GABA Modulators

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
DrugDrug NameDrug Indication
DB00186LorazepamLorazepam is FDA-approved for the short-term relief of anxiety symptoms related to anxiety disorders and anxiety associated with depressive symptoms such as anxiety-associated insomnia. It is as well used as an anesthesia premedication in adults to relieve anxiety or to produce sedation/amnesia and for the treatment of status epilepticus.[T385] Some off-label indications of lorazepam include rapid tranquilization of an agitated patient, alcohol withdrawal delirium, alcohol withdrawal syndrome, muscle spasms, insomnia, panic disorder, delirium, chemotherapy-associated anticipatory nausea and vomiting, and psychogenic catatonia.[T385]
DB00231TemazepamTemazepam is specifically indicated only for the short-term management of insomnia [FDA Label], [L5539]. Furthermore, such management is generally predominantly associated with the symptomatic relief of transient and short-term insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings and/or early morning awakenings [F3718]. In particular, the official prescribing information for temazepam typically specifies that the instructions issued for dispensed prescriptions of the medication should indicate specifically that patients are only expected to use the therapy for short periods of time - usually 7-10 days in general [FDA Label, F3718]. Subsequently, treatment with temazepam should usually not exceed 7 to 10 consecutive days and nor should it be prescribed in quantities exceeding a one-month supply [F3718]. Some regional prescribing information also notes that temazepam may be used for premedication prior to minor surgery or other related procedures [L5539].
DB00312PentobarbitalFor the short-term treatment of insomnia.
DB00404AlprazolamAlprazolam is indicated for the management of anxiety disorder, anxiety associated with depression, panic disorder, and panic disorder with agoraphobia.[Label] Alprazolam may also be prescribed off label for insomnia, premenstrual syndrome, and depression.[A177973]
DB00418SecobarbitalFor the Short-term treatment of intractable insomnia for patients habituated to barbiturates
DB00475ChlordiazepoxideFor the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.
DB00599ThiopentalFor use as the sole anesthetic agent for brief (15 minute) procedures, for induction of anesthesia prior to administration of other anesthetic agents, to supplement regional anesthesia, to provide hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation, for the control of convulsive states during or following inhalation anesthesia or local anesthesia, in neurosurgical patients with increased intracranial pressure, and for narcoanalysis and narcosynthesis in psychiatric disorders.
DB00628Clorazepic acidFor the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Also used as adjunctive therapy in the management of partial seizures and for the symptomatic relief of acute alcohol withdrawal.
DB00683Midazolam**Intravenous** Indicated for promoting preoperative sedation, anxiolysis, anesthesia induction, or amnesia.[F2434] **Intramuscular** Indicated for the treatment of status epilepticus in adults.[FDA label] **Nasal** Indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient’s usual seizure pattern in patients with epilepsy 12 years of age and older.[L6559]
DB00690FlurazepamFor short-term and intermittent use in patients with recurring insomnia and poor sleeping habits
DB00829DiazepamIn general, diazepam is useful in the symptomatic management of mild to moderate degrees of anxiety in conditions dominated by tension, excitation, agitation, fear, or aggressiveness such as may occur in psychoneurosis, anxiety reactions due to stress conditions, and anxiety states with somatic expression [F3160]. Moreover, in acute alcoholic withdrawal, diazepam may be useful in the symptomatic relief of acute agitation, tremor, and impending acute delirium tremens [F3160]. Furthermore, diazepam is a useful adjunct for the relief of skeletal muscle spasm due to reflex spasm to local pathologies, such as inflammation of the muscle and joints or secondary to trauma; spasticity caused by upper motor neuron disorders, such as cerebral palsy and paraplegia; athetosis and the rare "stiff man syndrome" [F3160]. Particular label information from the United Kingdom also lists particular age-specific indications, including for adults: (1) The short-term relief (2-4 weeks) only, of anxiety which is severe, disabling, or subjecting the individual to unacceptable distress, occurring alone or in association with insomnia or short-term psychosomatic, organic or psychotic illness, (2) cerebral palsy, (3) muscle spasm, (4) as an adjunct to certain types of epilepsy (eg. myoclonus), (5) symptomatic treatment of acute alcohol withdrawal, (6) as oral premedication for the nervous dental patient, and (7) for premedication before surgery [L5188]. In the same UK label information, diazepam is indicated in children for: (1) control of tension and irritability in cerebral spasticity in selected cases, (2) as an adjunct to the control of muscle spasm in tetanus, and for (3) oral premedication [L5188].
