Anti-Obesity Agents

Agents that increase energy expenditure and weight loss by neural and chemical regulation. Beta-adrenergic agents and serotoninergic drugs have been experimentally used in patients with non-insulin dependent diabetes mellitus (NIDDM) to treat obesity.
DrugDrug NameDrug Description
DB00191PhentermineA sympathomimetic anorectic agent used as a short-term adjunct therapy that is included in a regimen of weight reduction in cases of exogenous obesity.
DB00273TopiramateAn anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines.
DB00397PhenylpropanolamineA sympathomimetic that was previously used in nasal decongestants and weight loss products, but has been withdrawn by the FDA due to safety risks and lack of efficacy.
DB00830PhenmetrazineUsed as an anorectic in the treatment of obesity.
DB00937DiethylpropionAn appetite suppressant used for the short term treatment of exogenous obesity in addition to calorie restriction.
DB01083OrlistatA reversible inhibitor of gastrointestinal lipases indicated for weight loss and weight maintenance.
DB01105SibutramineA norepinephrine, serotonin and dopamine reuptake inhibitor indicated to assist with weight loss in obesity.
DB01486CathineUsed to decrease appetite.
DB04870Oleoyl-estroneFor the treatment of obesity.
DB05791PerflubronInvestigated for use/treatment in cardiac surgery, hemorrhage, and ileus.
DB09022BenfluorexBenfluorex is an anorectic and hypolipidemic agent that is structurally related to fenfluramine. It was patented and manufactured by a French pharmaceutical company Servier. The European Medicines Agency (EMA) recommended...
DB11700SetmelanotideSetmelanotide has been investigated for the treatment of obesity.
DB01276ExenatideA GLP-1 agonist used in the management of type 2 diabetes mellitus.
DB06155RimonabantFor use in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m2, or patients wih a BMI greater than 27 kg/m2 with associated...
DB06586CetilistatInvestigated for use/treatment in obesity.
DrugDrug NameTargetType
DB00191PhentermineSodium-dependent noradrenaline transportertarget
DB00191PhentermineSodium-dependent dopamine transportertarget
DB00191PhentermineAmine oxidase [flavin-containing] Atarget
DB00191PhentermineAmine oxidase [flavin-containing] Btarget
DB00191PhentermineSodium-dependent serotonin transportertarget
DB00191PhenterminePro-neuropeptide Ytarget
DB00191PhentermineCytochrome P450 3A4enzyme
DB00273TopiramateGamma-aminobutyric acid receptor subunit alpha-1target
DB00273TopiramateVoltage-gated sodium channel alpha subunittarget
DB00273TopiramateCarbonic anhydrase 2target
DB00273TopiramateCarbonic anhydrase 4target
DB00273TopiramateKainate receptorstarget
DB00273TopiramateCytochrome P450 2C19enzyme
DB00273TopiramateCytochrome P450 3A4enzyme
DB00273TopiramateCarbonic anhydrase 1target
DB00273TopiramateCarbonic anhydrase 3target
DB00273TopiramateVoltage gated L-type calcium channeltarget
DB00273TopiramateVoltage-dependent R-type calcium channeltarget
DB00273TopiramateSerum albumincarrier
DB00273TopiramateP-glycoprotein 1transporter
DB00273Topiramate5'-AMP-activated protein kinasetransporter
DB00397PhenylpropanolamineAmine oxidase [flavin-containing] Aenzyme
DB00397PhenylpropanolamineDopamine D1 receptortarget
DB00397PhenylpropanolamineBeta-1 adrenergic receptortarget
DB00397PhenylpropanolamineBeta-2 adrenergic receptortarget
DB00397PhenylpropanolamineAlpha-2 adrenergic receptorstarget
DB00830PhenmetrazineSodium-dependent noradrenaline transportertarget
DB00830PhenmetrazineSodium-dependent dopamine transportertarget
DB00937DiethylpropionSodium-dependent noradrenaline transportertarget
DB00937DiethylpropionSodium-dependent dopamine transportertarget
DB01083OrlistatPancreatic triacylglycerol lipasetarget
DB01083OrlistatFatty acid synthasetarget
DB01083OrlistatGastric triacylglycerol lipasetarget
DB01083OrlistatCytochrome P450 3A4enzyme
DB01083OrlistatCytosolic phospholipase A2enzyme
DB01105SibutramineSodium-dependent serotonin transportertarget
DB01105SibutramineSodium-dependent noradrenaline transportertarget
DB01105SibutramineCytochrome P450 3A4enzyme
DB01105SibutramineSodium-dependent dopamine transportertarget
DB01276ExenatideGlucagon-like peptide 1 receptortarget
DB01276ExenatideSerum albumincarrier
DB01276ExenatideDipeptidyl peptidase 4enzyme
DB06155RimonabantCannabinoid receptor 1target
DB06155RimonabantCytochrome P450 3A4enzyme
DB06155RimonabantG-protein coupled receptor 55target
DB06586CetilistatPancreatic triacylglycerol lipasetarget