Propanolamines

AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.
DrugDrug NameDrug Indication
DB00195BetaxololFor the management of hypertension.
DB00264MetoprololMetoprolol is indicated for the treatment of angina, heart failure, myocardial infarction, atrial fibrillation, atrial flutter and hypertension.[A175141] Some off-label uses of metoprolol include supraventricular tachycardia and thyroid storm.[A175141] All the indications of metoprolol are part of cardiovascular diseases. These conditions correspond to a number of diseases that involve the function of the heart and blood vessels. The underlying causes of these conditions are variable and can be due to genetic disposition, lifestyle decisions such as smoking, obesity, diet, and lack of exercise, and comorbidity with other conditions such as diabetes. The cardiovascular diseases are the leading cause of death on a global scale.[L5533]
DB00373Timolol Ophthalmic timolol is indicated for the treatment of increased intraocular pressure in patients with ocular hypertension or open-angle glaucoma. The oral form of this drug is used to treat high blood pressure.[L6724,L6727] In certain cases, timolol is used in the prevention of migraine headaches.[A179530,L6742]
DB00397PhenylpropanolamineFor the treatment of nasal congestion, control of urinary incontinence, priapism and obesity.
DB00521CarteololFor the treatment of intraocular hypertension and chronic open-angle glaucoma
DB00571PropranololFor the prophylaxis of migraine.
DB00610MetaraminolFor the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage
DB00612BisoprololFor management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI).
DB00723MethoxamineIndicated for the treatment and management of hypotension.
DB00852PseudoephedrineFor the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism.
DB00866AlprenololFor the treatment of hypertension, angina, and arrhythmia
DB00867RitodrineFor the treatment and prophylaxis of premature labour
DB00960PindololFor the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation.
DB01036TolterodineFor the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).
DB01193AcebutololFor the management of hypertension and ventricular premature beats in adults.
DB01203NadololUsed in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension.
DB01210LevobunololFor lowering intraocular pressure (IOP) and may be used in patients with chronic open-angle glaucoma or ocular hypertension.
DB01214MetipranololIndicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open angle glaucoma.
DB01297PractololUsed in the emergency treatment of cardiac arrhythmias.
DB01359PenbutololPenbutolol is indicated in the treatment of mild to moderate arterial hypertension. It may be used alone or in combination with other antihypertensive agents, especially thiazide-type diuretics.Penbutolol is contraindicated in patients with cardiogenic shock, sinus bradycardia, second and third degree atrioventricular conduction block, bronchial asthma, and those with known hypersensitivity.
DB01364EphedrineEphedrine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia.
DB01486CathineUsed to decrease appetite.
DB01580OxprenololUsed in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.
DB03811HistidinolNot Available
DB04846CeliprololCeliprolol is indicated for the management of mild to moderate hypertension and effort-induced angina pectoris.
DB06152NylidrinNylidrin is mainly indicated in conditions like arteriosclerosis, cerebrovascular disease, peripheral vascular disease, Raynaud's disease, thrombo-angitis obliterans, and thrombophlebitis [L2285]. It may sometimes be used in the treatment of peripheral vascular disorders in addition premature labor (however, the drug is not approved for premature labor)[A32531].
DB08807BopindololFor the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation.
DB08808BupranololUsed to manage hypertension and tachycardia. Also used to treat glaucoma.
DB08941IsoxsuprineNot Available
DB11587EtafedrineConditions characterized by bronchial congestion and bronchospasm when an expectorant or bronchodilator action is required, such as acute bronchitis, acute episodes of chronic bronchitis and bronchial asthma [L2565], [L2566].
DB11610OxilofrineUsed in combination with [DB11609] as an antitussive [FDA Label].
