Drugs that bind to but do not activate CHOLINERGIC RECEPTORS, thereby blocking the actions of ACETYLCHOLINE or cholinergic agonists.
DrugDrug NameDrug Indication
DB00245BenzatropineFor use as an adjunct in the therapy of all forms of parkinsonism and also for use in the control of extrapyramidal disorders due to neuroleptic drugs.
DB00332Ipratropium bromideFor maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema.
DB00376TrihexyphenidylIndicated for the treatment of parkinson's disease and extrapyramidal reactions caused by drugs.
DB00387ProcyclidineFor the treatment of all forms of Parkinson's Disease, as well as control of extrapyramidal reactions induced by antipsychotic agents.
DB00392EthopropazineFor use in the treatment of Parkinson's disease and also used to control severe reactions to certain medicines such as reserpine.
DB00572AtropineFor the treatment of poisoning by susceptible organophosphorous nerve agents having anti-cholinesterase activity (cholinesterase inhibitors) as well as organophosphorous or carbamate insecticides.
DB00747ScopolamineFor the treatment of excessive salivation, colicky abdominal pain, bradycardia, sialorrhoea, diverticulitis, irritable bowel syndrome and motion sickness.
DB00809TropicamideIndicated to induce mydriasis (dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) in diagnostic procedures, such as measurement of refractive errors and examination of the fundus of the eye.
DB00810BiperidenFor use as an adjunct in the therapy of all forms of parkinsonism and control of extrapyramidal disorders secondary to neuroleptic drug therapy.
DB00979CyclopentolateUsed mainly to produce mydriasis and cycloplegia for diagnostic purposes.
DB00986GlycopyrroniumFor use as a preoperative antimuscarinic to reduce salivary, tracheobronchial, and pharyngeal secretions, to reduce the volume and free acidity of gastric secretions and to block cardiac vagal inhibitory reflexes during induction of anesthesia and intubation. Also used to treat chronic obstructive pulmonary disease (COPD).
DB01173OrphenadrineIndicated for the treatment of Parkinson's disease.
DB01409TiotropiumUsed in the management of chronic obstructive pulmonary disease (COPD).
DB08997DexetimideNot Available
DB12278PropiverineNot Available
DB00340MetixeneUsed for the symptomatic treatment of parkinsonism.
DB08897AclidiniumAclidinium bromide inhalation powder is indicated for the long-term, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.
DB09076UmeclidiniumIndicated for the long-term, once-daily, maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD).
DB11181HomatropineNot Available
DB11315MethscopolamineNot Available
DB12086OxitropiumNot Available
DB00209TrospiumFor the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency, detrusor instability and frequency of micturition.
DB00219OxyphenoniumFor the treatment of visceral spasms
DB00424HyoscyamineFor treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease and rhinitis.
DB00483Gallamine TriethiodideFor use as adjuncts to anesthesia to induce skeletal muscle relaxation and to facilitate the management of patients undergoing mechanical ventilation
DB00496DarifenacinFor the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency and frequency.
DB00517Anisotropine MethylbromideFor use in conjunction with antacids or histamine H2-receptor antagonists in the treatment of peptic ulcer, to reduce further gastric acid secretion and delay gastric emptying.
DB00657MecamylamineFor the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension
DB00670PirenzepineFor the treatment of peptic ulcer, gastric ulcer, and duodenal ulcer.
DB00732Atracurium besylateFor use, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
DB00782PropanthelineFor the treatment of enuresis. It has also been used for hyperhidrosis, and cramps or spasms of the stomach, intestines or bladder.
DB00804DicyclomineFor the treatment of functional bowel/irritable bowel syndrome including Colicky abdominal pain; diverticulitis
DB00908QuinidineFor the treatment of ventricular pre-excitation and cardiac dysrhythmias
DB00940MethanthelineFor the treatment of peptic ulcer disease, irritable bowel syndrome, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, and reflex neurogenic bladder in children.
DB00967DesloratadineFor the relief of symptoms of seasonal allergic rhinitis, perennial (non-seasonal) allergic rhinitis. Desloratidine is also used for the sympomatic treatment of pruritus and urticaria (hives) associated with chronic idiopathic urticaria.
