Diagnostic Uses of Chemicals

Chemicals administered to patients in order to diagnose or study the pathology of medical conditions, diseases, or syndromes.
DrugDrug NameDrug Description
DB00225GadodiamideA gadolinium-based contrast agent used for the visualization of lesions with vascularity during magnetic resonance imaging (MRI) scans.
DB00271DiatrizoateAn injected contrast agent used in radiology.
DB00538GadoversetamideA gadolinium compound used as a contrast agent in MRI tests of the brain, spine, and liver.
DB00556PerflutrenA diagnostic medication to improve contrast during echocardiograms.
DB00597GadoteridolA medication used to improve the contrast of MRI scans for better visualization.
DB00693FluoresceinA dye used in angiography or angioscopy of the iris and retina.
DB00743Gadobenic acidA gadolinium compound used as a contrast agent in MRIs.
DB00789Gadopentetic acidA gadolinium compound used as a contrast agent in MRIs.
DB00965Ethiodized oilA contrast agent used in imaging procedures.
DB01187IophendylateIophendylate is used as a contrast agent to locate spinal tumors.
DB01249IodixanolA contrast agent used during coronary angiography, particularly in patients with renal dysfunction.
DB01362IohexolA contrast agent for intrathecal administration used in myelography and contrast enhancement for computerized tomography.
DB01578MetrizamideMetrizamide is used for lumbar, thoracic, cervical, and total columnar myelography to determine the presence of abnormalities in the spinal column, spinal canal, and central nervous system (CNS) as well...
DB04711IodipamideA contrast agent used in cholangiography and cholecystography.
DB05428Motexafin gadoliniumInvestigated for use/treatment in brain cancer, cancer/tumors (unspecified), lung cancer, and lymphoma (non-hodgkin's).
DB05528MipomersenAn oligonucleotide drug used for the treatment of homozygous familial hypercholesterolemia.
DB05791PerflubronInvestigated for use/treatment in cardiac surgery, hemorrhage, and ileus.
DB06642BevasiranibInvestigated for use/treatment in macular degeneration and diabetic retinopathy.
DB06703GadobutrolA contrast agent used during diagnostic procedures to visualize disrupted areas of blood brain barrier (BBB) and/or abnormal vascularity of the central nervous system.
DB06704IobenguaneA radiopharmaceutical agent used for the diagnosis of primary and metastatic pheochromocytoma or neuroblastoma.
DB06705Gadofosveset trisodiumAn intravenous contrast agent used during magnetic resonance angiography (MRA) to evaluate aortoiliac occlusive disease (AIOD) in adults with peripheral vascular disease.
DB06759FomivirsenIndicated for the local treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS), when other therapy has been ineffective or is considered unsuitable [FDA Label, L1428].
DB06796MangafodipirAn organ-specific paramagnetic contrast agent indicated for the imaging of the hepatobiliary system and detecting lesions in the liver and pancreas.
DB08884Gadoxetic acidA gadolinium-based contrast agent used in magnetic resonance imaging (MRI) to help characterize lesions in the liver.
DB08945Iotroxic acidIotroxic acid is a contrast medium molecule.
DB08946Iopanoic acidIopanoic acid contains iodine and is useful as a contrast medium in cholecystography.
DB08947IopamidolA diagnostic imaging agent used for angiography throughout the cardiovascular system.
DB08948IodamideIodamide is a contrast medium molecule that is no longer marketed in the United States.
DB09132Gadoteric acidA diagnostic contrast agent used with magnetic resonance imaging to provide contrast enhancement for intracranial and spinal lesions with abnormal blood brain barrier or abnormal vascularity, and for whole body imaging.
DB09133Iothalamic acidA diagnostic contrast agent used in various medical imaging procedures, such as angiography, arthrography, and computed tomographic scans.
DB09134IoversolA diagnostic contrast agent used in various medical imaging procedures, such as angiography, urography, and computed tomographic scans.
DB09135IoxilanA diagnostic contrast agent used in various medical imaging procedures, such as angiography, urography, and computed tomographic scans.
DB09137Technetium Tc-99m mebrofeninA diagnostic radiopharmaceutical agent used during hepatobiliary imaging tests.
DB09138Technetium Tc-99m medronateA diagnostic radiopharmaceutical agent used as a bone imaging agent to delineate areas of altered osteogenesis.
