Secologanin Tryptamine Alkaloids

Alkaloids from Rauwolfia serpentina Benth and other species. The prototype is RESERPINE, which is a depleter of catecholamines and serotonin from the sympathetic postganglionic fibers and brain areas. They have been used in hypertension and psychoses despite their wide range of potentially adverse effects.
DrugDrug NameDrug Indication
DB00206ReserpineFoe the treatment of hypertension
DB13575BietaserpineNot Available
DB00309VindesineFor the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia and acute panmyelosis
DB00361Vinorelbine Vinorelbine tartrate is indicated for adults in the treatment of advanced non-small cell lung cancer (NSCLC), as a single therapy or in combination with other chemotherapeutic drugs [L1998]. Used in relapsed or refractory Hodgkin lymphoma, in combination with other chemotherapy agents [L2011]. For the treatment of desmoid tumor or aggressive fibromatosis, in combination with methotrexate [L2011]. For the treatment of recurrent or metastatic squamous cell head and neck cancer [L2011]. For the treatment of recurrent ovarian cancer [L2011]. For the treatment of metastatic breast cancer, in patients previously treated with anthracyline and/or taxane therapy [L2011]. For the treatment of HER2-positive, trastuzumab-resistant, advanced breast cancer in patients previously treated with a taxane, in combination with trastuzumab and everolimus [L2011].
DB00541VincristineTreatment of acute lymphocytic leukemia (ALL), Hodgkin lymphoma, non-Hodgkin lymphomas, Wilms' tumor, neuroblastoma, rhabdomyosarcoma. Liposomal vincristine is indicated for the treatment of relapsed Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).
DB00570VinblastineFor treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
DB01089DeserpidineFor the treatment of hypertension.
DB01180RescinnamineFor the treatment of hypertension.
DB01392YohimbineIndicated as a sympatholytic and mydriatic. Impotence has been successfully treated with yohimbine in male patients with vascular or diabetic origins and psychogenic origins.
DB01426AjmalineFor use as an antiarrhythmic agent.
DB04877VoacamineFor the treatment of malaria. Also under investigation for the modulation of multidrug resistance in cancer cells.
DB05168VintafolideInvestigated for use/treatment in solid tumors.
DB11641VinflunineFor use as a monotherapy in adults with advanced or transitional cell carcinoma of the urothelial tract after failure of a prior platinum-containing therapy [L2381].
DB12131VinpocetineNot Available
DB13374VincamineNot Available
DB13555PrajmalineNot Available
DB13651LorajmineNot Available
DB13793VinburnineNot Available
DB13631MethoserpidineNot Available
DB09363Rauwolfia serpentina rootRauwolfia alkaloids are indicated in the treatment of hypertension [L1614]. Rauwolfia alkaloids have been used for relief of symptoms in agitated psychotic states such as schizophrenia; however, use as antipsychotics and sedatives have been replaced with the use of more effective, safer agents [L1614].
DB01430AlmitrineFor the treatment of chronic obstructive pulmonary disease.