DB00842OxazepamFor the treatment of anxiety disorders and alcohol withdrawal.
DB00849MethylphenobarbitalFor the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy.
DB00897TriazolamFor the short-term treatment of insomnia.
DB00962ZaleplonFor the treatment of short-term treatment of insomnia in adults.
DB01068ClonazepamClonazepam is indicated as monotherapy or as an adjunct in the treatment of Lennox-Gastaut syndrome (petit mal variant), akinetic, and myoclonic seizures [FDA Label] [F3787]. Furthermore, clonazepam may also be of some value in patients with absence spells (petit mal) who have failed to respond to succinimides [FDA Label] [F3787]. Additionally, clonazepam is also indicated for the treatment of panic disorder, with or without agoraphobia, as defined in the DSM-V [FDA Label]. Alternatively, some regional prescribing information note that clonazepam is indicated for all clinical forms of epileptic disease and seizures in adults, especially absence seizures (petit mal) including atypical absence; primary or secondarily generalised tonic-clonic (grand mal), tonic or clonic seizures; partial (focal) seizures with elementary or complex symptomatology; various forms of myoclonic seizures, myoclonus and associated abnormal movements [L5572, F3796]. Such regional label data also has clonazepam indicated for most types of epilepsy in infants and children, especially absences (petit mal), myoclonic seizures and tonic-clonic fits, whether due to primary generalized epilepsy or to secondary generalization of partial epilepsy [F3796].
DB01154ThiamylalUsed for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, and for inducing a hypnotic state.
DB01174PhenobarbitalFor the treatment of all types of seizures except absence seizures.
DB01205FlumazenilFor the complete or partial reversal of the sedative effects of benzodiazepines in cases where general anesthesia has been induced and/or maintained with benzodiazepines, and where sedation has been produced with benzodiazepines for diagnostic and therapeutic procedures. Also for the management of benzodiazepine overdose as an adjunct for appropriate supportive and symptomatic measures.
DB01215EstazolamFor the short-term management of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakenings.
DB01351AmobarbitalNot Available
DB01355HexobarbitalFor the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli.
DB01483BarbitalNot Available
DB01544FlunitrazepamFor short-term treatment of severe insomnias, that are not responsive to other hypnotics.
DB01558BromazepamFor the short-term treatment of insomnia, short-term treatment of anxiety or panic attacks, if a benzodiazepine is required, and the alleviation of the symptoms of alcohol- and opiate-withdrawal.
DB01588PrazepamFor the treatment of anxiety disorders.
DB01595NitrazepamUsed to treat short-term sleeping problems (insomnia), such as difficulty falling asleep, frequent awakenings during the night, and early-morning awakening.
DB06470ClomethiazoleInvestigated for use/treatment in strokes.
DB11555ZolazepamNot Available
DB12590IndiplonNot Available
DB13437MedazepamNot Available
DB13994AZD-7325Not Available
DB14028NordazepamNot Available
DB11859BrexanoloneBrexanolone is a synthetic neuroactive steroid gamma-aminobutyric acid A (GABA(a)) receptor positive modulator indicated for the treatment of postpartum depression (PPD) in adult women [FDA Label][A176080, A176083, F4063, F4066, F4072].
DB00794PrimidonePrimidone is commonly indicated for the management of grand mal, psychomotor, and focal epileptic seizures [L4645, FDA Label]. In addition, it has also been studied and utilized as an effective management of essential tremor [A39414, A39415, L4645].
