Muscarinic Agonists

Name
Muscarinic Agonists
Accession Number
DBCAT000447
Description

Drugs that bind to and activate muscarinic cholinergic receptors (RECEPTORS, MUSCARINIC). Muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the GI tract, urinary bladder and the eye. They may also be used to reduce heart rate.

Drugs
DrugDrug Description
BethanecholA muscarinic agonist used to treat postoperative and postpartum nonobstructive functional urinary retention and neurogenic atony of the bladder with retention.
CevimelineA muscarinic agonist with parasympathomimetic activities that is used for the symptomatic treatment of dry mouth in patients with Sjögren's Syndrome.
PilocarpineA muscarinic cholinergic agonist used on the eye to treat elevated intraocular pressure, various types of glaucoma, and to induce miosis. Also available orally to treat symptoms of dry mouth associated with Sjogren's syndrome and radiotherapy.
NGX267Investigated for use/treatment in alzheimer's disease and schizophrenia and schizoaffective disorders.
MethacholineA parasympathomimetic bronchoconstrictor used during the bronchial challenge test for the diagnosis of bronchial hyperreactivity in subjects who do not have clinically apparent asthma.
HomatropineAn anticholinergic agent used to dilate the pupil, treat inflammation of the uveal tract, and suppress a cough.
Homatropine methylbromideA muscarinic receptor antagonist used to treat peptic ulcers, gastric ulcers, and duodenal ulcers.
XanomelineXanomeline is under investigation in clinical trial NCT02831231 (Pilot Study Comparing Effects of Xanomeline Alone to Xanomeline Plus Trospium).
Drugs & Drug Targets
DrugTargetType
BethanecholMuscarinic acetylcholine receptor M2target
BethanecholMuscarinic acetylcholine receptor M1target
BethanecholMuscarinic acetylcholine receptor M3target
BethanecholMuscarinic acetylcholine receptor M4target
CevimelineMuscarinic acetylcholine receptor M1target
CevimelineMuscarinic acetylcholine receptor M3target
CevimelineCytochrome P450 3A4enzyme
CevimelineCytochrome P450 2D6enzyme
CevimelineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
PilocarpineMuscarinic acetylcholine receptor M1target
PilocarpineMuscarinic acetylcholine receptor M2target
PilocarpineCytochrome P450 2A6enzyme
PilocarpineMuscarinic acetylcholine receptor M3target
PilocarpineCytochrome P450 3A4enzyme
PilocarpineMuscarinic acetylcholine receptor M4target
NGX267Muscarinic acetylcholine receptor M1target
MethacholineMuscarinic acetylcholine receptor M3target
HomatropineLiver carboxylesterase 1enzyme
HomatropineMuscarinic acetylcholine receptor M1target
HomatropineMuscarinic acetylcholine receptor M2target
HomatropineMuscarinic acetylcholine receptor M3target
HomatropineMuscarinic acetylcholine receptor M4target
HomatropineMuscarinic acetylcholine receptor M5target
Homatropine methylbromideMuscarinic acetylcholine receptor M2target
Homatropine methylbromideMuscarinic acetylcholine receptor M1target
Homatropine methylbromideMuscarinic acetylcholine receptor M4target
Homatropine methylbromideMuscarinic acetylcholine receptor M5target
Homatropine methylbromideMuscarinic acetylcholine receptor M3target