DB01036TolterodineFor the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).
DB01062OxybutyninFor the treatment of overactive bladder.
DB01090PentoliniumUsed to produce controlled hypotension during surgical procedures and in hypertensive crises.
DB01116TrimethaphanFor the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies.
DB01199TubocurarineUsed as a diagnosis agent for myasthenia gravis, and also to facilitate the intubation after induction of anesthesia in surgical procedure
DB01337PancuroniumUsed as a muscle relaxant during anesthesia and surgical procedures.
DB01338PipecuroniumUsed as a muscle relaxant during anesthesia and surgical procedures.
DB01339VecuroniumVecuronium is a muscle relaxing agent and is used as an ajunct in general anesthesia.
DB01591SolifenacinFor the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency.
DB06702FesoterodineFor the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).
DB08960HexamethoniumNot Available
DB09007ChlorphenoxamineNot Available
DB09023BenactyzineNot Available
DB09300Scopolamine butylbromideUsed to treat abdmoninal cramping and pain [FDA Label].
DrugDrug NameTargetType
DB00245BenzatropineMuscarinic acetylcholine receptor M1target
DB00245BenzatropineSodium-dependent dopamine transportertarget
DB00245BenzatropineHistamine H1 receptortarget
DB00245BenzatropineCytochrome P450 2C19enzyme
DB00245BenzatropineCytochrome P450 2D6enzyme
DB00332Ipratropium bromideMuscarinic acetylcholine receptor M1target
DB00332Ipratropium bromideMuscarinic acetylcholine receptor M2target
DB00332Ipratropium bromideCytochrome P450 2D6enzyme
DB00332Ipratropium bromideCytochrome P450 3A4enzyme
DB00332Ipratropium bromideMuscarinic acetylcholine receptor M3target
DB00332Ipratropium bromideSolute carrier family 22 member 5transporter
DB00332Ipratropium bromideSolute carrier family 22 member 4transporter
DB00376TrihexyphenidylMuscarinic acetylcholine receptor M1target
DB00376TrihexyphenidylMuscarinic acetylcholine receptor M2target
DB00376TrihexyphenidylMuscarinic acetylcholine receptor M3target
DB00376TrihexyphenidylMuscarinic acetylcholine receptor M4target
DB00376TrihexyphenidylMuscarinic acetylcholine receptor M5target
DB00387ProcyclidineMuscarinic acetylcholine receptor M1target
DB00387ProcyclidineMuscarinic acetylcholine receptor M2target
DB00387ProcyclidineMuscarinic acetylcholine receptor M4target
DB00387ProcyclidineMuscarinic acetylcholine receptor M3target
DB00392EthopropazineGlutamate receptor ionotropic, NMDA 3Atarget
DB00392EthopropazineMuscarinic acetylcholine receptor M1target
DB00392EthopropazineCholinesteraseenzyme
DB00392EthopropazineMuscarinic acetylcholine receptor M2target
DB00572AtropineMuscarinic acetylcholine receptor M2target
DB00572AtropineMuscarinic acetylcholine receptor M1target
DB00572AtropineMuscarinic acetylcholine receptor M4target
DB00572AtropineMuscarinic acetylcholine receptor M5target
DB00572AtropineMuscarinic acetylcholine receptor M3target
DB00572AtropineCytochrome P450 1A2enzyme
DB00572AtropineGlycine receptor subunit alpha-1target
DB00572AtropineNeuronal acetylcholine receptor subunit alpha-4target
DB00572AtropineNeuronal acetylcholine receptor subunit beta-2target
DB00747ScopolamineMuscarinic acetylcholine receptor M1target
DB00747ScopolamineSucrase-isomaltase, intestinaltarget
DB00747ScopolamineMuscarinic acetylcholine receptor M2target
DB00747ScopolamineMuscarinic acetylcholine receptor M3target
DB00747ScopolamineMuscarinic acetylcholine receptor M4target
