Antimalarials

Name
Antimalarials
Accession Number
DBCAT000524
Description

Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)

ATC Classification
Drugs
DrugDrug Description
PyrimethamineAn antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria.
MefloquineAn antimalarial agent used as a schizonticidal agent.
QuinineAn alkaloid used to treat uncomplicated Plasmodium falciparum malaria.
AmodiaquineFor treatment of acute malarial attacks in non-immune subjects.
PrimaquineAn antimalarial indicated to prevent relapse of vivax malaria.
ProguanilA medication indicated for prophylaxis and treatment of Plasmodium falciparum malaria.
HalofantrineAn antimalarial used for the treatment of severe malaria.
HydroxychloroquineAn antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus.
ArtemetherAn antimalarial agent used in combination with lumefantrine for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum.
LumefantrineAn antimalarial agent used in combination with artemether for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum.
ArtesunateArtesunate is an artemesinin derivative indicated for the initial treatment of severe malaria.
ArtenimolFor the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB13941.
PyronaridinePyronaridine has been investigated for the treatment of Malaria.
ArtemotilArtemotil, also known as β-arteether, is a semi-synthetic derivative of artemisinin and a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria...
AtovaquoneAn antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria.
PiperaquineFor the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB11638.
QuinidineA medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.
QuinacrineFor the treatment of giardiasis and cutaneous leishmaniasis and the management of malignant effusions.
SulfadoxineA long acting sulfonamide used for the treatment or prevention of malaria.
TafenoquineAn antiparasitic agent used for the treatment and prevention of relapse of Vivax malaria.
ChlorproguanilChlorproguanil has been used in trials studying the treatment of MALARIA. It is a dichloro-derivative of chloroguanide.
MizoribineMizoribine has been investigated for the treatment of Rheumatoid Arthritis.
ArtemisininArtemisinin has been used in trials studying the treatment of Schizophrenia, Malaria, Falciparum, and Plasmodium Falciparum.
DapsoneA sulfone drug used to treat acne vulgaris, Hansen's disease, and dermatitis herpetiformis.
ChloroquineAn antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis.
TetrandrineNot Annotated
Betulinic AcidBetulinic Acid has been used in trials studying the treatment of Dysplastic Nevus Syndrome.
CycloguanilCycloguanil is the active metabolite of proguanil.
ArtefenomelArtefenomel has been investigated for the treatment of Malaria.
JPC-3210JPC-3210 is a potent antimalarial agent. It is an erythrocytic schizonticide with potent in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum lines, low cytotoxicity, potent in vivo efficacy against murine...
Drugs & Drug Targets
DrugTargetType
PyrimethamineBifunctional dihydrofolate reductase-thymidylate synthasetarget
PyrimethamineDihydrofolate reductasetarget
PyrimethamineCytochrome P450 2C8enzyme
PyrimethamineBeta-hexosaminidase subunit betatarget