DB12926CafedrineNot Available
DB13340SuloctidilNot Available
DB13398OxyfedrineNot Available
DB13530MepindololNot Available
DB13777PrenalterolNot Available
DB13781XamoterolNot Available
DB03322DexpropranololNot Available
DrugDrug NameTargetType
DB00195BetaxololBeta-1 adrenergic receptortarget
DB00195BetaxololBeta-2 adrenergic receptortarget
DB00195BetaxololCytochrome P450 1A2enzyme
DB00195BetaxololCytochrome P450 2D6enzyme
DB00264MetoprololBeta-1 adrenergic receptortarget
DB00264MetoprololCytochrome P450 2D6enzyme
DB00264MetoprololBeta-2 adrenergic receptortarget
DB00264MetoprololSolute carrier family 22 member 2transporter
DB00264MetoprololMultidrug resistance protein 1transporter
DB00264MetoprololSerum albumincarrier
DB00264MetoprololCytochrome P450 3A4enzyme
DB00373TimololBeta-1 adrenergic receptortarget
DB00373TimololBeta-2 adrenergic receptortarget
DB00373TimololCytochrome P450 2D6enzyme
DB00373TimololMultidrug resistance protein 1transporter
DB00373TimololCytochrome P450 2C19enzyme
DB00373TimololLysozymetarget
DB00397PhenylpropanolamineAmine oxidase [flavin-containing] Aenzyme
DB00397PhenylpropanolamineD(1A) dopamine receptortarget
DB00397PhenylpropanolamineBeta-1 adrenergic receptortarget
DB00397PhenylpropanolamineBeta-2 adrenergic receptortarget
DB00397PhenylpropanolamineAlpha-2 adrenergic receptorstarget
DB00521CarteololBeta-2 adrenergic receptortarget
DB00521CarteololBeta-1 adrenergic receptortarget
DB00521CarteololCytochrome P450 2D6enzyme
DB00571PropranololBeta-1 adrenergic receptortarget
DB00571PropranololBeta-2 adrenergic receptortarget
DB00571PropranololBeta-3 adrenergic receptortarget
DB00571Propranolol5-hydroxytryptamine receptor 1Atarget
DB00571Propranolol5-hydroxytryptamine receptor 1Btarget
DB00571PropranololCytochrome P450 1A2enzyme
DB00571PropranololCytochrome P450 2D6enzyme
DB00571PropranololAlpha-1-acid glycoprotein 1carrier
DB00571PropranololCytochrome P450 2C19enzyme
DB00571PropranololCytochrome P450 3A4enzyme
DB00571PropranololCytochrome P450 3A5enzyme
DB00571PropranololCytochrome P450 3A7enzyme
DB00571PropranololSolute carrier family 22 member 2transporter
DB00571PropranololMultidrug resistance protein 1transporter
DB00571PropranololCytochrome P450 1A1enzyme
DB00571PropranololAmine oxidase [flavin-containing] Aenzyme
DB00610MetaraminolAlpha-1A adrenergic receptortarget
DB00612BisoprololBeta-1 adrenergic receptortarget
DB00612BisoprololBeta-2 adrenergic receptortarget
DB00612BisoprololCytochrome P450 2D6enzyme
DB00612BisoprololCytochrome P450 3A4enzyme
DB00723MethoxamineAlpha-1A adrenergic receptortarget
DB00723MethoxamineAlpha-1B adrenergic receptortarget
DB00723MethoxamineAlpha-1D adrenergic receptortarget
DB00852PseudoephedrineAlpha-1A adrenergic receptortarget
DB00852PseudoephedrineAlpha-2A adrenergic receptortarget
DB00852PseudoephedrineBeta-2 adrenergic receptortarget
DB00852PseudoephedrineAmine oxidase [flavin-containing] Aenzyme
DB00852PseudoephedrineBeta-1 adrenergic receptortarget
DB00852PseudoephedrineCytochrome P450 2D6enzyme
DB00852PseudoephedrineSodium-dependent dopamine transportertarget
DB00852PseudoephedrineSodium-dependent noradrenaline transportertarget
DB00852PseudoephedrineSodium-dependent serotonin transportertarget
DB00852PseudoephedrineNuclear factor of activated T-cells, cytoplasmic 1target
DB00852PseudoephedrineTumor necrosis factortarget
DB00852PseudoephedrineNuclear factor kappa-light-chain-enhancer of activated B cellstarget
DB00852Pseudoephedrineactivator protein 1target
DB00852PseudoephedrineInterleukin-2target
DB00866AlprenololBeta-1 adrenergic receptortarget
DB00866AlprenololBeta-2 adrenergic receptortarget
DB00866Alprenolol5-hydroxytryptamine receptor 1Atarget
DB00866AlprenololCytochrome P450 2D6enzyme
DB00866AlprenololBeta-3 adrenergic receptortarget
