Piperazines

Name
Piperazines
Accession Number
DBCAT000513
Description

Compounds that are derived from PIPERAZINE

Drugs
DrugDrug Description
SildenafilA phosphodiesterase inhibitor used for the treatment of erectile dysfunction.
PipobromanFor the treatment of polycythaemia vera and refractory chronic myeloid leukaemia.
RanolazineAn anti-anginal drug used for the treatment of chronic angina.
CetirizineA selective Histamine-1 antagonist drug used in allergic rhinitis and chronic urticaria.
ThiethylperazineFor the treatment or relief of nausea and vomiting.
DexrazoxaneA cytoprotective drug used to prevent and improve cardiomyopathy associated with doxorubicin treatment for metastatic breast cancer.
EszopicloneA sedative-hypnotic used in the treatment of insomnia, improving both the latency phase and the maintenance phase of sleep.
BuspironeAn anxiolytic agent used for short-term treatment of generalized anxiety and second-line treatment of depression.
HydroxyzineAn antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria.
CinnarizineFor the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
ImatinibA tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
TrazodoneA serotonin uptake inhibitor used to treat major depressive disorder.
DelavirdineA non-nucleoside reverse transcriptase inhibitor used to treat HIV infection.
DiethylcarbamazineAn anthelmintic used to treat filarial infections like Wuchereria bancrofti and Loa loa.
MeclizineA histamine H1 antagonist used to treat nausea, vomiting, and dizziness associated with motion sickness.
VardenafilA phosphodiesterase 5 inhibitor used to treat erectile dysfunction.
FlupentixolA thioxanthene neuroleptic used to treat schizophrenia and depression.
KetoconazoleA broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.
ItraconazoleAn antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis.
CyclizineAn antihistamine and antiemetic drug used for the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo.
AripiprazoleAn atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome.
PipecuroniumA nondepolarizing neuromuscular blocking agent used to relax muscles during anesthesia and surgical procedures.
AlmitrineFor the treatment of chronic obstructive pulmonary disease.
HydroxyfasudilNot Available
FlunarizineA selective calcium-entry blocker used as migraine prophylaxis in patients with severe and frequent episodes who have not responded adequately to more common treatments.
PlinabulinInvestigated for use/treatment in cancer/tumors (unspecified).
PrasugrelA P2Y12 platelet inhibitor used to reduce risk of thrombotic cardiovascular events in unstable angina or non-ST-elevation myocardial infarction (NSTEMI), and in patients with STEMI when managed with either primary or delayed PCI.
LevocetirizineAn H1-receptor antagonist used to treat symptoms associated with chronic allergic rhinitis and uncomplicated cases of chronic idiopathic urticaria.
VilazodoneAn antidepressant agent used for the treatment of major depressive disorder that targets the 5-HT transporter and 5-HT1A receptors.
5-(2-methylpiperazine-1-sulfonyl)isoquinolineNot Available
TrimetazidineTrimetazidine is indicated for use in angina pectoris.
EtoperidoneEtoperidone has been studied for the treatment of depression , tremors in Parkinson, extrapyramidal symptoms and male impotence . It is not certain if it was ever approved and marketed...
EpelsibanEpelsiban has been investigated for the treatment of Premature Ejaculation.
PiribedilPiribedil has been investigated in Parkinson's Disease.
LidoflazineNot Annotated
Pipemidic acidNot Annotated
Aripiprazole lauroxilAn antipsychotic used to treat schizophrenia in adults.
FasudilFasudil has been investigated in Carotid Stenosis.
PiperazineA medication used to treat roundworm and pinworm.
VortioxetineAn atypical antipsychotic and antidepressant indicated for the treatment of major depressive disorder (MDD).
NNZ-2591NNZ-2591 (cyclo-L-glycyl-L-2-allylproline) is an investigational synthetic analog of cyclic glycine-proline (cGP), a breakdown product of human insulin-like growth factor 1 (IGF-1), that has been chemically modified to increase its half-life,...