PyrimethamineMultidrug and toxin extrusion protein 1transporter
PyrimethamineMultidrug and toxin extrusion protein 2transporter
MefloquineCholinesteraseenzyme
MefloquineCytochrome P450 3A4enzyme
MefloquineAdenosine receptor A2atarget
MefloquineFe(II)-protoporphyrin IXtarget
MefloquineP-glycoprotein 1transporter
MefloquineCytochrome P450 19A1enzyme
MefloquineAcetylcholinesteraseenzyme
Mefloquine80S ribosomal subunittarget
QuininePlatelet glycoprotein IXtarget
QuinineIntermediate conductance calcium-activated potassium channel protein 4target
QuinineCytochrome P450 3A4enzyme
QuinineCytochrome P450 3A5enzyme
QuinineCytochrome P450 1A1enzyme
QuinineCytochrome P450 2D6enzyme
QuinineCytochrome P450 1A2enzyme
QuinineCytochrome P450 2C8enzyme
QuinineCytochrome P450 2C9enzyme
QuinineCytochrome P450 2C19enzyme
QuinineCytochrome P450 2E1enzyme
QuinineCytochrome P450 3A7enzyme
QuinineSolute carrier family 22 member 2transporter
QuinineSolute carrier family 22 member 1transporter
QuinineSolute carrier family 22 member 5transporter
QuinineP-glycoprotein 1transporter
QuinineSolute carrier organic anion transporter family member 1A2transporter
QuinineSolute carrier family 22 member 4transporter
QuinineFe(II)-protoporphyrin IXtarget
QuinineSolute carrier organic anion transporter family member 1B1transporter
AmodiaquineHistamine N-methyltransferasetarget
AmodiaquineCytochrome P450 2C8enzyme
AmodiaquineCytochrome P450 2D6enzyme
AmodiaquineFe(II)-protoporphyrin IXtarget
AmodiaquineCytochrome P450 1A1enzyme
AmodiaquineCytochrome P450 1B1enzyme
AmodiaquineCytochrome P450 2C9enzyme
AmodiaquineP-glycoprotein 1transporter
PrimaquineCytochrome P450 1A1enzyme
PrimaquineCytochrome P450 1A2enzyme
PrimaquineCytochrome P450 3A4enzyme
PrimaquineKeratin, type II cytoskeletal 7target
PrimaquineCytochrome P450 1B1enzyme
PrimaquineCytochrome P450 2D6enzyme
PrimaquineRibosyldihydronicotinamide dehydrogenase [quinone]target
PrimaquineFe(II)-protoporphyrin IXtarget
PrimaquineP-glycoprotein 1transporter
ProguanilBifunctional dihydrofolate reductase-thymidylate synthasetarget
ProguanilDihydrofolate reductasetarget
ProguanilCytochrome P450 2C19enzyme
ProguanilCytochrome P450 2D6enzyme
ProguanilCytochrome P450 2C9enzyme
HalofantrineFe(II)-protoporphyrin IXtarget
HalofantrinePotassium voltage-gated channel subfamily H member 2target
HalofantrineCytochrome P450 3A4enzyme
HalofantrineCytochrome P450 2D6enzyme
HalofantrinePlasmepsin-2target
HalofantrineCytochrome P450 2C8enzyme
HalofantrineCytochrome P450 3A5enzyme
HydroxychloroquineDNAtarget
HydroxychloroquineToll-like receptor 7target
HydroxychloroquineToll-like receptor 9target
HydroxychloroquineCytochrome P450 2D6enzyme
HydroxychloroquineP-glycoprotein 1transporter
HydroxychloroquineSerum albumincarrier
Hydroxychloroquinealpha1-acid glycoproteincarrier
HydroxychloroquineCytochrome P450 3A4enzyme
HydroxychloroquineSolute carrier organic anion transporter family member 1A2transporter
HydroxychloroquineAngiotensin-converting enzyme 2target
HydroxychloroquineCytochrome P450 2C8enzyme
ArtemetherCytochrome P450 3A4enzyme
ArtemetherCytochrome P450 3A5enzyme
ArtemetherCytochrome P450 2B6enzyme
ArtemetherCytochrome P450 2C9enzyme
ArtemetherCytochrome P450 2C19enzyme
LumefantrineCytochrome P450 2D6enzyme
