Diagnostic Uses of Chemicals

Chemicals administered to patients in order to diagnose or study the pathology of medical conditions, diseases, or syndromes.
DrugDrug NameDrug Indication
DB11625PerflenapentNot Available
DB11705IomeprolNot Available
DB12091GadoliniumNot Available
DB12407IobitridolNot Available
DB12602PentetreotideNot Available
DB12821PerflubutaneNot Available
DB13539Iodoxamic acidNot Available
DB00225GadodiamideFor intravenous use in MRI to visualize lesions with abnormal vascularity (or those thought to cause abnormalities in the blood-brain barrier) in the brain (intracranial lesions), spine, and associated tissues.
DB00271DiatrizoateUsed, alone or in combination, for a wide variety of diagnostic imaging methods, including angiography, urography, cholangiography, computed tomography, hysterosalpingography, and retrograde pyelography. It can be used for imaging the gastrointestinal tract in patients allergic to barium.
DB00538GadoversetamideGadoversetamide is an MRI contrast agent used for MRI diagnostic procedures to provide increased enhancement and visualization of lesions of the brain, spine and liver, including tumors.
DB00556PerflutrenUsed as an ultrasound contrast imaging in cardiology and radiology.
DB00597GadoteridolGadoteridol is an MRI contrast agent used for contrast enhancement of the brain, spine and surrounding tissues resulting in improved visualization (compared with unenhanced MRI) of lesions with abnormal vascularity or those thought to cause a disruption of the normal blood brain barrier. Gadoteridol can also be used for whole body contrast enhanced MRI including the head, neck, liver, breast, musculoskeletal system and soft tissue pathologies.
DB00693FluoresceinFor diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.
DB00743Gadobenic acidGadobenate Dimeglumine is an MRI contrast agent used primarily for MR imaging of the liver. It can also be used for MRI of the heart, as well as and central nervous system in adults to visualize lesions with abnormal brain vascularity or abnormalities in the blood brain barrier, the brain, spine, or other associated tissues.
DB00789Gadopentetate dimeglumineFor use with magnetic resonance imaging (MRI) in adults, and pediatric patients (2 years of age and older) to visualize lesions with abnormal vascularity in the brain (intracranial lesions), spine and associated tissues as well as lesions with abnormal vascularity in the head and neck. Also used to facilitate the visualization of lesions with abnormal vascularity in the body (excluding the heart).
DB00965Ethiodized oilFor use as a radio-opaque medium for hysterosalpingography and lymphography, and as an antineoplastic agent when part of the iodine is 131-I. It is also used in follow-up imaging for chemoembolization.
DB01187IophendylateIophendylate is used as a contrast agent to locate spinal tumors.
DB01249IodixanolIodixanol is a contrast agent during coronary angiography.
DB01362IohexolIohexol ia used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures.
DB01578MetrizamideMetrizamide is used for lumbar, thoracic, cervical, and total columnar myelography to determine the presence of abnormalities in the spinal column, spinal canal, and central nervous system (CNS) as well as for cisternography by direct injection using standard radiologic techniques to visualize the basal cistern of the brain. For computerized tomography (CT) of the intracranial subarachnoid spaces and for ventriculography by direct injection using standard radiologic techniques to visualize the cerebral ventricles. Also used in pediatric angiocardiography to visualize lesions or malformations of the heart and obstructions or anomalies of the major thoracic vessels. Also used in adult peripheral arteriography to visualize specific regions of the vascular system and blood flow in such areas to help in the diagnosis and evaluation of neoplasms (known or suspected) or vascular diseases (congenital or acquired) that may cause changes in normal vascular anatomy or physiology. Metrizamide is also indicated in adults for intravenous digital arteriography of head and neck.
DB04711IodipamideIodipamide is used as a contrast agent for cholecystography and intravenous cholangiography.
DB05428motexafin gadoliniumInvestigated for use/treatment in brain cancer, cancer/tumors (unspecified), lung cancer, and lymphoma (non-hodgkin's).
DB05528MipomersenUsed in patients with homozygous familial hypercholesterolemia as an adjunct to diet and other lipid-lowering medications.