Drugs & Drug Targets
DrugTargetType
SildenafilcGMP-specific 3',5'-cyclic phosphodiesterasetarget
SildenafilCytochrome P450 2C9enzyme
SildenafilRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammatarget
SildenafilRetinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammatarget
SildenafilCytochrome P450 3A4enzyme
SildenafilCytochrome P450 3A5enzyme
SildenafilCytochrome P450 3A7enzyme
SildenafilMultidrug resistance-associated protein 4transporter
SildenafilMultidrug resistance-associated protein 5transporter
SildenafilMultidrug resistance-associated protein 7transporter
SildenafilCytochrome P450 2C19enzyme
SildenafilCytochrome P450 2D6enzyme
SildenafilCytochrome P450 2E1enzyme
SildenafilSolute carrier organic anion transporter family member 1B1transporter
SildenafilP-glycoprotein 1transporter
PipobromanDNAtarget
RanolazineCytochrome P450 3A4enzyme
RanolazineCytochrome P450 2D6enzyme
RanolazineBile salt export pumptransporter
RanolazineP-glycoprotein 1transporter
RanolazineSodium channel proteintarget
RanolazineInward rectifier potassium channeltarget
RanolazineVoltage gated L-type calcium channeltarget
RanolazineAlpha-1 adrenergic receptorstarget
RanolazineBeta-1 adrenergic receptortarget
RanolazineFatty acidtarget
RanolazineAlpha-1-acid glycoprotein 1carrier
RanolazineMultidrug and toxin extrusion protein 1transporter
RanolazineMultidrug and toxin extrusion protein 2transporter
CetirizineHistamine H1 receptortarget
CetirizineP-glycoprotein 1transporter
ThiethylperazineDopamine D2 receptortarget
DexrazoxaneDNA topoisomerase 2-alphatarget
DexrazoxaneDNA topoisomerase 2-betatarget
EszopicloneCytochrome P450 3A4enzyme
EszopicloneGamma-aminobutyric acid receptor subunit alpha-1target
EszopicloneGamma-aminobutyric acid receptor subunit alpha-2target
EszopicloneGamma-aminobutyric acid receptor subunit alpha-3target
EszopicloneGamma-aminobutyric acid receptor subunit alpha-5target
EszopicloneCytochrome P450 2C8enzyme
EszopicloneGABA(A) Receptortarget
Buspirone5-hydroxytryptamine receptor 1Atarget
BuspironeDopamine D2 receptortarget
BuspironeCytochrome P450 3A4enzyme
BuspironeCytochrome P450 3A5enzyme
BuspironeCytochrome P450 3A7enzyme
BuspironeP-glycoprotein 1transporter
BuspironeCytochrome P450 2D6enzyme
BuspironeSerum albumincarrier
BuspironeAlpha-1-acid glycoprotein 1carrier
BuspironeDopamine D3 receptortarget
BuspironeDopamine D4 receptortarget
BuspironeAlpha-1 adrenergic receptorstarget
HydroxyzineHistamine H1 receptortarget
HydroxyzineCytochrome P450 2D6enzyme
HydroxyzineCytochrome P450 3A4enzyme
HydroxyzineCytochrome P450 3A5enzyme
HydroxyzinePotassium voltage-gated channel subfamily H member 2target
HydroxyzineP-glycoprotein 1transporter
HydroxyzineSerum albumincarrier
CinnarizineHistamine H1 receptortarget
CinnarizineDopamine D2 receptortarget
CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
CinnarizineCytochrome P450 2D6enzyme
CinnarizineCytochrome P450 2B6enzyme
CinnarizineCytochrome P450 2C9enzyme
CinnarizineCytochrome P450 1A1enzyme
CinnarizineCytochrome P450 1A2enzyme