LumefantrineCytochrome P450 3A4enzyme
ArtesunateMalaria protein EXP-1target
ArtesunateCytochrome P450 2A6enzyme
ArtesunateUDP-glucuronosyltransferase 2B7enzyme
ArtesunateUDP-glucuronosyltransferase 1-9enzyme
ArtesunateATP-binding cassette sub-family G member 2transporter
ArtesunateP-glycoprotein 1transporter
ArtesunateSolute carrier organic anion transporter family member 1B1transporter
ArtesunateSolute carrier family 22 member 8transporter
ArtesunateSerum albumincarrier
ArtenimolActin, cytoplasmic 2target
ArtenimolAlpha-aminoadipic semialdehyde dehydrogenasetarget
ArtenimolAnnexin A2target
ArtenimolATP synthase subunit alpha, mitochondrialtarget
ArtenimolATP synthase subunit g, mitochondrialtarget
ArtenimolATP synthase subunit O, mitochondrialtarget
ArtenimolCalpastatintarget
ArtenimolT-complex protein 1 subunit gammatarget
ArtenimolCofilin-1target
ArtenimolChloride intracellular channel protein 1target
ArtenimolCysteine and glycine-rich protein 1target
ArtenimolDihydropyrimidinase-related protein 2target
ArtenimolDesmoplakintarget
ArtenimolElongation factor 1-alpha 1target
ArtenimolAlpha-enolasetarget
ArtenimolFilamin-Atarget
ArtenimolAlpha-ketoglutarate-dependent dioxygenase FTOtarget
ArtenimolGlucose-6-phosphate 1-dehydrogenasetarget
ArtenimolGlyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget
ArtenimolGlucose-6-phosphate isomerasetarget
ArtenimolHeterogeneous nuclear ribonucleoproteins A2/B1target
ArtenimolHeterogeneous nuclear ribonucleoprotein D0target
ArtenimolHeterogeneous nuclear ribonucleoprotein Ktarget
ArtenimolHeterochromatin protein 1-binding protein 3target
ArtenimolHeat shock protein beta-1target
ArtenimolRas GTPase-activating-like protein IQGAP1target
ArtenimolFar upstream element-binding protein 2target
ArtenimolL-lactate dehydrogenase A chaintarget
ArtenimolL-lactate dehydrogenase B chaintarget
ArtenimolGalectin-1target
ArtenimolMicrotubule-associated protein 4target
ArtenimolMalate dehydrogenase, cytoplasmictarget
ArtenimolPuromycin-sensitive aminopeptidasetarget
ArtenimolProfilin-1target
ArtenimolPhosphoglycerate kinase 1target
ArtenimolPyruvate kinase PKMtarget
ArtenimolPeptidyl-prolyl cis-trans isomerase Atarget
ArtenimolPeroxiredoxin-1target
Artenimol60S ribosomal protein L10target
Artenimol60S ribosomal protein L14target
Artenimol60S ribosomal protein L18target
Artenimol60S ribosomal protein L23atarget
Artenimol60S ribosomal protein L35target
Artenimol60S ribosomal protein L4target
Artenimol40S ribosomal protein S13target
Artenimol40S ribosomal protein S17target
Artenimol40S ribosomal protein S18target
Artenimol40S ribosomal protein S19target
Artenimol40S ribosomal protein S28target
Artenimol40S ribosomal protein S5target
Artenimol40S ribosomal protein S6target
Artenimol40S ribosomal protein S8target
Artenimol40S ribosomal protein S9target
ArtenimolSplicing factor 1target
ArtenimolSplicing factor, proline- and glutamine-richtarget
ArtenimolSmall nuclear ribonucleoprotein Sm D2target
ArtenimolSignal recognition particle 14 kDa proteintarget
ArtenimolSerine/arginine-rich splicing factor 4target
ArtenimolTransgelintarget
ArtenimolTransgelin-2target
ArtenimolTriosephosphate isomerasetarget
ArtenimolTropomyosin alpha-1 chaintarget