DB05791PerflubronInvestigated for use/treatment in cardiac surgery, hemorrhage, and ileus.
DB06642BevasiranibInvestigated for use/treatment in macular degeneration and diabetic retinopathy.
DB06703GadobutrolFor diagnostic use only. Indicated for adults and children age 2 and over for contrast enhancement during cranial and spinal MRI, and for contrast-enhanced magnetic resonance angiography (CE-MRA). Gadobutrol is particularly suited for the detection of very small lesions and for the visualization of tumors that do not readily take up contrast media. It may be a desired agent when the exclusion or demonstration of an additional pathology may influence the choice of therapy or patient management. It may also be suitable for perfusion studies in the diagnosis of stroke, detection of focal cerebral ischemia, and in studies of tumor perfusion.
DB06704IobenguaneDetection of primary and metastatic pheochromocytoma or neuroblastoma
DB06705Gadofosveset trisodiumGadofosveset trisodium is indicated for use as a contrast agent in magnetic resonance angiography (MRA) to evaluate aortoiliac occlusive disease (AIOD) in adults with known or suspected peripheral vascular disease.
DB06759FomivirsenIndicated for the local treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS), when other therapy has been ineffective or is considered unsuitable [FDA Label, L1428].
DB06796MangafodipirIndicated for use as an organ-specific paramagnetic contrast agent developed for imaging of the hepatobiliary system and detecting lesions in liver and pancreas.
DB08884Gadoxetic acidGadoxetate is used as a contrast medium for magnetic resonance imaging (MRI) to detect and characterize lesions in the liver.
DB08945Iotroxic acidNot Available
DB08946Iopanoic acidNot Available
DB08947IopamidolNot Available
DB08948IodamideNot Available
DB09132Gadoteric acidGadoteric acid is indicated for intravenous use with magnetic resonance imaging (MRI) in brain (intracranial), spine and associated tissues in adult and pediatric patients (2 years of age and older) to detect and visualize areas with disruption of the blood brain barrier (BBB) and/or abnormal vascularity.
DB09133Iothalamic acidConray is indicated for use in excretory urography, cerebral angiography, peripheral arteriography, venography, arthrography, direct cholangiography, endoscopic retrograde cholangiopancreatography, contrast enhancement of computed tomographic brain images, cranial computerized angiotomography, intravenous digital subtraction angiography and arterial digital subtraction angiography. Conray may also be used for enhancement of computed tomographic scans performed for detection and evaluation of lesions in the liver, pancreas, kidneys, abdominal aorta, mediastinum, abdominal cavity and retroperitoneal space.
DB09134IoversolOptiray 350 is indicated in adults for peripheral and coronary arteriography and left ventriculography. Optiray 350 is also indicated for contrast enhanced computed tomographic imaging of the head and body, intravenous excretory urography, intravenous digital subtraction angiography and venography. Optiray 350 is indicated in children for angiocardiography. Optiray 320 is indicated in adults for angiography throughout the cardiovascular system. The uses include cerebral, coronary, peripheral, visceral and renal arteriography, venography, aortography, and left ventriculography. Optiray 320 is also indicated for contrast enhanced computed tomographic imaging of the head and body, and intravenous excretory urography. Optiray 320 is indicated in children for angiocardiography, contrast enhanced computed tomographic imaging of the head and body, and intravenous excretory urography. Optiray 300 is indicated for cerebral angiography and peripheral arteriography. Optiray 300 is also indicated for contrast enhanced computed tomographic imaging of the head and body, venography, and intravenous excretory urography. Optiray 240 is indicated for cerebral angiography and venography. Optiray 240 is also indicated for contrast enhanced computed tomographic imaging of the head and body and intravenous excretory urography.
DB09135IoxilanWhen administered intra-arterially, Ioxilan is indicated for the following diagnostic tests: cerebral arteriography (300 mgI/mL), coronary arteriography and left ventriculography (350 mgI/mL), visceral angiography(350 mgI/mL), aortography(350 mgI/mL), and peripheral arteriography(350 mgI/mL). When administered intravenously, Ioxilan is indicated for excretory urography and contrast enhanced computed tomographic (CECT) imaging of the head and body (300 and 350 mgI/mL).