DB14718PyrazolamNot Available
DrugDrug NameTargetType
DB00186LorazepamTranslocator proteintarget
DB00186LorazepamUDP-glucuronosyltransferase 2B15enzyme
DB00186LorazepamGABA-A receptor (anion channel)target
DB00186LorazepamCytochrome P450 3A4enzyme
DB00231TemazepamTranslocator proteintarget
DB00231TemazepamCytochrome P450 2C19enzyme
DB00231TemazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB00231TemazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB00231TemazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB00231TemazepamGamma-aminobutyric acid receptor subunit alpha-4target
DB00231TemazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB00231TemazepamGamma-aminobutyric acid receptor subunit alpha-6target
DB00231TemazepamGamma-aminobutyric acid receptor subunit beta-1target
DB00231TemazepamGamma-aminobutyric acid receptor subunit beta-2target
DB00231TemazepamGamma-aminobutyric acid receptor subunit beta-3target
DB00231TemazepamGamma-aminobutyric acid receptor subunit gamma-1target
DB00231TemazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB00231TemazepamGamma-aminobutyric acid receptor subunit gamma-3target
DB00231TemazepamGamma-aminobutyric acid receptor subunit deltatarget
DB00231TemazepamGamma-aminobutyric acid receptor subunit epsilontarget
DB00231TemazepamGamma-aminobutyric acid receptor subunit pitarget
DB00231TemazepamGamma-aminobutyric acid receptor subunit rho-1target
DB00231TemazepamGamma-aminobutyric acid receptor subunit rho-2target
DB00231TemazepamGamma-aminobutyric acid receptor subunit thetatarget
DB00231TemazepamGamma-aminobutyric acid receptor subunit rho-3target
DB00231TemazepamCytochrome P450 3A4enzyme
DB00231TemazepamCytochrome P450 2B6enzyme
DB00231TemazepamCytochrome P450 2C8enzyme
DB00231TemazepamCytochrome P450 2C9enzyme
DB00231TemazepamGABA-A receptor (anion channel)target
DB00312PentobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
DB00312PentobarbitalCytochrome P450 3A4enzyme
DB00312PentobarbitalGamma-aminobutyric acid receptor subunit alpha-4target
DB00312PentobarbitalGamma-aminobutyric acid receptor subunit alpha-6target
DB00312PentobarbitalGamma-aminobutyric acid receptor subunit alpha-2target
DB00312PentobarbitalGamma-aminobutyric acid receptor subunit alpha-3target
DB00312PentobarbitalGamma-aminobutyric acid receptor subunit alpha-5target
DB00312PentobarbitalNeuronal acetylcholine receptor subunit alpha-4target
DB00312PentobarbitalNeuronal acetylcholine receptor subunit alpha-7target
DB00312PentobarbitalGlutamate receptor 2target
DB00312PentobarbitalGlutamate receptor ionotropic, kainate 2target
DB00312PentobarbitalCytochrome P450 2C19enzyme
DB00312PentobarbitalCytochrome P450 2A6enzyme
DB00312PentobarbitalGABA-A receptor (anion channel)target
DB00312PentobarbitalNMDA receptortarget
DB00312PentobarbitalNuclear receptor subfamily 1 group I member 2target
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-1target
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-6target
DB00404AlprazolamTranslocator proteintarget
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-3target
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-4target
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-5target
DB00404AlprazolamGamma-aminobutyric acid receptor subunit alpha-2target
DB00404AlprazolamCytochrome P450 3A4enzyme
DB00404AlprazolamCytochrome P450 2C9enzyme
DB00404AlprazolamCytochrome P450 3A5enzyme
DB00404AlprazolamCytochrome P450 3A7enzyme
DB00404AlprazolamGABA-A receptor (anion channel)target
DB00404AlprazolamSerum albumincarrier
DB00404Alprazolamalpha1-acid glycoproteincarrier
DB00418SecobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
DB00418SecobarbitalCytochrome P450 2C8enzyme
DB00418SecobarbitalCytochrome P450 2C9enzyme
DB00418SecobarbitalGamma-aminobutyric acid receptor subunit alpha-2target
DB00418SecobarbitalGamma-aminobutyric acid receptor subunit alpha-3target
DB00418SecobarbitalGamma-aminobutyric acid receptor subunit alpha-4target
DB00418SecobarbitalGamma-aminobutyric acid receptor subunit alpha-5target
DB00418SecobarbitalGamma-aminobutyric acid receptor subunit alpha-6target
DB00418SecobarbitalNeuronal acetylcholine receptor subunit alpha-4target
DB00418SecobarbitalNeuronal acetylcholine receptor subunit alpha-7target