DB00867RitodrineBeta-2 adrenergic receptortarget
DB00867Ritodrine6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00960PindololBeta-1 adrenergic receptortarget
DB00960PindololBeta-2 adrenergic receptortarget
DB00960Pindolol5-hydroxytryptamine receptor 1Atarget
DB00960Pindolol5-hydroxytryptamine receptor 1Btarget
DB00960PindololCytochrome P450 2D6enzyme
DB00960PindololBeta-3 adrenergic receptortarget
DB01036TolterodineMuscarinic acetylcholine receptor M1target
DB01036TolterodineMuscarinic acetylcholine receptor M2target
DB01036TolterodineMuscarinic acetylcholine receptor M3target
DB01036TolterodineCytochrome P450 2D6enzyme
DB01036TolterodineCytochrome P450 3A4enzyme
DB01036TolterodineCytochrome P450 2C9enzyme
DB01036TolterodineCytochrome P450 2C19enzyme
DB01036TolterodineMuscarinic acetylcholine receptor M4target
DB01036TolterodineMuscarinic acetylcholine receptor M5target
DB01193AcebutololBeta-1 adrenergic receptortarget
DB01193AcebutololCytochrome P450 2D6enzyme
DB01193AcebutololBeta-2 adrenergic receptortarget
DB01193AcebutololMultidrug resistance protein 1transporter
DB01203NadololBeta-1 adrenergic receptortarget
DB01203NadololBeta-2 adrenergic receptortarget
DB01203NadololMultidrug resistance protein 1transporter
DB01203NadololCytochrome P450 2D6enzyme
DB01210LevobunololBeta-1 adrenergic receptortarget
DB01210LevobunololBeta-2 adrenergic receptortarget
DB01210LevobunololCytochrome P450 2D6enzyme
DB01214MetipranololBeta-1 adrenergic receptortarget
DB01214MetipranololBeta-2 adrenergic receptortarget
DB01214MetipranololCytochrome P450 2D6enzyme
DB01297PractololBeta-1 adrenergic receptortarget
DB01297PractololCytochrome P450 2D6enzyme
DB01359PenbutololAlpha-1-acid glycoprotein 1carrier
DB01359PenbutololBeta-1 adrenergic receptortarget
DB01359PenbutololBeta-2 adrenergic receptortarget
DB01359Penbutolol5-hydroxytryptamine receptor 1Atarget
DB01359Penbutolol5-hydroxytryptamine receptor 1Btarget
DB01359PenbutololCytochrome P450 2D6enzyme
DB01364EphedrineAcetylcholinesterasetarget
DB01364EphedrineAlpha-1A adrenergic receptortarget
DB01364EphedrineSodium-dependent noradrenaline transportertarget
DB01364EphedrineSynaptic vesicular amine transportertarget
DB01364EphedrineCholinesteraseenzyme
DB01580OxprenololBeta-1 adrenergic receptortarget
DB01580OxprenololBeta-2 adrenergic receptortarget
DB01580OxprenololSolute carrier family 22 member 2transporter
DB01580OxprenololCytochrome P450 2D6enzyme
DB01580OxprenololBeta-3 adrenergic receptortarget
DB03811HistidinolHistidinol dehydrogenasetarget
DB03811HistidinolHistidine--tRNA ligasetarget
DB04846CeliprololBeta-1 adrenergic receptortarget
DB04846CeliprololBeta-2 adrenergic receptortarget
DB04846CeliprololBeta-3 adrenergic receptortarget
DB04846CeliprololAlpha-2A adrenergic receptortarget
DB04846CeliprololAlpha-2B adrenergic receptortarget
DB04846CeliprololAlpha-2C adrenergic receptortarget
DB04846CeliprololCytochrome P450 2D6enzyme
DB06152NylidrinCatechol O-methyltransferaseenzyme
DB06152NylidrinVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB06152NylidrinInterferon alpha/beta receptor 2target
DB06152NylidrinCytochrome P450 3A4enzyme
DB08807BopindololBeta-1 adrenergic receptortarget
DB08807BopindololBeta-2 adrenergic receptortarget
DB08807Bopindolol5-hydroxytryptamine receptor 1Atarget
DB08807Bopindolol5-hydroxytryptamine receptor 1Btarget
DB08807BopindololBeta-3 adrenergic receptortarget
DB08807BopindololCytochrome P450 2D6enzyme
DB08808BupranololBeta-1 adrenergic receptortarget
DB08808BupranololBeta-2 adrenergic receptortarget
DB08808BupranololBeta-3 adrenergic receptortarget
DB08808BupranololCytochrome P450 2D6enzyme
DB11587EtafedrineBeta-2 adrenergic receptortarget
DB13530MepindololCytochrome P450 2D6enzyme
DB13781XamoterolBeta-1 adrenergic receptortarget