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-4target
DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-7target
DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-3target
DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-6target
DB01273VareniclineNeuronal acetylcholine receptor subunit beta-2target
DB03128AcetylcholineAcetylcholinesterasetarget
DB03128AcetylcholineSolute carrier family 22 member 5transporter
DB03128AcetylcholineSolute carrier family 22 member 1transporter
DB03128AcetylcholineCytochrome P450 2D6enzyme
DB03128AcetylcholineMuscarinic acetylcholine receptor M1target
DB03128AcetylcholineMuscarinic acetylcholine receptor M2target
DB03128AcetylcholineMuscarinic acetylcholine receptor M3target
DB03128AcetylcholineMuscarinic acetylcholine receptor M4target
DB03128AcetylcholineNeuronal acetylcholine receptor subunit alpha-7target
DB04365ArecolineMuscarinic acetylcholine receptor M1target
DB04365ArecolineMuscarinic acetylcholine receptor M3target
DB05137LobelineNeuronal acetylcholine receptor subunit alpha-9target
DB05137LobelineNeuronal acetylcholine receptor subunit alpha-10target
DB05137LobelineNeuronal acetylcholine receptor subunit alpha-7target
DB05708GTS-21Neuronal acetylcholine receptor subunit alpha-7target
DB05708GTS-21Cytochrome P450 1A2enzyme
DB05708GTS-21Cytochrome P450 2E1enzyme
DB06709MethacholineMuscarinic acetylcholine receptor M3target
DB07720EpibatidineCHRNA7-FAM7A fusion proteintarget
DB07720EpibatidineNeuronal acetylcholine receptor subunit alpha-7target
DB07720EpibatidineNeuronal acetylcholine receptor subunit beta-2target
DB07720EpibatidineNeuronal acetylcholine receptor subunit alpha-2target
DB07720EpibatidineNeuronal acetylcholine receptor subunit alpha-3target
DB07720EpibatidineNeuronal acetylcholine receptor subunit alpha-4target
DB07720EpibatidineNeuronal acetylcholine receptor subunit beta-4target