Glucocorticoids

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
DrugDrug NameDrug Description
DB01384ParamethasoneFor the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary...
DB13208PrednylidenePrednylidene is an experimental systemic glucocorticoid.
DB00620TriamcinoloneA glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues.
DB00253MedrysoneA topical glucocorticoid applied ophthalmically for the treatment of various ocular inflammatory or allergic conditions.
DB00288AmcinonideA topical corticosteroid used in the treatment of inflammation and pruritus due to a variety of dermatoses.
DB00324FluorometholoneAn ophthalmic corticosteroid used for the relief of inflammation located in both the palpebral and bulbar conjunctiva, the cornea, and the anterior segment of the globe of the eye.
DB00394Beclomethasone dipropionateAn inhaled corticosteroid used as maintenance treatment in the prophylaxis of asthma attacks.
DB00443BetamethasoneA systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders.
DB00635PrednisoneA corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.
DB00896RimexoloneA glucocorticoid used to treat inflammation of the eye.
DB01013Clobetasol propionateA corticosteroid used to treat corticosteroid-responsive dermatoses and plaque psoriasis.
DB01047FluocinonideA high potency corticosteroid commonly used topically for a number of inflammatory skin conditions.
DB01410CiclesonideA glucocorticoid used in the symptomatic relief of nasal symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents.
DB08970FluprednideneFluprednidene is a corticosteroid.
DB08971FluocortoloneFluocortolone is a glucocorticoid with anti-inflammatory activity used topically for various skin disorders.
DB09095DifluocortoloneA topical corticosteroid used for the symptomatic treatment of inflammatory skin disorders like eczema, seborrheic eczema, lichen planus and psoriasis.
DB11487Dexamethasone isonicotinateDexamethasone isonicotinate is an anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, topically, and parenterally. Its unintended mineralocorticoid action may cause salt and water retention.
DB11750ClobetasolClobetasol is under investigation for the treatment of Scleroderma. Clobetasol has been investigated for the prevention of Psoriasis and Cutaneous Atrophy Due to Corticosteroids.
DB08906Fluticasone furoateAn inhaled corticosteroid that can be used as maintenance treatment of asthma and/or chronic obstructive pulmonary disease (COPD) depending on the product. Also available as a nasal spray to manage symptoms of allergic rhinitis.
DB09383MeprednisoneNot Annotated
DB11921DeflazacortA corticosteroid used to treat Duchenne muscular dystrophy.
DB13003CortivazolCortivazol is under investigation in clinical trial NCT00804895 (Cluster Headache Cortivazol Injection (CHCI)).
DB13843CloprednolCloprednol is a synthetic glucocorticoid that has been investigated for use in the treatment of asthma. [A31775,A31776]
DB00764MometasoneA corticosteroid used to treat asthma and allergic rhinitis.
DB01380Cortisone acetateA steroid hormone used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses and endocrine disorders associated with inadequate production of steroid hormones.
DB13867FluticasoneFluticasone's 2 esters are indicated as inhalers for the treatment and management of asthma by prophylaxis[FDA Label] as well as inflammatory and pruritic dermatoses . A DB00588 nasal spray is...
DB14512Mometasone furoateA corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus.
DB14631Prednisolone phosphateA corticosteroid used to treat inflammation, immune reactions, as well as endocrine or neoplastic conditions.
DB14633Prednisolone hemisuccinateNot Annotated
DB14634Fluprednidene acetateFluprednidene acetate is a corticosteroid. It has anti-inflammatory and anti-allergic properties.
DB14644Methylprednisolone hemisuccinateA water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders.
DB14646Prednisone acetateNot Annotated
DB14652Clocortolone acetateNot Annotated
DB14659Melengestrol acetateA 6-methyl progesterone acetate with reported glucocorticoid activity and effect on estrus.
DB14669Betamethasone phosphateNot Annotated
DB14681CortisoneA naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to...