DB00747ScopolamineMuscarinic acetylcholine receptor M5target
DB00747ScopolamineMultidrug resistance protein 1transporter
DB00747ScopolamineNeuronal acetylcholine receptor subunit alpha-4target
DB00747ScopolamineNeuronal acetylcholine receptor subunit beta-2target
DB00809TropicamideMuscarinic acetylcholine receptor M4target
DB00809TropicamideMuscarinic acetylcholine receptor M1target
DB00809TropicamideMuscarinic acetylcholine receptor M2target
DB00809TropicamideMuscarinic acetylcholine receptor M3target
DB00810BiperidenNeuronal acetylcholine receptor subunit alpha-2target
DB00810BiperidenMuscarinic acetylcholine receptor M1target
DB00810BiperidenMultidrug resistance protein 1transporter
DB00810BiperidenCytochrome P450 2D6enzyme
DB00979CyclopentolateMuscarinic acetylcholine receptor M1target
DB00979CyclopentolateCholinesteraseenzyme
DB00986GlycopyrroniumMuscarinic acetylcholine receptor M1target
DB00986GlycopyrroniumMuscarinic acetylcholine receptor M3target
DB00986GlycopyrroniumMuscarinic acetylcholine receptor M2target
DB01173OrphenadrineGlutamate receptor ionotropic, NMDA 1target
DB01173OrphenadrineGlutamate receptor ionotropic, NMDA 2Dtarget
DB01173OrphenadrineGlutamate receptor ionotropic, NMDA 3Btarget
DB01173OrphenadrineGlutamate receptor ionotropic, NMDA 3Atarget
DB01173OrphenadrineHistamine H1 receptortarget
DB01173OrphenadrineCytochrome P450 2B6enzyme
DB01173OrphenadrineCytochrome P450 2E1enzyme
DB01173OrphenadrineCytochrome P450 3A4enzyme
DB01173OrphenadrineSodium-dependent noradrenaline transportertarget
DB01173OrphenadrineSodium channel protein type 10 subunit alphatarget
DB01173OrphenadrineCytochrome P450 1A2enzyme
DB01409TiotropiumMuscarinic acetylcholine receptor M3target
DB01409TiotropiumCytochrome P450 2D6enzyme
DB01409TiotropiumCytochrome P450 3A4enzyme
DB01409TiotropiumMuscarinic acetylcholine receptor M1target
DB01409TiotropiumMuscarinic acetylcholine receptor M2target
DB01409TiotropiumSolute carrier family 22 member 5transporter
DB01409TiotropiumSolute carrier family 22 member 4transporter
DB01409TiotropiumMuscarinic acetylcholine receptor M4target
DB01409TiotropiumMuscarinic acetylcholine receptor M5target
DB00340MetixeneMuscarinic acetylcholine receptor M2target
DB00340MetixeneMuscarinic acetylcholine receptor M1target
DB00340MetixeneMuscarinic acetylcholine receptor M4target
DB00340MetixeneMuscarinic acetylcholine receptor M5target
DB00340MetixeneMuscarinic acetylcholine receptor M3target
DB08897AclidiniumMuscarinic acetylcholine receptor M1target
DB08897AclidiniumMuscarinic acetylcholine receptor M2target
DB08897AclidiniumMuscarinic acetylcholine receptor M3target
DB08897AclidiniumMuscarinic acetylcholine receptor M4target
DB08897AclidiniumMuscarinic acetylcholine receptor M5target
DB08897AclidiniumCholinesteraseenzyme
DB09076UmeclidiniumMuscarinic acetylcholine receptor M1target
DB09076UmeclidiniumMuscarinic acetylcholine receptor M2target
DB09076UmeclidiniumMuscarinic acetylcholine receptor M3target
DB09076UmeclidiniumMuscarinic acetylcholine receptor M4target
DB09076UmeclidiniumMuscarinic acetylcholine receptor M5target
DB09076UmeclidiniumCytochrome P450 2D6enzyme
DB09076UmeclidiniumMultidrug resistance protein 1transporter
DB11181HomatropineLiver carboxylesterase 1target
DB00209TrospiumMuscarinic acetylcholine receptor M1target
DB00209TrospiumCytochrome P450 2D6enzyme
DB00219OxyphenoniumMuscarinic acetylcholine receptor M1target
DB00424HyoscyamineMuscarinic acetylcholine receptor M1target