DB09137Technetium Tc-99m mebrofeninTechnetium Tc 99m Mebrofenin is indicated as a hepatobiliary imaging agent.
DB09138Technetium Tc-99m medronateTechnetium Tc 99m Medronate is indicated for use as a bone imaging agent to delineate areas of altered osteogenesis.
DB09156IopromideIopromide, as the product Iovist, is indicated for use as an X-ray contrast agent in the following procedures: Intra-arterial digital subtraction angiography (IA-DSA) (150 mg I/mL) Cerebral arteriography and peripheral arteriography (300 mg I/mL) Coronary arteriography and left ventriculography, visceral angiography and aortography (370 mg I/mL) Peripheral venography (240 mg I/mL) Excretory urography (300 mg I/mL) Contrast computed tomography (CT) imaging of head and body (300 mg I/mL and 370 mg I/mL)
DB09161Technetium Tc-99m sestamibiTechnetium Tc 99m Sestamibi is indicated for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and infarction (non-reversible defects); and 2) evaluating myocardial function and developing information for use in patient management decisions.
DB09163Technetium Tc-99m exametazimeTechnetium Tc99m exametazime scintigraphy (with or without methylene blue stabilization) may be useful as an adjunct in the detection of altered regional cerebral perfusion in stroke. Tc99m exametazime without methylene blue stabilization is indicated for leukocyte labeled scintigraphy as an adjunct in the localization of intra-abdominal infection and inflammatory bowel disease.
DB09164Technetium Tc-99m disofeninTechnetium Tc99m Disofenin is indicated as a hepatobiliary imaging agent. Hepatolite is indicated in the diagnosis of acute cholecystitis as well as to rule out the occurrence of acute cholecystitis in suspected patients with right upper quadrant pain, fever, jaundice, right upper quadrant tenderness and mass or rebound tenderness, but not limited to these signs and symptoms.
DB09165Technetium Tc-99m pyrophosphateFor use as a skeletal imaging agent used to demonstrate areas of altered osteogenesis, and a cardiac imaging agent used as an adjunct in the diagnosis of acute myocardial infarction [FDA Label]. May also be used to image gated blood pools and detect gastrointetinal bleeding.
DB09313Ioxaglic acidThis medicinal product is for diagnostic use only in adults and children as a low-osmolality medium [L1883], [A7924].
DB09314Technetium Tc-99m pertechnetateSodium Pertechnetate Tc99m Injection is indicated for use in adults for imaging in the following tissues: thyroid, salivary gland, urinary bladder (for detection of vesico-ureteral reflux), and nasolacrimal drainage system (dacryoscintigraphy). It is indicated for use in children for imaging the following tissues: thyroid and urinary bladder.
DB09333Iopodic acidIopodic acid is available as a cholecystographic agent. This denomination indicates the iopodic acid is a radiopaque substance that can be used to visualize the gallbladder and biliary channels in abdominal X-ray.[L1587, A32087] An abdominal X-ray uses a minimal amount of ionizing radiation to produce pictures of the inside of the abdominal cavity. It is commonly used to evaluate the stomach, liver, intestines, and spleen.[L1589] Iopodic acid has also been indicated for the treatment of hyperthyroidism such as Graves disease.[A32085, A32086] Hyperthyroidism refers to any condition where there is too much thyroid hormone produced in the body (overactive thyroid). When the overactivity involves the entire thyroid gland, it is known as Grave's disease.[L1590]
DB09340Tyropanoic acidFor use in cholecystography (X-ray diagnosis/imaging of gallstones).
DB09346Metrizoic acidFor use as a contrast medium [L1597].
DB09347Acetrizoic acidAcetrizoic acid indication was to be used as a contrast agent for X-ray. Some information indicates its nephrotropic property as one of the characteristics for the utilization of acetrizoic acid.[A32135] The X-ray imaging depends on the difference in tissue density which is provided by an X-ray attenuation between the area of interest and the surrounding tissue. The use of contrast agents will provoke a contrast enhancement or opacification and it will improve the differentiation of pathological processes from normal tissue.[T125]
DB09366PropyliodoneNot Available
DB09397Technetium Tc-99m sulfur colloidTechnetium 99m sulfur colloid is indicated as a diagnostic agent in adults for the following tests: localization of lymph nodes draining a primary tumor in patients with breast cancer or malignant melanoma; and evaluation of peritoneo-venous (LeVeen) shunt patency. It is indicated in both adult and pediatric patients for: imaging areas of functioning reticuloendothelial cells in the liver, spleen and bone marrow; and studies of esophageal transit and gastroesophageal reflux, and detection of pulmonary aspiration of gastric contents.