DB00418SecobarbitalGlutamate receptor 2target
DB00418SecobarbitalGlutamate receptor ionotropic, kainate 2target
DB00418SecobarbitalCytochrome P450 1A2enzyme
DB00418SecobarbitalNMDA receptortarget
DB00418SecobarbitalCytochrome P450 2C19enzyme
DB00475ChlordiazepoxideCytochrome P450 3A4enzyme
DB00475ChlordiazepoxideGABA-A receptor (anion channel)target
DB00599ThiopentalGamma-aminobutyric acid receptor subunit alpha-1target
DB00599ThiopentalFatty-acid amide hydrolase 1target
DB00599ThiopentalGamma-aminobutyric acid receptor subunit alpha-2target
DB00599ThiopentalGamma-aminobutyric acid receptor subunit alpha-3target
DB00599ThiopentalGamma-aminobutyric acid receptor subunit alpha-4target
DB00599ThiopentalGamma-aminobutyric acid receptor subunit alpha-5target
DB00599ThiopentalGamma-aminobutyric acid receptor subunit alpha-6target
DB00599ThiopentalNeuronal acetylcholine receptor subunit alpha-4target
DB00599ThiopentalNeuronal acetylcholine receptor subunit alpha-7target
DB00599ThiopentalGlutamate receptor 2target
DB00599ThiopentalGlutamate receptor ionotropic, kainate 2target
DB00599ThiopentalCytochrome P450 2E1enzyme
DB00599ThiopentalCytochrome P450 3A4enzyme
DB00599ThiopentalMuscarinic acetylcholine receptor M3target
DB00599ThiopentalCytochrome P450 2C19enzyme
DB00628Clorazepic acidTranslocator proteintarget
DB00628Clorazepic acidCytochrome P450 3A4enzyme
DB00628Clorazepic acidGABA-A receptor (anion channel)target
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-1target
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-5target
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-3target
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-2target
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-4target
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-6target
DB00683MidazolamCytochrome P450 3A4enzyme
DB00683MidazolamCytochrome P450 3A5enzyme
DB00683MidazolamUDP-glucuronosyltransferase 1-4enzyme
DB00690FlurazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit beta-1target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit beta-3target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit beta-2target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit alpha-4target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit alpha-6target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit gamma-1target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit gamma-3target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit deltatarget
DB00690FlurazepamGamma-aminobutyric acid receptor subunit epsilontarget
DB00690FlurazepamGamma-aminobutyric acid receptor subunit pitarget
DB00690FlurazepamGamma-aminobutyric acid receptor subunit rho-2target
DB00690FlurazepamGamma-aminobutyric acid receptor subunit thetatarget
DB00690FlurazepamGamma-aminobutyric acid receptor subunit rho-1target
DB00690FlurazepamCytochrome P450 3A4enzyme
DB00690FlurazepamGamma-aminobutyric acid receptor subunit rho-3target
DB00690FlurazepamMultidrug resistance protein 1transporter
DB00690FlurazepamCytochrome P450 2E1enzyme
DB00690FlurazepamCytochrome P450 2A6enzyme
DB00690FlurazepamSolute carrier family 22 member 2transporter
DB00829DiazepamTranslocator proteintarget
DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB00829DiazepamCytochrome P450 3A4enzyme
DB00829DiazepamSerum albumincarrier
DB00829DiazepamCytochrome P450 2C9enzyme
DB00829DiazepamCytochrome P450 2C19enzyme
DB00829DiazepamCytochrome P450 3A5enzyme
DB00829DiazepamCytochrome P450 3A7enzyme
DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB00829DiazepamGamma-aminobutyric acid receptor subunit beta-1target
DB00829DiazepamGamma-aminobutyric acid receptor subunit beta-2target
DB00829DiazepamGamma-aminobutyric acid receptor subunit beta-3target
DB00829DiazepamGamma-aminobutyric acid receptor subunit gamma-1target
DB00829DiazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB00829DiazepamGamma-aminobutyric acid receptor subunit gamma-3target
DB00829DiazepamGamma-aminobutyric acid receptor subunit deltatarget
DB00829DiazepamGamma-aminobutyric acid receptor subunit epsilontarget
DB00829DiazepamGamma-aminobutyric acid receptor subunit pitarget
DB00829DiazepamGamma-aminobutyric acid receptor subunit rho-1target