ArtenimolTubulin alpha-1A chaintarget
ArtenimolVimentintarget
ArtenimolZyxintarget
ArtenimolHeat shock cognate 71 kDa proteintarget
ArtenimolTubulin beta-6 chaintarget
ArtenimolTubulin beta-4A chaintarget
ArtenimolTubulin beta chaintarget
ArtenimolFructose-bisphosphate aldolase Atarget
ArtenimolGlyceraldehyde-3-phosphate dehydrogenasetarget
ArtenimolCytochrome ctarget
ArtenimolPhosphoglycerate mutase 1target
ArtenimolMyosin-9target
ArtenimolProtein disulfide-isomerasetarget
ArtenimolProbable ATP-dependent RNA helicase DDX5target
ArtenimolSerine hydroxymethyltransferase, mitochondrialtarget
ArtenimolSpliceosome RNA helicase DDX39Btarget
ArtenimolNucleophosmintarget
ArtenimolTranslationally-controlled tumor protein homologtarget
ArtenimolP-type Ca2+-transporting ATPasetarget
ArtenimolOrnithine aminotransferasetarget
ArtenimolElongation factor 1-alphatarget
ArtenimolMultidrug resistance proteintarget
ArtenimolElongation factor 2target
ArtenimolActin-1target
ArtenimolGlyceraldehyde-3-phosphate dehydrogenasetarget
ArtenimolFructose-bisphosphate aldolasetarget
ArtenimolCell division cycle protein 48 homologue,putativetarget
ArtenimolHeat shock protein 90target
ArtenimolEukaryotic initiation factor 4Atarget
ArtenimolPyruvate kinasetarget
ArtenimolL-lactate dehydrogenasetarget
ArtenimolProtein disulfide-isomerasetarget
ArtenimolThioredoxin-related protein, putativetarget
ArtenimolSpermidine synthasetarget
ArtenimolProbable ATP-dependent 6-phosphofructokinasetarget
ArtenimolGlutamate dehydrogenasetarget
ArtenimolEndoplasmin homolog, putativetarget
ArtenimolHypoxanthine-guanine-xanthine phosphoribosyltransferasetarget
ArtenimolEnolasetarget
Artenimol40S ribosomal protein S3target
ArtenimolNon-SERCA-type Ca2+-transporting P-ATPasetarget
ArtenimolTubulin alpha chaintarget
ArtenimolKnob-associated histidine-rich proteintarget
ArtenimolS-adenosylmethionine synthasetarget
ArtenimolV-type H(+)-translocating pyrophosphatase, putativetarget
Artenimol60S ribosomal protein L4target
ArtenimolPhosphoethanolamine N-methyltransferasetarget
Artenimol40S ribosomal protein S3atarget
ArtenimolConserved Plasmodium membrane proteintarget
Artenimol60S ribosomal protein L3target
ArtenimolHigh molecular weight rhoptry protein 2target
ArtenimolSerine repeat antigen 5target
Artenimol40S ribosomal protein S19target
ArtenimolGlycophorin-binding proteintarget
ArtenimolCalcium-transporting ATPasetarget
ArtenimolV-type proton ATPase catalytic subunit Atarget
Artenimol60S ribosomal protein L2target
ArtenimolAcyl-CoA synthetasetarget
ArtenimolPlasmepsin IVtarget
ArtenimolPlasmepsin-1target
ArtenimolChloroquine resistance transportertarget
Artenimol14-3-3 proteintarget
ArtenimolIsoleucine--tRNA ligase, putativetarget
ArtenimolPlasmodium exported proteintarget
ArtenimolTubulin beta chaintarget
Artenimol60S ribosomal protein L27target
ArtenimolSec62, putativetarget
ArtenimolAutophagy-related protein 18, putativetarget
ArtenimolMature parasite-infected erythrocyte surface antigentarget
ArtenimolImportin-7, putativetarget
ArtenimolImportin subunit alphatarget
ArtenimolPeptidyl-prolyl cis-trans isomerasetarget
ArtenimolDnaJ protein, putativetarget
ArtenimolMerozoite surface protein 1target
ArtenimolGlutamate--tRNA ligasetarget
ArtenimolT-complex protein 1 subunit etatarget