DB09487IotrolanNot Available
DB09502Fludeoxyglucose F-18The uptake of 18F-FDG by tissues is a marker for the tissue uptake of glucose, which in turn is closely correlated with certain types of tissue metabolism. Fludeoxyglucose F 18 Injection is indicated in positron emission tomography (PET) imaging for assessment of abnormal glucose metabolism to assist in the evaluation of malignancy in patients with known or suspected abnormalities found by other testing modalities, or in patients with an existing diagnoses of cancer.
DB11150Barium sulfate Barium sulfate is a radiographic contrast agent indicated for use in computed tomography (CT) of the abdomen to delineate the gastrointestinal (GI) tract in adult and pediatric patients [FDA label].
DrugDrug NameTargetType
DB00693FluoresceinIg kappa chain V-II region RPMI 6410target
DB00693FluoresceinDNAtarget
DB00693FluoresceinSolute carrier family 22 member 6transporter
DB00693FluoresceinBile salt export pumptransporter
DB00693FluoresceinMultidrug resistance-associated protein 1transporter
DB00693FluoresceinCytochrome P450 1A1enzyme
DB00743Gadobenic acidSerum albumincarrier
DB00789Gadopentetate dimeglumine6-phosphogluconate dehydrogenase, decarboxylatingtarget
DB04711IodipamideSerum albumincarrier
DB05428motexafin gadoliniumThioredoxin reductase 1, cytoplasmictarget
DB05428motexafin gadoliniumThioredoxin reductase 2, mitochondrialtarget
DB05428motexafin gadoliniumRibonucleoside-diphosphate reductase subunit M2target
DB05528MipomersenmRNA of ApoB-100target
DB06642BevasiranibVascular endothelial growth factor Atarget
DB06704IobenguaneSodium-dependent noradrenaline transportertransporter
DB06705Gadofosveset trisodiumSerum albumincarrier
DB06759Fomivirsen30 kDa immediate-early protein 2target
DB06759Fomivirsen45 kDa immediate-early protein 2target
DB06796MangafodipirAlpha-2-macroglobulincarrier
DB06796MangafodipirSerum albumincarrier
DB06796MangafodipirSuperoxide dismutase [Mn], mitochondrialenzyme
DB06796MangafodipirNatural resistance-associated macrophage protein 2transporter
DB08884Gadoxetic acidSolute carrier organic anion transporter family member 1B1transporter
DB08884Gadoxetic acidSolute carrier organic anion transporter family member 1B3transporter
DB08884Gadoxetic acidCanalicular multispecific organic anion transporter 2transporter
DB08884Gadoxetic acidCanalicular multispecific organic anion transporter 1transporter
DB08884Gadoxetic acidMultidrug resistance-associated protein 4transporter
DB09137Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B1transporter
DB09137Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B3transporter
DB09161Technetium Tc-99m sestamibiMultidrug resistance protein 1transporter
DB09161Technetium Tc-99m sestamibiMultidrug resistance-associated protein 1transporter
DB09165Technetium Tc-99m pyrophosphateHydroxyapatitetarget
DB09165Technetium Tc-99m pyrophosphateAmorphous calcium phosphatetarget
DB09333Iopodic acidThyroxine 5-deiodinasetarget
DB09333Iopodic acidSerum albumincarrier
DB09340Tyropanoic acidBeta-glucuronidaseenzyme
DB09347Acetrizoic acidSerum albumincarrier
DB09502Fludeoxyglucose F-18Hexokinase-1enzyme
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 4transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 2transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 1transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 3transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 9transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 5transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 6transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 7transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 8transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 10transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 11transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 12transporter