DB13728HalometasoneNot Annotated
DrugDrug NameTargetType
DB01384ParamethasoneCorticosteroid-binding globulincarrier
DB01384ParamethasoneGlucocorticoid receptortarget
DB01384ParamethasoneCytochrome P450 3A4enzyme
DB01384ParamethasoneCytochrome P450 3A5enzyme
DB13208PrednylideneCytochrome P450 3A4enzyme
DB13208PrednylideneCytochrome P450 3A5enzyme
DB00620TriamcinoloneCorticosteroid-binding globulincarrier
DB00620TriamcinoloneGlucocorticoid receptortarget
DB00620TriamcinoloneCytochrome P450 3A4enzyme
DB00620TriamcinoloneProstaglandin G/H synthase 2enzyme
DB00620TriamcinoloneCholinesteraseenzyme
DB00620TriamcinoloneCytochrome P450 3A5enzyme
DB00620TriamcinoloneCytochrome P450 3A7enzyme
DB00620TriamcinoloneSerum albumincarrier
DB00253MedrysoneCorticosteroid-binding globulincarrier
DB00253MedrysoneGlucocorticoid receptortarget
DB00253MedrysoneCytochrome P450 3A4enzyme
DB00253MedrysoneCytochrome P450 3A5enzyme
DB00288AmcinonideGlucocorticoid receptortarget
DB00288AmcinonideAnnexin A1target
DB00288AmcinonideCytochrome P450 3A4enzyme
DB00288AmcinonideCytochrome P450 3A5enzyme
DB00324FluorometholoneCorticosteroid-binding globulincarrier
DB00324FluorometholoneCytochrome P450 3A4enzyme
DB00324FluorometholoneGlucocorticoid receptortarget
DB00324FluorometholoneCytochrome P450 3A5enzyme
DB00394Beclomethasone dipropionateCorticosteroid-binding globulincarrier
DB00394Beclomethasone dipropionateGlucocorticoid receptortarget
DB00394Beclomethasone dipropionateCytochrome P450 3A5enzyme
DB00394Beclomethasone dipropionateCytochrome P450 3A4enzyme
DB00394Beclomethasone dipropionateP-glycoprotein 1transporter
DB00394Beclomethasone dipropionateATP-binding cassette sub-family G member 2transporter
DB00394Beclomethasone dipropionateSolute carrier organic anion transporter family member 1B1transporter
DB00394Beclomethasone dipropionateSolute carrier organic anion transporter family member 1B3transporter
DB00443BetamethasoneGlucocorticoid receptortarget
DB00443BetamethasoneCytochrome P450 3A4enzyme
DB00443BetamethasoneP-glycoprotein 1transporter
DB00443BetamethasoneCytochrome P450 19A1enzyme
DB00443BetamethasoneCytochrome P450 3A5enzyme
DB00635PrednisoneGlucocorticoid receptortarget
DB00635PrednisoneCytochrome P450 3A4enzyme
DB00635PrednisoneP-glycoprotein 1transporter
DB00635PrednisoneSolute carrier organic anion transporter family member 1A2transporter
DB00635PrednisoneCytochrome P450 2C19enzyme
DB00635PrednisoneSerum albumincarrier
DB00635PrednisoneCytochrome P450 3A5enzyme
DB00635PrednisoneCorticosteroid-binding globulincarrier
DB00635PrednisoneCytochrome P450 3A Subfamilyenzyme
DB00635PrednisoneCytochrome P450 2A6enzyme
DB00635PrednisoneCytochrome P450 1B1enzyme
DB00635PrednisoneCytochrome P450 2B6enzyme
DB00635PrednisoneCytochrome P450 2C8enzyme
DB00635PrednisoneCytochrome P450 2C9enzyme
DB00635PrednisoneCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
DB00896RimexoloneCorticosteroid-binding globulincarrier
DB00896RimexoloneGlucocorticoid receptortarget
DB00896RimexoloneCytochrome P450 3A4enzyme
DB00896RimexoloneCytochrome P450 3A5enzyme
DB01013Clobetasol propionateGlucocorticoid receptortarget
DB01013Clobetasol propionateCytochrome P450 3A4enzyme
DB01013Clobetasol propionateCytochrome P450 3A5enzyme
DB01013Clobetasol propionateAnnexin A1target
DB01013Clobetasol propionateMineralocorticoid receptortarget
DB01013Clobetasol propionateCorticosteroid-binding globulincarrier
DB01013Clobetasol propionateSerum albumincarrier
DB01047FluocinonideCorticosteroid-binding globulincarrier
DB01047FluocinonideGlucocorticoid receptortarget
DB01047FluocinonideSmoothened homologtarget
DB01047FluocinonideCytochrome P450 3A4enzyme
DB01047FluocinonideCytochrome P450 3A5enzyme
DB01410CiclesonideCorticosteroid-binding globulincarrier
DB01410CiclesonideCytochrome P450 3A4enzyme
DB01410CiclesonideCytochrome P450 2D6enzyme
DB01410CiclesonideGlucocorticoid receptortarget
DB01410CiclesonideLiver carboxylesterase 1enzyme
DB08970FluprednideneCytochrome P450 3A4enzyme
DB08970FluprednideneCytochrome P450 3A5enzyme
DB08971FluocortoloneCytochrome P450 3A4enzyme