DB09156IopromideAn X-ray contrast agent used during various types of imaging tests such as angiography and contrast computed tomography (CT) imaging tests.
DB09161Technetium Tc-99m sestamibiA radiopharmaceutical diagnostic agent used in nuclear medicine imaging tests to detect coronary artery disease and evaluate myocardial function.
DB09163Technetium Tc-99m exametazimeA radiopharmaceutical diagnostic agent used as an adjunct for scintigraphy in the detection of altered regional cerebral perfusion in stroke.
DB09164Technetium Tc-99m disofeninA radiopharmaceutical diagnostic agent used for hepatobiliary scans.
DB09165Technetium Tc-99m pyrophosphateA radiopharmaceutical diagnostic agent used for diagnostic imaging scans for the bones, heart, and gastrointestinal tract.
DB09313Ioxaglic acidA tri-iodinated benzoate contrast agent used in various radiological procedures including angiography, phlebography, urography, computed tomography (CT), and hysterosalpingography.
DB09314Technetium Tc-99m pertechnetateA radiocontrast agent used for the identification of various organs, including but not limited to the brain, thyroid, placenta, and bladder.
DB09333Iopodic acidAn iodine containing cholecystography agent.
DB09346Metrizoic acidFor use as a contrast medium .
DB09347Acetrizoic acidAcetrizoic acid indication was to be used as a contrast agent for X-ray. Some information indicates its nephrotropic property as one of the characteristics for the utilization of acetrizoic acid....
DB09366PropyliodoneRadiopaque medium usually in oil; used in bronchography.
DB09397Technetium Tc-99m sulfur colloidA radiopharmaceutical diagnostic agent used for the localization of lymph nodes, evaluation of peritoneovenous (LeVeen) shunt patency, imaging areas of functioning reticuloendothelial cells, and gastrointestinal imaging.
DB09480Iofetamine I-123Not Annotated
DB09487IotrolanNonionic, isotonic contrast medium designed for intrathecal use.
DB09502Fludeoxyglucose (18F)A radiopharmaceutical agent used for positron emission tomography (PET) imaging in oncology, cardiology, and neurology.
DB09508FerumoxidesNot Annotated
DB11150Barium sulfateA contrast agent used for CT scans of the gastrointestinal tract.
DB11625PerflenapentDodecafluoropentane is an ingredient in the EMA-withdrawn product EchoGen.
DB11705IomeprolIomeprol has been investigated for the diagnostic of Coronary Artery Disease.
DB12091GadoliniumGadolinium is under investigation in Hypertension, ACUTE KIDNEY INJURY, and Chronic Kidney Disease. Gadolinium has been investigated for the basic science of CAD, Multiple Sclerosis, and Coronary Artery Disease.
DB12407IobitridolIobitridol has been used in trials studying the diagnostic of Diagnostic Imaging, Coronary Artery Disease, Type 2 Diabetes Mellitus, and Coronary Atherosclerosis.
DB12602PentetreotidePentetreotide has been used in trials studying the diagnostic of cushing syndrome.
DB12821PerflubutanePerflubutane has been used in trials studying the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis, Portal Hypertension, and Peripheral Artery Disease. It is a cardiovascular drug designed to enable...
DB13428Iobenzamic acidNot Annotated
DB13444Ioxitalamic acidA contrast agent used for CT scans of the abdomen and pelvis.
DB13539Iodoxamic acidRadiopaque medium used in the diagnosis of gall bladder & bile duct diseases, usually as meglumine salt.
DB13568DiodoneNot Annotated
DB13741Ioglycamic acidNot Annotated
DB13861IopentolIopentol is used as a contrast medium.
DB14582PatisiranA transthyretin-directed small interfering RNA used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis.
DB15445Iodohippuric acidIodohippuric acid is under investigation in clinical trial NCT02599844 (Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults).
DB08824Ioflupane I-123A radiopharmaceutical used in single photon emission computed tomography (SPECT) brain imaging to help diagnose patients with suspected Parkinsonian syndromes.
DB09151Flutemetamol (18F)A radiopharmaceutical diagnostic agent used during Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients to diagnose the causes of cognitive impairment.
DB09160Technetium Tc-99m tetrofosminTechnetium-99m tetrofosmin is indicated for the diagnosis of heart abnormalities by exercise myocardial scintigraphy. The exercise myocardial scintigraphy is an established method for the diagnosis of the severity of coronary...