CinnarizineCytochrome P450 2A6enzyme
CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Starget
CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
CinnarizineD(1) dopamine receptortarget
CinnarizineMuscarinic acetylcholine receptortarget
CinnarizineCytochrome P450 3A4enzyme
ImatinibPlatelet-derived growth factor receptor betatarget
ImatinibTyrosine-protein kinase ABL1target
ImatinibMast/stem cell growth factor receptor Kittarget
ImatinibRET proto-oncogenetarget
ImatinibHigh affinity nerve growth factor receptortarget
ImatinibMacrophage colony-stimulating factor 1 receptortarget
ImatinibPlatelet-derived growth factor receptor alphatarget
ImatinibEpithelial discoidin domain-containing receptor 1target
ImatinibCytochrome P450 3A4enzyme
ImatinibBreakpoint cluster region proteintarget
ImatinibCytochrome P450 1A2enzyme
ImatinibCytochrome P450 2D6enzyme
ImatinibCytochrome P450 2C9enzyme
ImatinibCytochrome P450 2C19enzyme
ImatinibCytochrome P450 3A5enzyme
ImatinibCytochrome P450 3A7enzyme
ImatinibSolute carrier family 22 member 1transporter
ImatinibP-glycoprotein 1transporter
ImatinibSolute carrier family 22 member 2transporter
ImatinibATP-binding cassette sub-family G member 2transporter
ImatinibATP-binding cassette sub-family A member 3transporter
ImatinibProstaglandin G/H synthase 1enzyme
ImatinibSerum albumincarrier
ImatinibAlpha-1-acid glycoprotein 1carrier
ImatinibBile salt export pumptransporter
ImatinibCytochrome P450 2C8enzyme
Trazodone5-hydroxytryptamine receptor 2Atarget
TrazodoneSodium-dependent serotonin transportertarget
TrazodoneAlpha-1A adrenergic receptortarget
TrazodoneAlpha-2A adrenergic receptortarget
TrazodoneHistamine H1 receptortarget
Trazodone5-hydroxytryptamine receptor 1Atarget
TrazodoneCytochrome P450 2D6enzyme
TrazodoneCytochrome P450 3A4enzyme
Trazodone5-hydroxytryptamine receptor 2Ctarget
TrazodoneCytochrome P450 3A5enzyme
TrazodoneCytochrome P450 3A7enzyme
TrazodoneP-glycoprotein 1transporter
Trazodone5-hydroxytryptamine receptor 1Ctarget
DelavirdineCytochrome P450 3A4enzyme
DelavirdineCytochrome P450 2C9enzyme
DelavirdineCytochrome P450 2D6enzyme
DelavirdineCytochrome P450 3A5enzyme
DelavirdineCytochrome P450 3A7enzyme
DelavirdineCytochrome P450 2C19enzyme
DelavirdineReverse transcriptase/RNaseHtarget
DiethylcarbamazineArachidonate 5-lipoxygenasetarget
DiethylcarbamazineProstaglandin G/H synthase 1target
DiethylcarbamazineCholinesteraseenzyme
MeclizineHistamine H1 receptortarget
MeclizineNuclear receptor subfamily 1 group I member 3target
MeclizineCytochrome P450 2D6enzyme
MeclizineSerum albumincarrier
VardenafilcGMP-specific 3',5'-cyclic phosphodiesterasetarget
VardenafilCytochrome P450 3A4enzyme
VardenafilRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammatarget
VardenafilRetinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammatarget
VardenafilCytochrome P450 3A5enzyme
VardenafilP-glycoprotein 1transporter
FlupentixolAlpha-1A adrenergic receptortarget
FlupentixolDopamine D2 receptortarget
FlupentixolDopamine D1 receptortarget