DB00829DiazepamGamma-aminobutyric acid receptor subunit rho-2target
DB00829DiazepamGamma-aminobutyric acid receptor subunit rho-3target
DB00829DiazepamGamma-aminobutyric acid receptor subunit thetatarget
DB00829DiazepamMultidrug resistance protein 1transporter
DB00829DiazepamCytochrome P450 2B6enzyme
DB00829DiazepamProstaglandin G/H synthase 1enzyme
DB00829DiazepamCytochrome P450 2C18enzyme
DB00829DiazepamCytochrome P450 2C8enzyme
DB00829DiazepamCytochrome P450 2E1enzyme
DB00829DiazepamGABA-A receptor (anion channel)target
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-4target
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-6target
DB00842OxazepamGamma-aminobutyric acid receptor subunit beta-1target
DB00842OxazepamGamma-aminobutyric acid receptor subunit beta-2target
DB00842OxazepamGamma-aminobutyric acid receptor subunit beta-3target
DB00842OxazepamGamma-aminobutyric acid receptor subunit gamma-1target
DB00842OxazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB00842OxazepamGamma-aminobutyric acid receptor subunit gamma-3target
DB00842OxazepamGamma-aminobutyric acid receptor subunit deltatarget
DB00842OxazepamGamma-aminobutyric acid receptor subunit epsilontarget
DB00842OxazepamGamma-aminobutyric acid receptor subunit pitarget
DB00842OxazepamGamma-aminobutyric acid receptor subunit rho-1target
DB00842OxazepamGamma-aminobutyric acid receptor subunit rho-2target
DB00842OxazepamGamma-aminobutyric acid receptor subunit thetatarget
DB00842OxazepamGamma-aminobutyric acid receptor subunit rho-3target
DB00842OxazepamCytochrome P450 3A4enzyme
DB00842OxazepamCytochrome P450 3A43enzyme
DB00842OxazepamUDP-glucuronosyltransferase 2B15enzyme
DB00842OxazepamUDP-glucuronosyltransferase 2B7enzyme
DB00842OxazepamUDP-glucuronosyltransferase 1-9enzyme
DB00842OxazepamGABA-A receptor (anion channel)target
DB00849MethylphenobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
DB00849MethylphenobarbitalCytochrome P450 2C19enzyme
DB00849MethylphenobarbitalCytochrome P450 2B6enzyme
DB00849MethylphenobarbitalGamma-aminobutyric acid receptor subunit alpha-2target
DB00849MethylphenobarbitalGamma-aminobutyric acid receptor subunit alpha-3target
DB00849MethylphenobarbitalGamma-aminobutyric acid receptor subunit alpha-4target
DB00849MethylphenobarbitalGamma-aminobutyric acid receptor subunit alpha-5target
DB00849MethylphenobarbitalGamma-aminobutyric acid receptor subunit alpha-6target
DB00849MethylphenobarbitalNeuronal acetylcholine receptor subunit alpha-4target
DB00849MethylphenobarbitalNeuronal acetylcholine receptor subunit alpha-7target
DB00849MethylphenobarbitalGlutamate receptor 2target
DB00849MethylphenobarbitalGlutamate receptor ionotropic, kainate 2target
DB00849MethylphenobarbitalNuclear receptor subfamily 1 group I member 2target
DB00897TriazolamTranslocator proteintarget
DB00897TriazolamCytochrome P450 3A4enzyme
DB00897TriazolamCytochrome P450 3A5enzyme
DB00897TriazolamCytochrome P450 3A7enzyme
DB00897TriazolamGamma-aminobutyric acid receptor subunit alpha-1target
DB00897TriazolamGamma-aminobutyric acid receptor subunit alpha-2target
DB00897TriazolamGamma-aminobutyric acid receptor subunit alpha-3target
DB00897TriazolamGamma-aminobutyric acid receptor subunit alpha-4target
DB00897TriazolamGamma-aminobutyric acid receptor subunit alpha-5target
DB00897TriazolamGamma-aminobutyric acid receptor subunit alpha-6target
DB00897TriazolamGamma-aminobutyric acid receptor subunit beta-1target
DB00897TriazolamGamma-aminobutyric acid receptor subunit beta-2target
DB00897TriazolamGamma-aminobutyric acid receptor subunit beta-3target
DB00897TriazolamGamma-aminobutyric acid receptor subunit gamma-1target
DB00897TriazolamGamma-aminobutyric acid receptor subunit gamma-2target
DB00897TriazolamGamma-aminobutyric acid receptor subunit gamma-3target
DB00897TriazolamGamma-aminobutyric acid receptor subunit deltatarget
DB00897TriazolamGamma-aminobutyric acid receptor subunit epsilontarget
DB00897TriazolamGamma-aminobutyric acid receptor subunit pitarget
DB00897TriazolamGamma-aminobutyric acid receptor subunit rho-1target
DB00897TriazolamGamma-aminobutyric acid receptor subunit rho-2target
DB00897TriazolamGamma-aminobutyric acid receptor subunit rho-3target
DB00897TriazolamGamma-aminobutyric acid receptor subunit thetatarget
DB00897TriazolamCytochrome P450 2C8enzyme