ArtenimolPlasmepsin-2target
ArtenimolChaperone, putativetarget
ArtenimolRhoptry neck protein 3target
Artenimol40S ribosomal protein S5, putativetarget
ArtenimolSkeleton-binding protein 1target
ArtenimolPurine nucleotide phosphorylase, putativetarget
ArtenimolAdenosylhomocysteinasetarget
ArtenimolAdenosine deaminasetarget
ArtenimolMethionine--tRNA ligasetarget
ArtenimolCarbamoyl phosphate synthetasetarget
ArtenimolAspartate carbamoyltransferasetarget
ArtenimolSignal recognition particle receptor, beta subunittarget
ArtenimolParasite-infected erythrocyte surface proteintarget
ArtenimolCoatomer alpha subunit, putativetarget
ArtenimolHexokinasetarget
ArtenimolProteasome subunit alpha typetarget
ArtenimolHaloacid dehalogenase-like hydrolasetarget
ArtenimolInsulinase, putativetarget
Artenimol40S ribosomal protein S21target
ArtenimolUbiquitin-conjugating enzyme E2target
ArtenimolEukaryotic translation initiation factor 3 subunit Ctarget
Artenimol60S ribosomal protein L24, putativetarget
Artenimol60S ribosomal protein L23target
Artenimol60S ribosomal protein L17, putativetarget
ArtenimolHAP proteintarget
ArtenimolHeat shock protein 110, putativetarget
Artenimol60S ribosomal protein L10, putativetarget
ArtenimolLysophospholipase, putativetarget
ArtenimolPolyadenylate-binding proteintarget
ArtenimolUbiquitin-60S ribosomal protein L40target
ArtenimolPhosphoribosylpyrophosphate synthetasetarget
ArtenimolThioredoxin peroxidase 1target
ArtenimolProtein transport protein SEC31target
ArtenimolDipeptidyl aminopeptidase 1target
ArtenimolRing-infected erythrocyte surface antigentarget
ArtenimolATP-dependent RNA helicase UAP56target
ArtenimolCalcium-dependent protein kinase 4target
ArtenimolGTP-binding nuclear protein Rantarget
ArtenimolNucleoside transporter 2target
ArtenimolAnamorsin homologtarget
ArtenimolGlutamine synthetase, putativetarget
Artenimol60S ribosomal protein L30e, putativetarget
ArtenimolCasein kinase 2, alpha subunittarget
ArtenimolThreonine--tRNA ligasetarget
ArtenimolcAMP-dependent protein kinase regulatory subunittarget
ArtenimolElongation factor 1-gamma, putativetarget
ArtenimolThioredoxin-like proteintarget
Artenimol60S ribosomal protein L21target
Artenimol60S ribosomal protein L14, putativetarget
ArtenimolInner membrane complex sub-compartment protein 3target
ArtenimolHSP40, subfamily A, putativetarget
ArtenimolPyridoxal 5'-phosphate synthase subunit Pdx1target
ArtenimolUDP-glucuronosyltransferase 1-9enzyme
ArtenimolUDP-glucuronosyltransferase 2B7enzyme
ArtenimolSerum albumintarget
ArtenimolCytochrome P450 2D6enzyme
ArtenimolCytochrome P450 2C19enzyme
AtovaquoneDihydroorotate dehydrogenase (quinone), mitochondrialtarget
AtovaquoneDihydroorotate dehydrogenase (quinone), mitochondrialtarget
AtovaquoneCytochrome btarget
AtovaquoneCytochrome P450 2C9enzyme
AtovaquoneCytochrome P450 3A4enzyme
AtovaquoneP-glycoprotein 1transporter
PiperaquineCytochrome P450 3A4enzyme
PiperaquineCytochrome P450 2C19enzyme
PiperaquineCytochrome P450 2C9enzyme
PiperaquineCytochrome P450 2B6enzyme
PiperaquineCytochrome P450 2E1enzyme
QuinidineSodium channel protein type 5 subunit alphatarget
QuinidineAlpha-1-acid glycoprotein 1carrier
QuinidinePotassium voltage-gated channel subfamily H member 2target