FlupentixolAromatic-L-amino-acid decarboxylaseenzyme
Flupentixol5-hydroxytryptamine receptor 2Atarget
FlupentixolP-glycoprotein 1transporter
FlupentixolMuscarinic acetylcholine receptor M1target
KetoconazoleCytochrome P450 3A4enzyme
KetoconazoleCytochrome P450 2C9enzyme
KetoconazoleCytochrome P450 2C19enzyme
KetoconazoleCytochrome P450 3A5enzyme
KetoconazoleCytochrome P450 1A2enzyme
KetoconazoleCytochrome P450 2C8enzyme
KetoconazoleCytochrome P450 1A1enzyme
KetoconazoleCytochrome P450 2D6enzyme
KetoconazoleBile salt export pumptransporter
KetoconazoleP-glycoprotein 1transporter
KetoconazoleCytochrome P450 11B1, mitochondrialenzyme
KetoconazoleCytochrome P450 1B1enzyme
KetoconazoleCytochrome P450 2A6enzyme
KetoconazoleCytochrome P450 2B6enzyme
KetoconazoleLanosterol 14-alpha demethylasetarget
KetoconazoleAndrogen receptortarget
KetoconazoleSteroid 17-alpha-hydroxylase/17,20 lyasetarget
KetoconazoleSteroid 21-hydroxylasetarget
KetoconazolePotassium voltage-gated channel subfamily H member 2target
KetoconazoleNuclear receptor subfamily 1 group I member 2target
KetoconazoleNuclear receptor subfamily 1 group I member 3target
KetoconazoleUDP-glucuronosyltransferase 1-1enzyme
KetoconazoleUDP-glucuronosyltransferase 2B7enzyme
KetoconazoleSolute carrier organic anion transporter family member 1B1transporter
KetoconazoleCytochrome P450 4F12enzyme
KetoconazoleLeukotriene-B(4) omega-hydroxylase 1enzyme
KetoconazoleSerum albumincarrier
KetoconazoleSex hormone-binding globulincarrier
KetoconazoleCytochrome P450 19A1enzyme
KetoconazoleUDP-glucuronosyltransferase 1-7enzyme
ItraconazoleLanosterol 14-alpha demethylasetarget
ItraconazoleLanosterol 14-alpha demethylasetarget
ItraconazoleCytochrome P450 3A4enzyme
ItraconazoleCytochrome P450 3A5enzyme
ItraconazoleCytochrome P450 3A7enzyme
ItraconazoleCytochrome P450 2B6enzyme
ItraconazoleP-glycoprotein 1transporter
ItraconazoleCytochrome P450 1A1enzyme
ItraconazoleCytochrome P450 2E1enzyme
ItraconazoleSolute carrier organic anion transporter family member 2B1transporter
CyclizineHistamine H1 receptortarget
CyclizineEstrogen sulfotransferasetarget
CyclizineCytochrome P450 2C9enzyme
AripiprazoleDopamine D2 receptortarget
Aripiprazole5-hydroxytryptamine receptor 1Atarget
Aripiprazole5-hydroxytryptamine receptor 2Atarget
AripiprazoleCytochrome P450 3A4enzyme
AripiprazoleCytochrome P450 2D6enzyme
Aripiprazole5-hydroxytryptamine receptor 1Btarget
Aripiprazole5-hydroxytryptamine receptor 1Dtarget
Aripiprazole5-hydroxytryptamine receptor 1Etarget
AripiprazoleDopamine D1 receptortarget
AripiprazoleDopamine D5 receptortarget
AripiprazoleDopamine D3 receptortarget
AripiprazoleDopamine D4 receptortarget
Aripiprazole5-hydroxytryptamine receptor 2Ctarget
Aripiprazole5-hydroxytryptamine receptor 3Atarget
Aripiprazole5-hydroxytryptamine receptor 6target
Aripiprazole5-hydroxytryptamine receptor 7target
AripiprazoleHistamine H1 receptortarget
AripiprazoleAlpha-1A adrenergic receptortarget
AripiprazoleAlpha-1B adrenergic receptortarget
AripiprazoleAlpha-2A adrenergic receptortarget