DB00897TriazolamGABA-A receptor (anion channel)target
DB00962ZaleplonTranslocator proteintarget
DB00962ZaleplonGamma-aminobutyric acid receptor subunit alpha-1target
DB00962ZaleplonCytochrome P450 3A4enzyme
DB00962ZaleplonAldehyde oxidaseenzyme
DB00962ZaleplonCytochrome P450 3A5enzyme
DB00962ZaleplonCytochrome P450 3A7enzyme
DB01068ClonazepamTranslocator proteintarget
DB01068ClonazepamCytochrome P450 3A4enzyme
DB01068ClonazepamSerum albumincarrier
DB01068ClonazepamCytochrome P450 2E1enzyme
DB01068ClonazepamArylamine N-acetyltransferase 2enzyme
DB01068ClonazepamGABA-A receptor (anion channel)target
DB01068ClonazepamNuclear receptor subfamily 1 group I member 2target
DB01154ThiamylalGamma-aminobutyric acid receptor subunit alpha-1target
DB01154ThiamylalATP-sensitive inward rectifier potassium channel 8target
DB01154ThiamylalATP-sensitive inward rectifier potassium channel 11target
DB01154ThiamylalCytochrome P450 2C9enzyme
DB01154ThiamylalCytochrome P450 3A4enzyme
DB01154ThiamylalCytochrome P450 2E1enzyme
DB01174PhenobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
DB01174PhenobarbitalCytochrome P450 2C19enzyme
DB01174PhenobarbitalCytochrome P450 2C9enzyme
DB01174PhenobarbitalCytochrome P450 2B6enzyme
DB01174PhenobarbitalCytochrome P450 2C8enzyme
DB01174PhenobarbitalCytochrome P450 1A2enzyme
DB01174PhenobarbitalCytochrome P450 3A4enzyme
DB01174PhenobarbitalCanalicular multispecific organic anion transporter 2transporter
DB01174PhenobarbitalBile salt export pumptransporter
DB01174PhenobarbitalMultidrug resistance protein 1transporter
DB01174PhenobarbitalMultidrug resistance-associated protein 1transporter
DB01174PhenobarbitalSolute carrier organic anion transporter family member 2A1transporter
DB01174PhenobarbitalCanalicular multispecific organic anion transporter 1transporter
DB01174PhenobarbitalNeuronal acetylcholine receptor subunit alpha-4target
DB01174PhenobarbitalNeuronal acetylcholine receptor subunit alpha-7target
DB01174PhenobarbitalGlutamate receptor 2target
DB01174PhenobarbitalGlutamate receptor ionotropic, kainate 2target
DB01174PhenobarbitalCytochrome P450 2A6enzyme
DB01174PhenobarbitalCytochrome P450 2E1enzyme
DB01174PhenobarbitalCytochrome P450 3A5enzyme
DB01174PhenobarbitalCytochrome P450 4A11enzyme
DB01174PhenobarbitalCytochrome P450 1A1enzyme
DB01174PhenobarbitalCytochrome P450 1B1enzyme
DB01174PhenobarbitalCytochrome P450 2C18enzyme
DB01174PhenobarbitalCytochrome P450 3A7enzyme
DB01174PhenobarbitalCytochrome P450 4B1enzyme
DB01174PhenobarbitalNMDA receptortarget
DB01174PhenobarbitalNuclear receptor subfamily 1 group I member 2target
DB01174PhenobarbitalUDP-glucuronosyltransferase 1-1enzyme
DB01174PhenobarbitalUDP-glucuronosyltransferase 2B7enzyme
DB01205FlumazenilGamma-aminobutyric acid receptor subunit alpha-1target
DB01205FlumazenilGamma-aminobutyric acid receptor subunit gamma-2target
DB01205FlumazenilGamma-aminobutyric acid receptor subunit alpha-5target
DB01205FlumazenilGABA-A receptor (anion channel)target
DB01215EstazolamCytochrome P450 3A4enzyme
DB01215EstazolamGamma-aminobutyric acid receptor subunit alpha-1target
DB01215EstazolamGamma-aminobutyric acid receptor subunit alpha-2target
DB01215EstazolamGamma-aminobutyric acid receptor subunit alpha-3target
DB01215EstazolamGamma-aminobutyric acid receptor subunit alpha-5target
DB01215EstazolamGamma-aminobutyric acid receptor subunit gamma-1target
DB01215EstazolamGamma-aminobutyric acid receptor subunit gamma-2target
DB01215EstazolamGamma-aminobutyric acid receptor subunit gamma-3target
DB01215EstazolamGamma-aminobutyric acid receptor subunit beta-1target
DB01215EstazolamGamma-aminobutyric acid receptor subunit beta-2target
DB01215EstazolamGamma-aminobutyric acid receptor subunit beta-3target
DB01215EstazolamGamma-aminobutyric acid receptor subunit deltatarget
DB01215EstazolamGamma-aminobutyric acid receptor subunit epsilontarget
DB01215EstazolamGamma-aminobutyric acid receptor subunit pitarget
DB01215EstazolamGamma-aminobutyric acid receptor subunit rho-1target
DB01215EstazolamGamma-aminobutyric acid receptor subunit rho-2target
DB01215EstazolamGamma-aminobutyric acid receptor subunit rho-3target
DB01215EstazolamGABA-A receptor (anion channel)target
DB01351AmobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