DB13811OblimersenNot Annotated
DB14713InotersenAn antisense oligonucleotide used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis.
DB14901InclisiranInclisiran is under investigation in clinical trial NCT03705234 (A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Disease).
DB14907Bevacizumab zirconium Zr-89Bevacizumab zirconium Zr-89 is under investigation in clinical trial NCT01338090 (89Zr-bevacizumab PET Imaging in Patients With Neuroendocrine Tumors).
DB15033FlortaucipirFlortaucipir is under investigation in clinical trial NCT03507257 (Longitudinal Early-onset Alzheimer's Disease Study Protocol).
DB15058FlutemetamolFlutemetamol is under investigation in clinical trial NCT02353949 (Investigating the Clinical Consequences of Flutemetamol-PET-scanning).
DB15134Fluoroazomycin arabinoside F-18Fluoroazomycin arabinoside F-18 is under investigation in clinical trial NCT03257150 (A Study of the Use of Irreversible Electroporation in Pancreatic Ductal Cancer).
DrugDrug NameTargetType
DB00693FluoresceinIg kappa chain V-II region RPMI 6410target
DB00693FluoresceinDNAtarget
DB00693FluoresceinSolute carrier family 22 member 6transporter
DB00693FluoresceinBile salt export pumptransporter
DB00693FluoresceinMultidrug resistance-associated protein 1transporter
DB00743Gadobenic acidSerum albumincarrier
DB00789Gadopentetic acid6-phosphogluconate dehydrogenase, decarboxylatingtarget
DB04711IodipamideSerum albumincarrier
DB05428Motexafin gadoliniumThioredoxin reductase 1, cytoplasmictarget
DB05428Motexafin gadoliniumThioredoxin reductase 2, mitochondrialtarget
DB05428Motexafin gadoliniumRibonucleoside-diphosphate reductase subunit M2target
DB05528MipomersenmRNA of ApoB-100target
DB06642BevasiranibVascular endothelial growth factor Atarget
DB06704IobenguaneSodium-dependent noradrenaline transportertransporter
DB06705Gadofosveset trisodiumSerum albumincarrier
DB06759Fomivirsen30 kDa immediate-early protein 2target
DB06759Fomivirsen45 kDa immediate-early protein 2target
DB06796MangafodipirAlpha-2-macroglobulincarrier
DB06796MangafodipirSerum albumincarrier
DB06796MangafodipirSuperoxide dismutase [Mn], mitochondrialenzyme
DB06796MangafodipirNatural resistance-associated macrophage protein 2transporter
DB08884Gadoxetic acidSolute carrier organic anion transporter family member 1B1transporter
DB08884Gadoxetic acidSolute carrier organic anion transporter family member 1B3transporter
DB08884Gadoxetic acidCanalicular multispecific organic anion transporter 2transporter
DB08884Gadoxetic acidCanalicular multispecific organic anion transporter 1transporter
DB08884Gadoxetic acidMultidrug resistance-associated protein 4transporter
DB09137Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B1transporter
DB09137Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B3transporter
DB09161Technetium Tc-99m sestamibiP-glycoprotein 1transporter
DB09161Technetium Tc-99m sestamibiMultidrug resistance-associated protein 1transporter
DB09165Technetium Tc-99m pyrophosphateHydroxyapatitetarget
DB09165Technetium Tc-99m pyrophosphateAmorphous calcium phosphatetarget
DB09333Iopodic acidThyroxine 5-deiodinasetarget
DB09333Iopodic acidSerum albumincarrier
DB09347Acetrizoic acidSerum albumincarrier
DB09502Fludeoxyglucose (18F)Hexokinase-1enzyme
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 4transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 2transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 1transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 3transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 9transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 5transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 6transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 7transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 8transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 10transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 11transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 12transporter
DB14582PatisiranTransthyretin mRNAtarget
DB14582PatisiranSerum albumincarrier
DB14582Patisiranalpha1-acid glycoproteincarrier
DB08824Ioflupane I-123Sodium-dependent dopamine transportertransporter
DB09151Flutemetamol (18F)Amyloid beta A4 proteintarget
DB09160Technetium Tc-99m tetrofosminP-glycoprotein 1carrier
DB14713InotersenTransthyretin mRNAtarget