AripiprazoleAlpha-2B adrenergic receptortarget
AripiprazoleAlpha-2C adrenergic receptortarget
AripiprazoleCytochrome P450 3A5enzyme
AripiprazoleCytochrome P450 3A7enzyme
AripiprazoleSerum albumincarrier
Aripiprazole5-hydroxytryptamine receptor 2Btarget
Aripiprazole5-hydroxytryptamine receptor 5Atarget
AripiprazoleBeta-1 adrenergic receptortarget
AripiprazoleBeta-2 adrenergic receptortarget
AripiprazoleHistamine H2 receptortarget
AripiprazoleHistamine H3 receptortarget
AripiprazoleHistamine H4 receptortarget
AripiprazoleMuscarinic acetylcholine receptor M1target
AripiprazoleMuscarinic acetylcholine receptor M2target
AripiprazoleMuscarinic acetylcholine receptor M3target
AripiprazoleMuscarinic acetylcholine receptor M4target
AripiprazoleMuscarinic acetylcholine receptor M5target
AripiprazoleKappa-type opioid receptortarget
AripiprazoleMu-type opioid receptortarget
AripiprazoleDelta-type opioid receptortarget
AripiprazoleGlutamate (NMDA) receptortarget
AripiprazoleSodium-dependent dopamine transportertarget
AripiprazoleSodium-dependent serotonin transportertarget
PipecuroniumNeuronal acetylcholine receptor subunit alpha-2target
PipecuroniumMuscarinic acetylcholine receptor M2target
PipecuroniumMuscarinic acetylcholine receptor M3target
PipecuroniumCholinesteraseenzyme
AlmitrineSodium/potassium-transporting ATPase subunit alpha-1target
HydroxyfasudilRho-associated protein kinase 1target
HydroxyfasudilcAMP-dependent protein kinase catalytic subunit alphatarget
HydroxyfasudilcAMP-dependent protein kinase inhibitor alphatarget
FlunarizineHistamine H1 receptortarget
FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
FlunarizineCalmodulintarget
FlunarizineCytochrome P450 2D6enzyme
FlunarizineCytochrome P450 2C9enzyme
FlunarizineCytochrome P450 1A1enzyme
FlunarizineCytochrome P450 1A2enzyme
FlunarizineCytochrome P450 2A6enzyme
FlunarizineCytochrome P450 3A4enzyme
PlinabulinTumor necrosis factortarget
PrasugrelP2Y purinoceptor 12target
PrasugrelCocaine esteraseenzyme
PrasugrelCytochrome P450 3A4enzyme
PrasugrelCytochrome P450 2B6enzyme
PrasugrelCytochrome P450 2C9enzyme
PrasugrelCytochrome P450 2C19enzyme
PrasugrelSerum albumincarrier
LevocetirizineHistamine H1 receptortarget
LevocetirizineSolute carrier family 22 member 11transporter
LevocetirizineCytochrome P450 3A4enzyme
LevocetirizineSerum albumincarrier
Vilazodone5-hydroxytryptamine receptor 1Atarget
VilazodoneCytochrome P450 3A4enzyme
VilazodoneCytochrome P450 2D6enzyme
VilazodoneSodium-dependent serotonin transportertarget
VilazodoneCytochrome P450 2C19enzyme
5-(2-methylpiperazine-1-sulfonyl)isoquinolinecAMP-dependent protein kinase catalytic subunit alphatarget
5-(2-methylpiperazine-1-sulfonyl)isoquinolinecAMP-dependent protein kinase inhibitor alphatarget
Trimetazidine3-ketoacyl-CoA thiolase, peroxisomaltarget
EtoperidoneAlpha-1 adrenergic receptorstarget
EtoperidoneAlpha-2 adrenergic receptorstarget
EtoperidoneDopamine D2 receptortarget
EtoperidoneMuscarinic acetylcholine receptortarget
Etoperidone5-hydroxytryptamine receptor 2Atarget