DB01351AmobarbitalGamma-aminobutyric acid receptor subunit alpha-4target
DB01351AmobarbitalGamma-aminobutyric acid receptor subunit alpha-6target
DB01351AmobarbitalNeuronal acetylcholine receptor subunit alpha-4target
DB01351AmobarbitalNeuronal acetylcholine receptor subunit alpha-7target
DB01351AmobarbitalGlutamate receptor 2target
DB01351AmobarbitalGamma-aminobutyric acid receptor subunit alpha-2target
DB01351AmobarbitalGamma-aminobutyric acid receptor subunit alpha-3target
DB01351AmobarbitalGamma-aminobutyric acid receptor subunit alpha-5target
DB01351AmobarbitalGlutamate receptor ionotropic, kainate 2target
DB01351AmobarbitalCytochrome P450 2A6enzyme
DB01355HexobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
DB01355HexobarbitalCytochrome P450 2E1enzyme
DB01355HexobarbitalCytochrome P450 2C9enzyme
DB01355HexobarbitalCytochrome P450 2C19enzyme
DB01355HexobarbitalProstaglandin G/H synthase 1enzyme
DB01355HexobarbitalGamma-aminobutyric acid receptor subunit alpha-2target
DB01355HexobarbitalGamma-aminobutyric acid receptor subunit alpha-3target
DB01355HexobarbitalGamma-aminobutyric acid receptor subunit alpha-4target
DB01355HexobarbitalGamma-aminobutyric acid receptor subunit alpha-5target
DB01355HexobarbitalGamma-aminobutyric acid receptor subunit alpha-6target
DB01355HexobarbitalNeuronal acetylcholine receptor subunit alpha-4target
DB01355HexobarbitalNeuronal acetylcholine receptor subunit alpha-7target
DB01355HexobarbitalGlutamate receptor 2target
DB01355HexobarbitalGlutamate receptor ionotropic, kainate 2target
DB01355HexobarbitalCytochrome P450 3A4enzyme
DB01483BarbitalGamma-aminobutyric acid receptor subunit alpha-1target
DB01483BarbitalGamma-aminobutyric acid receptor subunit alpha-2target
DB01483BarbitalGamma-aminobutyric acid receptor subunit alpha-3target
DB01483BarbitalGamma-aminobutyric acid receptor subunit alpha-4target
DB01483BarbitalGamma-aminobutyric acid receptor subunit alpha-5target
DB01483BarbitalGamma-aminobutyric acid receptor subunit alpha-6target
DB01483BarbitalNeuronal acetylcholine receptor subunit alpha-4target
DB01483BarbitalNeuronal acetylcholine receptor subunit alpha-7target
DB01483BarbitalGlutamate receptor 2target
DB01483BarbitalGlutamate receptor ionotropic, kainate 2target
DB01483BarbitalCytochrome P450 3A4enzyme
DB01483BarbitalCytochrome P450 2C19enzyme
DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit alpha-4target
DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit alpha-6target
DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB01544FlunitrazepamTranslocator proteintarget
DB01544FlunitrazepamCytochrome P450 2C19enzyme
DB01544FlunitrazepamUDP-glucuronosyltransferase 2B7enzyme
DB01544FlunitrazepamCytochrome P450 2A6enzyme
DB01544FlunitrazepamCytochrome P450 2B6enzyme
DB01544FlunitrazepamCytochrome P450 2C9enzyme
DB01544FlunitrazepamCytochrome P450 3A4enzyme
DB01544FlunitrazepamCytochrome P450 2E1enzyme
DB01544FlunitrazepamUDP-glucuronosyltransferase 1-1enzyme
DB01544FlunitrazepamUDP-glucuronosyltransferase 1-3enzyme
DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit beta-3target
DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB01558BromazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB01558BromazepamCytochrome P450 3A4enzyme
DB01558BromazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB01558BromazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB01558BromazepamGamma-aminobutyric acid receptor subunit alpha-4target
DB01558BromazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB01558BromazepamGamma-aminobutyric acid receptor subunit alpha-6target
DB01558BromazepamGamma-aminobutyric acid receptor subunit beta-1target
DB01558BromazepamGamma-aminobutyric acid receptor subunit beta-2target
DB01558BromazepamGamma-aminobutyric acid receptor subunit beta-3target
DB01558BromazepamGamma-aminobutyric acid receptor subunit gamma-1target
DB01558BromazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB01558BromazepamGamma-aminobutyric acid receptor subunit gamma-3target
DB01558BromazepamGamma-aminobutyric acid receptor subunit deltatarget
DB01558BromazepamGamma-aminobutyric acid receptor subunit epsilontarget
DB01558BromazepamGamma-aminobutyric acid receptor subunit pitarget
DB01558BromazepamGamma-aminobutyric acid receptor subunit rho-1target