DrugDrug NameTargetType
DB00206ReserpineSynaptic vesicular amine transportertarget
DB00206ReserpineMultidrug resistance protein 1transporter
DB00206ReserpineSolute carrier family 22 member 1transporter
DB00206ReserpineBile salt export pumptransporter
DB00206ReserpineCanalicular multispecific organic anion transporter 1transporter
DB00206ReserpineSolute carrier family 22 member 2transporter
DB00206ReserpineCytochrome P450 3A5enzyme
DB00206ReserpineChromaffin granule amine transportertarget
DB00206ReserpineBaculoviral IAP repeat-containing protein 5target
DB00206ReserpineSolute carrier organic anion transporter family member 1B1transporter
DB00206ReserpineSolute carrier organic anion transporter family member 2B1transporter
DB00309VindesineTubulin beta-1 chaintarget
DB00309VindesineCytochrome P450 3A4enzyme
DB00361VinorelbineTubulin beta chaintarget
DB00361VinorelbineCytochrome P450 3A4enzyme
DB00361VinorelbineMultidrug resistance protein 1transporter
DB00361VinorelbineCytochrome P450 2D6enzyme
DB00541VincristineTubulin beta chaintarget
DB00541VincristineCytochrome P450 3A4enzyme
DB00541VincristineCytochrome P450 3A5enzyme
DB00541VincristineCytochrome P450 3A7enzyme
DB00541VincristineMultidrug resistance protein 1transporter
DB00541VincristineCanalicular multispecific organic anion transporter 2transporter
DB00541VincristineSolute carrier family 22 member 3transporter
DB00541VincristineMultidrug resistance-associated protein 1transporter
DB00541VincristineMultidrug resistance-associated protein 7transporter
DB00541VincristineCanalicular multispecific organic anion transporter 1transporter
DB00541VincristineBile salt export pumptransporter
DB00541VincristineATP-binding cassette sub-family G member 2transporter
DB00541VincristineTubulin alpha-4A chaintarget
DB00541VincristineRalA-binding protein 1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B3transporter
DB00570VinblastineTubulin beta chaintarget
DB00570VinblastineTranscription factor AP-1target
DB00570VinblastineCytochrome P450 3A4enzyme
DB00570VinblastineMultidrug resistance protein 1transporter
DB00570VinblastineMultidrug resistance-associated protein 1transporter
DB00570VinblastineCanalicular multispecific organic anion transporter 1transporter
DB00570VinblastineMultidrug resistance-associated protein 6transporter
DB00570VinblastineBile salt export pumptransporter
DB00570VinblastineTubulin alpha-1A chaintarget
DB00570VinblastineTubulin delta chaintarget
DB00570VinblastineTubulin epsilon chaintarget
DB00570VinblastineTubulin gamma-1 chaintarget
DB00570VinblastineCytochrome P450 2D6enzyme
DB00570VinblastineSolute carrier organic anion transporter family member 1B1transporter
DB01089DeserpidineSynaptic vesicular amine transportertarget
DB01180RescinnamineAngiotensin-converting enzymetarget
DB01392YohimbineAlpha-2A adrenergic receptortarget
DB01392YohimbineAlpha-2B adrenergic receptortarget
DB01392YohimbineAlpha-2C adrenergic receptortarget
DB01392Yohimbine5-hydroxytryptamine receptor 1Atarget
DB01392Yohimbine5-hydroxytryptamine receptor 1Btarget
DB01392Yohimbine5-hydroxytryptamine receptor 1Dtarget
DB01392YohimbineD(2) dopamine receptortarget
DB01392YohimbineD(3) dopamine receptortarget
DB01392Yohimbine5-hydroxytryptamine receptor 2Atarget
DB01392Yohimbine5-hydroxytryptamine receptor 2Ctarget
DB01392YohimbineCytochrome P450 2D6enzyme
DB01392YohimbineCytochrome P450 3A4enzyme
DB01392YohimbineATP-sensitive potassium channeltarget
DB01392Yohimbine5-hydroxytryptamine receptor 2Btarget
DB01426AjmalineAlpha-1-acid glycoprotein 1carrier
DB01426AjmalineSodium channel protein type 5 subunit alphatarget
DB04877VoacamineMultidrug resistance protein 1target
DB05168VintafolideFolate receptor betatarget
DB05168VintafolideFolate receptor gammatarget
DB05168VintafolideFolate receptor alphatarget
DB11641VinflunineATP-binding cassette sub-family B member 5transporter
DB11641VinflunineMultidrug resistance protein 1transporter
DB11641VinflunineSerum albumincarrier
DB11641VinflunineHigh density lipoproteincarrier
DB11641Vinfluninealpha1-acid glycoproteincarrier
DB11641VinflunineCytochrome P450 3A4enzyme
DB11641VinflunineTubulin beta chaintarget
DB12131VinpocetineCytochrome P450 3A4enzyme
DB09363Rauwolfia serpentina rootSynaptic vesicular amine transportertarget
DB09363Rauwolfia serpentina rootMonoamine oxidaseenzyme
DB09363Rauwolfia serpentina rootSodium-dependent noradrenaline transportertransporter
DB09363Rauwolfia serpentina rootvesicular monoamine transporter 2 (VMAT2)transporter
DB01430AlmitrineSodium/potassium-transporting ATPase subunit alpha-1target