DB00424HyoscyamineMuscarinic acetylcholine receptor M2target
DB00424HyoscyamineMuscarinic acetylcholine receptor M3target
DB00424HyoscyamineMuscarinic acetylcholine receptor M4target
DB00483Gallamine TriethiodideNeuronal acetylcholine receptor subunit alpha-2target
DB00483Gallamine TriethiodideMuscarinic acetylcholine receptor M2target
DB00483Gallamine TriethiodideAcetylcholinesterasetarget
DB00483Gallamine TriethiodideMuscarinic acetylcholine receptor M1target
DB00483Gallamine TriethiodideMuscarinic acetylcholine receptor M5target
DB00496DarifenacinMuscarinic acetylcholine receptor M3target
DB00496DarifenacinCytochrome P450 3A4enzyme
DB00496DarifenacinCytochrome P450 2D6enzyme
DB00496DarifenacinMuscarinic acetylcholine receptor M1target
DB00496DarifenacinMuscarinic acetylcholine receptor M2target
DB00496DarifenacinMuscarinic acetylcholine receptor M4target
DB00496DarifenacinMuscarinic acetylcholine receptor M5target
DB00517Anisotropine MethylbromideMuscarinic acetylcholine receptor M1target
DB00517Anisotropine MethylbromideMuscarinic acetylcholine receptor M2target
DB00517Anisotropine MethylbromideMuscarinic acetylcholine receptor M3target
DB00657MecamylamineNeuronal acetylcholine receptor subunit alpha-2target
DB00657MecamylamineNeuronal acetylcholine receptor subunit alpha-7target
DB00657MecamylamineNeuronal acetylcholine receptor subunit alpha-4target
DB00657MecamylamineNeuronal acetylcholine receptor subunit beta-2target
DB00670PirenzepineMuscarinic acetylcholine receptor M1target
DB00732Atracurium besylateNeuronal acetylcholine receptor subunit alpha-2target
DB00782PropanthelineMuscarinic acetylcholine receptor M1target
DB00804DicyclomineMuscarinic acetylcholine receptor M1target
DB00804DicyclomineMuscarinic acetylcholine receptor M2target
DB00804DicyclomineCytochrome P450 1A1enzyme
DB00908QuinidineSodium channel protein type 5 subunit alphatarget
DB00908QuinidineAlpha-1-acid glycoprotein 1carrier
DB00908QuinidinePotassium voltage-gated channel subfamily H member 2target
DB00908QuinidinePotassium channel subfamily K member 1target
DB00908QuinidinePotassium channel subfamily K member 6target
DB00908QuinidineCytochrome P450 1A2enzyme
DB00908QuinidineCytochrome P450 2E1enzyme
DB00908QuinidineCytochrome P450 1A1enzyme
DB00908QuinidineCytochrome P450 2D6enzyme
DB00908QuinidineCytochrome P450 3A4enzyme
DB00908QuinidineCytochrome P450 3A7enzyme
DB00908QuinidineSolute carrier family 22 member 2transporter
DB00908QuinidineSolute carrier family 22 member 1transporter
DB00908QuinidineSolute carrier family 22 member 5transporter
DB00908QuinidineBile salt export pumptransporter
DB00908QuinidineMultidrug resistance protein 1transporter
DB00908QuinidineSolute carrier organic anion transporter family member 1A2transporter
DB00908QuinidineSolute carrier family 22 member 8transporter
DB00908QuinidineCanalicular multispecific organic anion transporter 1transporter
DB00908QuinidineSolute carrier family 22 member 4transporter
DB00908QuinidineSolute carrier organic anion transporter family member 1B1transporter
DB00908QuinidineCytochrome P450 2B6enzyme
DB00908QuinidineCytochrome P450 2C8enzyme
DB00908QuinidineCytochrome P450 2C9enzyme
DB00908QuinidineAlpha-1A adrenergic receptortarget
DB00908QuinidineAlpha-1B adrenergic receptortarget
DB00908QuinidineAlpha-1D adrenergic receptortarget
DB00940MethanthelineMuscarinic acetylcholine receptor M1target
DB00940MethanthelineHistamine H2 receptortarget
DB00967DesloratadineHistamine H1 receptortarget