DB01558BromazepamGamma-aminobutyric acid receptor subunit rho-2target
DB01558BromazepamGamma-aminobutyric acid receptor subunit thetatarget
DB01558BromazepamGamma-aminobutyric acid receptor subunit rho-3target
DB01558BromazepamCytochrome P450 1A2enzyme
DB01558BromazepamCytochrome P450 2C19enzyme
DB01558BromazepamCytochrome P450 2E1enzyme
DB01588PrazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB01588PrazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB01588PrazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB01588PrazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB01588PrazepamGamma-aminobutyric acid receptor subunit gamma-1target
DB01588PrazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB01588PrazepamGamma-aminobutyric acid receptor subunit gamma-3target
DB01588PrazepamGamma-aminobutyric acid receptor subunit beta-1target
DB01588PrazepamGamma-aminobutyric acid receptor subunit beta-2target
DB01588PrazepamGamma-aminobutyric acid receptor subunit beta-3target
DB01588PrazepamGamma-aminobutyric acid receptor subunit deltatarget
DB01588PrazepamGamma-aminobutyric acid receptor subunit epsilontarget
DB01588PrazepamGamma-aminobutyric acid receptor subunit pitarget
DB01588PrazepamGamma-aminobutyric acid receptor subunit rho-1target
DB01588PrazepamGamma-aminobutyric acid receptor subunit rho-2target
DB01588PrazepamGamma-aminobutyric acid receptor subunit rho-3target
DB01588PrazepamCytochrome P450 3A4enzyme
DB01588PrazepamGABA-A receptor (anion channel)target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB01595NitrazepamSodium channel protein type 1 subunit alphatarget
DB01595NitrazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit alpha-4target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit alpha-6target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit beta-1target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit beta-2target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit beta-3target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit gamma-1target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit gamma-3target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit deltatarget
DB01595NitrazepamGamma-aminobutyric acid receptor subunit epsilontarget
DB01595NitrazepamGamma-aminobutyric acid receptor subunit pitarget
DB01595NitrazepamGamma-aminobutyric acid receptor subunit rho-1target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit rho-2target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit rho-3target
DB01595NitrazepamGamma-aminobutyric acid receptor subunit thetatarget
DB01595NitrazepamCytochrome P450 3A4enzyme
DB01595NitrazepamCytochrome P450 2E1enzyme
DB06470ClomethiazoleGamma-aminobutyric acid receptor subunit alpha-1target
DB06470ClomethiazoleCytochrome P450 2A6enzyme
DB06470ClomethiazoleCytochrome P450 2B6enzyme
DB06470ClomethiazoleCytochrome P450 2C19enzyme
DB06470ClomethiazoleCytochrome P450 3A4enzyme
DB13994AZD-7325Gamma-aminobutyric acid receptor subunit alpha-3target
DB13994AZD-7325Gamma-aminobutyric acid receptor subunit alpha-2target
DB11859BrexanoloneGABA-A receptor (anion channel)target
DB11859BrexanoloneSulfotransferaseenzyme
DB11859BrexanoloneGlucuronosyltransferaseenzyme
DB11859BrexanoloneAldose reductaseenzyme
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-1target
DB00794PrimidoneCytochrome P450 2C19enzyme
DB00794PrimidoneCytochrome P450 1A2enzyme
DB00794PrimidoneCytochrome P450 2B6enzyme
DB00794PrimidoneCytochrome P450 2C8enzyme
DB00794PrimidoneCytochrome P450 2C9enzyme
DB00794PrimidoneCytochrome P450 3A4enzyme
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-2target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-3target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-4target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-5target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-6target
DB00794PrimidoneNeuronal acetylcholine receptor subunit alpha-4target
DB00794PrimidoneNeuronal acetylcholine receptor subunit alpha-7target
DB00794PrimidoneGlutamate receptor 2target
DB00794PrimidoneGlutamate receptor ionotropic, kainate 2target
DB00794PrimidoneGABA-A receptor (anion channel)target
DB00794PrimidoneUDP-glucuronosyltransferase 1-1enzyme