DB08971FluocortoloneCytochrome P450 3A5enzyme
DB09095DifluocortoloneAnnexin A3target
DB09095DifluocortoloneGlucocorticoid receptortarget
DB09095DifluocortoloneCytochrome P450 3A4enzyme
DB09095DifluocortoloneCytochrome P450 3A5enzyme
DB11487Dexamethasone isonicotinateCytochrome P450 3A4enzyme
DB11487Dexamethasone isonicotinateCytochrome P450 3A5enzyme
DB11750ClobetasolCytochrome P450 3A4enzyme
DB11750ClobetasolCytochrome P450 3A5enzyme
DB08906Fluticasone furoateCytochrome P450 3A4enzyme
DB08906Fluticasone furoateGlucocorticoid receptortarget
DB08906Fluticasone furoateP-glycoprotein 1transporter
DB08906Fluticasone furoateCytochrome P450 2C8enzyme
DB08906Fluticasone furoateSolute carrier organic anion transporter family member 1B1transporter
DB08906Fluticasone furoateCorticosteroid-binding globulincarrier
DB08906Fluticasone furoateP-glycoprotein 1carrier
DB08906Fluticasone furoateSolute carrier organic anion transporter family member 1B1carrier
DB08906Fluticasone furoateCytochrome P450 3A5enzyme
DB08906Fluticasone furoateCytochrome P450 3A7enzyme
DB08906Fluticasone furoateProgesterone receptortarget
DB08906Fluticasone furoateMineralocorticoid receptortarget
DB09383MeprednisoneSerum albumincarrier
DB09383MeprednisoneCytochrome P450 3A4enzyme
DB09383MeprednisoneCytochrome P450 3A5enzyme
DB11921DeflazacortCytochrome P450 3A4enzyme
DB11921DeflazacortGlucocorticoid receptortarget
DB11921DeflazacortCytochrome P450 3A5enzyme
DB13003CortivazolGlucocorticoid receptortarget
DB13003CortivazolCytochrome P450 3A4enzyme
DB13003CortivazolCytochrome P450 3A5enzyme
DB13843CloprednolCytochrome P450 3A4enzyme
DB13843CloprednolCytochrome P450 3A5enzyme
DB00764MometasoneGlucocorticoid receptortarget
DB00764MometasoneCytochrome P450 2C8enzyme
DB00764MometasoneProgesterone receptortarget
DB00764MometasoneCytochrome P450 3A4enzyme
DB00764MometasoneCytochrome P450 3A5enzyme
DB01380Cortisone acetateGlucocorticoid receptortarget
DB01380Cortisone acetateCytochrome P450 3A4enzyme
DB01380Cortisone acetateCytochrome P450 3A5enzyme
DB13867FluticasoneCytochrome P450 3A4enzyme
DB13867FluticasoneCytochrome P450 2C8enzyme
DB13867FluticasoneP-glycoprotein 1carrier
DB13867FluticasoneSolute carrier organic anion transporter family member 1B1carrier
DB13867FluticasoneP-glycoprotein 1transporter
DB13867FluticasoneSolute carrier organic anion transporter family member 1B1transporter
DB13867FluticasoneGlucocorticoid receptortarget
DB13867FluticasoneCorticosteroid-binding globulincarrier
DB13867FluticasoneCytochrome P450 3A5enzyme
DB13867FluticasoneCytochrome P450 3A7enzyme
DB13867FluticasoneProgesterone receptortarget
DB13867FluticasoneCytosolic phospholipase A2target
DB13867FluticasoneMineralocorticoid receptortarget
DB14512Mometasone furoateGlucocorticoid receptortarget
DB14512Mometasone furoateCytochrome P450 2C8enzyme
DB14512Mometasone furoateProgesterone receptortarget
DB14512Mometasone furoateCytochrome P450 3A4enzyme
DB14512Mometasone furoateCytochrome P450 3A5enzyme
DB14631Prednisolone phosphateCytochrome P450 3A4enzyme
DB14631Prednisolone phosphateCytochrome P450 3A5enzyme
DB14633Prednisolone hemisuccinateCytochrome P450 3A4enzyme
DB14633Prednisolone hemisuccinateCytochrome P450 3A5enzyme
DB14634Fluprednidene acetateCytochrome P450 3A4enzyme
DB14634Fluprednidene acetateCytochrome P450 3A5enzyme
DB14644Methylprednisolone hemisuccinateCytochrome P450 3A4enzyme
DB14644Methylprednisolone hemisuccinateCytochrome P450 3A5enzyme
DB14646Prednisone acetateCytochrome P450 3A4enzyme
DB14646Prednisone acetateCytochrome P450 3A5enzyme
DB14652Clocortolone acetateCytochrome P450 3A4enzyme
DB14652Clocortolone acetateCytochrome P450 3A5enzyme
DB14659Melengestrol acetateCytochrome P450 3A4enzyme
DB14659Melengestrol acetateCytochrome P450 3A5enzyme
DB14669Betamethasone phosphateCytochrome P450 3A4enzyme
DB14669Betamethasone phosphateCytochrome P450 3A5enzyme
DB14681CortisoneCytochrome P450 3A4enzyme
DB14681CortisoneCytochrome P450 3A5enzyme
DB13728HalometasoneCytochrome P450 3A4enzyme
DB13728HalometasoneCytochrome P450 3A5enzyme