EtoperidoneSodium-dependent serotonin transportertransporter
EtoperidoneSodium-dependent noradrenaline transportertransporter
EtoperidoneSodium-dependent dopamine transportertransporter
Etoperidone5-hydroxytryptamine receptor 2Ctarget
PiribedilDopamine D2 receptortarget
PiribedilDopamine D3 receptortarget
LidoflazineCytochrome P450 3A4enzyme
Pipemidic acidCytochrome P450 1A2enzyme
Aripiprazole lauroxilDopamine D2 receptortarget
Aripiprazole lauroxil5-hydroxytryptamine receptor 1Atarget
Aripiprazole lauroxil5-hydroxytryptamine receptor 2Atarget
Aripiprazole lauroxilCytochrome P450 3A4enzyme
Aripiprazole lauroxilCytochrome P450 2D6enzyme
Aripiprazole lauroxil5-hydroxytryptamine receptor 1Btarget
Aripiprazole lauroxil5-hydroxytryptamine receptor 1Dtarget
Aripiprazole lauroxil5-hydroxytryptamine receptor 1Etarget
Aripiprazole lauroxilDopamine D1 receptortarget
Aripiprazole lauroxilDopamine D5 receptortarget
Aripiprazole lauroxilDopamine D3 receptortarget
Aripiprazole lauroxilDopamine D4 receptortarget
Aripiprazole lauroxil5-hydroxytryptamine receptor 2Ctarget
Aripiprazole lauroxil5-hydroxytryptamine receptor 3Atarget
Aripiprazole lauroxil5-hydroxytryptamine receptor 6target
Aripiprazole lauroxil5-hydroxytryptamine receptor 7target
Aripiprazole lauroxilHistamine H1 receptortarget
Aripiprazole lauroxilAlpha-1A adrenergic receptortarget
Aripiprazole lauroxilAlpha-1B adrenergic receptortarget
Aripiprazole lauroxilAlpha-2A adrenergic receptortarget
Aripiprazole lauroxilAlpha-2B adrenergic receptortarget
Aripiprazole lauroxilAlpha-2C adrenergic receptortarget
Aripiprazole lauroxilMuscarinic acetylcholine receptor M1target
Aripiprazole lauroxilMuscarinic acetylcholine receptor M2target
Aripiprazole lauroxilMuscarinic acetylcholine receptor M3target
Aripiprazole lauroxilMuscarinic acetylcholine receptor M4target
Aripiprazole lauroxilMuscarinic acetylcholine receptor M5target
Aripiprazole lauroxilCytochrome P450 3A5enzyme
Aripiprazole lauroxilCytochrome P450 3A7enzyme
Aripiprazole lauroxilSerum albumincarrier
FasudilcAMP-dependent protein kinase inhibitor alphatarget
FasudilcAMP-dependent protein kinase catalytic subunit alphatarget
FasudilRho-associated protein kinase 1target
FasudilRho-associated protein kinase 2target
PiperazineGamma-aminobutyric acid receptor subunit beta-3target
PiperazineCytochrome P450 2D6enzyme
VortioxetineSodium-dependent serotonin transportertarget
Vortioxetine5-hydroxytryptamine receptor 3Atarget
Vortioxetine5-hydroxytryptamine receptor 7target
Vortioxetine5-hydroxytryptamine receptor 1Btarget
Vortioxetine5-hydroxytryptamine receptor 1Atarget
VortioxetineBeta-1 adrenergic receptortarget
VortioxetineSodium-dependent noradrenaline transportertarget
VortioxetineCytochrome P450 2D6enzyme
VortioxetineCytochrome P450 3A4enzyme
VortioxetineCytochrome P450 3A5enzyme
VortioxetineCytochrome P450 2C19enzyme
VortioxetineCytochrome P450 2C9enzyme
VortioxetineCytochrome P450 2A6enzyme
VortioxetineCytochrome P450 2C8enzyme
VortioxetineCytochrome P450 2B6enzyme