QuinidinePotassium channel subfamily K member 1target
QuinidinePotassium channel subfamily K member 6target
QuinidineCytochrome P450 1A2enzyme
QuinidineCytochrome P450 2E1enzyme
QuinidineCytochrome P450 1A1enzyme
QuinidineCytochrome P450 2D6enzyme
QuinidineCytochrome P450 3A4enzyme
QuinidineCytochrome P450 3A7enzyme
QuinidineSolute carrier family 22 member 2transporter
QuinidineSolute carrier family 22 member 1transporter
QuinidineSolute carrier family 22 member 5transporter
QuinidineP-glycoprotein 1transporter
QuinidineSolute carrier organic anion transporter family member 1A2transporter
QuinidineSolute carrier family 22 member 8transporter
QuinidineCanalicular multispecific organic anion transporter 1transporter
QuinidineSolute carrier family 22 member 4transporter
QuinidineSolute carrier organic anion transporter family member 1B1transporter
QuinidineCytochrome P450 2B6enzyme
QuinidineCytochrome P450 2C9enzyme
QuinidineAlpha-1A adrenergic receptortarget
QuinidineAlpha-1B adrenergic receptortarget
QuinidineAlpha-1D adrenergic receptortarget
QuinidineBile salt export pumptransporter
QuinidineCytochrome P450 2C8enzyme
QuinacrineDNAtarget
Quinacrine85/88 kDa calcium-independent phospholipase A2target
QuinacrineCytosolic phospholipase A2target
QuinacrineInactive phospholipase C-like protein 1target
QuinacrineHistamine N-methyltransferaseenzyme
QuinacrineSolute carrier family 22 member 2transporter
QuinacrineP-glycoprotein 1transporter
QuinacrineCytochrome P450 3A4enzyme
QuinacrineCytochrome P450 3A5enzyme
SulfadoxineDihydropteroate synthetasetarget
SulfadoxineBifunctional dihydrofolate reductase-thymidylate synthasetarget
TafenoquineCytochrome P450 2D6enzyme
TafenoquineFerredoxin--NADP reductase, apicoplastenzyme
TafenoquineSolute carrier family 22 member 2transporter
TafenoquineMultidrug and toxin extrusion protein 1transporter
TafenoquineMultidrug and toxin extrusion protein 2transporter
ArtemisininCytochrome P450 2B6enzyme
DapsoneInactive dihydropteroate synthase 2target
DapsoneDihydropteroate synthase 1target
DapsoneCytochrome P450 2C9enzyme
DapsoneCytochrome P450 2E1enzyme
DapsoneCytochrome P450 3A4enzyme
DapsoneDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DapsoneProstaglandin G/H synthase 1enzyme
DapsoneProstaglandin G/H synthase 2enzyme
DapsoneCytochrome P450 2C8enzyme
DapsoneCytochrome P450 2C19enzyme
DapsoneArylamine N-acetyltransferase 2enzyme
DapsoneCytochrome P450 3A5enzyme
DapsoneCytochrome P450 3A7enzyme
DapsoneMyeloperoxidaseenzyme
DapsoneCytochrome P450 2C18enzyme
ChloroquineTumor necrosis factortarget
ChloroquineToll-like receptor 9target
ChloroquineGlutathione S-transferase A2target
ChloroquineCytochrome P450 2D6enzyme
ChloroquineCytochrome P450 3A4enzyme
ChloroquineCytochrome P450 1A1enzyme
ChloroquineCytochrome P450 2C8enzyme
ChloroquineCytochrome P450 3A5enzyme
ChloroquineGlutathione S-transferasetarget
ChloroquineP-glycoprotein 1transporter
ChloroquineSerum albumincarrier
Chloroquinealpha1-acid glycoproteincarrier
ChloroquineHigh mobility group protein B1target
ChloroquineGlutathione S-transferase Mu 1target
ChloroquineAngiotensin-converting enzyme 2target
TetrandrineP-glycoprotein 1target
TetrandrineCytochrome P450 3A4enzyme
TetrandrineP-glycoprotein 1transporter