DB00967DesloratadineCytochrome P450 2C9enzyme
DB00967DesloratadineCytochrome P450 2C19enzyme
DB00967DesloratadineCytochrome P450 1A2enzyme
DB00967DesloratadineCytochrome P450 2D6enzyme
DB00967DesloratadineMultidrug resistance protein 1transporter
DB01036TolterodineMuscarinic acetylcholine receptor M1target
DB01036TolterodineMuscarinic acetylcholine receptor M2target
DB01036TolterodineMuscarinic acetylcholine receptor M3target
DB01036TolterodineCytochrome P450 2D6enzyme
DB01036TolterodineCytochrome P450 3A4enzyme
DB01036TolterodineCytochrome P450 2C9enzyme
DB01036TolterodineCytochrome P450 2C19enzyme
DB01036TolterodineMuscarinic acetylcholine receptor M4target
DB01036TolterodineMuscarinic acetylcholine receptor M5target
DB01062OxybutyninMuscarinic acetylcholine receptor M1target
DB01062OxybutyninMuscarinic acetylcholine receptor M2target
DB01062OxybutyninMuscarinic acetylcholine receptor M3target
DB01062OxybutyninCytochrome P450 3A4enzyme
DB01062OxybutyninCytochrome P450 2C8enzyme
DB01062OxybutyninCytochrome P450 2D6enzyme
DB01062OxybutyninCytochrome P450 3A5enzyme
DB01090PentoliniumNeuronal acetylcholine receptor subunit alpha-10target
DB01090PentoliniumNeuronal acetylcholine receptor subunit alpha-3target
DB01090PentoliniumNeuronal acetylcholine receptor subunit beta-4target
DB01116TrimethaphanNeuronal acetylcholine receptor subunit alpha-10target
DB01116TrimethaphanCholinesteraseenzyme
DB01199TubocurarineNeuronal acetylcholine receptor subunit alpha-2target
DB01199TubocurarineAcetylcholinesterasetarget
DB01199Tubocurarine5-hydroxytryptamine receptor 3Atarget
DB01199TubocurarineSolute carrier family 22 member 1transporter
DB01199TubocurarineSolute carrier family 22 member 2transporter
DB01199TubocurarineNeuronal acetylcholine receptor subunit alpha-7target
DB01337PancuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB01337PancuroniumCholinesteraseenzyme
DB01337PancuroniumMuscarinic acetylcholine receptor M2target
DB01337PancuroniumMuscarinic acetylcholine receptor M3target
DB01337PancuroniumSolute carrier family 22 member 1transporter
DB01337PancuroniumSolute carrier family 22 member 2transporter
DB01338PipecuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB01338PipecuroniumMuscarinic acetylcholine receptor M2target
DB01338PipecuroniumMuscarinic acetylcholine receptor M3target
DB01338PipecuroniumCholinesteraseenzyme
DB01339VecuroniumSolute carrier family 22 member 1transporter
DB01339VecuroniumMultidrug resistance protein 1transporter
DB01339VecuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB01591SolifenacinMuscarinic acetylcholine receptor M3target
DB01591SolifenacinMuscarinic acetylcholine receptor M1target
DB01591SolifenacinCytochrome P450 3A4enzyme
DB01591SolifenacinMuscarinic acetylcholine receptor M2target
DB01591SolifenacinMuscarinic acetylcholine receptor M4target
DB01591SolifenacinMuscarinic acetylcholine receptor M5target
DB06702FesoterodineMuscarinic acetylcholine receptor M1target
DB06702FesoterodineMuscarinic acetylcholine receptor M3target
DB06702FesoterodineCytochrome P450 3A4enzyme
DB06702FesoterodineMuscarinic acetylcholine receptor M2target
DB06702FesoterodineMuscarinic acetylcholine receptor M4target
DB06702FesoterodineMuscarinic acetylcholine receptor M5target
DB06702FesoterodineCytochrome P450 2D6enzyme
DB06702FesoterodineMultidrug resistance protein 1transporter
DB09300Scopolamine butylbromideMuscarinic acetylcholine receptor M3target
DB09300Scopolamine butylbromideMuscarinic acetylcholine receptor M2target